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ClinicalTrials.gov public records Last synced Oct 12, 2026, 7:55 AM EDT

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Showing 25–48 of 751 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Total Knee Replacements Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Meditation and Opioid Consumption in Total Joint Replacement Patients Undergo Primary Total Hip and Knee Replacement

NCT05669066
View directory record Official record
Conditions
Arthropathy of Knee, Osteo Arthritis Knee, Osteonecrosis, Meditation, Knee Osteoarthritis, Knee Disease, Knee Injuries, Opioid Use, Opioid Dependence, Opioid Use Disorder
Interventions
Mindful meditation
Behavioral
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 89 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 30, 2022 · Synced Oct 12, 2026, 7:55 AM EDT
Recruiting Not applicable Interventional

The Benefits Of Cryoablation In Patients Undergoing Total Knee Arthroplasty

NCT06991231
View directory record Official record
Conditions
Post-Operative Pain, Total Knee Arthroplasty
Interventions
Total knee arthroplasty (TKA), Cryoablation
Procedure · Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
215 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 3, 2026 · Synced Oct 12, 2026, 7:55 AM EDT
Completed Not applicable Interventional Results available

Analgesic Value of Adductor Canal vs Femoral Block After Total Knee Arthroplasty

NCT03395990
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Active comparator: chloroprocaine, Sham comparator: saline
Procedure
Lead sponsor
Duke University
Other
Eligibility
56 Years to 85 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 17, 2020 · Synced Oct 12, 2026, 7:55 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Comparison of Mobile-Bearing and Fixed-Bearing All-Polyethylene Tibia Total Knee Designs

NCT00894361
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
TKA surgery with the rotating platform mobile-bearing knee design, TKA surgery with the all-polyethylene tibia knee design
Procedure
Lead sponsor
Minneapolis Veterans Affairs Medical Center
Federal
Eligibility
60 Years to 85 Years
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2007
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 7, 2020 · Synced Oct 12, 2026, 7:55 AM EDT
Completed Early Phase 1 Interventional

Intraoperative Ketamine for Patients Undergoing Total Joint Arthroplasty

NCT04437888
View directory record Official record
Conditions
Pain, Postoperative, Arthroplasty Complications
Interventions
Ketamine
Drug
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Sep 27, 2024 · Synced Oct 12, 2026, 7:55 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Adductor Canal Block Versus Femoral Nerve Block for Total Knee Arthroplasty

NCT03133481
View directory record Official record
Conditions
Arthropathy of Knee
Interventions
Adductor Canal Nerve Block, Femoral Nerve Block
Procedure · Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years to 100 Years
Enrollment
94 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 16, 2019 · Synced Oct 12, 2026, 7:55 AM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Effects of Oral Tranexamic Acid Following Total Knee Arthroplasty

NCT06479161
View directory record Official record
Conditions
Postoperative Pain
Interventions
Tranexamic acid
Drug
Lead sponsor
Matthew Grosso, MD
Other
Eligibility
18 Years to 89 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 13, 2024 · Synced Oct 12, 2026, 7:55 AM EDT
Completed No phase listed Observational

A Prospective Clinical Trial Comparing Serum Mast Cell Tryptase (SMCT) Levels to Arthrofibrosis Rates Among Primary Total Knee Arthroplasty (TKA) Patients

NCT03598829
View directory record Official record
Conditions
Knee Osteoarthritis, Arthropathy of Knee, Arthrofibrosis
Interventions
Tryptase, Serum test
Diagnostic Test
Lead sponsor
Mayo Clinic
Other
Eligibility
20 Years to 100 Years
Enrollment
219 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Oct 12, 2026, 7:55 AM EDT
Completed Not applicable Interventional Results available

Motor-Sparing Peripheral Nerve Blockade Facilitates Mobility Post Total Knee Arthroplasty: A Randomized Controlled Trial

NCT02773537
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
Femoral nerve catheter and sciatic nerve block, Adductor canal catheter and selective tibial block, Adductor canal catheter only
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 27, 2019 · Synced Oct 12, 2026, 7:55 AM EDT
Active, not recruiting No phase listed Observational

Functional Recovery After Total Knee Arthroplasty

NCT06821269
View directory record Official record
Conditions
Arthritis Knee
Interventions
Robotic assisted total knee arthroplasty, Manual total knee arthroplasty, Robotic assisted revision total knee arthroplasty, Manual revision total knee arthroplasty
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
40 Years to 90 Years
Enrollment
30 participants
Timeline
2023 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Oct 12, 2026, 7:55 AM EDT
Completed Not applicable Interventional

Swelling Management After Total Knee Arthroplasty

NCT04841356
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Immediate Compression Garment
Procedure
Lead sponsor
University of Colorado, Denver
Other
Eligibility
50 Years to 85 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 21, 2022 · Synced Oct 12, 2026, 7:55 AM EDT
Completed Not applicable Interventional

A Novel Physical Therapy Administered Physical Activity Intervention After TKR: A Pilot Study

NCT02724137
View directory record Official record
Conditions
Physical Activity
Interventions
Fitbit®, Physical Therapy Rehab
Behavioral · Other
Lead sponsor
University of Delaware
Other
Eligibility
45 Years and older
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Nov 20, 2018 · Synced Oct 12, 2026, 7:55 AM EDT
Terminated Phase 3 Interventional Results available

