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ClinicalTrials.gov public records Last synced Nov 15, 2026, 4:29 AM EST

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Showing 25–48 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: Tobacco Use Disorder, Schizophrenia
Interventions: sensorimotor replacement, 42 mg transdermal nicotine replacement, Placebo transdermal nicotine, usual brand smoking; Behavioral · Drug · Other
Lead sponsor: Brown University; Other
Eligibility: 18 Years to 99 Years
Enrollment: 75 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2011
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Adherence, Tobacco Use Cessation, Alcohol & Drug Use, Nicotine Transdermal System
Interventions: Lifestyle counseling; Behavioral
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 25 Years
Enrollment: 41 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2008
U.S. locations: 3
States / cities: Jacksonville, Florida • Rochester, Minnesota

Conditions: Stimulant Use, Depression
Interventions: Accelerated Repetitive Transcranial Magnetic Stimulation; Device
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years to 65 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Gambling, Alcohol Consumption, Cannabis
Interventions: Personalized Feedback Intervention; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 17 Years to 24 Years
Enrollment: 361 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2015
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Smoking Cessation, Smoking, Nicotine Dependence
Interventions: Varenicline, Nicotine lozenge, Nicotine Patch; Drug
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years to 99 Years
Enrollment: 1,086 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2017
U.S. locations: 2
States / cities: Madison, Wisconsin • Milwaukee, Wisconsin

Conditions: Opioid Use Disorder, Posttraumatic Stress Disorder (PTSD)
Interventions: HOPE Therapy; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 70 Years
Enrollment: 76 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Tobacco Use Disorder
Interventions: AAT-experiment, AAT-placebo; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 13 Years to 18 Years
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Alcohol; Use, Problem
Interventions: BASICS, Deviance Regulation Theory (DRT); Behavioral
Lead sponsor: University of Central Florida; Other
Eligibility: 18 Years to 26 Years
Enrollment: 300 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Orlando, Florida

Conditions: Smoking, Nicotine Dependence, Mental Disorders
Interventions: Cognitive / Motivational Individual Sessions, Attention Control Individual Sessions, Nicotine Patch, Group Curriculum; Behavioral · Drug
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years to 99 Years
Enrollment: 270 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Nicotine Dependence, ADHD
Interventions: Very low nicotine content cigarettes, Conventional nicotine content cigarettes; Other
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 40 Years
Enrollment: 71 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2019
U.S. locations: 2
States / cities: Durham, North Carolina • Pittsburgh, Pennsylvania

Conditions: Anxiety Disorders, Depression, Psychological Distress, Tobacco Dependence, Smoking, Tobacco, Smoking, Cigarette
Interventions: PFI for Smoking & Distress Tolerance, PFI for Smoking Only; Behavioral
Lead sponsor: University of Houston; Other
Eligibility: 18 Years and older
Enrollment: 121 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Heavy Episodic Drinking
Interventions: Alcohol administration; Other
Lead sponsor: New York University; Other
Eligibility: 21 Years to 29 Years
Enrollment: 160 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: New York, New York

Conditions: Social Skills, Self-Criticism, Post-traumatic Stress Disorder, Depression, Alcohol Abuse, Drinking, College, Alcohol Drinking, Alcohol; Harmful Use, Social Stigma, Social Norms, Social Responsibility, Social Behavior, Empathy, Coping Skills, Coping Behavior
Interventions: Supporting Survivors and Self: An Intervention for Social Supports of Survivors of Partner Abuse and Sexual Aggression (SSS); Behavioral
Lead sponsor: University of New Hampshire; Other
Eligibility: 18 Years to 24 Years
Enrollment: 1,268 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Durham, New Hampshire

Conditions: Opioid-use Disorder, Recidivism
Interventions: NIATx Coaching, ECHO; Behavioral
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 256 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Drug Use Disorders, Alcohol-Related Disorders, Substance Use Disorder (SUD)
Interventions: Care Navigation; Behavioral
Lead sponsor: Kaiser Permanente; Other
Eligibility: 18 Years and older
Enrollment: 360 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Nicotine Dependence, Symptoms of Anxiety, HIV
Interventions: Integrated cognitive-behavioral therapy for smoking cessation and anxiety, Control; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2015
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Tobacco Use Disorder
Interventions: Paroxetine, Placebo; Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 65 Years
Enrollment: 105 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2010
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Nicotine Dependence, Tobacco Use Disorder
Interventions: Varenicline Pill, Contingency management, Counseling; Drug · Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 40 Years
Enrollment: 105 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 3
States / cities: Charleston, South Carolina • Lancaster, South Carolina • Pickens, South Carolina

Conditions: Nicotine Dependence
Interventions: Tailored treatment, Standard Treatment; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 64 Years · Female only
Enrollment: 28 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Pain, Postoperative
Interventions: Caffeine Citrate, Dextrose Water; Drug
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 71 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Smoking, Pulmonary Disease, Chronic Obstructive, Tobacco Use Disorder
Interventions: Standard Smoking Cessation, Extended Nicotine Replacement Therapy, Nicotine replacement therapy; Other · Drug
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 398 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Kansas City, Kansas

Conditions: Opioid-use Disorder, Stigma, Social
Interventions: Opioid Use Disorder Stigma Reduction; Behavioral
Lead sponsor: Karen Derefinko, PhD; Other
Eligibility: 18 Years and older
Enrollment: 199 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021
U.S. locations: 1
States / cities: Memphis, Tennessee

Conditions: Smoking, Smoking Cessation
Interventions: Coordinated Care, Usual Care; Other
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Enrollment: 633 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2015
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Alcohol Use, Underage, Substance Use, Underage Drinking
Interventions: Motivational Interviewing, Psychoeducation; Behavioral
Lead sponsor: Pacific Institute for Research and Evaluation; Other
Eligibility: 13 Years to 20 Years
Enrollment: 75 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Valley Center, California

Search by objective public record fields.

Nicotine and Sensorimotor Replacement for Smoking in Smokers With Schizophrenia

Smoking Cessation for Young Adults Who Binge Drink - 1

Accelerated rTMS for Substance Use Disorder and Depression

Web-based vs In-person Personalized Feedback Intervention for Comorbid Substance Use and Disordered Gambling

A Comparative Effectiveness & Long Term Health Study in Wisconsin Smokers

Integrated Treatment for Opioid Use Disorder and PTSD

Tobacco Approach Avoidance Training for Adolescent Smokers-2

DRT Mobile Intervention to Increase Safe Drinking

Helping Those With Mental Illness Quit Smoking

Effects of Nicotine Reduction on Smoking Behavior in ADHD Smokers

Personalized Feedback for Distress Intolerant Smokers

Understanding the Associations Between Romantic Relationship Conflict, Psychophysiological Responding and Alcohol Misuse Among Emerging Adults

Development and Pilot Trial of an Intervention to Reduce Disclosure Recipients Negative Social Reactions and Victims Psychological Distress and Problem Drinking

Fostering MAT Use in Justice Populations

Addressing Barriers to Care for Substance Use Disorder Trial

Integrated Treatment for Smoking Cessation & Anxiety in People With HIV

Effect of Paroxetine on Smokers' Cardiovascular Response to Stress - 1

E-cigarette Cessation in Adults Who Co-use Cannabis

A Smoking Cessation Treatment for Adult Women

Caffeine and Neurologic Recovery Following Surgery and General Anesthesia

Smoking Cessation Versus Long-term Nicotine Replacement Among High-risk Smokers

SMART Trial: Community Stigma Reduction

Connect to Quit for Smoking

Strategies: Motivational Interviewing/Psychoeducation