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ClinicalTrials.gov public records Last synced Nov 15, 2026, 7:57 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 265–288 of 798 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Smoking Cigarette Clear all

Conditions: Cigarette Smoking
Interventions: D-cycloserine, Nicotine Replacement Therapy (patch), Smoking Cue Exposure, Progressive Muscle Relaxation, Placebo; Drug · Behavioral
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 21 Years to 55 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: New York, New York

Conditions: Cigarette Smoking, Smoking Cessation
Interventions: Contingency Management (CM), Transdermal nicotine skin patches (i.e. Habitrol), Supportive Counseling; Behavioral · Drug · Other
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 33 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Smoking Cessation, Electronic Cigarette Use
Interventions: Varenicline, Nicotine patch, Dual Focused Cessation Counseling, Smoking Focused Cessation Counseling, Counseling Intensity: 1 Session, Counseling Intensity: 4 Sessions; Drug · Behavioral · Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 21 Years and older
Enrollment: 500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Smoking
Interventions: Brenipatide, Placebo; Drug
Lead sponsor: Eli Lilly and Company; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 222 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 18
States / cities: Rogers, Arkansas • DeLand, Florida • Hollywood, Florida + 15 more

Conditions: Electronic Cigarette Use
Interventions: RELX ENDS Tobacco Flavor 1, RELX ENDS Tobacco Flavor 2, RELX ENDS Menthol Flavor 1, RELX ENDS Menthol Flavor 2; Other
Lead sponsor: Cheerain HK Limited; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021
U.S. locations: 1
States / cities: Burbank, California

Conditions: Smoking, Heavy Episodic Drinking
Interventions: Tobacco Status Project Intervention, Tobacco Status Project + Alcohol Intervention, nicotine patch; Behavioral · Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 25 Years
Enrollment: 179 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Pulmonary Disease, Chronic Obstructive, Cigarette Smoking, Telemedicine
Interventions: smoking cessation, early COPD detection, electronic visit, Treatment As Usual; Behavioral · Other
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 40 Years and older
Enrollment: 125 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Electronic Cigarette Use
Interventions: Social Media Use Reduction; Behavioral
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 25 Years
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Tobacco Smoking Behavior
Interventions: Reduced Nicotine Cigarettes, Reduced ROS/RNS, Control; Other
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 21 Years to 65 Years
Enrollment: 37 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Cigarette Smoking, Nicotine Dependence
Interventions: Choose to Change, Enhanced usual care; Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older
Enrollment: 190 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
Interventions: Product A1, Product B, Product C, Product D, Product A2, Product E, Product F, Product G, Product H, Product N; Other
Lead sponsor: RAI Services Company; Industry
Eligibility: 21 Years to 60 Years
Enrollment: 75 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Knoxville, Tennessee

Conditions: Tobacco Use Disorder
Interventions: Camel Snus, Marlboro Snus, Stonewall, Ariva, General Snus; Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 70 Years
Enrollment: 104 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2010
U.S. locations: 2
States / cities: Minneapolis, Minnesota • Eugene, Oregon

Conditions: E-Cig Use
Interventions: E-cig use; Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years to 29 Years
Enrollment: 41 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Smoking
Interventions: E-cigarette; Other
Lead sponsor: Prisma Health-Upstate; Other
Eligibility: 21 Years and older
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Greenville, South Carolina

Conditions: Cigarette Smoking, Inflammatory Response
Interventions: Cigarette Type Switching; Other
Lead sponsor: Rosalind Franklin University of Medicine and Science; Other
Eligibility: 21 Years to 85 Years
Enrollment: 68 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: North Chicago, Illinois

