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Showing 1–24 of 28 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Transperineal Clear all
Recruiting Not applicable Interventional

Comparison of New SUREcore Biopsy of Needle to Standard of Care During Transperineal Prostate Biopsies

NCT06907446
View directory record Official record
Conditions
Prostate Cancer
Interventions
Comparison of Biopsy Needle Types for Prostate Biopsy
Diagnostic Test
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older · Male only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Sep 10, 2026, 9:23 PM EDT
Completed Phase 2 Interventional Results available

Ultrasound-Guided Implant Radiation Therapy in Treating Patients With Locally Recurrent Prostate Cancer Previously Treated With External-Beam Radiation Therapy

NCT00450411
View directory record Official record
Conditions
Prostate Cancer
Interventions
125-Iodine, 103-palladium
Radiation
Lead sponsor
Radiation Therapy Oncology Group
Network
Eligibility
18 Years to 120 Years · Male only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2022
U.S. locations
13
States / cities
Phoenix, Arizona • Fresno, California • Aurora, Colorado + 10 more
Source: ClinicalTrials.gov public record
Updated Jun 20, 2022 · Synced Sep 10, 2026, 9:23 PM EDT
Completed Not applicable Interventional

Prostate Biopsy, Transrectal vs. Transperineal: Efficacy and Complications

NCT04081636
View directory record Official record
Conditions
Prostate Cancer, PSA, Infection
Interventions
Systematic Transrectal biopsy (TR-Bx), Targeted Transrectal biopsy (TR-Bx), Systematic Transperineal biopsy (TP-Bx), Targeted Transperineal biopsy (TP-Bx)
Procedure
Lead sponsor
Albany Medical College
Other
Eligibility
Male only
Enrollment
840 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Sep 10, 2026, 9:23 PM EDT
Suspended Not applicable Interventional

ClariCore System Used in Transperineal Prostate Biopsy

NCT03734575
View directory record Official record
Conditions
Prostate Cancer
Interventions
ClariCore System
Device
Lead sponsor
Precision Biopsy, Inc.
Industry
Eligibility
Male only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
2
States / cities
Baltimore, Maryland • New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 10, 2019 · Synced Sep 10, 2026, 9:23 PM EDT
Completed No phase listed Observational

The Use of Transperineal Ultrasound for Radiation Therapy Treatment Planning and Image Guidance in the Treatment of Prostate Cancer

NCT01545154
View directory record Official record
Conditions
Prostate Cancer
Interventions
Transperineal Ultrasound
Device
Lead sponsor
H. James Wallace, MD
Other
Eligibility
18 Years and older · Male only
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Mar 27, 2014 · Synced Sep 10, 2026, 9:23 PM EDT
Recruiting No phase listed Observational

Laser Ablation a Salvage Treatment for Obstructive Benign Prostatic Hyperplasia

NCT07016620
View directory record Official record
Conditions
Benign Prostatic Hyperplasia (BPH)
Interventions
Transperineal Laser Ablation (TPLA)
Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
40 Years and older · Male only
Enrollment
20 participants
Timeline
2026 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Sep 10, 2026, 9:23 PM EDT
Completed Phase 3 Interventional Results available

Interstitial Brachytherapy With or Without External-Beam Radiation Therapy in Treating Patients With Prostate Cancer

NCT00063882
View directory record Official record
Conditions
Prostate Cancer
Interventions
Brachytherapy (100/110), Brachytherapy (125/145), External Beam Radiation Therapy
Radiation
Lead sponsor
Radiation Therapy Oncology Group
Network
Eligibility
18 Years to 120 Years · Male only
Enrollment
588 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2022
U.S. locations
168
States / cities
Phoenix, Arizona • Auburn, California • Berkeley, California + 122 more
Source: ClinicalTrials.gov public record
Updated Mar 4, 2026 · Synced Sep 10, 2026, 9:23 PM EDT
Terminated Not applicable Interventional Results available

Comparative Analysis of Transperineal Versus Transrectal Approaches for MRI-Targeted Biopsy of the Prostate for the Detection and Characterization of Prostate Cancer

