Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 7, 2026, 6:27 AM EST

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Showing 25–48 of 505 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Abuse Problem Clear all

Conditions: Substance Use Disorders
Interventions: A Woman's Path to Recovery, 12-Step Facilitation; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2015
U.S. locations: 2
States / cities: Bedford, Massachusetts • Boston, Massachusetts

Conditions: Substance Abuse, Intravenous
Interventions: Abstinence-contingent wage supplements, Individual Placement and Support (IPS) supported employment; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 91 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Adolescent Substance Abuse, Attention Deficit Hyperactivity Disorder
Interventions: Medication integration protocol; Behavioral
Lead sponsor: The National Center on Addiction and Substance Abuse at Columbia University; Other
Eligibility: 13 Years to 17 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: New York, New York

Conditions: Alcoholism
Interventions: Topiramate; Drug
Lead sponsor: Bankole Johnson; Other
Eligibility: 21 Years to 45 Years
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2008
U.S. locations: 2
States / cities: Charlottesville, Virginia • Richmond, Virginia

Conditions: Substance Abuse, Child Abuse, Child Neglect
Interventions: Comprehensive Community Treatment, MST-BSF; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 6 Years and older
Enrollment: 191 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2016
U.S. locations: 1
States / cities: New Britain, Connecticut

Conditions: Cocaine Dependence, Cocaine Abuse
Interventions: Contingency Management; Behavioral
Lead sponsor: Treatment Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 166 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2008
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Substance Abuse
Interventions: atomoxetine, placebo; Drug
Lead sponsor: Sharon Walsh; Other
Eligibility: 18 Years to 60 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2011
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Adolescent, Depression, Substance Use Disorders
Interventions: Adolescent Coping With Depression/Functional Family Therapy; Behavioral
Lead sponsor: Oregon Research Institute; Other
Eligibility: 13 Years to 17 Years
Enrollment: 180 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2013
U.S. locations: 1
States / cities: Eugene, Oregon

Conditions: Substance Abuse
Interventions: Acupuncture, Relaxation Response; Procedure · Behavioral
Lead sponsor: VA Boston Healthcare System; Federal
Eligibility: 18 Years and older
Enrollment: 67 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 1
States / cities: Bedford, Massachusetts

Conditions: Alcohol Dependence, Alcohol Abuse
Interventions: Naltrexone, Modified Behavioral Self-Control Psychotherapy, Brief Behavioral Compliance Enhancement Therapy, Placebo; Drug · Behavioral
Lead sponsor: Research Foundation for Mental Hygiene, Inc.; Other
Eligibility: 18 Years to 65 Years · Male only
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2007
U.S. locations: 1
States / cities: New York, New York

Conditions: Substance Abuse, Mental Disorders
Interventions: Double Trouble in Recovery, Treatment as usual; Behavioral
Lead sponsor: Western Michigan University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 352 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2014
U.S. locations: 4
States / cities: Grand Rapids, Michigan • Brooklyn, New York • New York, New York

Conditions: Alcohol Dependence, Alcohol Abuse
Interventions: Naltrexone, Brenda Therapy Sessions, Placebo; Drug · Behavioral
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 65 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Domestic Violence, Substance Abuse
Interventions: Motivational Enhancement Therapy, Educational information; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older · Male only
Enrollment: 140 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Substance Abuse, Child Neglect
Interventions: ITSAN, Services as Usual; Behavioral
Lead sponsor: Oregon Social Learning Center; Other
Eligibility: Female only
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2012
U.S. locations: 1
States / cities: Eugene, Oregon