Conditions: Cigarette Smoking
Interventions: Enhanced Intervention Condition; Other
Lead sponsor: Boston University Charles River Campus; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Tobacco Smoking
Interventions: Smoking sessions; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 29 Years
Enrollment: 37 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Nicotine Dependence
Interventions: zonisamide, placebo; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 74 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Smoking, Tobacco
Interventions: P1213416, P1213422, P1213716, P1213722, P1211216, P1211222, P1213616, P1213622, P1213816, P1213822, P1211916, P1211922; Other
Lead sponsor: RAI Services Company; Industry
Eligibility: 21 Years to 60 Years
Enrollment: 1,845 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 12
States / cities: Phoenix, Arizona • Fort Lauderdale, Florida • Orlando, Florida + 9 more

Conditions: Smoking
Interventions: FT210771, FT210751, 6T30134157764, G41A7C071, M011161212, FT21002; Other
Lead sponsor: RAI Services Company; Industry
Eligibility: 21 Years to 60 Years
Enrollment: 210 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017
U.S. locations: 5
States / cities: Tempe, Arizona • Lexington, Kentucky • St Louis, Missouri + 2 more

Conditions: Cigarette Smoking
Interventions: Brief Intervention #1, Brief Intervention #2, Brief Intervention #3; Behavioral
Lead sponsor: i4Health; Other
Eligibility: 18 Years and older
Enrollment: 345 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Cigarette Smoking
Interventions: High-ventilated cigarette alone, Low-ventilated cigarette alone, High- and low-ventilated cigarette with high-ventilated cigarettes increasing in price, Low- and high-ventilated cigarette with high-ventilated cigarettes increasing in price, Usual, high- and low-ventilated cigarette with usual cigarettes increasing in price.; Behavioral
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 21 Years and older
Enrollment: 89 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Smoking
Interventions: Normal nicotine content cigarettes (NNC, Baseline), Very low nicotine content (VLNC); Other
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 31 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Smoking Cessation, Smoking Behaviors, Smoking Reduction, Smoking, Cigarette, Smoking, Nicotine Dependence
Interventions: Clickotine®; Device
Lead sponsor: Click Therapeutics, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 78 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021
U.S. locations: 1
States / cities: New York, New York

Search by objective public record fields.

Effects of Nicotine Replacement Therapy and D-cycloserine on Nicotine Treatment Seekers

Contingency Management, Quitting Smoking, and ADHD

The Avenues Study: Dual Use Cessation

A Study of Brenipatide in Adults Who Quit Smoking Cigarettes and Want to Avoid Relapse

Use Behavior, Nicotine Uptake, and Subjective Effects Comparison of Tobacco and Menthol e-Liquids by ENDS Consumers

Smoking Tobacco and Drinking Study

E-Visit for COPD and Smoking Cessation

Effects of Social Media Use on Young Adults' E-Cigarette Use

Switching to Reduced Oxidant or Nicotine Content Cigarettes in Smokers

Reducing Tobacco Use Disparities Among Low-Income Adults

CSD200907: A Study to Assess Elements of Abuse Liability for a Heated Tobacco Product With Four Non-Combusted Cigarette Variants

Evaluation of Oral Tobacco as a Harm Reduction Method for Smokers

The Impact of Chronic E-Cigarette Usage on Microvascular Health

E-cigarettes as a Harm Reduction Strategy

Menthol, Inflammation, and Nicotine Transition Study

Cognitive and Emotional Skills to Aid Smoking Cessation

Cigarette Smoking Decision Study

Zonisamide Augmentation of Varenicline Treatment for Smoking Cessation

CSD201204 An Actual Use Study of P12 Electronic Nicotine Delivery System Among U.S. Adult Smokers

CSD170304: Study to Assess Nicotine Uptake in Smokers From Electronic and Combustible Cigarettes

"Quit Smoking on Your Own" Brief Online Study

Effects of Narratives on Demand for Low and High Ventilated Cigarettes and Substitution for Alternative Products

Impact of Exclusive Use of Low Nicotine Cigarettes on Compensatory Smoking

Clinical Learning Study for a Mobile Smoking Cessation Program