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ClinicalTrials.gov public records Last synced Nov 15, 2026, 4:54 AM EST

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Showing 73–96 of 1,374 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Substance Use Behavior Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Acute Alcohol Response In Bipolar Disorder: a fMRI Study

NCT04063384
View directory record Official record
Conditions
Bipolar Disorder, Alcohol Drinking, Alcohol Use Disorder
Interventions
alcohol beverage, Placebo beverage
Other
Lead sponsor
University of Texas at Austin
Other
Eligibility
21 Years to 26 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Dec 11, 2025 · Synced Nov 15, 2026, 4:54 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Remotely Delivered Programs Targeting COVID-19 Stress-Related Depression and Substance Use

NCT04595084
View directory record Official record
Conditions
Depression, Anxiety, Substance Use, Stress, Psychological, Stress, Emotional, Alcohol Use, Unspecified, Drug Use, Covid19
Interventions
Mindfulness Based Cognitive Therapy for Resilience During COVID-19 plus CHAMindWell, Internet Cognitive Behavioral Therapy plus CHAMindWell, CHAMindWell
Behavioral
Lead sponsor
Cambridge Health Alliance
Other
Eligibility
18 Years to 70 Years
Enrollment
113 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Nov 15, 2026, 4:54 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Behavioral Therapy for Reduction in Smoking Craving

NCT00449293
View directory record Official record
Conditions
Smoking Cessation, Tobacco Dependence
Interventions
standard cognitive behavioral therapy, Mindfulness Based Cognitive Therapy
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 31, 2017 · Synced Nov 15, 2026, 4:54 AM EST
Completed Not applicable Interventional Results available

Cognitive Retraining and Brain Stimulation for Alcohol Use

NCT02045108
View directory record Official record
Conditions
Binge Drinking
Interventions
Active Retraining, Sham TDCS, Active TDCS, Sham Retraining
Behavioral · Device
Lead sponsor
The Mind Research Network
Other
Eligibility
21 Years to 30 Years
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Mar 20, 2018 · Synced Nov 15, 2026, 4:54 AM EST
Recruiting Not applicable Interventional Accepts healthy volunteers

TRAC-ER Intervention to Reduce Risky Alcohol Use and HIV Risk

NCT05576350
View directory record Official record
Conditions
Risk Behavior, Alcohol Use Disorder, HIV Infections
Interventions
Smartphone Based Alcohol Monitoring (SAM), Tracking and Reducing Alcohol Consumption (TRAC), TRAC-ER
Behavioral
Lead sponsor
University of Kentucky
Other
Eligibility
18 Years to 35 Years
Enrollment
405 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
2
States / cities
New Haven, Connecticut • Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Mar 30, 2025 · Synced Nov 15, 2026, 4:54 AM EST
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

A Hybrid Program to Prevent Substance Use Risk Among Upper Elementary School Students Using a Positive Youth Development Approach

NCT07162155
View directory record Official record
Conditions
Vaping, E Cig Use, Prescription Drug Misuse
Interventions
School-based Hybrid Intervention to Prevent Vaping and Prescription Drug Misuse
Behavioral
Lead sponsor
Christopher Williams
Industry
Eligibility
7 Years to 11 Years
Enrollment
3,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
White Plains, New York
Source: ClinicalTrials.gov public record
Updated Sep 9, 2025 · Synced Nov 15, 2026, 4:54 AM EST
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Development of a mHealth Intervention for Ambivalent Smokers

NCT04560868
View directory record Official record
Conditions
Tobacco Use Disorder, Smoking Cessation, Motivation, Behavior, Smoking
Interventions
Control mHealth program, Experimental mHealth program, Nicotine patch
Device · Drug
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 23, 2023 · Synced Nov 15, 2026, 4:54 AM EST
Recruiting Not applicable Interventional

Enhancing Wellness Through Affirming Services and Education

NCT05700474
View directory record Official record
Conditions
HIV, Mental Health Disorder, Substance Use
Interventions
Comprehensive outpatient behavioral health care
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 9, 2026 · Synced Nov 15, 2026, 4:54 AM EST
Terminated Phase 2 Interventional Results available

Biased Opioid Agonists for Treatment of Opioid Withdrawal in OUD

NCT04316559
View directory record Official record
Conditions
Opioid-Use Disorder
Interventions
Placebo, TRV734, Oxycodone
Other · Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 75 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Nov 15, 2026, 4:54 AM EST
Completed No phase listed Observational

Nicotine Reinforcement and Smoking-Cue Reactivity: Association With Genetic Polymorphisms

NCT01505725
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 64 Years
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 5, 2018 · Synced Nov 15, 2026, 4:54 AM EST
Active, not recruiting Not applicable Interventional

Behavioral Economic and Wellness-based Approaches for Reducing Alcohol Use and Consequences Among Emerging Adults

NCT04776278
View directory record Official record
Conditions
Alcohol Abuse
Interventions
Brief Alcohol Intervention (BAI), Substance-free Activity Session (SFAS), Relaxation Training (RT), Education Control
Behavioral · Other
Lead sponsor
University of Memphis
Other
Eligibility
18 Years to 29 Years
Enrollment
525 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 10, 2025 · Synced Nov 15, 2026, 4:54 AM EST
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Prazosin and Naltrexone (PaN) Study for Veterans With Alcohol Use Disorders

NCT02322047
View directory record Official record
Conditions
Alcohol Use Disorder, Posttraumatic Stress Disorder (PTSD)
Interventions
Prazosin, Naltrexone, Placebo (Prazosin), Placebo (Naltrexone)
Drug
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years to 80 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 29, 2020 · Synced Nov 15, 2026, 4:54 AM EST
Completed No phase listed Observational

A Follow-up Study to Assess Long-term Immunogenicity and Safety of NicVAX/Placebo as an Aid to Smoking Cessation

