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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Symptoms of Depression Clear all
Completed Not applicable Interventional

Impact of Massage Therapy and Music Therapy on the Quality of Life of Hospice Patients

NCT03217682
View directory record Official record
Conditions
Pain, Anxiety, Depression, Quality of Life
Interventions
Music Therapy, Massage Therapy
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 9, 2022 · Synced Sep 28, 2026, 3:43 AM EDT
Completed Phase 4 Interventional Results available

Antidepressant Treatment of Melancholia in Late Life

NCT00000378
View directory record Official record
Conditions
Depression, Melancholia
Interventions
Sertraline, Nortriptyline
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
60 Years to 95 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2002
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 6, 2015 · Synced Sep 28, 2026, 3:43 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Caregiver Stress and Sleep Study

NCT05219955
View directory record Official record
Conditions
Depressive Symptoms, Caregiver Burden
Interventions
Morning Action Plan Execution, Activity Strategy-based Session with Therapist, Attention-based Session with Therapist, Advance sleep-wake time
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
55 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Sep 28, 2026, 3:43 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

VITAL-DEP: Depression Endpoint Prevention in the VITamin D and OmegA-3 TriaL

NCT01696435
View directory record Official record
Conditions
Depression, Depressive Symptoms, Mood
Interventions
vitamin D3, omega-3 fatty acids (fish oil), Fish oil placebo, Vitamin D placebo
Dietary Supplement · Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
50 Years and older
Enrollment
18,353 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced Sep 28, 2026, 3:43 AM EDT
Completed Not applicable Interventional Results available

A Pilot Study on Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment of Bipolar Depression

NCT00699218
View directory record Official record
Conditions
Mood Disorder, Bipolar Disorder, Major Depression, Depression
Interventions
Magnetic Stimulator Rapid2 made by Magstim Company Ltd. U.K.
Device
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Jul 22, 2018 · Synced Sep 28, 2026, 3:43 AM EDT
Completed Phase 2 Interventional

Use of Omega-3 Fatty Acids for Perinatal Depression

NCT00402389
View directory record Official record
Conditions
Depression, Depression, Postpartum
Interventions
Omega-3 Fatty Acids (EPA plus DHA), Supportive psychotherapy, Placebo
Drug · Behavioral
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Mar 28, 2013 · Synced Sep 28, 2026, 3:43 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Journal Program on Wellbeing of NICU Parents

NCT04331925
View directory record Official record
Conditions
Anxiety, Depression
Interventions
Anxiety and depression screening, Journaling
Behavioral
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
Not listed
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 1, 2020 · Synced Sep 28, 2026, 3:43 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Targeting Specific Brain Networks to Treat Specific Symptoms in Depression

NCT05523817
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Intermittent Theta Burst Stimulation (iTBS)
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 28, 2025 · Synced Sep 28, 2026, 3:43 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Storytelling and Mindfulness for Graduate Student Wellbeing

NCT05826860
View directory record Official record
Conditions
Depression, Anxiety, Burnout, Student
Interventions
Mindfulness Practice, Storytelling Workshop
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Sep 28, 2026, 3:43 AM EDT
Completed Not applicable Interventional Results available

tDCS for Increasing Exercise Adherence in Depressed Individuals

NCT03178903
View directory record Official record
Conditions
Depression, Physical Activity
Interventions
tDCS, Sham tDCS, Aerobic Exercise (AE)
Other · Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Feb 26, 2023 · Synced Sep 28, 2026, 3:43 AM EDT
Completed Phase 3 Interventional Results available

Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) vs. Escitalopram in Postmenopausal Women

NCT00406640
View directory record Official record
Conditions
Depression, Depressive Disorder, Depressive Disorder, Major
Interventions
Desvenlafaxine succinate sustained-release (DVS SR), Escitalopram
Drug
Lead sponsor
Wyeth is now a wholly owned subsidiary of Pfizer
Industry
Eligibility
40 Years to 70 Years · Female only
Enrollment
595 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
52
States / cities
Peoria, Arizona • Pasadena, California • San Diego, California + 46 more
Source: ClinicalTrials.gov public record
Updated Dec 27, 2023 · Synced Sep 28, 2026, 3:43 AM EDT
Completed Not applicable Interventional

Applied Clinical Neuroscience Care for Self-reported Symptoms of Depression and Cerebellar Function in Adults

NCT03997240
View directory record Official record
Conditions
Depression
Interventions
Chiropractic Applied Clinical Neuroscience
Procedure
Lead sponsor
Life University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Marietta, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 1, 2024 · Synced Sep 28, 2026, 3:43 AM EDT
Completed Not applicable Interventional

Brief Inpatient Psychotherapy for Depression

NCT03091582
View directory record Official record
Conditions
Depression
Interventions
Cognitive factors, Behavioral factors, Increase engagement of pleasant events
Behavioral
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years to 80 Years · Female only
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 27, 2018 · Synced Sep 28, 2026, 3:43 AM EDT
Completed Not applicable Interventional