Conditions: Marijuana Dependence
Interventions: Oxytocin, Saline; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Addiction, Substance Abuse Drug Chronic, Child Neglect, Child Neglect Emotional, Child Abuse, Parenting, Parent-Child Problem, Parent-Child Relations, Parent / Child Problem, Parenteral Drug Abuse, Parents
Interventions: Mothering From the Inside Out (MIO), Parent Education; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 60 Years · Female only
Enrollment: 97 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: HIV, Substance Use
Interventions: Vr2L 2Spirit; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older · Male only
Enrollment: 79 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Substance Abuse, Substance Dependence, Alcohol Abuse, Drug Use, Relapse
Interventions: Dual Processing, Relapse Prevention; Behavioral
Lead sponsor: Inova Health Care Services; Other
Eligibility: 18 Years and older
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 2
States / cities: Washington D.C., District of Columbia • Falls Church, Virginia

Conditions: Other Drug Substance Abuse
Interventions: Iwin: Individual Well-Being Navigator; Behavioral
Lead sponsor: Pro-Change Behavior Systems; Other
Eligibility: 18 Years to 54 Years
Enrollment: 253 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 4
States / cities: Watertown, Massachusetts • Poughkeepsie, New York • South Kingstown, Rhode Island + 1 more

Conditions: Acquired Immunodeficiency Syndrome
Interventions: Couples HIV counseling and testing, Women's relationship-focused HIV counseling and testing; Behavioral
Lead sponsor: National Development and Research Institutes, Inc.; Other
Eligibility: 18 Years and older
Enrollment: 780 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2008
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Alcohol-related Disorders, Alcohol Drinking, Alcoholism, Alcohol Abuse
Interventions: Naltrexone, Modified Behavioral Self-Control Psychotherapy, Brief Behavioral Compliance Enhancement Therapy; Drug · Behavioral
Lead sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA); NIH
Eligibility: 18 Years to 65 Years · Male only
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2010
U.S. locations: 1
States / cities: New York, New York

Conditions: Substance Abuse Disorder
Interventions: PET scan, fMRI; Radiation · Other
Lead sponsor: University of California, Irvine; Other
Eligibility: 21 Years to 65 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005
U.S. locations: 1
States / cities: Irvine, California

Conditions: Substance Abuse
Interventions: Free2b, Attention-Placebo; Behavioral
Lead sponsor: Columbia University; Other
Eligibility: 15 Years to 17 Years
Enrollment: 1,216 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: New York, New York

Conditions: Employment
Interventions: Group vocational intervention, Supported Employment Condition; Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 140 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2019
U.S. locations: 1
States / cities: Dallas, Texas

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Women Veterans' Substance Abuse Treatment

The Long-Term Treatment of Drug Addiction and Unemployment

Family-Based Protocol for Medication Integration in Treatment of Comorbid ASU/ADHD in Routine Care

New Medications to Treat Alcohol Dependence

Family-Based Treatment for Parental Substance Abuse and Child Maltreatment

Long Term Maintenance of Drug Abstinence

Evaluation of Atomoxetine for Cocaine Dependence: A Pilot Trial

Sequenced vs. Integrated Delivery of Treatment for Adolescent Depression and SUD

Acupuncture and the Relaxation Response for Substance Abuse

Medication and Counseling for Controlled Drinking

Efficacy of Dual Focus Mutual Aid for Persons With Co-occurring Disorders

Sweet Preference and Alcohol Craving

The Men's Domestic Abuse Check-Up Engages Adult Men Concerned About Their Abusive Behavior and Alcohol or Drug Use

Integrating Interventions for Maternal Substance Abuse

Effect of Oxytocin on Craving and Therapy Response

Stage III Community-based Efficacy Trial for Mothering From the Inside Out

American Indian and Alaska Native Men Who Have Sex With Men HIV & Substance Abuse Research

fMRI Study of a Dual Process Treatment Protocol With Substance Dependent Adults

Iwin: Individual Well-Being Navigator

HIV Prevention Intervention for Couples

Medication and Counseling for Controlled Drinking (Project SMART)

Brain Imaging Studies of the Effects of Cocaine Abstinence

Preventing Drug Abuse Among Sexual Minority Youth

Assessing Supported Employment With Veterans With Felony Convictions and Mental Illness or Substance Abuse