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ClinicalTrials.gov public records Last synced Oct 13, 2026, 6:41 PM EDT

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Showing 97–120 of 185 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Total Knee Arthroplasty \(TKA\) Clear all
Not listed Phase 4 Interventional

Improving Pain Management and Decreasing LOS After Total Hip Arthroplasty (THA) and Total Knee Arthroplasty (TKA)

NCT05307341
View directory record Official record
Conditions
Pain
Interventions
sufentanil
Drug
Lead sponsor
More Foundation
Other
Eligibility
50 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 1, 2022 · Synced Oct 13, 2026, 6:41 PM EDT
Terminated No phase listed Observational

A Prospective Study to Evaluate the ConforMIS iTotal® (PS) Knee Replacement System

NCT03152162
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
iTotal PS KRS
Device
Lead sponsor
Restor3D
Industry
Eligibility
18 Years and older
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
4
States / cities
Chapel Hill, North Carolina • Austin, Texas • Morrisville, Vermont + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 25, 2023 · Synced Oct 13, 2026, 6:41 PM EDT
Recruiting Not applicable Interventional

Observation of Wheeled Device Use After TKA

NCT06080152
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Mobility Tool
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 99 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Oct 13, 2026, 6:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Total Knee Replacement With Tourniquet or Aquamantys

NCT04016285
View directory record Official record
Conditions
Knee Replacement
Interventions
Aquamantys, Tourniquet
Device
Lead sponsor
Stephen Duncan
Other
Eligibility
18 Years to 100 Years
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 18, 2024 · Synced Oct 13, 2026, 6:41 PM EDT
Recruiting Phase 2Phase 3 Interventional

Evaluation of PLG0206 in Prevention of Recurrent Infection in Patients Undergoing Debridement, Antibiotics, and Implant Retention (DAIR) for Treatment of a Periprosthetic Joint Infection (PJI) Following Knee Arthroplasty

NCT07214311
View directory record Official record
Conditions
Prosthetic-joint Infection
Interventions
PLG0206, Placebo
Drug
Lead sponsor
Peptilogics
Industry
Eligibility
18 Years to 85 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
15
States / cities
Sarasota, Florida • Tamarac, Florida • Shreveport, Louisiana + 12 more
Source: ClinicalTrials.gov public record
Updated Oct 6, 2026 · Synced Oct 13, 2026, 6:41 PM EDT
Completed Not applicable Interventional Results available

Tourniquet on Total Knee Arthroplasty

NCT04923724
View directory record Official record
Conditions
Arthritis Knee
Interventions
tourniquet, No tourniquet
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
165 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Creve Coeur, Missouri
Source: ClinicalTrials.gov public record
Updated May 15, 2025 · Synced Oct 13, 2026, 6:41 PM EDT
Completed Phase 3 Interventional

Safety and Efficacy Study of 4975 in Patients Undergoing Total Knee Replacement

NCT00681356
View directory record Official record
Conditions
Total Knee Arthroplasty (Replacement)
Interventions
4975, 15 and 5 mg, Placebo Comparator, 4975 - 5 mg
Drug
Lead sponsor
Anesiva, Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
214 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
25
States / cities
Birmingham, Alabama • Mobile, Alabama • Sheffield, Alabama + 20 more
Source: ClinicalTrials.gov public record
Updated May 4, 2009 · Synced Oct 13, 2026, 6:41 PM EDT
Withdrawn Not applicable Interventional

Pain Control With Pre-operative Cryoneurolysis Following TKA

NCT03818022
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Cryoneurolysis (Iovera)
Procedure
Lead sponsor
Fondren Orthopedic Group L.L.P.
Other
Eligibility
18 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 23, 2024 · Synced Oct 13, 2026, 6:41 PM EDT
Completed Not applicable Interventional

Alterations in Muscle After Total Knee Arthroplasty

NCT02281877
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Neuromuscular electrical stimulation (NMES), Standard Rehabilitation Protocol
Procedure · Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
50 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
2
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 9, 2021 · Synced Oct 13, 2026, 6:41 PM EDT
Recruiting Not applicable Interventional

A Comparison Of Primary TKA Rehabilitation Using A Smart Orthotic Versus Outpatient Physical Therapy

NCT04924205
View directory record Official record
Conditions
Arthropathy of Knee
Interventions
FM2 Knee Brace
Device
Lead sponsor
Nicolas Noiseux, MD, MS, FRCSC
Other
Eligibility
18 Years to 100 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2028
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 25, 2026 · Synced Oct 13, 2026, 6:41 PM EDT
Completed Not applicable Interventional Results available

Acupuncture for Low-Dose Opioid for TKA Replacement

NCT04084288
View directory record Official record
Conditions
Knee Osteoarthritis, Pain, Postoperative, Acupuncture
Interventions
Acupuncture, Peripheral Nerve Stimulator
Other · Device
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 70 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 27, 2024 · Synced Oct 13, 2026, 6:41 PM EDT
Not listed No phase listed Observational