Effectiveness of Culturally Based Congruent Care in Treating Hispanics With Major Depressive Disorder

NCT00247195
View directory record Official record
Conditions
Depression
Interventions
Culturally Congruent Assessment and Treatment
Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 80 Years
Enrollment
113 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 24, 2012 · Synced Sep 28, 2026, 3:43 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Tools for Wellbeing COVID-19 National Study of Undergraduate Students

NCT04414371
View directory record Official record
Conditions
Stress, Anxiety, Depression, Resilience, Wellbeing, Mood
Interventions
Yoga
Other
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 3, 2020 · Synced Sep 28, 2026, 3:43 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Vitamin D Supplementation and Effects on Mood in Emergency Medicine Residents

NCT03739671
View directory record Official record
Conditions
Seasonal Mood Disorder
Interventions
Vitamin D, No Vitamin D
Dietary Supplement
Lead sponsor
Corewell Health South
Other
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Saint Joseph, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 28, 2024 · Synced Sep 28, 2026, 3:43 AM EDT
Completed No phase listed Observational Results available

Examining Validity and Reliability of the Shared Decision Making Process Survey in Adults With Depression

NCT04343534
View directory record Official record
Conditions
Depression
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
494 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 4, 2024 · Synced Sep 28, 2026, 3:43 AM EDT
Completed Not applicable Interventional Results available

A Comparative Effectiveness Trial of Optimal Patient-Centered Care

NCT02274688
View directory record Official record
Conditions
Post Traumatic Concerns, Post Traumatic Stress Disorder, Depression and Suicide Ideation, Alcohol and Drug Use
Interventions
Stepped Care Management
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
14 Years and older
Enrollment
171 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Nov 20, 2017 · Synced Sep 28, 2026, 3:43 AM EDT
Completed Phase 4 Interventional Results available

Effectiveness of Antidepressant Treatment for Depression in People With Parkinson's Disease

NCT00304161
View directory record Official record
Conditions
Depressive Disorder, Parkinson Disease
Interventions
Atomoxetine, Placebo
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
30 Years to 79 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
2
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 29, 2017 · Synced Sep 28, 2026, 3:43 AM EDT
Completed Phase 3 Interventional Results available

Lamotrigine for Symptoms of Geriatric Bipolar Depression

NCT00621842
View directory record Official record
Conditions
Bipolar Disorder, Depression, Bipolar
Interventions
Lamotrigine regular tablet formulation, Lamotrigine novel formulation
Drug
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
60 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
5
States / cities
White Plains, New York • Cleveland, Ohio • Philadelphia, Pennsylvania + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 29, 2014 · Synced Sep 28, 2026, 3:43 AM EDT
Active, not recruiting Phase 3 Interventional

Psilocybin for Major Depressive Disorder (MDD)

NCT06308653
View directory record Official record
Conditions
Depressive Disorder, Major
Interventions
Psilocybin 25 mg, Inactive Placebo, Psilocybin 5 mg, Psychosocial Support
Drug · Behavioral
Lead sponsor
Usona Institute
Other
Eligibility
18 Years and older
Enrollment
238 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
29
States / cities
Birmingham, Alabama • Fayetteville, Arkansas • Little Rock, Arkansas + 25 more
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Sep 28, 2026, 3:43 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Reliability and Validity of the MINI International Neuropsychiatric Interview for Children and Adolescents (MINI-KID)

NCT00579267
View directory record Official record
Conditions
Major Depression, Mania, Anxiety Disorders, Psychotic Disorder, Alcohol Dependence, Drug Dependence, Eating Disorders, Suicidality, Dysthymia, ADHD, Tourettes Disorder, Conduct Disorder, Oppositional Defiant Disorder, Pervasive Developmental Disorder
Interventions
MINI-KID
Other
Lead sponsor
University of South Florida
Other
Eligibility
6 Years to 17 Years
Enrollment
230 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2008
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Feb 15, 2009 · Synced Sep 28, 2026, 3:43 AM EDT
Completed Not applicable Interventional

Maintenance Interpersonal Psychotherapy for Sustaining Remission of Depression

NCT00227981
View directory record Official record
Conditions
Depression
Interventions
Interpersonal Psychotherapy, Fluoxetine
Behavioral · Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
20 Years to 60 Years · Female only
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1995 – 2001
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 24, 2013 · Synced Sep 28, 2026, 3:43 AM EDT
Completed Phase 2 Interventional

Women's Depression Treatment Study

NCT00843700
View directory record Official record
Conditions
Depression
Interventions
Interpersonal Psychotherapy-Trauma in Community Settings, Treatment as Usual
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older · Female only
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jan 8, 2014 · Synced Sep 28, 2026, 3:43 AM EDT