NCT03366792
View directory record Official record
Conditions
Prostate Cancer
Interventions
Artemis™ software system
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
40 Years to 85 Years · Male only
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 22, 2022 · Synced Sep 10, 2026, 9:23 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

TRANBERG® Transperineal MR/US Fusion Laser--Induced Thermal Therapy for Men With Prostate Cancer

NCT05698576
View directory record Official record
Conditions
Prostate Cancer, Adverse Effects Surgery, MRI, Ultrasound, Sexual Function Disturbances, Urinary Incontinence, Urinary Function Disorders, Prostate Biopsy, Ablation
Interventions
TRANBERG® Transperineal Fusion Laser--Induced Thermal Therapy of Prostate Cancer (TPF-LITT)
Device
Lead sponsor
Urological Research Network, LLC
Other
Eligibility
50 Years to 80 Years · Male only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2033
U.S. locations
1
States / cities
Hialeah, Florida
Source: ClinicalTrials.gov public record
Updated Jan 25, 2023 · Synced Sep 10, 2026, 9:23 PM EDT
Recruiting Not applicable Interventional

Improving Cryoablation Efficacy With BARRigel Rectal Spacing (ICE-BARR)

NCT07567027
View directory record Official record
Conditions
Prostate Cancer (Diagnosis), Transperineal Cryoablation
Interventions
Barrigel Injectable Gel, Cryoablation
Device · Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
40 Years to 95 Years · Male only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Sep 10, 2026, 9:23 PM EDT
Completed Phase 1Phase 2 Interventional

Buffered Lidocaine for Reducing Pain in Patients Undergoing Prostate Biopsy, BURN Trial

NCT06661902
View directory record Official record
Conditions
Prostate Cancer
Interventions
Buffered Lidocaine (1% Lidocaine + 8.4% Sodium Bicarbonate, in a 3:1 ratio), Lidocaine, Biopsy of Prostate, Questionnaire Administration
Drug · Procedure · Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older · Male only
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Sep 10, 2026, 9:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Sound Check-Correlation Between Transperineal and Digital Cervical Exam in 3rd Trimester Pregnancy

NCT05260333
View directory record Official record
Conditions
Cervix; Pregnancy
Interventions
Butterfly iQ transperineal ultrasound exam
Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 26, 2023 · Synced Sep 10, 2026, 9:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Prostate Biopsy Access Needle & Needle Guide Feasibility Study

NCT02828839
View directory record Official record
Conditions
Prostate Cancer
Interventions
Access needle
Procedure
Lead sponsor
Perineologic
Industry
Eligibility
18 Years to 80 Years · Male only
Enrollment
230 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2022
U.S. locations
1
States / cities
Cumberland, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 20, 2022 · Synced Sep 10, 2026, 9:23 PM EDT
Completed Phase 1 Interventional

Cross-linked Hyaluronan Gel Reduces Rectal Toxicity Due to Radiation Therapy for Prostate Cancer

NCT00882232
View directory record Official record
Conditions
Prostate Cancer
Interventions
Cross-linked hyaluronan gel
Device
Lead sponsor
Cancer Center of Irvine
Other
Eligibility
18 Years and older · Male only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Feb 14, 2013 · Synced Sep 10, 2026, 9:23 PM EDT
Not yet recruiting Not applicable Interventional

Transperineal Micro-ultrasound for the Detection of Prostate Cancer During Biopsy

NCT07075705
View directory record Official record
Conditions
Prostate Carcinoma
Interventions
Biopsy of Prostate, Magnetic Resonance Imaging, Micro-ultrasound Imaging
Procedure
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
18 Years and older · Male only
Enrollment
138 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 10, 2026, 9:23 PM EDT
Completed Not applicable Interventional Results available

