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ClinicalTrials.gov public records Last synced Oct 13, 2026, 10:49 AM EDT

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Showing 73–96 of 751 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Total Knee Replacements Clear all
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Is There an Alternative to Immediate Home Physical Therapy Following Total Knee Arthroplasty

NCT04060251
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
CyMedica e-vive™ System; CY-1000, iGetBetter telemedicine physical therapy
Device · Other
Lead sponsor
Wolfgang Fitz, M.D.
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 7, 2023 · Synced Oct 13, 2026, 10:49 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Exparel Use in Adductor Canal Block After Total Knee Arthroplasty

NCT04910165
View directory record Official record
Conditions
Arthritis Knee, Pain, Postoperative, Opioid Use
Interventions
Exparel, Ropivacaine
Drug
Lead sponsor
St. Luke's Hospital, Pennsylvania
Other
Eligibility
18 Years to 99 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Bethlehem, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 20, 2022 · Synced Oct 13, 2026, 10:49 AM EDT
Terminated Phase 4 Interventional Results available

Combination of Peripheral Nerve Block and DepoDur in Total Knee Joint Replacement

NCT00895531
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
Depodur, sciatic nerve block
Drug · Procedure
Lead sponsor
University of Louisville
Other
Eligibility
18 Years to 70 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 27, 2017 · Synced Oct 13, 2026, 10:49 AM EDT
Terminated Not applicable Interventional Results available

Static vs. Articulating Antibiotic Spacer for Periprosthetic Joint Infection in Total Knee Arthroplasty

NCT02547129
View directory record Official record
Conditions
Prosthetic Joint Infection of the Knee
Interventions
Static Antibiotic Spacer Surgical Implant, Articulating Antibiotic Spacer Surgical Implant
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 100 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 15, 2019 · Synced Oct 13, 2026, 10:49 AM EDT
Completed Not applicable Interventional

Effects of tDCS Combined With CBI on Postsurgical Pain

NCT04199780
View directory record Official record
Conditions
Total Knee Arthroplasty (Postoperative Pain), Total Hip Arthroplasty (Postoperative Pain)
Interventions
Transcranial Direct Current Stimulation, Cognitive-Behavioral (CB) intervention
Device · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 90 Years
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Oct 13, 2026, 10:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

To Evaluate the Safety and Efficacy of the Saline-coupled Bipolar Sealer in Primary Unilateral Total Knee Arthroplasty

NCT03952546
View directory record Official record
Conditions
Surgical Blood Loss
Interventions
Saline-coupled Bipolar Sealer, Unipolar electrocautery
Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
211 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Syosset, New York
Source: ClinicalTrials.gov public record
Updated Feb 15, 2023 · Synced Oct 13, 2026, 10:49 AM EDT
Completed No phase listed Observational

A Clinical Investigation of the Vanguard™ Complete Knee System

NCT00698854
View directory record Official record
Conditions
Osteoarthritis, Traumatic Arthritis, Rheumatoid Arthritis, Lower Limb Deformity, Complications, Arthroplasty
Interventions
Vanguard™ Complete Knee System, Vanguard™ Patient-Specific Femur
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
552 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2024
U.S. locations
8
States / cities
Cedar Rapids, Iowa • Rockville, Maryland • Cape Girardeau, Missouri + 5 more
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 13, 2026, 10:49 AM EDT
Completed Not applicable Interventional

Adductor Canal Blocks With Bupivacaine and Magnesium After Same-day Discharge Total Knee Arthroplasty Improve Post-operative Pain Relief and Decrease Opioid Consumption: a Prospective Randomized Controlled Trial

NCT05004636
View directory record Official record
Conditions
Post-operative Pain, Acute
Interventions
Adding Magnesium as an adjuvant to the adductor canal Block (ACB) for same-day discharge total knee arthroplasty
Drug
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 100 Years
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Pontiac, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 13, 2021 · Synced Oct 13, 2026, 10:49 AM EDT
Completed No phase listed Observational Results available

