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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Spastic Clear all
Completed No phase listed Observational

Attainment of Person-centred Goals After Botulinum Toxin Treatment for Upper Limb Spasticity in Real Life Practice

NCT02454803
View directory record Official record
Conditions
Upper Limb Spasticity
Interventions
Not listed
Lead sponsor
Ipsen
Industry
Eligibility
18 Years and older
Enrollment
1,004 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
5
States / cities
Doral, Florida • Chicago, Illinois • Overland Park, Kansas + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 4, 2019 · Synced Jul 22, 2026, 11:02 AM EDT
Completed Phase 2 Interventional

Botulinum Toxin (BOTOX) for Cerebral Palsy

NCT00060957
View directory record Official record
Conditions
Cerebral Palsy, Muscle Spasticity
Interventions
Botulinum toxin type A
Drug
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
3 Years to 12 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 1997
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 25, 2016 · Synced Jul 22, 2026, 11:02 AM EDT
Completed Not applicable Interventional

Transcutaneous Electrical Stimulation for Spasticity in Patients With Primary Lateral Sclerosis

NCT06012110
View directory record Official record
Conditions
Primary Lateral Sclerosis
Interventions
Transcutaneous electrical stimulation
Device
Lead sponsor
Nova Southeastern University
Other
Eligibility
18 Years to 90 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Davie, Florida
Source: ClinicalTrials.gov public record
Updated Sep 3, 2024 · Synced Jul 22, 2026, 11:02 AM EDT
Completed Not applicable Interventional

National Fully Remote Use of IpsiHand Device in Hemiparetic Stroke

NCT05965713
View directory record Official record
Conditions
Stroke, Hemiparesis, Spasticity as Sequela of Stroke, Brain Computer Interface
Interventions
Neurolutions IpsiHand System, Standard of Care - Home Exercise Program for Upper Extremity
Device · Other
Lead sponsor
Neurolutions, Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
109 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 14, 2025 · Synced Jul 22, 2026, 11:02 AM EDT
No Longer Available No phase listed Expanded access

Individual Patient Expanded Access IND of Hope Biosciences Autologous Adipose-derived Mesenchymal Stem Cells for the Treatment of Cerebral Palsy

NCT04029896
View directory record Official record
Conditions
Cerebral Palsy
Interventions
HB-adMSCs
Biological
Lead sponsor
Hope Biosciences Research Foundation
Industry
Eligibility
3 Years and older · Male only
U.S. locations
1
States / cities
Sugar Land, Texas
Source: ClinicalTrials.gov public record
Updated Sep 28, 2025 · Synced Jul 22, 2026, 11:02 AM EDT
Completed Phase 3 Interventional Results available

Efficacy and Safety Study of Botulinum Toxin Type A Against Placebo to Treat Spasticity in the Arm After a Stroke

NCT01392300
View directory record Official record
Conditions
Post-stroke Spasticity of the Upper Limb
Interventions
IncobotulinumtoxinA (400 Units), Placebo Comparator
Drug
Lead sponsor
Merz Pharmaceuticals GmbH
Industry
Eligibility
18 Years to 80 Years
Enrollment
317 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
13
States / cities
Downey, California • Fountain Valley, California • Miami, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Jan 15, 2017 · Synced Jul 22, 2026, 11:02 AM EDT
Completed Phase 2 Interventional

Recombinant Human Interferon Beta-1a (Avonex) for the Treatment of Patients With HTLV-1-Associated Myelopathy (HAM)

NCT00001785
View directory record Official record
Conditions
HTLV-I Infection, Spinal Cord Disease, Tropical Spastic Paraparesis
Interventions
Recombinant human interferon beta-1a
Drug
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
Not listed
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2004
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jul 22, 2026, 11:02 AM EDT
Completed Not applicable Interventional

Robotic Rehabilitation of Cerebral Palsy

NCT02359799
View directory record Official record
Conditions
Spastic Cerebral Palsy
Interventions
IntelliStretch
Device
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
6 Years to 17 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 12, 2023 · Synced Jul 22, 2026, 11:02 AM EDT
Completed Not applicable Interventional

