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ClinicalTrials.gov public records Last synced Nov 14, 2026, 8:34 AM EST

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Showing 25–48 of 86 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Total Joint Replacement Surgery Clear all

Conditions: Hip Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis, Post-traumatic Osteoarthritis, Femoral Neck Fractures, Trochanteric Fractures, Surgery
Interventions: Insignia uncemented Hip Stem; Device
Lead sponsor: Stryker Orthopaedics; Industry
Eligibility: 18 Years and older
Enrollment: 313 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2034
U.S. locations: 11
States / cities: Phoenix, Arizona • San Francisco, California • Chicago, Illinois + 8 more

Conditions: Tourniquets, Knee Arthroplasty, Total, Knee Replacement, Total
Interventions: Tourniquet Cuff Pressure; Procedure
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years to 80 Years
Enrollment: 21 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016
U.S. locations: 2
States / cities: Bermuda Run, North Carolina • Winston-Salem, North Carolina

Conditions: Total Knee Arthroplasty; Total Hip Arthroplasty
Interventions: Health Partner, Standard Care; Behavioral
Lead sponsor: DePuy Orthopaedics; Industry
Eligibility: 18 Years and older
Enrollment: 79 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 3
States / cities: Newberg, Oregon • Spokane, Washington

Conditions: Opioid Dependence, Opioid Use, Pain, Joint
Interventions: Lucid Lane Therapy Program, Surgical Preparedness Course; Behavioral
Lead sponsor: Lucid Lane, Inc; Industry
Eligibility: 21 Years to 90 Years
Enrollment: 103 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Osteoarthritis
Interventions: Evicel fibrin sealant; Drug
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 20 Years to 90 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: New York, New York

Conditions: Degenerative Joint Disease, Osteoarthritis, Knee Injury, Trauma, Connective Tissue Disorder, Pain, Loss of Function
Interventions: Not listed
Lead sponsor: Loma Linda University; Other
Eligibility: 40 Years to 80 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: San Bernardino, California

Conditions: Knee Osteoarthritis
Interventions: MPPA, SV; Procedure
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 35 Years to 85 Years
Enrollment: 131 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2012
U.S. locations: 1
States / cities: Lebanon, New Hampshire

Conditions: Osteoarthritis
Interventions: Patient record review, Radiographs, and questionaires.; Other
Lead sponsor: Medacta USA; Industry
Eligibility: Not listed
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Boise, Idaho

Conditions: Arthroplasty, Replacement, Knee, Arthroplasty, Replacement, Hip
Interventions: Not listed
Lead sponsor: Henry Ford Health System; Other
Eligibility: 18 Years and older
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Knee Arthroplasty
Interventions: Baseline Questionnaire, Operative Data, Intra-operative data will be collected post-operatively, In-hospital post-operative data will be collected, Satisfaction data will be extracted from Press/Ganey and on follow-up questionnaires, Cost Data, Follow-up questionnaires; Procedure
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 18 Years and older
Enrollment: 3,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Shoulder Arthroplasty
Interventions: Liposomal bupivacaine, Bupivacaine with adjuvants; Drug
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Arthroplasty, Replacement, Knee, Pain, Postoperative
Interventions: Genetic Panel for Analgesics; Genetic
Lead sponsor: TriHealth Inc.; Other
Eligibility: 18 Years and older
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Non-inflammatory Degenerative Joint Disease, Osteoarthritis, Avascular Necrosis, Post-Traumatic Osteoarthritis of Hip
Interventions: COC 36mm; Device
Lead sponsor: DePuy Orthopaedics; Industry
Eligibility: 21 Years to 75 Years
Enrollment: 172 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2023
U.S. locations: 9
States / cities: Sacramento, California • Denver, Colorado • Tampa, Florida + 5 more

Conditions: Osteoarthritis, Knee
Interventions: Custom Patient Instrumentation, Conventional Instruments; Other
Lead sponsor: DePuy Orthopaedics; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2013
U.S. locations: 3
States / cities: Mooresville, Indiana • Bartlesville, Oklahoma • Reston, Virginia

Conditions: Osteo Arthritis Knee
Interventions: Cryoneurolysis (Iovera); Procedure
Lead sponsor: Fondren Orthopedic Group L.L.P.; Other
Eligibility: 18 Years to 90 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Arthroplasty, Replacement, Knee, Anesthesia, Conduction, Acute Pain
Interventions: adductor canal block, SPANK, Ropivacaine; Procedure · Drug
Lead sponsor: Bruce Ben-David; Other
Eligibility: 19 Years to 90 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Arthroplasty
Interventions: Tapentadol IR (CG5503), Placebo, Oxycodone HCL IR; Drug
Lead sponsor: Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 367 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 45
States / cities: Birmingham, Alabama • Mobile, Alabama • Sheffield, Alabama + 42 more

