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Showing 1–24 of 3,257 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Substance Use Clear all
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Effects of Pregnancy-associated Hormones on THC Metabolism in Women

NCT04374773
View directory record Official record
Conditions
Pregnancy Related, Cannabis Use
Interventions
Dronabinol
Drug
Lead sponsor
University of Washington
Other
Eligibility
21 Years to 45 Years · Female only
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Jul 22, 2026, 2:43 PM EDT
Not yet recruiting Not applicable Interventional

Feasibility of an Interdisciplinary Intervention to Improve Care Transitions for Hospitalized Patients With Substance Use Disorders

NCT07575373
View directory record Official record
Conditions
Substance Use Disorders
Interventions
IntACT, Usual Care
Behavioral
Lead sponsor
Michael Incze
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Jul 22, 2026, 2:43 PM EDT
Completed Not applicable Interventional

Mindful Body Awareness With Medication Treatment for Opioid Use Disorder

NCT04082637
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
Mindful Awareness in Body-oriented Therapy
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
303 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
5
States / cities
Bellingham, Washington • Port Angeles, Washington • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 23, 2025 · Synced Jul 22, 2026, 2:43 PM EDT
Completed No phase listed Observational

Rural MOUD Telemedicine in Primary Care Phase 1

NCT04418453
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
Integration of telemedicine for MOUD in primary care
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 80 Years
Enrollment
36,762 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
7
States / cities
Cottonwood, Idaho • Grangeville, Idaho • Belfast, Maine + 4 more
Source: ClinicalTrials.gov public record
Updated May 10, 2023 · Synced Jul 22, 2026, 2:43 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Survey on Consumer Use of Over-the-Counter (OTC) Nicotine Patches

NCT00134927
View directory record Official record
Conditions
Nicotine Dependence, Tobacco Use Disorder
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years and older
Enrollment
600 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2006
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jan 9, 2017 · Synced Jul 22, 2026, 2:43 PM EDT
Completed Not applicable Interventional

Testing of the Integrated Rapid Access to HIV Prevention Program for People Who Inject Drugs Program

NCT04531670
View directory record Official record
Conditions
HIV Prevention Program, Opioid-use Disorder
Interventions
iRaPID, Standard of Care
Behavioral · Other
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 20, 2023 · Synced Jul 22, 2026, 2:43 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Reducing Opioid Mortality in Illinois

NCT04925427
View directory record Official record
Conditions
Opioid Use, Opioid-use Disorder
Interventions
Case Management and Peer Recovery, Naloxone-Only
Behavioral
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
1,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
5
States / cities
Chicago, Illinois • Murphysboro, Illinois • Ottawa, Illinois + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 20, 2024 · Synced Jul 22, 2026, 2:43 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Re-Connect Application for Smoking Cessation

NCT05224154
View directory record Official record
Conditions
Smoking Cessation, Acceptability of Health Care, Nicotine Dependence, Cigarettes
Interventions
Abstinent Contingent (AC) Re-Connect, Submission Contingent (SC) Re-Connect
Behavioral
Lead sponsor
Rowan University
Other
Eligibility
18 Years and older
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Glassboro, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 27, 2025 · Synced Jul 22, 2026, 2:43 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Novel Determinants and Measures of Smokeless Tobacco Use: Study 1

NCT01067586
View directory record Official record
Conditions
Smokeless Tobacco Use, Tobacco Dependence
Interventions
Not listed
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
359 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
3
States / cities
Minneapolis, Minnesota • Eugene, Oregon • Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Dec 21, 2022 · Synced Jul 22, 2026, 2:43 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Combining a Smoke Ending Aid With Behavioral Treatment - 1

NCT00006151
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Behavioral Therapy
Behavioral
Lead sponsor
Peter Gariti
Other
Eligibility
21 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2002
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 2, 2015 · Synced Jul 22, 2026, 2:43 PM EDT
Completed Phase 2 Interventional Results available

D-Cycloserine Facilitation of Cocaine - Cue Extinction

NCT00759473
View directory record Official record
Conditions
Cocaine Use Disorders
Interventions
D-Cycloserine (DCS), Placebo
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
2
States / cities
Charleston, South Carolina • Pickens, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 12, 2016 · Synced Jul 22, 2026, 2:43 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Neurobehavioral Signatures of Sign- and Goal-Tracking in Emerging Adults: Translation of a Preclinical Model

NCT07094061
View directory record Official record
Conditions
Substance Use, Healthy
Interventions
fMRI, Questionnaires and surveys, Behavioral tasks and eye tracking
Device · Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 22 Years
Enrollment
294 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
2
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Jul 22, 2026, 2:43 PM EDT
Recruiting Not applicable Interventional