Kinematics in Posterior Cruciate Retaining and Bi-Cruciate Retaining Total Knee Replacements

NCT03088748
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee, Osteoarthritis, Knee
Interventions
Journey II posterior cruciate retaining total knee arthroplasty, Journey II posterior bi-cruciate retaining total knee arthroplasty
Device
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
40 Years to 85 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
4
States / cities
Chattanooga, Tennessee • Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 12, 2021 · Synced Oct 13, 2026, 10:49 AM EDT
Completed Not applicable Interventional

The Effect of Prolonged Multimodal Analgesic Regimen on Post Hospital Discharge Opioid Use and Pain Control After Primary Total Knee Arthroplasty

NCT04003350
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Oxycodone, Tramadol, Tylenol, Meloxicam, Gabapentin, Metaxalone, Esomeprazole 20mg
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
216 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 1, 2019 · Synced Oct 13, 2026, 10:49 AM EDT
Withdrawn Not applicable Interventional

Treatment of Postoperative Pain After Total Knee Arthroplasy Using Intravenous Lidocaine Infusion

NCT00616850
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Continuous femoral catheter block, Lidocaine, Preservative free normal saline
Procedure · Drug · Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated May 22, 2014 · Synced Oct 13, 2026, 10:49 AM EDT
Completed Not applicable Interventional

Multimodal DVT Protocol in Tourniquet-less Total Knee Arthroplasty

NCT02102828
View directory record Official record
Conditions
Deep Vein Thrombosis
Interventions
extended compression, Aspirin
Device · Other
Lead sponsor
TriHealth Inc.
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 10, 2019 · Synced Oct 13, 2026, 10:49 AM EDT
Recruiting Not applicable Interventional

Physica System Total Knee Replacement Registry Study

NCT03048201
View directory record Official record
Conditions
Osteoarthritis, Knee, Traumatic Arthritis, Avascular Necrosis, Degenerative Joint Disease of Knee, Rheumatoid Arthritis, Deformity of Knee
Interventions
Physica Kinematic Retaining Knee System, Physica Cruciate Retaining Knee System, Physica Posterior Stabilized Knee System, Physica Cruciate Retaining Knee System with LMC Liner
Device
Lead sponsor
Limacorporate S.p.a
Industry
Eligibility
22 Years and older
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2030
U.S. locations
5
States / cities
Rancho Mirage, California • Daytona Beach, Florida • Aurora, Illinois + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 21, 2023 · Synced Oct 13, 2026, 10:49 AM EDT
Completed Not applicable Interventional Results available

Can Single-Injection Adductor Canal Blocks Improve PostOp Pain Relief in Patients Undergoing Total Knee Arthroplasty?

NCT02276495
View directory record Official record
Conditions
Pain Management
Interventions
ACB Control - 20 ml saline injection for ACB, ACB Study - 20 ml 0.5% Ropivacaine for Adductor Canal Block, Local infiltration - 100 mLs of a solution containing: Ropivacaine + Epinephrine + Ketorolac + Clonidine + 0.9% Normal saline
Other · Drug
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2024
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Oct 29, 2024 · Synced Oct 13, 2026, 10:49 AM EDT
Completed No phase listed Observational

Early Clinical Results of Mobile-Bearing Revision Total Knee Arthroplasty

NCT01398800
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
Not listed
Lead sponsor
Colorado Joint Replacement
Other
Eligibility
Not listed
Enrollment
340 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2019
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 24, 2019 · Synced Oct 13, 2026, 10:49 AM EDT
Completed No phase listed Observational

How Variations in Pharmacogenomic Profiles Affect Pain and Narcotic Needs Following Total Knee Arthroplasty (TKA)

