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Showing 1–24 of 94 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Spinal Cord Injury, Acute Clear all
Terminated Not applicable Interventional Accepts healthy volunteers

The Effect of Acute Exercise on Cardiac Autonomic, Cerebrovascular, and Cognitive Function in Spinal Cord Injury

NCT05542238
View directory record Official record
Conditions
Spinal Cord Injuries, Cardiovascular Abnormalities, Cerebrovascular Disease; Sequelae, Cognitive Impairment
Interventions
One bout of moderate-intensity sub-maximal aerobic exercise
Behavioral
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years to 55 Years
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Mar 5, 2025 · Synced Sep 26, 2026, 2:26 AM EDT
Completed Not applicable Interventional Results available

Exoskeletal-Assisted Walking in SCI Acute Inpatient Rehabilitation

NCT04221373
View directory record Official record
Conditions
Spinal Cord Injuries, Inpatient
Interventions
Ekso™ powered exoskeleton, Standard of care
Device · Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 25, 2023 · Synced Sep 26, 2026, 2:26 AM EDT
Recruiting Phase 1 Interventional

A Study to Evaluate the Safety of a Delivery Device for Administering LCTOPC1 in Participants With Spinal Cord Injury

NCT06841770
View directory record Official record
Conditions
Spinal Cord Injury Cervical, Spinal Cord Injury Thoracic, Spinal Cord Injury, Acute, Spinal Cord Injury, Spinal Cord Injury, Chronic
Interventions
OPC1
Biological
Lead sponsor
Lineage Cell Therapeutics, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2037
U.S. locations
2
States / cities
Downey, California • La Jolla, California
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Sep 26, 2026, 2:26 AM EDT
Enrolling by invitation Not applicable Interventional

Duraplasty for Acute Traumatic Spinal Cord Injury

NCT07280351
View directory record Official record
Conditions
Spinal Cord Injury, Acute, Spinal Cord Injury (SCI), Initial Encounter, Spinal Cord Injury Cervical
Interventions
Expansile duraplasty
Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 80 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Sep 26, 2026, 2:26 AM EDT
Not listed Early Phase 1 Interventional

Combining Wearable Robotic Orthosis With Visual and Haptic Feedback to Enhance the Recovery of Upper Extremity Motor Function and ADL in Persons With Acute SCI

NCT05386537
View directory record Official record
Conditions
SCI - Spinal Cord Injury
Interventions
MyoMo orthosis and VR games, MyoPro robot only, Games only, Control
Combination Product · Device · Other
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated May 5, 2023 · Synced Sep 26, 2026, 2:26 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Acute Tendon and Nerve Responses to Exercise

NCT01197599
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
Not listed
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jul 21, 2014 · Synced Sep 26, 2026, 2:26 AM EDT
Withdrawn No phase listed Observational

Comparison of Gait Training Methods in Sub-acute Stroke and Spinal Cord Injury

NCT06169657
View directory record Official record
Conditions
Stroke, Incomplete Spinal Cord Injury
Interventions
Body-weight-supported treadmill training (BWSTT), EksoNR exoskeleton gait training, Overground gait training
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 24, 2025 · Synced Sep 26, 2026, 2:26 AM EDT
Terminated Not applicable Interventional Results available

Pairing Intermittent Hypoxia and Transcutaneous Electrical Spinal Cord Stimulation to Promote Arm Use After Cervical SCI

NCT04854057
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
AIH - Intermittent Hypoxia - hypoxia air mixture, SHAM - Intermittent Room Air - room air mixture, TESS - Transcutaneous Electrical Spinal Cord Stimulation + Functional Task Practice
Other · Device
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 9, 2024 · Synced Sep 26, 2026, 2:26 AM EDT
Completed Phase 3 Interventional Results available

Zoledronic Acid in Acute Spinal Cord Injury

NCT01642901
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
Zoledronic acid, normal saline 0.9%
Drug
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years to 65 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 22, 2023 · Synced Sep 26, 2026, 2:26 AM EDT
Completed Not applicable Interventional Results available

Randomized Trial of Early Hemodynamic Management of Patients Following Acute Spinal Cord Injury

NCT02878850
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
Augmented Blood Pressure
Other
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years and older
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
11
States / cities
Los Angeles, California • New Haven, Connecticut • Kansas City, Kansas + 7 more
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Sep 26, 2026, 2:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Measuring the Neurological Benefits of Intermittent Hypoxia Therapy With MRI

NCT05183113
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
Acute Intermittent Hypoxia
Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 60 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Sep 26, 2026, 2:26 AM EDT
Active, not recruiting Not applicable Interventional

Hypnotic Cognitive Therapy Reduce Acute & Chronic SCI Pain in Inpatient Rehabilitation

NCT05047120
View directory record Official record
Conditions
Spinal Cord Injuries, Pain, Chronic, Spinal Cord Injury, Acute
Interventions
Hypnosis enhanced cognitive behavioral therapy, Pain Education
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
16 Years to 85 Years
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Sep 26, 2026, 2:26 AM EDT
Completed Phase 2 Interventional

Study to Assess the Efficacy and Safety of MT-3921 in Subjects With Acute Traumatic Cervical Spinal Cord Injury

NCT04683848
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
MT-3921, Placebo
Biological
Lead sponsor
Tanabe Pharma America, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
15
States / cities
Orange, California • Tallahassee, Florida • Augusta, Georgia + 12 more
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Sep 26, 2026, 2:26 AM EDT
Terminated Phase 2Phase 3 Interventional

