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ClinicalTrials.gov public records Last synced Nov 5, 2026, 3:41 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 57 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Tissue Oxygenation Clear all

Conditions: Diabetic Foot Ulcers
Interventions: Not listed
Lead sponsor: HyperMed; Industry
Eligibility: 21 Years to 85 Years
Enrollment: 256 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2008
U.S. locations: 3
States / cities: Sylmar, California • Cleveland, Ohio • Philadelphia, Pennsylvania

Conditions: Radiation Toxicity
Interventions: Not listed
Lead sponsor: Essentia Health; Other
Eligibility: 18 Years and older · Female only
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Duluth, Minnesota

Conditions: Oxygenation
Interventions: StO2 monitoring; Device
Lead sponsor: The University of Texas Health Science Center at San Antonio; Other
Eligibility: 18 Years and older
Enrollment: 47 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2008
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Oxygen Saturation
Interventions: Clarifi Modulum, Perimed PeriFlux 5000, Apple Watch Oxygen Sensor, Innovo iP 900AP; Device
Lead sponsor: Indiana University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 2
States / cities: Indianapolis, Indiana • Pittsburgh, Pennsylvania

Conditions: Pneumonia
Interventions: Antibiotic stewardship messaging; Behavioral
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 643 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Vascular Disease, Peripheral, Chronic Wound of the Lower Limb (Leg Ulcer or Foot Ulcer)
Interventions: Not listed
Lead sponsor: MIMOSA Diagnostics Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 60 participants
Timeline: 2025
U.S. locations: 1
States / cities: Lake Success, New York

Conditions: Anesthesia, Local
Interventions: Not listed
Lead sponsor: Nationwide Children's Hospital; Other
Eligibility: Not listed
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Wounds
Interventions: MolecuLightDX+ with OxySight Module; Device
Lead sponsor: MolecuLight Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 18 participants
Timeline: 2026
U.S. locations: 1
States / cities: Monroeville, Pennsylvania

Conditions: Critical Limb Ischemia
Interventions: Not listed
Lead sponsor: HyperMed; Industry
Eligibility: 18 Years to 85 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Phoenix, Arizona

Conditions: Hemoglobin, Cerebral Oxygenation, Congenital Heart Disease
Interventions: Noninvasive hemoglobin monitoring; Device
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 0 Days to 21 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Transfusion Related Complication
Interventions: SNO, Normal Saline, Red Blood Cell; Drug
Lead sponsor: James Reynolds; Other
Eligibility: 18 Years to 35 Years
Enrollment: 35 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2028
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Peripheral Arterial Disease
Interventions: Beetroot Juice (Beet-It Stamina Shot) & Supervised Exercise Training, Placebo Comparator Beverage (Beet-It Stamina Shot) & Exercise Training; Drug · Other
Lead sponsor: Duke University; Other
Eligibility: 40 Years to 75 Years
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Infant, Premature, Congenital Heart Disease, Patent Ductus Arteriosus, Necrotizing Enterocolitis
Interventions: Near-infrared spectroscopy (NIRS); Procedure
Lead sponsor: University of Utah; Other
Eligibility: 12 Days to 6 Months
Enrollment: 64 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2022
U.S. locations: 3
States / cities: Murray, Utah • Salt Lake City, Utah

Conditions: Mixed Venous Oxygen Saturation, Tissue Oxygenation
Interventions: Cerebral/Somatic Tissue Oximeter device, Pulmonary artery catheter; Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2013
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Premature Infant, Patent Ductus Arteriosus, Hemodynamic Instability
Interventions: Resonance Raman Spectroscopy (RRS); Device
Lead sponsor: University of Florida; Other
Eligibility: Not listed
Enrollment: 55 participants
Timeline: 2015 – 2018
U.S. locations: 2
States / cities: Gainesville, Florida • Boston, Massachusetts

