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Showing 25–40 of 16 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Substrate Metabolism Clear all
Terminated Not applicable Interventional Accepts healthy volunteers

Metabolic Adaptations to High-fat Diet

NCT06537401
View directory record Official record
Conditions
Adiposity, Insulin Sensitivity, Impaired Glucose Tolerance, Metabolic Disturbance
Interventions
Hypercaloric, High Fat Diet
Behavioral
Lead sponsor
George Washington University
Other
Eligibility
20 Years to 45 Years
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 25, 2025 · Synced Sep 21, 2026, 5:22 AM EDT
Completed Phase 3 Interventional Results available

A Study of Eliglustat Tartrate (Genz-112638) in Patients With Gaucher Disease Who Have Reached Therapeutic Goals With Enzyme Replacement Therapy (ENCORE)

NCT00943111
View directory record Official record
Conditions
Gaucher Disease, Type 1
Interventions
Eliglustat tartrate, Imiglucerase
Drug
Lead sponsor
Genzyme, a Sanofi Company
Industry
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
17
States / cities
Beverly Hills, California • San Francisco, California • Aurora, Colorado + 13 more
Source: ClinicalTrials.gov public record
Updated Nov 24, 2016 · Synced Sep 21, 2026, 5:22 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Ketone Supplements and Substrate Oxidation and Physical Performance

NCT04737694
View directory record Official record
Conditions
Ketosis, Glucose Metabolism
Interventions
Ketone ester, Glucose
Dietary Supplement
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
18 Years to 39 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Natick, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 13, 2021 · Synced Sep 21, 2026, 5:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Fat Burning After a Meal

NCT02211599
View directory record Official record
Conditions
Postprandial Effect of Carbohydrate Beverage Consumption
Interventions
15% protein, 30% protein, Sweetened beverage
Other
Lead sponsor
USDA Grand Forks Human Nutrition Research Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Grand Forks, North Dakota
Source: ClinicalTrials.gov public record
Updated Feb 1, 2022 · Synced Sep 21, 2026, 5:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Breakfast Consumption and Energy Balance in Active Adult Males

NCT04862208
View directory record Official record
Conditions
Energy Intake, Substrate Utilization, Hormones, Satiety
Interventions
Maltodextrin supplement, Whey supplement, Water
Dietary Supplement
Lead sponsor
Ohio University
Other
Eligibility
18 Years to 45 Years · Male only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Athens, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 6, 2023 · Synced Sep 21, 2026, 5:22 AM EDT
Recruiting No phase listed Observational

Relationship Between Aspirin Metabolism and Markers of Metabolic Dysfunction Among Pregnant Persons at Risk of Pre-eclampsia

NCT06802861
View directory record Official record
Conditions
Preeclampsia, Preeclampsia (PE), Preeclampsia (PE) Risk, Obesity and Obesity-related Medical Conditions, Pregnancy, Pregnancy Complications, Gestational Diabetes, Gestational Diabetes Mellitus in Pregnancy, Gestational Complications
Interventions
Not listed
Lead sponsor
University of Tennessee Graduate School of Medicine
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 9, 2025 · Synced Sep 21, 2026, 5:22 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Diet-Induced Changes in GEnetic Material

NCT06252922
View directory record Official record
Conditions
Diet, Healthy, Body Weight, Metabolic Disturbance
Interventions
Not listed
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
20 Years to 35 Years · Male only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated May 30, 2025 · Synced Sep 21, 2026, 5:22 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Insulin Receptor Substrate 1 (IRS-1) Regulation in Insulin Resistance

NCT01240252
View directory record Official record
Conditions
Type 2 Diabetes Mellitus
Interventions
Human insulin
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
30 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Jun 4, 2013 · Synced Sep 21, 2026, 5:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Caloric Content and Timing of Meal on Postprandial Substrate Oxidation and Pulse Wave Analysis

NCT07122765
View directory record Official record
Conditions
Feeding, Metabolism, Indirect Calorimetry, Blood Flow Velocity, Pulse Wave Analysis, Pulse Wave Velocity, Carbohydrate Metabolism, Fatty Acid Metabolism, Healthy Participants
Interventions
Mixed Meal Feeding Challenge
Other
Lead sponsor
George Washington University
Other
Eligibility
18 Years to 45 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Sep 21, 2026, 5:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Ordered Eating and Acute Exercise

NCT06242015
View directory record Official record
Conditions
Glucose Metabolism Disorders, Hunger
Interventions
Carbohydrate-first meal, Carbohydrate-last meal
Other
Lead sponsor
Old Dominion University
Other
Eligibility
18 Years to 60 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 31, 2025 · Synced Sep 21, 2026, 5:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Black Pepper on Energy Expenditure and Substrate Utilization

NCT01729143
View directory record Official record
Conditions
Obesity
Interventions
24-hour energy expenditure and substrate utilization
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
50 Years to 65 Years · Female only
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Kannapolis, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 5, 2016 · Synced Sep 21, 2026, 5:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Energy Expenditure and Substrate Utilization During Acute Under- and Over-feeding

NCT01740765
View directory record Official record
Conditions
Obesity
Interventions
24-hour energy expenditure
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
50 Years to 65 Years · Female only
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Kannapolis, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 3, 2012 · Synced Sep 21, 2026, 5:22 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Phase 1 Study of ALXN1840 on the Metabolism of a CYP2C9 Substrate in Healthy Participants.

NCT04526197
View directory record Official record
Conditions
Wilson Disease
Interventions
ALXN1840, Celecoxib
Drug
Lead sponsor
Alexion Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 50 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Aug 20, 2023 · Synced Sep 21, 2026, 5:22 AM EDT
Completed Phase 2 Interventional

Substrate Cycling in Energy Metabolism

NCT00361751
View directory record Official record
Conditions
Burns, Insulin Resistance
Interventions
fenofibrate
Drug
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
4 Years to 18 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
1
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 14, 2010 · Synced Sep 21, 2026, 5:22 AM EDT
Completed Phase 3 Interventional Results available

A Study of Eliglustat Tartrate (Genz-112638) in Patients With Gaucher Disease (ENGAGE)

NCT00891202
View directory record Official record
Conditions
Gaucher Disease, Type 1
Interventions
Eliglustat tartrate, Placebo
Drug
Lead sponsor
Genzyme, a Sanofi Company
Industry
Eligibility
16 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2016
U.S. locations
6
States / cities
San Francisco, California • New Haven, Connecticut • Decatur, Georgia + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 2, 2017 · Synced Sep 21, 2026, 5:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sleep Restriction and Energy Expenditure

NCT01751581
View directory record Official record
Conditions
Obesity
Interventions
Short Sleep, Habitual sleep
Behavioral
Lead sponsor
St. Luke's-Roosevelt Hospital Center
Other
Eligibility
21 Years to 45 Years · Female only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 1, 2013 · Synced Sep 21, 2026, 5:22 AM EDT