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ClinicalTrials.gov public records Last synced Oct 24, 2026, 5:52 AM EDT

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Showing 1–24 of 56 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Thyroid Nodule Clear all
Completed Phase 1 Interventional

Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors

NCT00413322
View directory record Official record
Conditions
Tumor
Interventions
belinostat, 5-Fluorouracil (5-FU)
Drug
Lead sponsor
Valerio Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
3
States / cities
Scottsdale, Arizona • Omaha, Nebraska • Portsmouth, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jul 8, 2015 · Synced Oct 24, 2026, 5:52 AM EDT
Enrolling by invitation No phase listed Observational

Pressure-enabled Retrograde Occlusive Therapy With Embolization for Control of Thyroid Disease (PROTECT Registry): A Multicenter Registry

NCT06868459
View directory record Official record
Conditions
Hyperthyroidism; Goiter, Multinodular Goiter, Thyroid Nodules, Thyroid Disease, Hyperthyroidism, Toxic Multinodular Goiter
Interventions
Data Collection
Other
Lead sponsor
Sarasota Memorial Health Care System
Other
Eligibility
18 Years to 89 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
4
States / cities
Jacksonville, Florida • Sarasota, Florida • Atlanta, Georgia + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 24, 2026, 5:52 AM EDT
Recruiting No phase listed Observational

RFA of Benign Thyroid Nodules: Clinical Outcomes and Quality of Life Study

NCT05189314
View directory record Official record
Conditions
Thyroid Nodules
Interventions
Thyroidectomy, Radiofrequency Ablation
Procedure · Device
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Timeline
2019 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 29, 2026 · Synced Oct 24, 2026, 5:52 AM EDT
Recruiting No phase listed Observational

Diagnostic DNA Methylation Signature in Diagnosing Thyroid Cancer After Fine-Needle Aspiration in Patients With Thyroid Nodules

NCT03676647
View directory record Official record
Conditions
Thyroid Gland Nodule
Interventions
Diagnostic DNA Methylation Signature
Other
Lead sponsor
City of Hope Medical Center
Other
Eligibility
19 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2028
U.S. locations
1
States / cities
Duarte, California
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Oct 24, 2026, 5:52 AM EDT
Active, not recruiting No phase listed Observational

Randomized Trial Comparing Performance of Molecular Markers for Indeterminate Thyroid Nodules

NCT02681328
View directory record Official record
Conditions
Thyroid
Interventions
Afirma GEC, ThyroSeq v.2, Afirma GSC, ThyroSeq v.3
Other
Lead sponsor
Jonsson Comprehensive Cancer Center
Other
Eligibility
18 Years to 100 Years
Enrollment
328 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Oct 24, 2026, 5:52 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Integrated Cancer Repository for Cancer Research

NCT02012699
View directory record Official record
Conditions
Pancreatic Cancer, Thyroid Cancer, Lung Cancer, Esophageal Cancer, Thymus Cancer, Colon Cancer, Rectal Cancer, Gastrointestinal Stromal Tumors, Anal Cancer, Bile Duct Cancer, Duodenal Cancer, Gallbladder Cancer, Gastric Cancer, Liver Cancer, Small Intestine Cancer, Peritoneal Surface Malignancies, Familial Adenomatous Polyposis, Lynch Syndrome, Bladder Cancer, Kidney Cancer, Penile Cancer, Prostate Cancer, Testicular Cancer, Ureter Cancer, Urethral Cancer, Hypopharyngeal Cancer, Laryngeal Cancer, Lip Cancer, Oral Cavity Cancer, Nasopharyngeal Cancer, Oropharyngeal Cancer, Paranasal Sinus Cancer, Nasal Cavity Cancer, Salivary Gland Cancer, Skin Cancer, Central Nervous System Tumor, Central Nervous System Cancer, Mesothelioma, Breast Cancer, Leukemia, Melanoma, Sarcoma, Unknown Primary Tumor, Multiple Myeloma, Ovarian Cancer, Endometrial Cancer, Vaginal Cancer, Neuroendocrine Tumors, Plasma Cell Dyscrasia, Healthy Control
Interventions
Not listed
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years to 110 Years
Enrollment
999,999 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2099
U.S. locations
42
States / cities
Greenwood Village, Colorado • Manchester, Connecticut • Daytona Beach, Florida + 34 more
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Oct 24, 2026, 5:52 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Leptin Levels in Papillary Thyroid Cancer

NCT01659385
View directory record Official record
Conditions
Thyroid Cancer, Papillary, Leptin Levels
Interventions
Not listed
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years to 75 Years · Female only
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 6, 2023 · Synced Oct 24, 2026, 5:52 AM EDT
Terminated No phase listed Observational

Radioiodine Planar and a SPECT/CT Imaging With Iodine-123 for Evaluation of Follicular Thyroid Nodules Prior to Surgery

NCT05591092
View directory record Official record
Conditions
Thyroid Gland Follicular Carcinoma
Interventions
Computed Tomography, Iodine I-123, Planar Imaging, Single Photon Emission Computed Tomography
Procedure · Radiation
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 24, 2026, 5:52 AM EDT
Recruiting Not applicable Interventional

Decision Aid and Thyroid Nodules Management

NCT05264857
View directory record Official record
Conditions
Thyroid Nodule
Interventions
Thyroid Nodule Management Education
Behavioral
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years and older
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Oct 24, 2026, 5:52 AM EDT
Completed Not applicable Interventional Results available

Diagnostic Accuracy of Shear-Wave Elastography for the Preoperative Risk Stratification of Follicular Lesions of the Thyroid