Conditions: Breast Cancer
Interventions: Imaging with S-FLARE imaging system; Device
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 21 Years and older · Female only
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Necrotizing Enterocolitis
Interventions: Not listed
Lead sponsor: Nationwide Children's Hospital; Other
Eligibility: Up to 7 Days
Enrollment: 450 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2026
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Tourette's Syndrome, Chronic Motor Tic Disorder, Chronic Motor Vocal Disorder
Interventions: Not listed
Lead sponsor: National Institute of Neurological Disorders and Stroke (NINDS); NIH
Eligibility: Not listed
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2001 – 2005
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Non-Diabetic Patients, Wound Leg, Chronic Ulcer Leg/Foot
Interventions: Not listed
Lead sponsor: Chandan Sen; Other
Eligibility: 30 Years and older
Enrollment: 54 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2023
U.S. locations: 3
States / cities: Indianapolis, Indiana • Columbus, Ohio

Conditions: SCD
Interventions: Non-Invasive Infrared Spectroscopy; Diagnostic Test
Lead sponsor: National Heart, Lung, and Blood Institute (NHLBI); NIH
Eligibility: 18 Years to 100 Years
Enrollment: 49 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Healthy
Interventions: O2 MedTech cerebral oximeter (Oxygen desaturation); Device
Lead sponsor: O2 MedTech, Inc.; Industry
Eligibility: 18 Years to 50 Years
Enrollment: 42 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Blood Pressure
Interventions: NIRS Monitoring; Device
Lead sponsor: Boston Children's Hospital; Other
Eligibility: Up to 6 Months
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Overweight
Interventions: Weight Control; Other
Lead sponsor: University of California, Irvine; Other
Eligibility: 18 Years to 65 Years
Enrollment: 21 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Irvine, California

Conditions: Esophageal Cancer
Interventions: wireless pulse oximeter (Wipox); Device
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 21 Years and older
Enrollment: 166 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: New York, New York

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Hyperspectral Imaging to Assess and Predict Diabetic Foot Ulcers

Normal Tissue Oxygenation Following Radiotherapy

Evaluation of a Radial Arterial Line's Effect on StO2 Monitoring

Comparison of Tissue Oxygenation Measurement Using Multimodal Devices

Decreasing Unnecessary Antibiotics Prescribed for Possible Pneumonia Despite Normal Respiratory Rate and Oxygenation

Correlating Multispectral Near-Infrared Imaging to Standard Vascular Diagnostics

Changes in Tissue Oxygenation Following Regional Anesthesia

MolecuLight All-in-One Oxygenation Clinical Utility

Validation of OxyVu for Assessing Level of Amputation With Comparison to Other Modalities

Observational Data Collection for Blood Hemoglobin Algorithm Validation in Pediatrics

S-Nitrosylation (SNO) Therapy During Autologous Blood Transfusion

Nitrites, Exercise, and Peripheral Arterial Disease

Splanchnic and Renal Tissue Oxygenation During Enteral Feedings in Neonates With Patent Ductus Arteriosus

Validation of Mixed Venous Blood Oxygen Saturation Obtained With a Novel Mathematical Equation

Non-Invasive Detection of Tissue Oxygen Deprivation in Premature Infants With Patent Ductus Arteriosus.

Tissue Oxygenation Measurements With Modulated Light (S-FLARE)

Early Predictors of Necrotizing Enterocolitis in Neonates

Brain Activation in Vocal and Motor Tics

Role of Tissue Oxygenation and the miR-210 Gene In Wound Healing

Exploring Near Infrared Spectroscopy (NIRS) Technologies for Assessment of Muscle Physiology, Tissue Oxygenation, and Blood Flow in Patients With Sickle Cell Disease (SCD)

Accuracy of the O2 MedTech PMS-3000 Monitor

The Newborn Project: Examining the Oxygenation of Brain Tissue During General Anesthesia

The Use of Diffuse Optical Spectroscopy to Characterize in Response to Weight-Loss Intervention

Tissue Oxygenation Are Associated With Anastomotic Leak Rates After an Ivor Lewis Esophagectomy