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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Tobacco Use Behavior Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Sex Differences in E-cig Perception: Study 1

NCT05432830
View directory record Official record
Conditions
Nicotine Addiction, E-Cig Use, Cigarette Smoking, Sex Differences
Interventions
E-liquid Flavor 1, E-liquid Flavor 2, E-liquid Flavor 3
Other
Lead sponsor
Yale University
Other
Eligibility
21 Years to 44 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Sep 25, 2026, 8:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Culturally Targeted & Individually Tailored Smoking Cessation Study: LGBT Smokers

NCT01633567
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Culturally Targeted Cessation Program, Non-Targeted Cessation Program
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years to 65 Years
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 3, 2017 · Synced Sep 25, 2026, 8:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Shrinking the Size of the Tobacco Power Wall

NCT04632030
View directory record Official record
Conditions
Tobacco Use
Interventions
Tobacco power wall size and tobacco products displayed
Behavioral
Lead sponsor
RAND
Other
Eligibility
11 Years to 20 Years
Enrollment
275 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 24, 2023 · Synced Sep 25, 2026, 8:03 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Mobile Media-Rich Interactive Guideline System (MMRIGS) Pilot Study

NCT02302859
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
Nicotine Patch, Questionnaires, Pamphlet, Phone Counseling Sessions, Saliva Test, Smart phone
Drug · Behavioral · Other + 1 more
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 26, 2020 · Synced Sep 25, 2026, 8:03 AM EDT
Completed Phase 4 Interventional

Varenicline Treatment in Alcohol and Nicotine Dependent Patients With Schizophrenia

NCT00727103
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder, Alcohol Dependence, Nicotine Dependence
Interventions
Varenicline, Placebo
Drug
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years to 69 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Feb 7, 2024 · Synced Sep 25, 2026, 8:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study of Unfiltered Cigarettes Among Committed Smokers

NCT03749876
View directory record Official record
Conditions
Cigarette Smoking, Tobacco Smoking
Interventions
Unfiltered Cigarettes, Filtered Cigarettes
Other
Lead sponsor
San Diego State University
Other
Eligibility
21 Years to 65 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
San Marcos, California
Source: ClinicalTrials.gov public record
Updated Oct 21, 2020 · Synced Sep 25, 2026, 8:03 AM EDT
Completed Phase 4 Interventional Results available

Neurobehavioral Substrates of Propranolol's Effects on Drug Cue Reactivity

NCT03309943
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Propranolol, Placebo
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 55 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 12, 2020 · Synced Sep 25, 2026, 8:03 AM EDT
Recruiting Not applicable Interventional

Feasibility and Acceptability Trial to Reduce Tobacco and Cannabis Use During Pregnancy and Postpartum

NCT07489443
View directory record Official record
Conditions
Perinatal, Cannabis Use, Tobacco Use, Smoking Cessation
Interventions
Perinatal smoking cessation treatment and maintenance sessions
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older · Female only
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 5, 2026 · Synced Sep 25, 2026, 8:03 AM EDT
Completed Not applicable Interventional Results available

Pharmacokinetic and Subjective Effects of Heated Tobacco Products

NCT06356610
View directory record Official record
Conditions
Tobacco Use
Interventions
Product A, Product B, Product C, Product D, Product E, Product F
Other
Lead sponsor
Altria Client Services LLC
Industry
Eligibility
22 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
3
States / cities
Lexington, Kentucky • Springfield, Missouri • Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Sep 25, 2026, 8:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Does Abstinence From E-cigarettes Produce Withdrawal Symptoms?

NCT02825459
View directory record Official record
Conditions
Substance Withdrawal Syndrome
Interventions
Abstinence from e-cigarettes
Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
147 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
2
States / cities
Baltimore, Maryland • Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Nov 19, 2018 · Synced Sep 25, 2026, 8:03 AM EDT
Active, not recruiting Phase 2 Interventional Results available

Nivolumab for the Reversal of Squamous Dysplasia in High Risk Current and Former Smokers

NCT03347838
View directory record Official record
Conditions
Bronchial Dysplasia, Tobacco Smoking, History of Non-Small Cell Lung Cancer, History of Head and Neck Cancer
Interventions
Nivolumab
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 80 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
2
States / cities
Aurora, Colorado • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 11, 2025 · Synced Sep 25, 2026, 8:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nicotine Lozenges and Assisted Self-help for Smokeless Tobacco Cessation

NCT01341938
View directory record Official record
Conditions
Smokeless Tobacco Cessation
Interventions
Commit® nicotine lozenges (4 mg) & self-help materials, Commit® nicotine lozenges (4 mg) & phone counseling & self-help materials, Phone counseling & self-help materials
Drug · Behavioral
Lead sponsor
Oregon Research Institute
Other
Eligibility
18 Years and older
Enrollment
1,067 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 3, 2021 · Synced Sep 25, 2026, 8:03 AM EDT
Completed Not applicable Interventional Results available

Comparison of the Substitution Between Different Tobacco/Nicotine Products as a Function of Tobacco-user Type