0.25% Bupivacaine Versus a Mixture of 0.25% Bupivacaine and 1.3 % Liposomal Bupivacaine in Patients Undergoing Tka

NCT03303794
View directory record Official record
Conditions
Anesthesia
Interventions
Exparel, 0.25% bupivacaine
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
40 Years to 80 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 20, 2020 · Synced Oct 12, 2026, 7:55 AM EDT
Completed Not applicable Interventional

Pain Neuroscience Education in Total Knee Arthroplasty

NCT03231566
View directory record Official record
Conditions
Total Knee Replacement
Interventions
Pain Neuroscience Education
Behavioral
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jul 27, 2017 · Synced Oct 12, 2026, 7:55 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Exparel Use in Adductor Canal Block After Total Knee Arthroplasty

NCT04910165
View directory record Official record
Conditions
Arthritis Knee, Pain, Postoperative, Opioid Use
Interventions
Exparel, Ropivacaine
Drug
Lead sponsor
St. Luke's Hospital, Pennsylvania
Other
Eligibility
18 Years to 99 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Bethlehem, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 20, 2022 · Synced Oct 12, 2026, 7:55 AM EDT
Completed Phase 4 Interventional Results available

Prospective Evaluation of Vitagel for Reduction in Blood Loss and Pain Following Unilateral Total Knee Arthroplasty

NCT01027286
View directory record Official record
Conditions
Arthritis
Interventions
Vitagel
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 29, 2012 · Synced Oct 12, 2026, 7:55 AM EDT
Not yet recruiting Phase 4 Interventional

Role of Suzetrigine as a Part of a Multimodal Regimen to Reduce Pain and Opioid Use After Total Knee Arthroplasty

NCT07624526
View directory record Official record
Conditions
Knee Arthritis, Knee Osteoarthritis
Interventions
Suzetrigine
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years to 95 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
3
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Oct 12, 2026, 7:55 AM EDT
Recruiting Phase 3 Interventional

Suzetrigine for Treatment and Reduction of Intense Discomfort After knEe Replacement PAIN

NCT07548385
View directory record Official record
Conditions
Total Knee Replacement Surgery, Post-operative Pain
Interventions
Suzetrigine, Placebo
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 85 Years
Enrollment
235 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Oct 12, 2026, 7:55 AM EDT
Terminated Not applicable Interventional

Medial Peel Release Technique TKA Randomized Clinical Trial

NCT05154058
View directory record Official record
Conditions
Total Knee Arthroplasty, Osteoarthritis, Knee
Interventions
Medial Subperiosteal Release with Sharp Dissection, Medial Subperiosteal Release with Electrocautery
Procedure
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 27, 2023 · Synced Oct 12, 2026, 7:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Robotic Assisted TKA

NCT06062615
View directory record Official record
Conditions
Total Knee Replacement
Interventions
Total knee replacement using Omnibot Knee System, Conventional Total knee replacement, Omnibot Robotic Knee System
Procedure · Device
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 4, 2025 · Synced Oct 12, 2026, 7:55 AM EDT
Recruiting Not applicable Interventional

Cold and Compression Post TKA

NCT07023185
View directory record Official record
Conditions
Primary Osteoarthritis Patients Scheduled for Total Knee Replacement Surgery
Interventions
Cold and Compression, SOC (Standard of care)
Device · Other
Lead sponsor
Ochsner Health System
Other
Eligibility
50 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 2, 2026 · Synced Oct 12, 2026, 7:55 AM EDT
Not listed Not applicable Interventional

Botulinum Toxin A to Treat Flexion Contracture After Total Knee Arthroplasty

NCT01829087
View directory record Official record
Conditions
Flexion Contracture Following Total Knee Replacement
Interventions
Botox, placebo
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
2
States / cities
Bryn Mawr, Pennsylvania • Lankenau, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 13, 2013 · Synced Oct 12, 2026, 7:55 AM EDT
Completed Phase 3 Interventional Results available

Dabigatran Etexilate vs Enoxaparin in Prevention of Venous Thromboembolism (VTE) Post Total Knee Replacement

NCT00152971
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee, Thromboembolism
Interventions
Dabigatran Dose 1 - day 2 to completion, Dabigatran Dose 1 - day 1, Dabigatran Dose 2 - day 2 to completion, Dabigatran Dose 2 - day 1, Enoxaparin
Drug
Lead sponsor
Boehringer Ingelheim
Industry
Eligibility
18 Years and older
Enrollment
2,615 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2004
U.S. locations
59
States / cities
Birmingham, Alabama • Northport, Alabama • Tucson, Arizona + 48 more
Source: ClinicalTrials.gov public record
Updated May 5, 2014 · Synced Oct 12, 2026, 7:55 AM EDT
Completed Phase 3 Interventional Results available

Study of Apixaban for the Prevention of Thrombosis-related Events Following Knee Replacement Surgery

NCT00371683
View directory record Official record
Conditions
Deep Vein Thrombosis, Pulmonary Embolism
Interventions
Enoxaparin + Placebo, Apixaban + Placebo
Drug
Lead sponsor
Bristol-Myers Squibb
Industry
Eligibility
18 Years and older
Enrollment
3,608 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
25
States / cities
Birmingham, Alabama • Tuscaloosa, Alabama • Little Rock, Arkansas + 17 more
Source: ClinicalTrials.gov public record
Updated Dec 30, 2015 · Synced Oct 12, 2026, 7:55 AM EDT