Riluzole in Spinal Cord Injury Study

NCT01597518
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
Riluzole, Placebo
Drug
Lead sponsor
AOSpine North America Research Network
Network
Eligibility
18 Years to 75 Years
Enrollment
193 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
20
States / cities
Phoenix, Arizona • San Jose, California • Miami, Florida + 16 more
Source: ClinicalTrials.gov public record
Updated Apr 18, 2021 · Synced Sep 26, 2026, 2:26 AM EDT
Recruiting Not applicable Interventional

BioFLO for Respiratory Recovery in SCI

NCT06011876
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
Acute Intermittent Hypoxia (AIH), Acute Intermittent Hypercapnic-Hypoxia (AIHH), Sham AIH
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 70 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 13, 2026 · Synced Sep 26, 2026, 2:26 AM EDT
Not listed Phase 1 Interventional

Effects of Anticholinergic or Long-Acting Beta 2 Agonist on FeNO and Pulmonary Function in SCI

NCT01355991
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
Tiotropium, Salmeterol
Drug
Lead sponsor
James J. Peters Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
2
States / cities
West Orange, New Jersey • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Oct 22, 2015 · Synced Sep 26, 2026, 2:26 AM EDT
Recruiting Not applicable Interventional

TSCS for Acute SCI

NCT05305118
View directory record Official record
Conditions
Acute Spinal Cord Injury, Blood Pressure, Hypotension
Interventions
TSCS Mapping, Transcutaneous spinal cord stimulation
Procedure · Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 89 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 23, 2026 · Synced Sep 26, 2026, 2:26 AM EDT
Completed Phase 4 Interventional Results available

tSCI Contrast Enhanced Ultrasound Study

NCT04056988
View directory record Official record
Conditions
Acute Spinal Cord Injury
Interventions
Perflutren Lipid Microsphere
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Sep 26, 2026, 2:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Advancing Understanding of Transportation Options

NCT04141891
View directory record Official record
Conditions
Diabetic Retinopathy, Macular Degeneration, Glaucoma, Retinitis Pigmentosa, Vision Disorders, Acute Coronary Syndrome, Implantable Defibrillator User, Congestive Heart Failure, Hypertrophic Obstructive Cardiomyopathy, Orthostatic Hypotension, Syncope, Presyncope, Narcolepsy, Dementia, Multiple Sclerosis, Parkinson Disease, Brain Injuries, Spinal Cord Injuries, Stroke, Vertigo, Dizziness, Seizures, Substance Use, Insulin Dependent Diabetes Mellitus, Arthritis, Foot--Abnormalities, Chronic Obstructive Pulmonary Disease, Obstructive Sleep Apnea, End Stage Renal Disease, Sleep Apnea, Insomnia, Restless Legs Syndrome
Interventions
Driving Decision Aid, Older Drivers Website
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
529 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
3
States / cities
La Jolla, California • Aurora, Colorado • Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 20, 2025 · Synced Sep 26, 2026, 2:26 AM EDT
Not listed Phase 1 Interventional

Acute and Chronic Effects of Inhaled Steroids on Pulmonary Function in Persons With Spinal Cord Injury

NCT01353599
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
Mometasone furoate
Drug
Lead sponsor
James J. Peters Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2011
U.S. locations
2
States / cities
West Orange, New Jersey • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Oct 22, 2015 · Synced Sep 26, 2026, 2:26 AM EDT
Recruiting Not applicable Interventional

Spinal Decompression Plus Nerve Graft Implantation Following TSCI

NCT06243211
View directory record Official record
Conditions
Spinal Cord Injuries, Acute Traumatic Spinal Cord Injury
Interventions
DMED, ANGI
Procedure
Lead sponsor
Francis Farhadi
Other
Eligibility
18 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced Sep 26, 2026, 2:26 AM EDT
Terminated Not applicable Interventional

Mean Arterial Blood Pressure Treatment for Acute Spinal Cord Injury

NCT02232165
View directory record Official record
Conditions
Acute Spinal Cord Injury
Interventions
Hypotension avoidance, Induced hypertension
Other
Lead sponsor
University of Calgary
Other
Eligibility
16 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Sep 24, 2019 · Synced Sep 26, 2026, 2:26 AM EDT
Completed Phase 2 Interventional

Safety And Efficacy Study Of Intravenous (IV) Administration Of Elezanumab To Assess Change In Upper Extremity Motor Score (UEMS) In Adult Participants With Acute Traumatic Cervical Spinal Cord Injury (SCI)

NCT04295538
View directory record Official record
Conditions
Spinal Cord Injury (SCI)
Interventions
Elezanumab, Placebo
Drug
Lead sponsor
AbbVie
Industry
Eligibility
18 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
22
States / cities
Sacramento, California • Atlanta, Georgia • Chicago, Illinois + 15 more
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Sep 26, 2026, 2:26 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Spasticity and Functional Recovery After SCI

NCT06030531
View directory record Official record
Conditions
Acute Spinal Cord Injury, Spinal Cord Injuries
Interventions
Measures of spasticity, connectivity and analysis of single nucleotide polymorphisms and biomarkers of inflammation, Analysis of biomarkers
Other
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 10, 2023 · Synced Sep 26, 2026, 2:26 AM EDT