NCT05177848
View directory record Official record
Conditions
Cigarette Smoking, Nicotine Vaping
Interventions
All nicotine/ tobacco products at market price, Nicotine vaping products at 1/2 market price, Nicotine vaping products at 2x market price, Heated tobacco products at 1/2 market price., Heated tobacco products at 2x market price., Nicotine pouch products at 1/2 market price., Nicotine pouch products at 2x market price.
Other
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
21 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 29, 2025 · Synced Sep 25, 2026, 8:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Yoga and Cardiovascular Exercise on Smoking Motivation

NCT01423578
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Hatha Yoga (HY), Cardiovascular Exercise (CE), Smoking Cessation Counseling
Behavioral
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
18 Years to 55 Years
Enrollment
79 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2017
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jun 25, 2017 · Synced Sep 25, 2026, 8:03 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Pilot Study to Evaluate the Efficacy and Safety of Ariva® Silver Wintergreen in Healthy Smokers

NCT01337817
View directory record Official record
Conditions
Tobacco Use Disorder, Smoking
Interventions
Ariva Silver Wintergreen, Ariva Wintergreen
Other
Lead sponsor
Star Scientific, Inc
Industry
Eligibility
23 Years to 72 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009
U.S. locations
1
States / cities
Martinsburg, West Virginia
Source: ClinicalTrials.gov public record
Updated Oct 23, 2014 · Synced Sep 25, 2026, 8:03 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Development of a mHealth Intervention for Ambivalent Smokers

NCT04560868
View directory record Official record
Conditions
Tobacco Use Disorder, Smoking Cessation, Motivation, Behavior, Smoking
Interventions
Control mHealth program, Experimental mHealth program, Nicotine patch
Device · Drug
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 22, 2023 · Synced Sep 25, 2026, 8:03 AM EDT
Withdrawn Phase 1 Interventional

Stage Ib Trial of mSMART With Varenicline

NCT03069768
View directory record Official record
Conditions
Nicotine Dependence
Interventions
mSMART, Chantix
Device · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 16, 2018 · Synced Sep 25, 2026, 8:03 AM EDT
Completed Not applicable Interventional Results available

Correcting Public Misperceptions About Very Low Nicotine Content Cigarettes

NCT04974489
View directory record Official record
Conditions
Tobacco Use, Cigarette Use
Interventions
Emotion-based messages about the harm of VLNC, Continued-harm-framed messages about the harm of VLNC, Myth-refuting messages about the harm of VLNC, Control messages about littering
Behavioral
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
1,153 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 7, 2022 · Synced Sep 25, 2026, 8:03 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Effectiveness of Various Smoking Cessation Therapies in Reducing Smoking in Adolescents - 1

NCT00158171
View directory record Official record
Conditions
Smoking Cessation, Tobacco Use Disorder
Interventions
Nicotine Replacement Therapies, Nicotine patch, Folic Acid
Drug · Dietary Supplement
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
13 Years to 18 Years
Enrollment
128 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2004
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 9, 2017 · Synced Sep 25, 2026, 8:03 AM EDT
Completed Phase 2 Interventional

Brief Voluntary Alcohol and Drug Intervention for Middle School Youth

NCT01081119
View directory record Official record
Conditions
Alcohol Drinking, Cigarette Smoking, Marijuana Smoking
Interventions
Project CHOICE
Behavioral
Lead sponsor
RAND
Other
Eligibility
11 Years to 15 Years
Enrollment
6,455 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 9, 2014 · Synced Sep 25, 2026, 8:03 AM EDT
Not listed Phase 2 Interventional Accepts healthy volunteers

QuitAdvisorMD: A Point-of-care Tool for Brief Smoking Cessation Interventions

NCT01065493
View directory record Official record
Conditions
Smoking, Tobacco Use Disorder
Interventions
QuitAdvisorMD Software Algorithm, Standard Smoking Cessation Counseling
Other · Behavioral
Lead sponsor
Silverchair Science & Communications, LLC
Industry
Eligibility
Not listed
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 18, 2014 · Synced Sep 25, 2026, 8:03 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Naltrexone and Varenicline: Weight Gain and Tolerability in Cigarette Smokers

NCT00502216
View directory record Official record
Conditions
Smoking, Nicotine Dependence
Interventions
Naltrexone, Varenicline
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 16, 2018 · Synced Sep 25, 2026, 8:03 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Persistent Poverty Counties Pregnant Women With Medicaid

NCT05415371
View directory record Official record
Conditions
Tobacco Cessation, Tobacco Use, Tobacco Smoking, Smoking Cessation Financial Incentives, Socioeconomic Status, Contingency Management, Pregnancy
Interventions
Standard Care + Financial Incentives, Standard Care
Behavioral · Other
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 105 Years · Female only
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Sep 25, 2026, 8:03 AM EDT
Completed Phase 2 Interventional Results available

Adaptive Pharmacotherapy for Smoking Cessation

NCT02501265
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Varenicline Standard Protocol, Nicotine Patch Standard Protocol, Varenicline Adaptive Protocol, Nicotine Adaptive Protocol
Behavioral · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
188 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 18, 2021 · Synced Sep 25, 2026, 8:03 AM EDT