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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Traumatic Encephalopathy Clear all
Completed Phase 4 Interventional Results available

Buspirone for the Treatment of Traumatic Brain Injury (TBI) Irritability and Aggression

NCT01821690
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Buspirone, Placebo
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 70 Years
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2025
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 23, 2026 · Synced Jun 26, 2026, 2:12 AM EDT
Completed No phase listed Observational

Patient Participation Beliefs and Post-Traumatic Stress Disorder (PTSD)

NCT01419223
View directory record Official record
Conditions
Post-Traumatic Stress Disorder, Brain Injuries, Traumatic
Interventions
Not listed
Lead sponsor
INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Oct 28, 2013 · Synced Jun 26, 2026, 2:12 AM EDT
Completed Not applicable Interventional

Noninvasive Brain Stimulation to Enhance Cognition at Home Following a TBI.

NCT07428980
View directory record Official record
Conditions
TBI Traumatic Brain Injury
Interventions
Transcutaneous Vagus Nerve Stimulation (tVNS)
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 75 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Jun 26, 2026, 2:12 AM EDT
Withdrawn Phase 2 Interventional

Exogenous Sodium Lactate Infusion in Traumatic Brain Injury (ELI-TBI)

NCT02776488
View directory record Official record
Conditions
Brain Injuries, Traumatic
Interventions
Sodium Lactate, Placebo
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 14, 2021 · Synced Jun 26, 2026, 2:12 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Using Virtual Technologies to Prevent Injuries in Adolescents With Acquired Brain Injury

NCT04768946
View directory record Official record
Conditions
Acquired Brain Injury, Traumatic Brain Injury, Stroke
Interventions
Not listed
Lead sponsor
Ohio State University
Other
Eligibility
12 Years and older
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
2
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 13, 2022 · Synced Jun 26, 2026, 2:12 AM EDT
Completed No phase listed Observational

Transforming Research and Clinical Knowledge in Traumatic Brain Injury

NCT02119182
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
In-Person Outcome Assessment, Phone Outcome Assessment, 3T Magnetic Resonance Imaging (MRI), Blood Draw for Plasma, DNA, Serum, RNA
Behavioral · Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
1 Year to 100 Years
Enrollment
2,996 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
23
States / cities
San Francisco, California • Denver, Colorado • Englewood, Colorado + 17 more
Source: ClinicalTrials.gov public record
Updated Sep 15, 2020 · Synced Jun 26, 2026, 2:12 AM EDT
Not yet recruiting Not applicable Interventional

Effectiveness of VestAid App

NCT06683417
View directory record Official record
Conditions
MTBI - Mild Traumatic Brain Injury, Vestibular Disease, Balance Deficits, Vestibular Disorders, Dizziness
Interventions
Vestibular Rehabilitation Aid, Standard of care vestibular rehabilitation
Device · Other
Lead sponsor
BlueHalo
Industry
Eligibility
18 Years to 60 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 11, 2024 · Synced Jun 26, 2026, 2:12 AM EDT
Recruiting Phase 3 Interventional

Quetiapine to Reduce Post Concussive Syndrome After Mild Traumatic Brain Injury (mTBI)

NCT06333990
View directory record Official record
Conditions
Mild Traumatic Brain Injury
Interventions
Quetiapine Fumarate, TAU
Drug
Lead sponsor
Foundation for Advancing Veterans' Health Research
Other
Eligibility
18 Years to 65 Years
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
2
States / cities
Albuquerque, New Mexico • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 10, 2025 · Synced Jun 26, 2026, 2:12 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Study to Improve Ambulation in Individuals With TBI Using Virtual Reality -Based Treadmill Training

NCT05130658
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Virtual reality treadmill training, Treadmill Training
Device · Other
Lead sponsor
Kessler Foundation
Other
Eligibility
13 Years to 35 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Dec 18, 2023 · Synced Jun 26, 2026, 2:12 AM EDT
Terminated No phase listed Observational