NCT04020471
View directory record Official record
Conditions
Knee Osteoarthritis, Total Knee Arthroplasty (TKA)
Interventions
Pain Scale/Medication Log
Other
Lead sponsor
Endeavor Health
Other
Eligibility
18 Years and older
Enrollment
375 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Skokie, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 27, 2023 · Synced Oct 13, 2026, 10:49 AM EDT
Completed Not applicable Interventional

Pain Neuroscience Education in Total Knee Arthroplasty

NCT03231566
View directory record Official record
Conditions
Total Knee Replacement
Interventions
Pain Neuroscience Education
Behavioral
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jul 27, 2017 · Synced Oct 13, 2026, 10:49 AM EDT
Completed Not applicable Interventional

Continuous Femoral Nerve Block Following Total Knee Replacement

NCT00135889
View directory record Official record
Conditions
Pain
Interventions
Femoral perineural infusion
Drug
Lead sponsor
National Institute of General Medical Sciences (NIGMS)
NIH
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
2
States / cities
La Jolla, California • Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 8, 2009 · Synced Oct 13, 2026, 10:49 AM EDT
Completed Phase 4 Interventional Results available

Desflurane or Propofol Anesthesia in Elderly Obese Patients Undergoing Total Knee Replacement

NCT01270620
View directory record Official record
Conditions
Obesity, Arthritis
Interventions
propofol, Desflurane
Drug
Lead sponsor
Pedro Paulo Tanaka
Other
Eligibility
65 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Oct 22, 2015 · Synced Oct 13, 2026, 10:49 AM EDT
Completed Not applicable Interventional Results available

Triathlon Total Stabilizer (TS) Outcomes Study

NCT00958789
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
Triathlon TS Knee System
Device
Lead sponsor
Stryker Orthopaedics
Industry
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2019
U.S. locations
12
States / cities
Phoenix, Arizona • Jacksonville, Florida • Chicago, Illinois + 9 more
Source: ClinicalTrials.gov public record
Updated Oct 22, 2021 · Synced Oct 13, 2026, 10:49 AM EDT
Completed Phase 4 Interventional Results available

Effects of Catheter Location on Postoperative Analgesia for Continuous Adductor Canal and Popliteal-Sciatic Nerve Blocks

NCT02523235
View directory record Official record
Conditions
Post-surgical Pain, Total Knee Arthroplasty, Foot/Ankle Surgery, Catheterization for Postop Analgesia
Interventions
ropivacaine 0.2%
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 3, 2019 · Synced Oct 13, 2026, 10:49 AM EDT
Completed Not applicable Interventional Results available

Evaluation of Electrical Nerve Stimulation (TENS) Therapy for Pain Relief Following Total Knee Arthroplasty (TKA)

NCT01641471
View directory record Official record
Conditions
Osteoarthritis, Knee, Arthritis, Pain
Interventions
EMPI Select TENS, Placebo EMPI Select TENS
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 7, 2018 · Synced Oct 13, 2026, 10:49 AM EDT
Not listed No phase listed Observational

Assessing Renal Function in Patients With an Antibiotic Laden Spacer

NCT01683734
View directory record Official record
Conditions
Infected Total Hip or Knee Arthroplasty
Interventions
Not listed
Lead sponsor
Central DuPage Hospital
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
2
States / cities
Chicago, Illinois • Winfield, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 4, 2015 · Synced Oct 13, 2026, 10:49 AM EDT
Completed Not applicable Interventional Results available

Liposomal Bupivacaine Versus Standard Analgesia in Total Joint Arthroplasty (TJA)

NCT02197273
View directory record Official record
Conditions
Osteoarthritis, Knee, Osteoarthritis, Hip, Osteoarthritis, Shoulder
Interventions
Liposomal bupivacaine, Standard of care analgesia
Drug
Lead sponsor
OhioHealth
Other
Eligibility
18 Years and older
Enrollment
211 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 21, 2016 · Synced Oct 13, 2026, 10:49 AM EDT