PReclude Infection EVEnts With No Prophylaxis Transperineal Biopsy 2

NCT04815876
View directory record Official record
Conditions
Infection
Interventions
Transperineal MRI-guided prostate biopsy, Transrectal MRI-guided prostate biopsy, Antibiotic (prophylaxis)
Procedure · Drug
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older · Male only
Enrollment
1,040 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
16
States / cities
Los Angeles, California • Farmington, Connecticut • Washington D.C., District of Columbia + 11 more
Source: ClinicalTrials.gov public record
Updated Aug 23, 2026 · Synced Sep 10, 2026, 9:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Detection of Clinically Significant Prostate Cancer Using Transperineal Targeted Biopsy Compared to Standard Transrectal Biopsy

NCT03044197
View directory record Official record
Conditions
Prostate Cancer, Magnetic Resonance Imaging, Target Lesion, Fusion Biopsy, Clinically Significant Prostate Cancer, Transperineal
Interventions
MRI/ultrasound transperineal prostate biopsy, transrectal ultrasound-guided prostate biopsy
Device
Lead sponsor
The University of Texas Medical Branch, Galveston
Other
Eligibility
18 Years to 75 Years · Male only
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 4, 2019 · Synced Sep 10, 2026, 9:23 PM EDT
Terminated Not applicable Interventional Results available

A Prospective, Randomized Trial Comparing Office-based MR-guided Prostate Biopsy Approaches

NCT03632655
View directory record Official record
Conditions
Prostate Cancer, Elevated PSA
Interventions
prostate biopsy
Procedure
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older · Male only
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 30, 2024 · Synced Sep 10, 2026, 9:23 PM EDT
Completed Phase 2 Interventional

Hormone Therapy Followed By Internal Radiation Therapy in Treating Patients With Locally Recurrent Prostate Cancer

NCT00032006
View directory record Official record
Conditions
Prostate Cancer
Interventions
brachytherapy, radiation therapy
Radiation
Lead sponsor
Alliance for Clinical Trials in Oncology
Other
Eligibility
18 Years and older · Male only
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2003
U.S. locations
8
States / cities
Scottsdale, Arizona • Jacksonville, Florida • Urbana, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 12, 2016 · Synced Sep 10, 2026, 9:23 PM EDT
Terminated No phase listed Observational

Assessment of 3D Transperineal Ultrasound Imaging w/ Matrix Array Transducers in Prostate Radiotherapy

NCT02432820
View directory record Official record
Conditions
Prostate Cancer
Interventions
Not listed
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older · Male only
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jun 10, 2021 · Synced Sep 10, 2026, 9:23 PM EDT
Completed Not applicable Interventional Results available

Prostate Resection After Microwave Ablation (PRAMA)

NCT06128525
View directory record Official record
Conditions
Prostate Carcinoma
Interventions
Biospecimen Collection, Microwave Ablation, Multiparametric Magnetic Resonance Imaging, Questionnaire Administration, Radical Prostatectomy
Procedure · Device · Other
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older · Male only
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 27, 2025 · Synced Sep 10, 2026, 9:23 PM EDT
Completed No phase listed Observational

Evaluation Of Transperineal Ultrasound For Image Guidance In The Treatment Of Prostate Cancer in Men Following Prostatectomy

NCT02110667
View directory record Official record
Conditions
Prostate Cancer, Post-Prostatectomy
Interventions
Transperineal Ultrasound
Device
Lead sponsor
University of Vermont Medical Center
Other
Eligibility
18 Years to 100 Years · Male only
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated May 2, 2017 · Synced Sep 10, 2026, 9:23 PM EDT
Completed Not applicable Interventional Results available

Study of Robotic Template Guidance for Needle Placement in Transperineal Prostate Brachytherapy

NCT00381966
View directory record Official record
Conditions
Prostate Cancer
Interventions
robotic placement device
Device
Lead sponsor
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Other
Eligibility
18 Years and older · Male only
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 25, 2019 · Synced Sep 10, 2026, 9:23 PM EDT
Completed Not applicable Interventional

Virtual Reality Headset and/or Aromatherapy for Patients Undergoing a Transperineal Prostate Biopsy

NCT06296147
View directory record Official record
Conditions
Prostate Cancer
Interventions
Virtual Reality Headset, Aromatherapy Patch, Standard of Care
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older · Male only
Enrollment
208 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Sep 10, 2026, 9:23 PM EDT