Using Clinical Decision Support to Provide Social Risk-Informed Care for Opioid Use Disorder in the Emergency Department

NCT06872190
View directory record Official record
Conditions
Opioid Use Disorder, Social Determinants of Health (SDOH)
Interventions
ED-Based Clinical Decision Support for Opioid Use Disorder, Social Care-Enhanced Clinical Decision Support for Opioid Use Disorder
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Jul 22, 2026, 2:43 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Multiple Ascending Dose Study of TMP-301 in Healthy Subjects

NCT06025396
View directory record Official record
Conditions
Cocaine Use Disorder, Substance Use Disorders, Healthy Volunteers
Interventions
Cohort 1 - TMP-301, Placebo, Cohort 2 - TMP-301, Cohort 3 - TMP-301, Cohort 4 - TMP-301
Drug
Lead sponsor
Tempero Bio, Inc.
Industry
Eligibility
18 Years to 59 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Jul 28, 2025 · Synced Jul 22, 2026, 2:43 PM EDT
Not listed Early Phase 1 Interventional Accepts healthy volunteers

Nicotine and Pavlovian Bias

NCT06027723
View directory record Official record
Conditions
Nicotine Vaping, Nicotine Dependence
Interventions
Nicotine, Placebo
Drug · Other
Lead sponsor
University of Southern California
Other
Eligibility
21 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 8, 2023 · Synced Jul 22, 2026, 2:43 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nicotine Withdrawal and Reward Processing

NCT05041959
View directory record Official record
Conditions
Cigarette Smoking, Nicotine Dependence, Nicotine Withdrawal
Interventions
Smoking Abstinence, Ad Lib Smoking
Other
Lead sponsor
University of Oklahoma
Other
Eligibility
21 Years to 55 Years
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated May 7, 2024 · Synced Jul 22, 2026, 2:43 PM EDT
Completed Not applicable Interventional

Written Exposure in Substance Treatment

NCT06296940
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Substance Use Disorders
Interventions
Written Exposure Therapy, Treatment as Usual
Behavioral
Lead sponsor
Potomac Health Foundations
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 9, 2025 · Synced Jul 22, 2026, 2:43 PM EDT
Completed Not applicable Interventional Results available

The Gender-Sex Hormone Interface With Craving & Stress-Related Changes in Smoking

NCT01576874
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Oxytocin, placebo
Drug
Lead sponsor
Kevin Gray, MD
Other
Eligibility
18 Years to 45 Years
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 30, 2020 · Synced Jul 22, 2026, 2:43 PM EDT
Completed Phase 2 Interventional

Examining the Role of the Orexin System in Sleep and Stress in Persons With Opioid Use Disorder

NCT04287062
View directory record Official record
Conditions
Sleep Disturbance, Opioid-use Disorder
Interventions
Suvorexant, Placebos
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years to 65 Years
Enrollment
138 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
5
States / cities
Baltimore, Maryland • Bel Air, Maryland • Elkton, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 19, 2025 · Synced Jul 22, 2026, 2:43 PM EDT
Completed Not applicable Interventional Results available

Usability Testing for the Reward-based Technology to Improve OUD Treatment

NCT05159362
View directory record Official record
Conditions
Opioid-use Disorder, Contingency Management, Medication for Opioid-use Disorder
Interventions
Software Application
Other
Lead sponsor
Q2i, LLC
Industry
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 29, 2023 · Synced Jul 22, 2026, 2:43 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

An Effectiveness Trial of Maintenance Therapy for Nicotine Dependence

NCT01047527
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Transdermal nicotine patch
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
525 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2014
U.S. locations
2
States / cities
Chicago, Illinois • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 7, 2015 · Synced Jul 22, 2026, 2:43 PM EDT
Not listed No phase listed Observational

The Use of Medicinal Cannabinoids as Adjunctive Treatment for Medically Refractory Epilepsy

NCT02523183
View directory record Official record
Conditions
Epilepsy, Unspecified, Refractory (Medically)
Interventions
Medical Cannabis
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
1 Month to 20 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 17, 2020 · Synced Jul 22, 2026, 2:43 PM EDT
Recruiting Phase 2 Interventional

Ketamine for Opioid Use Disorder

NCT06943859
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Treatment with Ketamine, Treatment with Very Low Dose Ketamine
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 12, 2026 · Synced Jul 22, 2026, 2:43 PM EDT
Recruiting Phase 1 Interventional

Diclofenac Dose Response Study

NCT06636227
View directory record Official record
Conditions
Alcohol Use Disorder (AUD), Alcohol-Related Disorders
Interventions
Diclofenac 100mg, Diclofenac 75mg, Diclofenac 50mg, Placebo control
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
21 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Catonsville, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Jul 22, 2026, 2:43 PM EDT