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Showing 1–24 of 32 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Tooth Lesions Clear all
Active, not recruiting Phase 3 Interventional

Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS) (REMODEL-1)

NCT05147220
View directory record Official record
Conditions
Relapsing Multiple Sclerosis
Interventions
Remibrutinib, Teriflunomide
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
18 Years to 55 Years
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2030
U.S. locations
52
States / cities
Phoenix, Arizona • Tucson, Arizona • Fort Smith, Arkansas + 47 more
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Sep 4, 2026, 9:21 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Evaluation Of A New Two-Component Self-Etch Universal Adhesive

NCT01464996
View directory record Official record
Conditions
Composite Restorations, Tooth Lesions
Interventions
Adhesive: OptiBond XTR; Composite: Herculite Ultra, Adhesive: OptiBond FL; Composite: Herculite Ultra
Procedure
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 80 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 26, 2015 · Synced Sep 4, 2026, 9:21 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Split-Mouth Clinical Trial Evaluating the Bond Failure Rate of a New Etch-Free Orthodontic Adhesive

NCT07091422
View directory record Official record
Conditions
Bracket Bonding, Orthodontic Treatment, Dental Adhesives/Restorations Performance, White Spot Lesion of Tooth
Interventions
Etch-Free Adhesive, Conventional Etch-and-Bond Adhesive
Device
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
14 Years to 35 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 9, 2025 · Synced Sep 4, 2026, 9:21 AM EDT
Completed Not applicable Interventional Results available

High-strength Glass-ionomer Dental Restorations

NCT01523613
View directory record Official record
Conditions
Dental Caries
Interventions
Chemfil ROCK Glassionomer restoration, Fuji IX GP Extra Glassionomer restoration
Device
Lead sponsor
Mathilde Peters, DMD, PhD
Other
Eligibility
7 Years to 16 Years
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Flint, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 2, 2017 · Synced Sep 4, 2026, 9:21 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

DPBRN Longitudinal Study of Questionable Occlusal Caries Lesions

NCT01309971
View directory record Official record
Conditions
Dental Caries
Interventions
Not listed
Lead sponsor
Dental Practice-Based Research Network
Network
Eligibility
6 Years and older
Enrollment
2,624 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
6
States / cities
Birmingham, Alabama • Gainesville, Florida • Minneapolis, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 18, 2014 · Synced Sep 4, 2026, 9:21 AM EDT
Completed Not applicable Interventional Results available

Radiographic Progression of Infiltrated Caries Lesions In-vivo

NCT01496456
View directory record Official record
Conditions
Dental Caries
Interventions
Resin infiltration, Caries management
Device · Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
14 Years to 35 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 7, 2017 · Synced Sep 4, 2026, 9:21 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Orthodontic Varnish Microbiology Study

NCT04528134
View directory record Official record
Conditions
Dental Caries, Dental Plaque, Dental White Spot
Interventions
Extended Contact RMGI (Resin-modified Glass Ionomer) Varnish, 5% Sodium Fluoride Varnish
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
12 Years to 27 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Sep 4, 2026, 9:21 AM EDT
Completed Not applicable Interventional

Clinical Performance of Posterior Glass Ionomer Restorations in Adolescents (KETAC)

NCT02705729
View directory record Official record
Conditions
Dental Caries
Interventions
Ketac Universal, Ketac Molar Quick
Device
Lead sponsor
Louisiana State University Health Sciences Center in New Orleans
Other
Eligibility
12 Years to 17 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Jul 26, 2021 · Synced Sep 4, 2026, 9:21 AM EDT
Not listed Not applicable Interventional

A Comparative Study of Hall Technique, Modified Hall Technique and Conventional Stainless-Steel Crown Restorations in the Treatment of Primary Molars With Proximal Caries Lesions.

NCT04822233
View directory record Official record
Conditions
Dental Caries
Interventions
Hall Technique (HT), Modified Hall Technique (MHT), Conventional Technique (CT)
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
5 Years to 8 Years
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 18, 2023 · Synced Sep 4, 2026, 9:21 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Lesion Progression After Icon Treatment in Young Adults

NCT01988337
View directory record Official record
Conditions
Caries, Salivary Function, Tooth Sensitivity
Interventions
Resin infiltration, Mock treatment
Device · Other
Lead sponsor
DMG Dental Material Gesellschaft mbH
Industry
Eligibility
19 Years and older
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 3, 2022 · Synced Sep 4, 2026, 9:21 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

3D Scanning as an Advanced Tool for Identifying Tooth Lesions in Children

NCT06829550
View directory record Official record
Conditions
Dental Caries in Children, Tooth Erosion, Fluorosis, Dental, Dental Caries
Interventions
indirect- 3D digital scanning
Diagnostic Test
Lead sponsor
Indiana University
Other
Eligibility
3 Years to 12 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 4, 2026, 9:21 AM EDT
Completed No phase listed Observational

Using a Narcotic to Enhance the Numbing Effect of the Local Anesthetic Lidocaine on Inflamed Molar Teeth

NCT00001952
View directory record Official record
Conditions
Healthy, Inflammation, Mouth Disease, Pain
Interventions
Not listed
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
275 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2002
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Sep 4, 2026, 9:21 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Prevention of Enamel Demineralization by Use of K18-smooth Surface Sealant

