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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Substance Use Prevention Clear all
Completed Not applicable Interventional

Screening, Brief Intervention and Referral to Treatment for Substance Abuse in Mental Health Treatment Settings

NCT01883791
View directory record Official record
Conditions
Substance Use Disorders, Mental Illness
Interventions
SBIRT, Health Education
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
1,080 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
2
States / cities
Los Angeles, California • Oxnard, California
Source: ClinicalTrials.gov public record
Updated Nov 1, 2018 · Synced Sep 18, 2026, 1:28 AM EDT
Completed Not applicable Interventional Results available

Boston ARCH 4F Intervention to Reduce Fall Risk in People With HIV and Alcohol Use

NCT04804579
View directory record Official record
Conditions
HIV Infection, Alcohol Consumption, Falls, Accidental, Falls
Interventions
Fall Prevention Intervention
Behavioral
Lead sponsor
Boston University
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 28, 2023 · Synced Sep 18, 2026, 1:28 AM EDT
Completed Phase 2 Interventional

Brief Voluntary Alcohol and Drug Intervention for Middle School Youth

NCT01081119
View directory record Official record
Conditions
Alcohol Drinking, Cigarette Smoking, Marijuana Smoking
Interventions
Project CHOICE
Behavioral
Lead sponsor
RAND
Other
Eligibility
11 Years to 15 Years
Enrollment
6,455 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 9, 2014 · Synced Sep 18, 2026, 1:28 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Tobacco Zero: Interactive Tobacco Education for Teens

NCT00670995
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Interactive Tobacco Education
Behavioral
Lead sponsor
Deschutes Research, Inc.
Other
Eligibility
11 Years to 15 Years
Enrollment
1,864 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Feb 16, 2012 · Synced Sep 18, 2026, 1:28 AM EDT
Recruiting Phase 4 Interventional

Optimizing Evidence-based HIV Prevention Targeting People Who Inject Drugs on PrEP

NCT05669534
View directory record Official record
Conditions
Hiv, Opioid Use Disorder
Interventions
community-friendly health recovery program, Pre-Exposure Prophylaxis and Post-Exposure Prophylaxis
Behavioral · Drug
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years and older
Enrollment
256 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Sep 18, 2026, 1:28 AM EDT
Not listed Phase 2 Interventional

Computerized Chemosensory-Based Orbitofrontal Cortex (CBOT) for Opioid Use Disorder

NCT04850664
View directory record Official record
Conditions
Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe, Withdrawal Symptoms, Craving, Negative Affectivity
Interventions
CBOT + TAU, Sham + TAU
Drug
Lead sponsor
Evon Medics LLC
Industry
Eligibility
18 Years to 70 Years
Enrollment
190 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
4
States / cities
Washington D.C., District of Columbia • Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 5, 2021 · Synced Sep 18, 2026, 1:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Fetal Alcohol Damage Prevention Study

NCT00696085
View directory record Official record
Conditions
Fetal Alcohol Syndrome, Substance Abuse
Interventions
Brief motivational intervention
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older · Female only
Enrollment
612 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2008
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 11, 2008 · Synced Sep 18, 2026, 1:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of a Brief Tobacco Intervention in the US Military

NCT03196102
View directory record Official record
Conditions
Tobacco Use, Tobacco Smoking, Smoking, Cigar, Smoking, Pipe, Smoking, Hookah, Nicotine Dependence
Interventions
BTI, Cigarette smoking military tailored pamphlet, Standard smoking cessation intervention
Behavioral
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
2,999 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Lackland Air Force Base, Texas
Source: ClinicalTrials.gov public record
Updated Oct 6, 2021 · Synced Sep 18, 2026, 1:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pilot Test of Parent-Focused Cannabis-Related Actions and Practices Intervention for Adolescent Marijuana Abuse

NCT04923230
View directory record Official record
Conditions
Cannabis Use Disorder, Mild, Cannabis Use Disorder, Moderate
Interventions
Cannabis Actions and Practices Resource for Parents
Behavioral
Lead sponsor
Oregon Research Institute
Other
Eligibility
13 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Sep 25, 2023 · Synced Sep 18, 2026, 1:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

An Innovative HIV Prevention Intervention Using Social Networking Technology

NCT01381653
View directory record Official record
Conditions
Sexual Risk, Substance Use
Interventions
Behavioral: HIV prevention intervention
Other
Lead sponsor
Hunter College of City University of New York
Other
Eligibility
18 Years to 29 Years · Male only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 2, 2013 · Synced Sep 18, 2026, 1:28 AM EDT
Completed No phase listed Observational

Mindfulness and Meditation-Based Relapse Prevention for Substance Use Disorders

NCT07417579
View directory record Official record
Conditions
Substance Use Disorders, Behavioral Health, Addiction Psychological, Addiction Disorders, Meditation, Mindfulness Based Stress Reduction, Prevention
Interventions
Mindfulness and Meditation-Based Relapse Prevention Program
Behavioral
Lead sponsor
Bout Me Healing
Industry
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Boca Raton, Florida
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Sep 18, 2026, 1:28 AM EDT
Completed Phase 3 Interventional