NCT01304810
View directory record Official record
Conditions
Smoking Cessation, Nicotine Dependence
Interventions
NicVAX vaccine, Placebo
Biological
Lead sponsor
Nabi Biopharmaceuticals
Industry
Eligibility
18 Years to 65 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
12
States / cities
Newport Beach, California • San Diego, California • Miami, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated May 14, 2012 · Synced Nov 15, 2026, 4:54 AM EST
Completed Phase 3 Interventional Results available

Attention Deficit Hyperactivity Disorder (ADHD) in Adolescents With Substance Use Disorders (SUD)

NCT00264797
View directory record Official record
Conditions
ADHD, Substance Abuse
Interventions
Methylphenidate (OROS-MPH), Methylphenidate (OROS-MPH) - Placebo
Drug
Lead sponsor
University of Cincinnati
Other
Eligibility
13 Years to 18 Years
Enrollment
303 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
12
States / cities
Denver, Colorado • Jacksonville, Florida • St. Petersburg, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Jun 7, 2013 · Synced Nov 15, 2026, 4:54 AM EST
Recruiting Not applicable Interventional

Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction

NCT06077240
View directory record Official record
Conditions
Smoking, Smoking Behaviors, Nicotine Dependence
Interventions
E-cigarette with 2.4% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 2.4% Nicotine with Tobacco Flavor Only, E-cigarette with 5% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 5% Nicotine with Tobacco Flavor Only, Tobacco Pouches with 3mg Nicotine with Menthol and Tobacco Flavors, Tobacco Pouches with 3mg Nicotine with Tobacco Flavor Only, Tobacco Pouches with 6mg Nicotine with Menthol and Tobacco Flavors, Tobacco Pouches with 6mg Nicotine with Tobacco Flavor Only
Behavioral
Lead sponsor
Yale University
Other
Eligibility
21 Years and older
Enrollment
256 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Nov 15, 2026, 4:54 AM EST
Completed Not applicable Interventional Results available

RCT of an Internet Cessation Program Plus Online Social Network for HIV+ Smokers

NCT02781090
View directory record Official record
Conditions
Tobacco Use Disorder, HIV
Interventions
PSFW+, AHA, Nicotine polacrilex
Behavioral · Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
512 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
2
States / cities
Baltimore, Maryland • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Aug 4, 2023 · Synced Nov 15, 2026, 4:54 AM EST
Recruiting Not applicable Interventional

Evaluating Caregiver Involvement in Primary Care-Based Brief Interventions for Adolescent Alcohol Use Problems

NCT06593652
View directory record Official record
Conditions
Alcohol Use, Adolescent, Mild Alcohol Use Disorder, Mild Substance Use Disorder
Interventions
Teen Intervene - Adolescent Only, Teen Intervene with Caregiver Session, Family Check Up
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
12 Years to 18 Years
Enrollment
615 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Nov 9, 2026 · Synced Nov 15, 2026, 4:54 AM EST
Not listed Not applicable Interventional

Emotion Regulation Interventions for Preventing Collegiate Escalations in Drinking

NCT04492982
View directory record Official record
Conditions
Alcohol Abuse
Interventions
Yoga, Distress Tolerance
Behavioral
Lead sponsor
University of Connecticut
Other
Eligibility
Not listed
Enrollment
197 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Storrs, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 31, 2022 · Synced Nov 15, 2026, 4:54 AM EST
Recruiting No phase listed Observational Accepts healthy volunteers

Olfactory Function and Model-Based Behavior in People Living With HIV and SUD

NCT07637669
View directory record Official record
Conditions
HIV, Substance Use Disorder
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2031
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 13, 2026 · Synced Nov 15, 2026, 4:54 AM EST
Completed Not applicable Interventional

Targeting Sleep Homeostasis to Improve Alcohol Use Disorder Treatment Outcomes (M-STAR Study)

NCT04457674
View directory record Official record
Conditions
Insomnia, Alcohol Use Disorder
Interventions
Cognitive Behavioral Therapy for insomnia (CBTi), Sleep Hygiene Education (SHE)
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 65 Years
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Nov 15, 2026, 4:54 AM EST
Completed No phase listed Observational Accepts healthy volunteers

Effectiveness of Using Reduced Nicotine Cigarettes in Men and Women Smokers to Combat Nicotine Addiction

NCT00264342
View directory record Official record
Conditions
Nicotine Dependence, Tobacco Use Disorder
Interventions
Not listed
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 70 Years
Enrollment
135 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2010
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 23, 2013 · Synced Nov 15, 2026, 4:54 AM EST
Completed Phase 2Phase 3 Interventional

Tobacco Use in Opioid Agonist Treated Pregnant Women

NCT00497068
View directory record Official record
Conditions
Nicotine Dependence
Interventions
tobacco abstinent contingent, non-contingent, control
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 5, 2013 · Synced Nov 15, 2026, 4:54 AM EST
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

CONNECT Cancer Survivors With Tobacco Treatment

NCT07020273
View directory record Official record
Conditions
Tobacco Use, Tobacco Use Cessation, Smoking Cessation, Nicotine Addiction, Tobacco Smoking
Interventions
ELEVATE, ELEVATE-S
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
3,543 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 13, 2026 · Synced Nov 15, 2026, 4:54 AM EST
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

The Human Stress Response in a Simulated ED Setting

NCT04317482
View directory record Official record
Conditions
Stress Physiology, Stress Reaction, Substance Use Disorders, Methamphetamine-dependence, Stress, Emotional
Interventions
Standard social stress task, Stressful experience in the ED
Behavioral
Lead sponsor
University of Arkansas
Other
Eligibility
21 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Oct 16, 2026 · Synced Nov 15, 2026, 4:54 AM EST