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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Tibia Fractures Clear all
Terminated No phase listed Observational

Safety Study of Treatment of Leg Fractures

NCT03881241
View directory record Official record
Conditions
Tibial Fractures
Interventions
Not listed
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
2
States / cities
Athens, Georgia • Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Apr 9, 2020 · Synced Jun 10, 2026, 1:36 PM EDT
Completed Phase 3 Interventional

Assessment of Fixation Strategies for Severe Open Tibia Fractures

NCT01494519
View directory record Official record
Conditions
Severe Open Fractures of the Tibia (Shin) Bone
Interventions
Surgery with an external ring fixator, Definitive fixation with a locked IM nail or plate
Procedure
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years to 64 Years
Enrollment
442 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
33
States / cities
Birmingham, Alabama • San Diego, California • San Francisco, California + 27 more
Source: ClinicalTrials.gov public record
Updated May 25, 2026 · Synced Jun 10, 2026, 1:36 PM EDT
Withdrawn Not applicable Interventional

Blood Flow Restriction Therapy Improves Tibial Plateau Fracture Recovery

NCT06589115
View directory record Official record
Conditions
Tibial Plateau Fractures
Interventions
Blood Flow Restriction Cuff, Physical Therapy
Other
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Nov 9, 2025 · Synced Jun 10, 2026, 1:36 PM EDT
Terminated Phase 2Phase 3 Interventional

A Phase 2/3 Multicenter, Controlled Trial Of rhBMP-2/CPM In Tibial Fractures

NCT00387686
View directory record Official record
Conditions
Fractures
Interventions
rhBMP-2/CPM
Drug
Lead sponsor
Wyeth is now a wholly owned subsidiary of Pfizer
Industry
Eligibility
18 Years and older
Enrollment
367 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
17
States / cities
Birmingham, Alabama • Aurora, Colorado • Denver, Colorado + 13 more
Source: ClinicalTrials.gov public record
Updated Feb 27, 2013 · Synced Jun 10, 2026, 1:36 PM EDT
Terminated Phase 3 Interventional Accepts healthy volunteers Results available

Tibial Delayed Healing Pivotal Clinical Trial

NCT01016067
View directory record Official record
Conditions
Tibial Delayed Healing
Interventions
INFUSE/MASTERGRAFT, Autograft bone
Device · Procedure
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
21 Years and older
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
16
States / cities
Denver, Colorado • Fort Lauderdale, Florida • Jacksonville, Florida + 13 more
Source: ClinicalTrials.gov public record
Updated Jan 20, 2015 · Synced Jun 10, 2026, 1:36 PM EDT
Withdrawn Phase 3 Interventional

Bone Healing Accelerant Versus Standard of Care for Open Tibia Fractures

NCT03826784
View directory record Official record
Conditions
Tibial Fractures
Interventions
BHA
Combination Product
Lead sponsor
Carmell Therapeutics Corporation
Industry
Eligibility
18 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 22, 2020 · Synced Jun 10, 2026, 1:36 PM EDT
Terminated Not applicable Interventional Results available

Light Therapy in the Treatment of Leg Pain

NCT00253981
View directory record Official record
Conditions
Tibial Fractures, Leg Injuries
Interventions
Monochromatic Near-Infrared Light Energy (MIRE)
Device
Lead sponsor
Samueli Institute for Information Biology
Other
Eligibility
18 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated Jun 12, 2016 · Synced Jun 10, 2026, 1:36 PM EDT
Terminated Not applicable Interventional Results available

The Effect of Botulinum Toxin A Injections on Ankle Dorsiflexion Following Internal Fixation of Tibial Pilon Fractures

NCT02051933
View directory record Official record
Conditions
Equinus Contracture
Interventions
Botulinum toxin type A, sodium chloride
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 20, 2022 · Synced Jun 10, 2026, 1:36 PM EDT
Enrolling by invitation Phase 4 Interventional

Fracture Recovery for Returning to Duty (Teriparatide STRONG)

NCT04589819
View directory record Official record
Conditions
Stress Fracture of Tibia or Fibula
Interventions
Teriparatide, Placebos
Drug
Lead sponsor
University of South Carolina
Other
Eligibility
Not listed
Enrollment
183 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 12, 2023 · Synced Jun 10, 2026, 1:36 PM EDT
Recruiting Not applicable Interventional

Comparison of Healing Measures Tibial Fractures Following Standard Intramedullary Nailing or Micromotion Tibial Intramedullary Nailing

NCT06679049
View directory record Official record
Conditions
Tibial Fractures
Interventions
micromotion intramedullary nail cohort, standard intramedullary nail cohort
Procedure
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Jun 10, 2026, 1:36 PM EDT
Completed Phase 2Phase 3 Interventional

Hyperbaric Oxygen in Lower Leg Trauma

NCT00264511
View directory record Official record
Conditions
Tibial Fracture, Soft Tissue Injury
Interventions
Hyperbaric Oxygen Treatment
Other
Lead sponsor
Bayside Health
Government
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2016
U.S. locations
1
States / cities
Concord, California
Source: ClinicalTrials.gov public record
Updated Sep 4, 2023 · Synced Jun 10, 2026, 1:36 PM EDT
Withdrawn Not applicable Interventional

