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ClinicalTrials.gov public records Last synced Nov 8, 2026, 11:55 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 692 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Tooth Diseases Clear all

Conditions: Tooth, Nonvital
Interventions: Regenerative Endodontic Procedure (REP); Other
Lead sponsor: Boston University; Other
Eligibility: 7 Years to 18 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Dental Cavity, Caries,Dental
Interventions: Nutritional Counseling; Behavioral
Lead sponsor: Loma Linda University; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Loma Linda, California

Conditions: Tooth Discoloration
Interventions: ToothWave, powered toothbrush; Device
Lead sponsor: Home Skinovations Ltd.; Industry
Eligibility: 18 Years to 70 Years
Enrollment: 91 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Dental Erosion, Acid Wear
Interventions: Sodium Fluoride, Potassium nitrate; Drug
Lead sponsor: GlaxoSmithKline; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 56 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Gingival Inflammation
Interventions: Instructed Brushing Method; Other
Lead sponsor: Tufts University; Other
Eligibility: 18 Years and older
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Toothache
Interventions: Placebo gel, benzocaine; Drug
Lead sponsor: Wyeth is now a wholly owned subsidiary of Pfizer; Industry
Eligibility: 12 Years and older
Enrollment: 577 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 8
States / cities: Baltimore, Maryland • Boston, Massachusetts • Detroit, Michigan + 5 more

Conditions: Dental Caries
Interventions: xylitol wipe, placebo wipe; Dietary Supplement
Lead sponsor: University of California, San Francisco; Other
Eligibility: 6 Months to 35 Months
Enrollment: 88 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2008
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Dental Plaque
Interventions: Experimental: U-shaped Power Toothbrush, Placebo Comparator: Soft Manual Toothbrush; Device
Lead sponsor: Lander Enterprises, LLC; Industry
Eligibility: 5 Years to 8 Years
Enrollment: 22 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 1
States / cities: Fort Wayne, Indiana

Conditions: Wound Healing and Prevention, Oral Inflammation, Photobiomodulation, Post-operative Pain Management, Tooth Extraction Site Healing
Interventions: Low-level laser therapy; Other
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 39 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Traumatic Brain Injury (TBI), Chronic Traumatic Encephalopathy (CTE)
Interventions: Fish Oil (DPA+EPA 2:1 ratio) Capsules, High Oleic Safflower Oil Capsules; Dietary Supplement
Lead sponsor: University of Arizona; Other
Eligibility: 18 Years to 25 Years · Male only
Enrollment: 38 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Tucson, Arizona

Conditions: Dental Caries
Interventions: Not listed
Lead sponsor: University of Michigan; Other
Eligibility: 9 Months to 15 Months
Enrollment: 1,326 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2017
U.S. locations: 3
States / cities: Indianapolis, Indiana • Iowa City, Iowa • Durham, North Carolina

Conditions: Bruxism, Sleep-Related
Interventions: Not listed
Lead sponsor: Otis Dental, LLC; Industry
Eligibility: 18 Years to 50 Years · Male only
Enrollment: 2 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Dental Plaque
Interventions: Stannous fluoride dentifrice, Positive control dentifrice, Negative control dentifrice; Drug
Lead sponsor: Procter and Gamble; Industry
Eligibility: 18 Years and older
Enrollment: 2,359 participants
Timeline: 2018
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Cavity, Cavities of Teeth
Interventions: Composite with 90 degree cavosurface angle, Composite with wide bevel; Device
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Dental Caries
Interventions: Dispersed phase amalgam restoration /composite restoration; Device
Lead sponsor: Carelon Research; Other
Eligibility: 6 Years to 10 Years
Enrollment: 534 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1997 – 2005
U.S. locations: 1
States / cities: Watertown, Massachusetts

Conditions: Periodontal Disease, Periapical Disease, Pregnancy, Diabetes, Cardiovascular Disease, Dental Caries
Interventions: Not listed
Lead sponsor: Roger Johnson; Other
Eligibility: 10 Years and older · Female only
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2011
U.S. locations: 1
States / cities: Jackson, Mississippi

Conditions: Caries, Dental
Interventions: 10% w/v chlorhexidine acetate coating FDA IND #45466, Placebo; Drug · Other
Lead sponsor: Tufts University; Other
Eligibility: 18 Years and older
Enrollment: 983 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2010
U.S. locations: 4
States / cities: Tuba City, Arizona • Boston, Massachusetts • Portland, Oregon