Knee Arthroplasty Registry

NCT01132365
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
any knee joint arthroplasty device
Device
Lead sponsor
Heekin Orthopedic Research Institute
Other
Eligibility
21 Years to 93 Years
Enrollment
7,793 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2018
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 26, 2016 · Synced Oct 13, 2026, 6:41 PM EDT
Withdrawn Not applicable Interventional

Utilization of a Knee Brace With Extension Swing

NCT05179044
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Guardian Sport Rehabilitator knee brace
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 24, 2023 · Synced Oct 13, 2026, 6:41 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Comparison of Mobile-Bearing and Fixed-Bearing All-Polyethylene Tibia Total Knee Designs

NCT00894361
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
TKA surgery with the rotating platform mobile-bearing knee design, TKA surgery with the all-polyethylene tibia knee design
Procedure
Lead sponsor
Minneapolis Veterans Affairs Medical Center
Federal
Eligibility
60 Years to 85 Years
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2007
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 7, 2020 · Synced Oct 13, 2026, 6:41 PM EDT
Completed Not applicable Interventional Results available

interACTION: A Portable Joint Function Monitoring and Training System for Remote Rehabilitation Following TKA

NCT02646761
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
InterACTION, Standard of Care Physical Therapy
Device · Other
Lead sponsor
James J. Irrgang
Other
Eligibility
40 Years to 80 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 5, 2019 · Synced Oct 13, 2026, 6:41 PM EDT
Completed Not applicable Interventional

Combined NMES and BFR Training After TKA

NCT04347343
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Standard Rehabilitation + Neuromuscular Electrical Stimulation and Blood Flow Restriction
Procedure
Lead sponsor
University of Colorado, Denver
Other
Eligibility
50 Years to 85 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 7, 2022 · Synced Oct 13, 2026, 6:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

TKA Melatonin and Sleep Quality

NCT05332717
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee, Sleep Initiation and Maintenance Disorders
Interventions
Melatonin 5 mg, Placebo (Vitamin C)
Dietary Supplement
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years and older
Enrollment
176 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 14, 2023 · Synced Oct 13, 2026, 6:41 PM EDT
Not yet recruiting Phase 4 Interventional

Aprepitant to Improve Same Day Discharge for TKA

NCT07639723
View directory record Official record
Conditions
PONV
Interventions
Aprepitant Injection, Ondansetron (Zofran), Dexamethasone, Placebo
Drug · Other
Lead sponsor
Endeavor Health
Other
Eligibility
18 Years to 90 Years
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Skokie, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Oct 13, 2026, 6:41 PM EDT
Completed Not applicable Interventional

Thigh Pain After Total Knee Arthroplasty (TKA)

NCT02262988
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Total knee replacement
Procedure
Lead sponsor
Fondren Orthopedic Group L.L.P.
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 7, 2022 · Synced Oct 13, 2026, 6:41 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

JOURNEY™ II CR Total Knee System

NCT02440672
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
JOURNEY™ II CR Total Knee System (J II CR TKS)
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
22 Years to 75 Years
Enrollment
170 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2028
U.S. locations
6
States / cities
Phoenix, Arizona • Chicago, Illinois • Annapolis, Maryland + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 12, 2026 · Synced Oct 13, 2026, 6:41 PM EDT
Withdrawn No phase listed Observational

In Vivo Kinematics for Subjects Having a MicroPort Medial Pivot or DePuy Attune PCR TKA

NCT04103502
View directory record Official record
Conditions
Total Knee Arthroplasty, Osteo Arthritis Knee, Knee Injuries, Knee Imlant
Interventions
MicroPort Medial Pivot TKA, DePuy Attune PCR TKA
Device
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
3
States / cities
Las Vegas, Nevada • Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Oct 13, 2026, 6:41 PM EDT
Completed No phase listed Observational Results available

Analysis of Competitive Posterior Cruciate Retaining (PCR) and Posterior Stabilized (PS) Total Knee Arthroplasty (TKA)

NCT04321356
View directory record Official record
Conditions
Knee Osteoarthritis, Total Knee Arthroplasty, Knee
Interventions
Triathlon PCR TKA, Triathlon PS TKA, Persona PCR TKA, Persona PS TKA
Device
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
18 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
2
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 28, 2023 · Synced Oct 13, 2026, 6:41 PM EDT
Completed Not applicable Interventional Results available

Controlled Study of Kneehab XP for Patients Undergoing Total Knee Replacement

NCT01548040
View directory record Official record
Conditions
Total Knee Replacement
Interventions
Kneehab XP, Quadriceps TENS
Device
Lead sponsor
Theragen Inc.
Industry
Eligibility
40 Years and older
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 11, 2018 · Synced Oct 13, 2026, 6:41 PM EDT
Recruiting Not applicable Interventional

ARVIS TKA vs Conventional TKA

NCT06663384
View directory record Official record
Conditions
Osteoarthritis
Interventions
Evaluation of Augmented Reality technology in TKA compared to standard TKA
Other
Lead sponsor
Foundation for Orthopaedic Research and Education
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Oct 13, 2026, 6:41 PM EDT