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Showing 1–24 of 48 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Syphilis Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Ending the HIV Epidemic Through Point-of-Care Technologies (EHPOC)

NCT04793750
View directory record Official record
Conditions
HIV Infections, Syphilis
Interventions
Cepheid GeneXpert HIV-1 Qual POC HIV VL test, DPP HIV-Syphilis test system, OraQuick
Diagnostic Test
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
224 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
3
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Sep 5, 2026, 1:21 PM EDT
Not yet recruiting No phase listed Observational Accepts healthy volunteers

Feasibility and Acceptability of Point of Care Rapid Syphilis Testing Among Patients Seeking Family Planning Services in Hawai'i

NCT07358949
View directory record Official record
Conditions
Syphilis Infection
Interventions
Rapid Syphilis Test
Diagnostic Test
Lead sponsor
Queen's Medical Center
Other
Eligibility
14 Years and older · Female only
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Honolulu, Hawaii
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Sep 5, 2026, 1:21 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Azithromycin/Bicillin Syphilis

NCT00031499
View directory record Official record
Conditions
Syphilis
Interventions
Azithromycin, Benzathine Penicillin, Doxycycline
Drug
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 55 Years
Enrollment
593 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2000 – 2009
U.S. locations
7
States / cities
Birmingham, Alabama • Indianapolis, Indiana • New Orleans, Louisiana + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 28, 2013 · Synced Sep 5, 2026, 1:21 PM EDT
Not yet recruiting Phase 4 Interventional

Congenital Syphilis Treatment Trial (CONSISTENT) in Neonates

NCT07457385
View directory record Official record
Conditions
Syphilis, Congenital
Interventions
Benzathine Penicillin, Amoxicillin
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
0 Days to 30 Days
Enrollment
374 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
11
States / cities
Birmingham, Alabama • Mobile, Alabama • Orange, California + 8 more
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Sep 5, 2026, 1:21 PM EDT
Completed Not applicable Interventional

A Pilot Study Evaluating Penicillin G and Ceftriaxone as Therapies for Presumed Neurosyphilis in HIV Seropositive Individuals

NCT00000648
View directory record Official record
Conditions
HIV Infections, Neurosyphilis
Interventions
Penicillin G potassium, Ceftriaxone sodium
Drug
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
13 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Ends 1996
U.S. locations
42
States / cities
Birmingham, Alabama • San Diego, California • San Francisco, California + 23 more
Source: ClinicalTrials.gov public record
Updated Oct 26, 2021 · Synced Sep 5, 2026, 1:21 PM EDT
Completed Not applicable Interventional Results available

Lumbar Puncture and Syphilis Outcome

NCT02031146
View directory record Official record
Conditions
Syphilis
Interventions
Lumbar puncture
Procedure
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
231 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 24, 2021 · Synced Sep 5, 2026, 1:21 PM EDT
Recruiting Not applicable Interventional

Offering Routine and Rapid Point of Care (POC) Syphilis Testing in Pregnant Patients Presenting to the Emergency Department

NCT06645106
View directory record Official record
Conditions
Syphilis
Interventions
Rapid Point of Care (POC) Syphilis testing
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
1,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 5, 2026, 1:21 PM EDT
Completed Not applicable Interventional Results available

Zenyth: Motivational Interviewing-based Telehealth Intervention for Bacterial Sexually Transmitted Infection Screening

NCT06100250
View directory record Official record
Conditions
Sexually Transmitted Diseases, Gonorrhea, Chlamydia, Syphilis, HIV
Interventions
Motivational interviewing and specimen self-collection
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 30, 2025 · Synced Sep 5, 2026, 1:21 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Combination Primary Care and Prevention Services for Women Who Inject Drugs and Exchange Sex in Seattle, Washington

NCT06187064
View directory record Official record
Conditions
Opioid Use Disorder, HIV Infections, Chlamydia, Gonorrhea, Syphilis, Trichomonas
Interventions
Mobile Van Clinic
Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Sep 5, 2026, 1:21 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Rapid HIV, Hep C, and Syphilis Screening in a Rural Street Medicine Clinic