NCT03306433
View directory record Official record
Conditions
Dental Caries
Interventions
UDMA-K18 smooth surface sealant
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
12 Years to 89 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 6, 2021 · Synced Sep 4, 2026, 9:21 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Intra Oral Appliance (IOA) Model Evaluating the Efficacy of Sensitive Toothpaste

NCT07419763
View directory record Official record
Conditions
Dental Caries
Interventions
Negative Control Toothpaste, Active Comparator, Test toothpaste
Drug
Lead sponsor
Church & Dwight Company, Inc.
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Noblesville, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Sep 4, 2026, 9:21 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Prevalence of White Spot Lesions During Orthodontic Treatment With Fixed Appliances

NCT04186065
View directory record Official record
Conditions
Dental Caries
Interventions
Not listed
Lead sponsor
Hiroko Nagaoka
Other
Eligibility
10 Years to 70 Years
Enrollment
111 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 23, 2020 · Synced Sep 4, 2026, 9:21 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Exploration of the Utility of Dental-dedicated MRI for Dentistry

NCT06948162
View directory record Official record
Conditions
Dental Crowding, Dental Occlusion, Traumatic, Endodontic Disease, Orthodontic Treatment, Endodontic Lesions, PeriodontalConditions, Oral Surgery Conditions, Tooth Extractions, Local Anesthesia, Traumatic Dental Pain, TMJ, Orthodontics, Endodontic Histopathology, Periodontal Diseases
Interventions
dental-dedicated MRI (ddMRI)
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Sep 4, 2026, 9:21 AM EDT
Completed Not applicable Interventional

Clinical Performance of Posterior Composite Tooth Fillings in Adults

NCT03175627
View directory record Official record
Conditions
Dental Caries, Dental Restoration Failure
Interventions
Filtek One, Filtek Z250
Device
Lead sponsor
Louisiana State University Health Sciences Center in New Orleans
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Jun 27, 2021 · Synced Sep 4, 2026, 9:21 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Decision Aids for the Management of Suspicious Occlusal Caries Lesions

NCT02340767
View directory record Official record
Conditions
Dental Caries
Interventions
Spectra Device, DIAGNOdent
Device
Lead sponsor
The National Dental Practice-Based Research Network
Network
Eligibility
6 Years and older
Enrollment
3,085 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
6
States / cities
Birmingham, Alabama • Gainesville, Florida • Minneapolis, Minnesota + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 2, 2019 · Synced Sep 4, 2026, 9:21 AM EDT
Completed Phase 3 Interventional

Noncarious Cervical Lesion Treatment Outcomes

NCT00867997
View directory record Official record
Conditions
Noncarious Cervical Lesions
Interventions
Chemoactive (remineralizing, neuroactive) dentifrice treatment, Clearfil S3 Bond; Clearfil Liner Bond 2 Protect Liner F, Clearfil S3 Bond; Premise Flowable resin-based composite
Other
Lead sponsor
Pearl Network
Network
Eligibility
18 Years and older
Enrollment
304 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
17
States / cities
Darien, Connecticut • Potomac, Maryland • Southborough, Massachusetts + 13 more
Source: ClinicalTrials.gov public record
Updated Feb 28, 2012 · Synced Sep 4, 2026, 9:21 AM EDT
Completed Not applicable Interventional Results available

Clinical Study on a New Flowable Composite as a Restorative in Adult Teeth

NCT01369108
View directory record Official record
Conditions
Dental Caries
Interventions
Flowable composite, Conventional composite restorative
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
19 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Sep 4, 2026, 9:21 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Intraoral Appliance (IOA) Model Evaluating the Efficacy of a Whitening Toothpaste

NCT07419685
View directory record Official record
Conditions
Dental Caries
Interventions
Negative Control Toothpaste, Active Comparator, Test Toothpaste
Drug
Lead sponsor
Church & Dwight Company, Inc.
Industry
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Noblesville, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Sep 4, 2026, 9:21 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Silver Diamine Fluoride Pilot Study (SDF)

NCT02591147
View directory record Official record
Conditions
Dental Caries
Interventions
Silver Diamine Fluoride 38%, Group 2 (Placebo)
Device
Lead sponsor
Justine Kolker
Other
Eligibility
21 Years to 64 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 13, 2023 · Synced Sep 4, 2026, 9:21 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparison of Three Toothpastes for the Prevention and Reduction of White Spot Lesions

NCT03440996
View directory record Official record
Conditions
White Spot Lesion, Orthodontic Treatment, Decalcification; Teeth
Interventions
Clinpro™ 5000, Clinpro™ Tooth Crème, MI-Paste Plus
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
12 Years to 60 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Feb 21, 2018 · Synced Sep 4, 2026, 9:21 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Treatment of Interproximal Cavities on Primary Molar Teeth With Silver Diamine Fluoride

NCT03770286
View directory record Official record
Conditions
Dental Caries in Children, Dental Caries Class II, Dental Caries
Interventions
5% Fluoride Varnish, 38% Silver diamine fluoride, Super Floss
Device
Lead sponsor
Children's Hospital Los Angeles
Other
Eligibility
3 Years to 12 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 14, 2024 · Synced Sep 4, 2026, 9:21 AM EDT