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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Total Joint Arthroplasty Clear all
Completed Not applicable Interventional

Local Anesthetic Infiltration and Infusion for Pain Control After Hip Replacement

NCT01409278
View directory record Official record
Conditions
Osteoarthritis
Interventions
Ropivacaine infiltration and saline infusion., Ropivacaine infiltration and infusion., Normal Saline
Procedure
Lead sponsor
Trinity Health Of New England
Other
Eligibility
18 Years to 80 Years
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 3, 2011 · Synced Jun 7, 2026, 4:40 PM EDT
Completed Phase 4 Interventional Results available

MUA to Treat Postoperative Stiffness After Total Knee Arthroplasty

NCT02739035
View directory record Official record
Conditions
Stiffness Following Total Knee Arthroplasty
Interventions
Dexamethasone, Celecoxib
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 90 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
16
States / cities
Little Rock, Arkansas • Denver, Colorado • Chicago, Illinois + 11 more
Source: ClinicalTrials.gov public record
Updated Nov 20, 2023 · Synced Jun 7, 2026, 4:40 PM EDT
Withdrawn Not applicable Interventional

Treatment of Postoperative Pain After Total Knee Arthroplasy Using Intravenous Lidocaine Infusion

NCT00616850
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Continuous femoral catheter block, Lidocaine, Preservative free normal saline
Procedure · Drug · Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated May 21, 2014 · Synced Jun 7, 2026, 4:40 PM EDT
Completed Phase 4 Interventional

Computer Assisted Total Knee Replacement

NCT00279838
View directory record Official record
Conditions
Total Knee Arthroplasty, Osteoarthritis
Interventions
Computer Assisted Navigation Knee Replacement
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 22, 2011 · Synced Jun 7, 2026, 4:40 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Technology Interventions to Improve Outcomes After Knee Replacement

NCT04482400
View directory record Official record
Conditions
Knee Arthroplasty
Interventions
NEAT!2, MyKneeGuide
Behavioral
Lead sponsor
University of South Carolina
Other
Eligibility
40 Years to 79 Years
Enrollment
83 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Jun 7, 2026, 4:40 PM EDT
Completed Phase 4 Interventional

Dilute Betadine Lavage in the Prevention of Postoperative Infection

NCT01175044
View directory record Official record
Conditions
Prosthesis-Related Infections, Arthroplasty
Interventions
Betadine Lavage, Saline Lavage
Procedure
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 90 Years
Enrollment
505 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2019
U.S. locations
2
States / cities
Chicago, Illinois • Winfield, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 16, 2021 · Synced Jun 7, 2026, 4:40 PM EDT
Active, not recruiting Not applicable Interventional

Patient Utilization of Opioid Destruction Bags in the Post-op Period

NCT05875857
View directory record Official record
Conditions
Opioid Use, Opioid Use, Unspecified, Patient Empowerment, Total Knee Arthoplasty, Total Hip Arthroplasty
Interventions
Opioid destruction education
Behavioral
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years to 100 Years
Enrollment
163 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Jun 7, 2026, 4:40 PM EDT
Completed Not applicable Interventional

Alterations in Muscle After Total Knee Arthroplasty

NCT02281877
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Neuromuscular electrical stimulation (NMES), Standard Rehabilitation Protocol
Procedure · Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
50 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
2
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 8, 2021 · Synced Jun 7, 2026, 4:40 PM EDT
Completed Phase 4 Interventional Results available

Dexamethasone and Pain Following Total Knee Arthroplasty

NCT02271698
View directory record Official record
Conditions
Acute Pain, Chronic Pain
Interventions
Dexamethasone, Placebo
Drug · Other
Lead sponsor
Duke University
Other
Eligibility
55 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 19, 2018 · Synced Jun 7, 2026, 4:40 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparing Surgical and Economical Parameters of Total Knee Replacement.

NCT03427047
View directory record Official record
Conditions
Osteo Arthritis Knee, Total Knee Arthroplasty
Interventions
MyKnee with single use Efficiency Instrument, Stryker Navigational with conventional metal instruments
Device
Lead sponsor
Medacta USA
Industry
Eligibility
16 Years to 75 Years
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 12, 2023 · Synced Jun 7, 2026, 4:40 PM EDT
Withdrawn Not applicable Interventional

Utilization of a Knee Brace With Extension Swing

NCT05179044
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Guardian Sport Rehabilitator knee brace
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 23, 2023 · Synced Jun 7, 2026, 4:40 PM EDT
Not yet recruiting Phase 2 Interventional

Immunosuppressant Management in Rheumatology Patients Undergoing Elective Total Shoulder Arthroplasty

NCT07138898
View directory record Official record
Conditions
Rheumatic Disease
Interventions
Methotrexate, Sulfasalazine, Hydroxychloroquine, Leflunomide, Azathioprine, Mycophenolate, Cyclosporine, Tacrolimus, Etanercept, Adalimumab, Golimumab, Certolizumab, Infliximab, Rituximab, Belimumab, Tocilizumab, Anakinra, Canakinumab, Abatacept, Secukinumab, Ixekizumab, Bimekizumab, Ustekinumab, Guselkumab, Risankizumab, Tofacitinib, Upadacitinib
Drug · Biological
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 23, 2025 · Synced Jun 7, 2026, 4:40 PM EDT
Completed No phase listed Observational