NCT07317687
View directory record Official record
Conditions
HIV Testing, HEPATITIS C (HCV), Syphilis, Hepatitis B Virus (HBV)
Interventions
Rapid Fingerstick Test, Blood Draw for lab test
Diagnostic Test
Lead sponsor
West Virginia University
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Harpers Ferry, West Virginia
Source: ClinicalTrials.gov public record
Updated Aug 12, 2026 · Synced Sep 5, 2026, 1:21 PM EDT
Withdrawn Not applicable Interventional

Point-Of-Care Testing for Congenital Syphilis in Mothers and Newborns

NCT03814096
View directory record Official record
Conditions
Maternal Syphilis During Pregnancy - Baby Not Yet Delivered, Congenital Syphilis
Interventions
Syphilis Health Check POC-test (Diagnostics Direct LLC, NJ)
Diagnostic Test
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
2
States / cities
San Jose, California • Stanford, California
Source: ClinicalTrials.gov public record
Updated Dec 12, 2019 · Synced Sep 5, 2026, 1:21 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

This Study Evaluates the ALPCO Syphilis-T and Syphilis-NT CLIA Kits for Detecting Syphilis Antibodies in Serum and Plasma. Samples From At-risk, HIV-positive, Pregnant, and Healthy Individuals Will Assess Assay Performance Versus Established Comparator Tests.

NCT07089836
View directory record Official record
Conditions
Treponema Pallidum, Treponema Pallidum Infection, Syphilis Infection, Serum, Plasma, Blooddraw, Sexually Transmitted Infection (STI)
Interventions
ALPCO Syphilis-T, ALPCO Syphilis-NT CLIA Kits
Device
Lead sponsor
American Laboratory Products Company
Industry
Eligibility
13 Years and older
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
6
States / cities
Lancaster, California • Los Angeles, California • North Miami, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Sep 5, 2026, 1:21 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Utilization of the Community Popular Opinion Leader (C-POL) Model in Alabama

NCT00260754
View directory record Official record
Conditions
Risk Behavior, Sexually Transmitted Diseases
Interventions
Community-Popular Opinion Leader Model, Diffusion of Innovations
Behavioral
Lead sponsor
Centers for Disease Control and Prevention
Federal
Eligibility
18 Years and older
Enrollment
600 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2005
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated May 30, 2006 · Synced Sep 5, 2026, 1:21 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men

NCT03980223
View directory record Official record
Conditions
Gonorrhea, Chlamydia, Syphilis
Interventions
Doxycycline Hyclate Delayed-Release 200 mg
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older · Male only
Enrollment
641 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
3
States / cities
San Francisco, California • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 11, 2024 · Synced Sep 5, 2026, 1:21 PM EDT
Recruiting No phase listed Observational

Study of Ceftriaxone and Benzathine Penicillin G During Pregnancy

NCT07207876
View directory record Official record
Conditions
Pregnancy
Interventions
Ceftriaxon, Benzathine penicillin G
Drug
Lead sponsor
International Maternal Pediatric Adolescent AIDS Clinical Trials Group
Network
Eligibility
Female only
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
8
States / cities
Los Angeles, California • Chicago, Illinois • Stony Brook, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Sep 5, 2026, 1:21 PM EDT
Completed No phase listed Observational

NOWDx Test for the Diagnosis of Syphilis

NCT05063344
View directory record Official record
Conditions
Syphilis Infection, Treponema Pallidum Infection
Interventions
Diagnostic Test: NOWDx Syphilis Test
Device
Lead sponsor
NOWDiagnostics, Inc.
Industry
Eligibility
18 Years to 64 Years
Enrollment
1,535 participants
Timeline
2021 – 2023
U.S. locations
6
States / cities
Tempe, Arizona • Los Angeles, California • North Miami, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 28, 2024 · Synced Sep 5, 2026, 1:21 PM EDT
Completed Phase 1 Interventional