Conditions: Obesity, Dental Caries
Interventions: Kiosk, paper, Kiosk PLUS paper, Kiosk PLUS web; Other
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 160 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Dental Malocclusion, Angle Class II, Angle Class I, Crowding, Tooth
Interventions: BRIUS; Device
Lead sponsor: State University of New York at Buffalo; Other
Eligibility: 10 Years to 17 Years
Enrollment: 13 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Dental Plaque, Gingivitis
Interventions: Stannous Fluoride Toothpaste (Parodontax Complete Protection Toothpaste), CPC Mouthwash (Parodontax Active Gum Health Mouthwash), Regular Fluoride Toothpaste (Crest Cavity Protection); Drug
Lead sponsor: HALEON; Industry
Eligibility: 18 Years and older
Enrollment: 199 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Fort Wayne, Indiana

Conditions: Partial Edentulism, Tooth Disease
Interventions: Not listed
Lead sponsor: ZimVie; Industry
Eligibility: 18 Years and older
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2009
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Dentin Sensitivity
Interventions: Experimental Oral Rinse 1, Experimental Oral Rinse 2, Placebo Oral Rinse, Fluoride toothpaste; Device · Other · Drug
Lead sponsor: GlaxoSmithKline; Industry
Eligibility: 18 Years to 55 Years
Enrollment: 240 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015
U.S. locations: 1
States / cities: Fort Wayne, Indiana

Conditions: Caries,Dental
Interventions: Self-determination theory; Behavioral
Lead sponsor: University of Iowa; Other
Eligibility: 18 Years to 45 Years
Enrollment: 1,268 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 16
States / cities: Anamosa, Iowa • Belle Plaine, Iowa • Cedar Rapids, Iowa + 11 more

Conditions: Jaw, Edentulous, Partially
Interventions: Straumann Bone Level Implant; Device
Lead sponsor: Institut Straumann AG; Industry
Eligibility: 18 Years and older
Enrollment: 145 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2013
U.S. locations: 2
States / cities: Boca Raton, Florida • Gainesville, Florida

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Endodontic Regenerative Procedure for Immature Non-vital Teeth

Effectiveness of a Nutritional Counseling Tool in Reducing the Amount and Frequency of Sugar Intake

Safety and Efficacy of the ToothWave Powered Toothbrush for Extrinsic Stain Reduction (Texas)

Evaluation of Efficacy of Experimental Gel to Foam Dentifrices in Dental Erosion

Toothbrush Wear and Its Effect on Subgingival Inflammation Using Two Different Brushing Techniques

Benzocaine Gel Toothache Dose-Response Study

Study on Use of Xylitol-wipes to Prevent Dental Caries

Plaque Removal Efficacy of a U-Shaped Sonic Power Toothbrush in Children

Impact of Nd:YAG Laser Photobiostimulation on Healing of Gingiva

The Effects of Fish Oil Supplementation on the Brain Health of Collegiate Football Athletes

Predicting Caries Risk in Underserved Toddlers in Primary Healthcare Settings

A Sensor-enhanced Mouth Guard to Quantitatively Measure Bite Compression Forces.

Meta-analysis of Stannous Fluoride and the Effects on Dental Plaque

In Vivo Assessment of the Tooth-Resin Composite Interface Using Optical Coherence Tomography

The Children's Amalgam Trial

Periodontal and Periapical Inflammation and Pregnancy

Prevention of Adult Caries Study (PACS)

Nutrition Knowledge for Spanish-speaking Parents

BRIUS Vs FFA Efficiency

A Study to Evaluate the Efficacy of a Stannous Fluoride Toothpaste With a Cetylpyridinium Chloride Mouthwash in Improving Gingival Health and Reducing Plaque Accumulation

A Study of Osseotite Certain Prevail Implants Used to Support Short Fixed Bridges With Immediate Occlusal Loading.

A Study in Dentinal Hypersensitivity (DH) Participants to Assess the Efficacy of an Occluding Dentifrice.

Birth to Three - Cavity Free

Clinical Study Comparing Submerged Versus Trans-mucosal Healing of P.004 Implants in the Anterior Mandible and Maxilla