SmartSteps: A Context-Aware, PrEP Adherence Intervention for Individuals With Substance Use Disorder

NCT05378399
View directory record Official record
Conditions
HIV Infections, Substance Use, Adherence, Medication, Adherence, Treatment
Interventions
Descovy or Truvada, ID-Cap System, Beiwe
Drug · Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older · Male only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Sep 18, 2026, 1:28 AM EDT
Not yet recruiting Not applicable Interventional

Homeless Overdose Prevention- Expansion

NCT07716202
View directory record Official record
Conditions
Homelessness, Opioid Education and Naloxone Distribution (OEND), Substance Use Disorder
Interventions
Homeless Overdose Prevention- Expansion (HOPE) - Low Intensity, Homeless Overdose Prevention- Expansion (HOPE) - High Intensity
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
1,200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Sep 18, 2026, 1:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Prevention of Substance Use in Youth in Ukraine

NCT02347644
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Brief Motivational Interview
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 25 Years
Enrollment
121 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 2, 2015 · Synced Sep 18, 2026, 1:28 AM EDT
Completed Not applicable Interventional Results available

Women's Treatment and Early Recovery

NCT02977988
View directory record Official record
Conditions
Substance-related Disorders
Interventions
Mindfulness Meditation, Brain and Recovery (B&R)
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Pomona, California
Source: ClinicalTrials.gov public record
Updated Jan 12, 2026 · Synced Sep 18, 2026, 1:28 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Clinician Practice Companion to Address Youth Substance Use

NCT07725289
View directory record Official record
Conditions
Substance Use, Substance-Related Disorders, Adolescent Substance Use, Cannabis Use, Opioid Use Disorder, Drug Overdose, Overdose Prevention, Co-occurring Mental Health Conditions
Interventions
Practice Companion
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
14 Years to 24 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2027 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Sep 18, 2026, 1:28 AM EDT
Completed Phase 1 Interventional Results available

Facilitating the Behavioral Treatment of Cannabis Use Disorder

NCT02946489
View directory record Official record
Conditions
Cannabis Dependence
Interventions
CI-581a
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
21 Years to 60 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 10, 2020 · Synced Sep 18, 2026, 1:28 AM EDT
Active, not recruiting Not applicable Interventional

Substance Use Prevention for Youth With Parents in Recovery

NCT05397691
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Modified Family Talk, Control-like parameter estimation
Other
Lead sponsor
Brown University
Other
Eligibility
12 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Pawtucket, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Sep 18, 2026, 1:28 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

15 Year Follow-up of New Beginnings Program for Divorced Families

NCT01407120
View directory record Official record
Conditions
Mental Disorder, Substance Use
Interventions
New Beginnings Program
Behavioral
Lead sponsor
Arizona State University
Other
Eligibility
9 Years to 12 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
Tempe, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 1, 2011 · Synced Sep 18, 2026, 1:28 AM EDT
Recruiting Not applicable Interventional

Prevent Language Delays and Disorders Among Children of Caregivers With Substance Use Disorders With Community Groups and Individualized Services

NCT07529327
View directory record Official record
Conditions
Language Delay, Substance Use Disorders, Language Disorders in Children, Language Development, Prevention Intervention
Interventions
Comilia Group, Interaction Review Enhancement, Practical Support Enhancement
Behavioral
Lead sponsor
University of Oregon
Other
Eligibility
18 Years and older
Enrollment
244 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 19, 2026 · Synced Sep 18, 2026, 1:28 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Equitable Smoking Relapse Prevention

NCT05625685
View directory record Official record
Conditions
Tobacco Use Disorder, Tobacco Dependence
Interventions
Quitbuddy, Control, SDoH Augmentation, SDoH Control
Other
Lead sponsor
Bryan W. Heckman
Other
Eligibility
21 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 7, 2024 · Synced Sep 18, 2026, 1:28 AM EDT
Completed Not applicable Interventional

Exercise: Addressing Stress in Relapse Prevention for Substance Use Disorders

NCT01828307
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Motivational enhancement therapy (MET), Contingency management, Standard Aftercare Treatment
Behavioral
Lead sponsor
St. Louis University
Other
Eligibility
18 Years and older
Enrollment
147 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 3, 2019 · Synced Sep 18, 2026, 1:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of the Media Detective Program for Elementary School-Aged Children to Prevention Substance Use

NCT01060852
View directory record Official record
Conditions
Alcohol Drinking, Tobacco Smoking
Interventions
Media Detective
Behavioral
Lead sponsor
Innovation Research & Training
Other
Eligibility
7 Years to 12 Years
Enrollment
679 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 10, 2014 · Synced Sep 18, 2026, 1:28 AM EDT
Not yet recruiting Not applicable Interventional

Permanent Supportive Housing Overdose Prevention+ Study

NCT07214519
View directory record Official record
Conditions
Overdose, Substance Use
Interventions
TA Intervention
Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
2,940 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2031
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 18, 2026, 1:28 AM EDT