Theta-burst Transcranial Magnetic Stimulation

NCT00878787
View directory record Official record
Conditions
Dystonia
Interventions
Transcranial magnetic stimulation
Device
Lead sponsor
University of Southern California
Other
Eligibility
2 Years to 29 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated May 29, 2014 · Synced Jul 22, 2026, 11:02 AM EDT
Completed Not applicable Interventional

Feasibility Study on PoRi Device

NCT06842901
View directory record Official record
Conditions
Hand Spasticity
Interventions
Portable Rehabilitation (PoRi) device
Device
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Jul 22, 2026, 11:02 AM EDT
Terminated Phase 1Phase 2 Interventional

A Study to Evaluate Administration of SBT101 Gene Therapy in Adult Patients With Adrenomyeloneuropathy (AMN)

NCT05394064
View directory record Official record
Conditions
AMN, AMN Gene Mutation, X-ALD
Interventions
SBT101, Imitation Procedure
Genetic · Procedure
Lead sponsor
SwanBio Therapeutics, Inc.
Industry
Eligibility
18 Years to 65 Years · Male only
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Jul 22, 2026, 11:02 AM EDT
Completed Phase 4 Interventional

Vanderbilt University Spasticity Management Program Evaluation Plan

NCT00179114
View directory record Official record
Conditions
Spasticity
Interventions
Botulinum Toxin Type A, Intrathecal baclofen administered by the Medtronic SyncroMed(TM) pump (ITB)
Drug
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2006
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 19, 2007 · Synced Jul 22, 2026, 11:02 AM EDT
Completed Not applicable Interventional

Extracorporeal Shockwave Therapy for Spasticity in People With Spinal Cord Injury

NCT05432999
View directory record Official record
Conditions
Spinal Cord Injuries, Spasticity, Muscle, Spastic Paraplegia, Spastic Quadriplegia, Spastic Tetraplegia, Paraplegia, Tetraplegia
Interventions
Extracorporeal Shockwave Therapy
Device
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Jul 22, 2026, 11:02 AM EDT
Not listed Not applicable Interventional

Electrical Stimulation After Botulinum Toxin Injections to the Upper Extremity

NCT04217187
View directory record Official record
Conditions
Stroke
Interventions
Neuromuscular Electrical Stimulation, Sham Electrical Stimulation
Device
Lead sponsor
Texas Woman's University
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 6, 2020 · Synced Jul 22, 2026, 11:02 AM EDT
Completed No phase listed Observational

Study to Assess the Effectiveness of AboBoNT-A Injections for Adult Lower Limb Spasticity in a Real Life Cohort

NCT04050527
View directory record Official record
Conditions
Adult Lower Limb Spasticity
Interventions
Not listed
Lead sponsor
Ipsen
Industry
Eligibility
18 Years and older
Enrollment
438 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
16
States / cities
Downey, California • Washington D.C., District of Columbia • Leawood, Kansas + 13 more
Source: ClinicalTrials.gov public record
Updated Aug 4, 2022 · Synced Jul 22, 2026, 11:02 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Study of Air Stream in Voice Production

NCT00015795
View directory record Official record
Conditions
Spastic Dysphonia, Healthy
Interventions
airway interruption test
Device
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
Not listed
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2003
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jul 22, 2026, 11:02 AM EDT
Completed Phase 3 Interventional

Safety Study of 3 mg/mL Baclofen Injection (Intrathecal) Using A Programmable Pump

NCT01520545
View directory record Official record
Conditions
Severe Spasticity
Interventions
Gablofen® 3 mg/mL (baclofen injection), SynchroMed® II Programmable Pump
Drug · Device
Lead sponsor
Piramal Critical Care, Ltd.
Industry
Eligibility
4 Years and older
Enrollment
153 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
13
States / cities
Little Rock, Arkansas • Loma Linda, California • Miami, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated May 2, 2019 · Synced Jul 22, 2026, 11:02 AM EDT
Completed Phase 3 Interventional Results available