NCT03106337
View directory record Official record
Conditions
Thyroid Nodule, Follicular Neoplasm
Interventions
Shear-Wave Elastography
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 16, 2017 · Synced Oct 24, 2026, 5:52 AM EDT
Completed Not applicable Interventional

Shared Decision Making in Patients With Thyroid Nodules

NCT02878044
View directory record Official record
Conditions
Thyroid Nodule, Thyroid Cancer
Interventions
Thyroid Decision Aid
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
2
States / cities
Jacksonville, Florida • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 6, 2022 · Synced Oct 24, 2026, 5:52 AM EDT
Not listed Not applicable Interventional

Shear Wave Ultrasound Elastography in Noninvasive Diagnosis of Thyroid Nodules

NCT01757834
View directory record Official record
Conditions
Thyroid Nodule
Interventions
SWUS Elastography
Device
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
175 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 28, 2015 · Synced Oct 24, 2026, 5:52 AM EDT
Not listed No phase listed Observational

Genomic Profiling of Nodular Thyroid Disease and Thyroid Cancer

NCT03170804
View directory record Official record
Conditions
Thyroid Nodule, Thyroid Cancer, Thyroid Diseases, Thymic Carcinoma
Interventions
Not listed
Lead sponsor
Aventura Hospital and Medical Center
Other
Eligibility
16 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Aventura, Florida
Source: ClinicalTrials.gov public record
Updated May 31, 2017 · Synced Oct 24, 2026, 5:52 AM EDT
Recruiting No phase listed Observational

Nanosecond Pulsed Field Ablation in the Management of Benign Thyroid Nodules

NCT07226804
View directory record Official record
Conditions
Thyroid Nodules, Pulsed Field Ablation
Interventions
Questionnaire
Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Oct 24, 2026, 5:52 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Use of an In Vivo Optical Probe to Discriminate Benign From Malignant Thyroid Nodules

NCT01401855
View directory record Official record
Conditions
Cancer, Thyroid
Interventions
Not listed
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 17, 2016 · Synced Oct 24, 2026, 5:52 AM EDT
Completed Phase 2 Interventional

Molecular Testing to Direct Extent of Initial Thyroid Surgery

NCT02947035
View directory record Official record
Conditions
Thyroid Cancer
Interventions
Thyroid lobectomy, Total thyroidectomy with CCND
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 14, 2023 · Synced Oct 24, 2026, 5:52 AM EDT
Completed Not applicable Interventional Results available

The Effect of Surgeon Emotional Support on Treatment Choice for Low-risk Thyroid Cancer

NCT05132478
View directory record Official record
Conditions
Thyroid Cancer, Thyroid Nodule, Benign Thyroid Nodule
Interventions
Emotionally Supportive Video, Standard Video
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Apr 3, 2024 · Synced Oct 24, 2026, 5:52 AM EDT
Completed Not applicable Interventional

Pilot Study on Laser Ablation of Symptomatic Benign Thyroid Masses

NCT00615537
View directory record Official record
Conditions
Thyroid Nodule, Thyroid Cancer, Thyroid Neoplasms, Nodular Goiter
Interventions
Laser Ablation of Thyroid Nodule
Procedure
Lead sponsor
BioTex, Inc.
Industry
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 5, 2011 · Synced Oct 24, 2026, 5:52 AM EDT
Terminated No phase listed Observational

Thyroid Abnormalities Associated With Exposure to Atmospheric Emissions of Radioactive Iodine

NCT00342693
View directory record Official record
Conditions
Thyroid Abnormalities
Interventions
Not listed
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
51 Years to 52 Years
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 5, 2018 · Synced Oct 24, 2026, 5:52 AM EDT
Completed No phase listed Observational

Electrical Impedance Scanning of Thyroid Nodules Prior to Thyroid Surgery: a Prospective Study

NCT00571077
View directory record Official record
Conditions
Thyroid Neoplasms, Thyroid Nodules
Interventions
Electrical Impedance Scanning (EIS) of the Thyroid gland
Device
Lead sponsor
Hadassah Medical Organization
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2007
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated May 13, 2008 · Synced Oct 24, 2026, 5:52 AM EDT
Completed Not applicable Interventional Results available

Study of the Efficacy of Local Analgesia as an Adjunct to General Anesthesia in Thyroidectomy and Parathyroidectomy

NCT02205801
View directory record Official record
Conditions
Thyroid Neoplasms, Goiter, Nodular, Thyroid Nodule, Graves' Disease, Hyperparathyroidism
Interventions
Superficial Cervical Plexus Block, Local Wound Infiltration, 0.9% saline, Marcaine
Procedure · Drug
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 9, 2018 · Synced Oct 24, 2026, 5:52 AM EDT
Recruiting No phase listed Observational

Radiofrequency Ablation for Management of Benign/Indeterminate Thyroid Nodules and Low Risk Papillary Thyroid Cancers

NCT07140757
View directory record Official record
Conditions
Low Risk, Papillary Thyroid Cancer, Radiofrequency Ablation
Interventions
Questionnaire
Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Oct 24, 2026, 5:52 AM EDT
Completed No phase listed Observational

The Role of an Optical Probe in Thyroid Cancer Diagnosis: Pilot Study

NCT01792492
View directory record Official record
Conditions
Thyroid Nodule, Thyroid Neoplasms, Thyroid Cancer
Interventions
Not listed
Lead sponsor
Boston Medical Center
Other
Eligibility
Not listed
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 29, 2016 · Synced Oct 24, 2026, 5:52 AM EDT
Completed No phase listed Observational Results available

Assess Vitamin D Levels in Those With & Without Thyroid Cancer

NCT00719615
View directory record Official record
Conditions
Thyroid Cancer
Interventions
Not listed
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Oct 16, 2023 · Synced Oct 24, 2026, 5:52 AM EDT