Conditions: Postoperative Pain
Interventions: HTX-011, Saline Placebo, Bupivicaine HCl, Ropivacaine; Drug
Lead sponsor: Heron Therapeutics; Industry
Eligibility: 18 Years and older
Enrollment: 285 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 24
States / cities: Mobile, Alabama • Sheffield, Alabama • Phoenix, Arizona + 13 more

Conditions: Osteoarthritis
Interventions: Modafinil, Gabapentin, Placebo; Drug
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years to 80 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Arthritis, Osteoarthritis, Knee, Osteoarthritis, Hip, Thromboembolism
Interventions: Rivaroxaban; Drug
Lead sponsor: Ortho-McNeil Janssen Scientific Affairs, LLC; Industry
Eligibility: 18 Years to 99 Years
Enrollment: 56 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010
U.S. locations: 5
States / cities: Denver, Colorado • Hollywood, Florida • Tamarac, Florida + 2 more

Conditions: Knee Osteoarthristis
Interventions: Cognitive-Behavioral Therapy for Insomnia, Bright Light therapy via the Re-Timer®, Negative Ion exposure via IonMi Device, Sleep / Knee Osteoarthritis Education; Behavioral · Device
Lead sponsor: Johns Hopkins University; Other
Eligibility: 60 Years and older
Enrollment: 252 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 2
States / cities: Baltimore, Maryland • Chestnut Hill, Massachusetts

Conditions: Total Joint Replacement Surgery
Interventions: VERA clinic; Device
Lead sponsor: Derek Amanatullah; Other
Eligibility: 18 Years to 99 Years
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Redwood City, California

Conditions: Knee Replacement Surgery, Osteoarthritis, Knee
Interventions: Epidiolex oral solution, Placebo; Drug · Other
Lead sponsor: Chad Brummett; Other
Eligibility: 18 Years to 80 Years
Enrollment: 380 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2029
U.S. locations: 2
States / cities: Ann Arbor, Michigan • Detroit, Michigan

Conditions: Pain, Postoperative
Interventions: Pre-operative Ultrasound FICB Group, Intra-operative FICB Group; Procedure
Lead sponsor: Randy Fayne, DO; Other
Eligibility: 18 Years to 65 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: Royal Oak, Michigan

Search by objective public record fields.

Insignia™ Hip Stem Outcomes Study

Tourniquet Pressure in Primary Total Knee Arthroplasty

Health Partner Evaluation at Providence

Impact of a Behavioral Tele-health Program on the Quality of Recovery for Patients Undergoing Total Joint Replacement Surgery

The Use of Evicel to Reduce Blood Loss in Total Knee Replacement Surgery

Comparison of Clinical Outcomes and Performance of Total Knee Replacement Patients Before and After Surgery

Minimally Invasive Knee Replacement Outcomes (MIKRO) Study

A Post-Market Retrospective Study on Revision Total Knee Arthroplasty Using Medacta GMK® Revision Prosthesis

Sleep Patterns After Total Joint Replacement Surgery

Hospital for Special Surgery Knee Arthroplasty Cohort

Interscalene Block With Liposomal Bupivacaine vs. Interscalene Block With Bupivacaine and Adjuvants

Pharmacogenomics Information in Enhancing Post-operative Total Joint Replacement Pain Management: a Pilot Study

Ceramic-on-Ceramic (COC) 36mm Acetabular Bearing Insert Post Approval Study-New Subjects (COC36mmPAS)

Comparison of Surgical Time and Efficiency of Total Knee Arthroplasty

Pain Control With Pre-operative Cryoneurolysis Following TKA

Adductor Canal Vs Adductor Canal Plus SPANK Block for Postoperative Pain in Knee Arthroplasty Surgery

A Study to Evaluate the Effectiveness and Safety of Tapentadol(CG5503) in the Treatment of Acute Pain After Hip Replacement Surgery Compared With Oxycodone and Placebo Followed by a Voluntary Open-Label Extension For Safety

Total Knee Arthroplasty Infiltration Study for Postoperative Analgesia

Pain Expectations in Subjects With Osteoarthritis

Switching Drug Therapy for the Prevention of Blood Clot Formation From Enoxaparin to Rivaroxaban After Orthopedic Surgery for Either Total Hip or Total Knee Replacement

Sleep TO Prevent Post-surgical Pain

A Rehabilitation Tool to Determine Patient's Stay in Hospital After Joint Replacement

Cannabidiol for Postoperative Opioid Reduction in Primary Total Knee Arthroplasty

Efficacy of Fascia Iliaca Block Versus Intraoperative Nerve Infiltration During Anterior Hip Replacement Surgery