BOTOX® Treatment in Pediatric Upper Limb Spasticity

NCT01603602
View directory record Official record
Conditions
Pediatrics, Muscle Spasticity, Cerebral Palsy, Stroke
Interventions
botulinum toxin Type A, Normal Saline (Placebo)
Biological · Drug
Lead sponsor
Allergan
Industry
Eligibility
2 Years to 16 Years
Enrollment
235 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
20
States / cities
Pasadena, California • Pomona, California • Aurora, Colorado + 15 more
Source: ClinicalTrials.gov public record
Updated Aug 13, 2018 · Synced Jul 22, 2026, 11:02 AM EDT
Completed Phase 2 Interventional Results available

A Randomized Study of Autologous Umbilical Cord Blood Reinfusion in Children With Cerebral Palsy

NCT01147653
View directory record Official record
Conditions
Cerebral Palsy, CP, Spastic Cerebral Palsy
Interventions
Autologous UCB Reinfusion, Placebo
Biological · Other
Lead sponsor
Joanne Kurtzberg, MD
Other
Eligibility
12 Months to 6 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Jul 22, 2026, 11:02 AM EDT
Completed Phase 4 Interventional

MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study

NCT03226119
View directory record Official record
Conditions
HTLV-I Infections, HTLV-II Infections, Human T-lymphotropic Virus 1, Human T-lymphotropic Virus 2, HTLV I Associated T Cell Leukemia Lymphoma, HTLV I Associated Myelopathies
Interventions
MP Diagnostics HTLV Blot 2.4
Diagnostic Test
Lead sponsor
MP Biomedicals, LLC
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
3
States / cities
Philadelphia, Pennsylvania • San Antonio, Texas • Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 12, 2018 · Synced Jul 22, 2026, 11:02 AM EDT
Not listed Phase 3 Interventional

" Treating MS Patients With Lower Extremity Spasticity Using Dysport"

NCT03585569
View directory record Official record
Conditions
Multiple Sclerosis, Spasticity, Muscle
Interventions
Abobotulinumtoxin A
Biological
Lead sponsor
Neurology Center of New England P.C.
Other
Eligibility
Not listed
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Foxborough, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 12, 2018 · Synced Jul 22, 2026, 11:02 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Phenotype, Genotype & Biomarkers in ALS and Related Disorders

NCT02327845
View directory record Official record
Conditions
Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, Primary Lateral Sclerosis, Hereditary Spastic Paraplegia, Progressive Muscular Atrophy, Multisystem Proteinopathy
Interventions
Not listed
Lead sponsor
University of Miami
Other
Eligibility
Not listed
Enrollment
708 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2031
U.S. locations
13
States / cities
Palo Alto, California • San Diego, California • San Francisco, California + 10 more
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Jul 22, 2026, 11:02 AM EDT
Recruiting Not applicable Interventional

tDCS and Bimanual Therapy for Children With Hemiplegic Cerebral Palsy

NCT03402854
View directory record Official record
Conditions
Cerebral Palsy, Hemiplegic Cerebral Palsy, Spastic Hemiplegic Cerebral Palsy, Spastic Hemiparesis, Spastic Hemiplegia
Interventions
active transcranial direct current stimulation, bimanual training
Device · Behavioral
Lead sponsor
Burke Medical Research Institute
Other
Eligibility
6 Years to 18 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
White Plains, New York
Source: ClinicalTrials.gov public record
Updated Jul 15, 2024 · Synced Jul 22, 2026, 11:02 AM EDT
Not listed Not applicable Interventional

The Feasibility of Telehealth HEP for CP (HEP: Home Exercise Program), (CP: Cerebral Palsy)

NCT04423653
View directory record Official record
Conditions
Cerebral Palsy, Spastic, Telemedicine
Interventions
Telehealth home exercise program
Behavioral
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
11 Years to 18 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Jun 8, 2020 · Synced Jul 22, 2026, 11:02 AM EDT