Outcomes Following Total Knee Arthroplasty

NCT02364011
View directory record Official record
Conditions
Osteoarthritis
Interventions
Not listed
Lead sponsor
University of Utah
Other
Eligibility
40 Years to 90 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2025
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Nov 17, 2025 · Synced Jun 7, 2026, 4:40 PM EDT
Completed Not applicable Interventional

Efficacy and Patient Satisfaction With AQUACEL® Ag Surgical Dressing Compared to Standard Surgical Dressing

NCT01258270
View directory record Official record
Conditions
Wound Healing
Interventions
Postop Dressing
Procedure
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
18 Years to 90 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 9, 2013 · Synced Jun 7, 2026, 4:40 PM EDT
Terminated Not applicable Interventional

Early Ambulation After Adductor Canal Block for Total Knee Arthroplasty

NCT01459861
View directory record Official record
Conditions
Pain, Osteoarthritis
Interventions
Canal Block and Capsular Injection, Femoral Nerve Block with Tibial Nerve Block
Procedure
Lead sponsor
Trinity Health Of New England
Other
Eligibility
18 Years to 80 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 5, 2013 · Synced Jun 7, 2026, 4:40 PM EDT
Completed Phase 4 Interventional

Systemic Lidocaine Versus Ultrasound-guided Adductor Canal Block for Patients Undergoing Total Knee Arthroplasty

NCT04828083
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee, Total Knee Arthroplasty
Interventions
Lidocaine IV, Saline IV
Drug
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Jun 7, 2026, 4:40 PM EDT
Completed Not applicable Interventional

Obturator Nerve Block With Femoral and Sciatic Block

NCT01409460
View directory record Official record
Conditions
Nerve Block; Pain Medication
Interventions
Oburator Nerve block, Sham Injection in pectineus muscle.
Procedure
Lead sponsor
Trinity Health Of New England
Other
Eligibility
18 Years to 85 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 3, 2011 · Synced Jun 7, 2026, 4:40 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Randomized, Study to Evaluate the Iovera° Device in Treating Pain Associated With Total Knee Arthroplasty

NCT02284113
View directory record Official record
Conditions
Arthritis of the Knee
Interventions
iovera°, iovera° Sham
Device
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
22 Years to 79 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
8
States / cities
San Diego, California • Englewood, Colorado • Fort Lauderdale, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Jan 23, 2024 · Synced Jun 7, 2026, 4:40 PM EDT
Terminated No phase listed Observational Results available

Using Intraoperative Sensing Technology to Evaluate Revision Total Knee Arthroplasty

NCT03023410
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
VERASENSE
Procedure
Lead sponsor
Orthosensor, Inc.
Industry
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Jan 28, 2025 · Synced Jun 7, 2026, 4:40 PM EDT
Recruiting No phase listed Observational

Functional Recovery After Total Knee Arthroplasty

NCT06821269
View directory record Official record
Conditions
Arthritis Knee
Interventions
Robotic assisted total knee arthroplasty, Manual total knee arthroplasty, Robotic assisted revision total knee arthroplasty, Manual revision total knee arthroplasty
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
40 Years to 90 Years
Enrollment
30 participants
Timeline
2023 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 10, 2025 · Synced Jun 7, 2026, 4:40 PM EDT
Completed Not applicable Interventional

Minimally Invasive Surgical Approaches In Total Knee Arthroplasty

NCT01461356
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Minimally invasive total knee replacement, Standard approach total knee replacement
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
45 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 27, 2011 · Synced Jun 7, 2026, 4:40 PM EDT
Not listed Not applicable Interventional

Shared Decision Aid for Post-Total Knee Arthroplasty Opioid Prescribing

NCT04564729
View directory record Official record
Conditions
Knee Arthroplasty, Total, Analgesia, Opioid Use, Unspecified
Interventions
Shared Decision Making
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
2
States / cities
Chicago, Illinois • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 26, 2022 · Synced Jun 7, 2026, 4:40 PM EDT
Completed Phase 4 Interventional Results available

Antibiotic Elution in Total Knee Arthroplasty

NCT03928522
View directory record Official record
Conditions
Total Knee Replacement
Interventions
hand mixed vancomycin, hand mixed tobramycin, pre-mixed tobramycin
Drug · Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 1, 2020 · Synced Jun 7, 2026, 4:40 PM EDT
Withdrawn No phase listed Observational

REDAPT Revision System Study to Assess 5 Year Revision Rate & up to 10 Year Revision Rate and Safety and Effectiveness

NCT02344160
View directory record Official record
Conditions
Total Hip Arthroplasty (THA)
Interventions
Phlebotomy
Other
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2028
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Dec 15, 2016 · Synced Jun 7, 2026, 4:40 PM EDT