Phase 1 Study of the Pharmacokinetics of Amoxicillin in Pregnancy

NCT05309928
View directory record Official record
Conditions
Pregnancy Related
Interventions
Amoxicillin
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
16 Years to 50 Years · Female only
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 16, 2025 · Synced Sep 5, 2026, 1:21 PM EDT
Recruiting Phase 4 Interventional

Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections

NCT06738407
View directory record Official record
Conditions
Gonorrhea, Chlamydia, Syphilis, Sexually Transmitted Infections (STIs)
Interventions
Doxycycline hyclate delayed released 200 mg, Doxycycline hyclate delayed released 200 mg weekly, Per standard of care with quarterly STI testing/treatment and sexual health counseling
Drug · Other
Lead sponsor
Westat
Other
Eligibility
13 Years to 29 Years · Female only
Enrollment
760 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
13
States / cities
Los Angeles, California • San Francisco, California • Washington D.C., District of Columbia + 10 more
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Sep 5, 2026, 1:21 PM EDT
Completed Phase 4 Interventional Results available

Phase 4 Comparative Trial of Benzathine Penicillin G for Treatment of Early Syphilis in Subjects With or Without HIV Infection

NCT03637660
View directory record Official record
Conditions
Syphilis
Interventions
Benzathine Penicillin
Drug
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 99 Years
Enrollment
249 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
10
States / cities
Birmingham, Alabama • Atlanta, Georgia • Indianapolis, Indiana + 7 more
Source: ClinicalTrials.gov public record
Updated Jan 13, 2025 · Synced Sep 5, 2026, 1:21 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Video Tool to Promote Knowledge of Syphilis as Facilitator of HIV Transmission

NCT00553111
View directory record Official record
Conditions
Syphilis
Interventions
educational video
Other
Lead sponsor
Jacobi Medical Center
Other
Eligibility
Male only
Enrollment
168 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
2
States / cities
Manhattan, New York
Source: ClinicalTrials.gov public record
Updated Nov 4, 2007 · Synced Sep 5, 2026, 1:21 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Syph-Check Syphilis Antibody Point of Care (POC) Test

NCT00732355
View directory record Official record
Conditions
Screening for Syphilis Infections
Interventions
Syph-Check POC
Device
Lead sponsor
Healthcare Providers Direct, Inc.
Industry
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 1, 2016 · Synced Sep 5, 2026, 1:21 PM EDT
Active, not recruiting Phase 2 Interventional

Linezolid for Syphilis Pilot Study

NCT05548426
View directory record Official record
Conditions
Syphilis
Interventions
Group B, Linezolid 10d, Group A, Penicillin
Drug
Lead sponsor
University of Southern California
Other
Eligibility
16 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
5
States / cities
Chicago, Illinois • Jackson, Mississippi • Greensboro, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced Sep 5, 2026, 1:21 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Improving Maternal and Child Health Through Point-of-care STI Testing

NCT07290439
View directory record Official record
Conditions
Treponema Pallidum Infection, Chlamydia Trachomatis Infection, Neisseria Gonorrheae Infection, Trichomonas Vaginalis Vaginitis, Sexually Transmitted Infection
Interventions
Point-of-care STI tests, Standard of care STI testing
Diagnostic Test
Lead sponsor
Emory University
Other
Eligibility
Female only
Enrollment
756 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 5, 2026, 1:21 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Lay Health Advisors for Sexually Transmitted Disease Prevention

NCT00207506
View directory record Official record
Conditions
Syphilis, Gonorrhea, Chlamydia Infections, HIV Infections
Interventions
HoMBReS: A lay health advisor approach to STD prevention
Behavioral
Lead sponsor
Centers for Disease Control and Prevention
Federal
Eligibility
18 Years and older · Male only
Enrollment
354 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2007
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 10, 2012 · Synced Sep 5, 2026, 1:21 PM EDT