Auricular Acupuncture as Part of Multimodal Analgesia After Lower Leg Fracture

NCT05984433
View directory record Official record
Conditions
Pain, Postoperative, Fracture, Ankle, Pilon Fracture of Tibia, Foot Fracture
Interventions
Auricular acupuncture
Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 64 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Jun 10, 2026, 1:36 PM EDT
Completed No phase listed Observational

Assessment of Severe Extremity Wound Bioburden at the Time of Definitive Wound Closure or Coverage

NCT01496014
View directory record Official record
Conditions
Open Fracture
Interventions
Not listed
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years to 64 Years
Enrollment
646 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2022
U.S. locations
40
States / cities
San Diego, California • San Francisco, California • Denver, Colorado + 34 more
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Jun 10, 2026, 1:36 PM EDT
Terminated Not applicable Interventional Results available

Lateral Versus Anterior Spanning External Fixator for Tibial Plateau Fractures

NCT00610701
View directory record Official record
Conditions
Fractures, Closed
Interventions
Anterior pin placement, Lateral pin placement
Device
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2014
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 23, 2017 · Synced Jun 10, 2026, 1:36 PM EDT
Completed Early Phase 1 Interventional

Continuous Femoral Nerve Block With a Tibial Plateau Fracture

NCT02168959
View directory record Official record
Conditions
Tibial Plateau Fracture
Interventions
bupivacaine
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 13, 2016 · Synced Jun 10, 2026, 1:36 PM EDT
Recruiting Phase 3 Interventional

Incisional Negative Pressure Wound Therapy to Reduce Infection and Complications in High-Risk Fractures

NCT06337292
View directory record Official record
Conditions
Fracture of Tibia, Wound Heal, Infected Wound, Wound Complication, Wound Dehiscence
Interventions
Incisional Negative Pressure Wound Therapy (NPWT)
Device
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years and older
Enrollment
352 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
6
States / cities
Baltimore, Maryland • Lebanon, New Hampshire • Nashville, Tennessee + 2 more
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Jun 10, 2026, 1:36 PM EDT
Completed Not applicable Interventional

A Study of Immediate and Delayed Closure of Type II and IIIa Open Tibia Fractures

NCT01315392
View directory record Official record
Conditions
Type II and IIa Open Tibia Fractures
Interventions
delayed closure, immediate wound closure
Procedure
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
15 Years and older
Enrollment
451 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2000
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 20, 2022 · Synced Jun 10, 2026, 1:36 PM EDT
Active, not recruiting Early Phase 1 Interventional

Role of Multimodal Analgesia in Decreasing Perioperative Pain in Tibial Plateau Fractures

NCT05037812
View directory record Official record
Conditions
Tibial Plateau Fractures
Interventions
Saline injection, Multimodal injections
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 79 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2028
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Jun 10, 2026, 1:36 PM EDT
Terminated Not applicable Interventional Results available

Intraoperative Methadone vs Morphine for Postoperative Pain Control in Patients Undergoing Surgery of the Tibia

NCT01430182
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Methadone, Morphine
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 50 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 3, 2016 · Synced Jun 10, 2026, 1:36 PM EDT
Completed No phase listed Observational Results available

Zimmer® MotionLoc® in Distal Tibia Fractures

NCT02717546
View directory record Official record
Conditions
Distal Tibia Fractures
Interventions
Zimmer MotionLoc Screw
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
3
States / cities
Springfield, Illinois • Indianapolis, Indiana • Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 3, 2021 · Synced Jun 10, 2026, 1:36 PM EDT
Withdrawn Not applicable Interventional

Bimodal Analgesia as Form of Pain Control Post Long Bone Fracture

NCT00240396
View directory record Official record
Conditions
Tibia Fracture, Femur Fracture, Humerus Fracture
Interventions
Narcotics alone, Narcotics and NSAIDS
Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 100 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 21, 2017 · Synced Jun 10, 2026, 1:36 PM EDT
Completed Not applicable Interventional

Effects of Early Weight Bearing on Rehabilitation Outcomes in Patients With Traumatic Ankle and Tibial Plateau Fractures

NCT04028414
View directory record Official record
Conditions
Rehabilitation
Interventions
Early Weight Bearing
Other
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years and older
Enrollment
435 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
17
States / cities
Birmingham, Alabama • San Francisco, California • Indianapolis, Indiana + 14 more
Source: ClinicalTrials.gov public record
Updated May 25, 2026 · Synced Jun 10, 2026, 1:36 PM EDT
Completed No phase listed Observational

Reliability of Sensor Spacing for NIRS in Traumatic Tibia Fractures

NCT02301832
View directory record Official record
Conditions
Orthopedic Disorders, Tibial Fractures
Interventions
Not listed
Lead sponsor
Emory University
Other
Eligibility
18 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 5, 2017 · Synced Jun 10, 2026, 1:36 PM EDT
Recruiting Not applicable Interventional

Continuous Passive Motion Following Fixation of Pelvic and Knee Fractures

NCT04389749
View directory record Official record
Conditions
Fractures, Bone
Interventions
CPM
Device
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Jun 10, 2026, 1:36 PM EDT