Blood Biomarkers of Injury and Outcome in Traumatic Brain Injury

NCT01730443
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Not listed
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
576 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
37
States / cities
Phoenix, Arizona • Tucson, Arizona • Palo Alto, California + 25 more
Source: ClinicalTrials.gov public record
Updated Dec 3, 2014 · Synced Jun 26, 2026, 2:12 AM EDT
Completed Not applicable Interventional Results available

Optimizing Cognitive, Environmental, and Neuromotor Stimulation in Traumatic Brain Injury

NCT04073225
View directory record Official record
Conditions
Traumatic Brain Injury, Dementia Alzheimers, Military Activity
Interventions
MindPod Dolphin, 10 Keys to Healthy Aging
Device · Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
40 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 6, 2025 · Synced Jun 26, 2026, 2:12 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Effectiveness of Amantadine Hydrochloride for Treatment of Severe Traumatic Brain Injury (TBI)

NCT00970944
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Amantadine Hydrochloride, Placebo
Drug
Lead sponsor
JFK Medical Center
Other
Eligibility
16 Years to 65 Years
Enrollment
184 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2010
U.S. locations
8
States / cities
Braintree, Massachusetts • Jackson, Mississippi • New York, New York + 5 more
Source: ClinicalTrials.gov public record
Updated Sep 23, 2012 · Synced Jun 26, 2026, 2:12 AM EDT
Recruiting No phase listed Observational

Validating a Blood Test for the Detection of Traumatic Brain Injury in Children

NCT06940232
View directory record Official record
Conditions
Pediatric Traumatic Brain Injury
Interventions
Blood Test for Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin C-terminal Hydrolase L1 (UCH-L1) Acute Biomarkers
Diagnostic Test
Lead sponsor
University of Nebraska
Other
Eligibility
Up to 17 Years
Enrollment
330 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Jul 29, 2025 · Synced Jun 26, 2026, 2:12 AM EDT
Completed Not applicable Interventional

Mobile Subthreshold Exercise Program for Concussion

NCT03691363
View directory record Official record
Conditions
Brain Concussion
Interventions
M-STEP
Behavioral
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
9 Years to 25 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 5, 2021 · Synced Jun 26, 2026, 2:12 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Neuroimaging Biomarker for Seizures

NCT03441867
View directory record Official record
Conditions
Seizure Disorder, Seizure Disorder, Post Traumatic, Traumatic Brain Injury, Non-Epileptic Seizure, Conversion Disorder, Magnetic Resonance Imaging, Head Injury, Epilepsy
Interventions
Cognitive Behavioral Therapy for Seizures, Standard Medical Care
Behavioral · Other
Lead sponsor
Providence VA Medical Center
Federal
Eligibility
18 Years to 60 Years
Enrollment
224 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
3
States / cities
Birmingham, Alabama • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 4, 2022 · Synced Jun 26, 2026, 2:12 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Measuring Blood Flow in the Brain

NCT00466934
View directory record Official record
Conditions
Traumatic Brain Injury, Healthy
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years to 60 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Jun 26, 2026, 2:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Treatment Comparison for Undergraduate College Students With Traumatic Brain Injury

NCT04628741
View directory record Official record
Conditions
Traumatic Brain Injury, Concussion, Brain
Interventions
Dynamic Coaching Model, Apprenticeship Approach
Behavioral
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated May 18, 2022 · Synced Jun 26, 2026, 2:12 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Mobile Health Self-Management and Support System for Chronic and Complex Health Conditions

NCT02592291
View directory record Official record
Conditions
Spinal Cord Injuries, Cerebral Palsy, Spinal Dysraphism, Brain Injuries, Spina Bifida, Traumatic Brain Injury
Interventions
MHealth
Device
Lead sponsor
University of Pittsburgh
Other
Eligibility
12 Years and older
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 2, 2025 · Synced Jun 26, 2026, 2:12 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Effects of Multiple Concussions in Retired NHL Players

NCT02746523
View directory record Official record
Conditions
Cognitive Deficits, Proprioceptive Disorders
Interventions
Sensory Organization Test, Biomarkers, Conners' Adult ADHD Rating Scale (CAARS), Depression Scale, Cognitive Assessment
Other · Genetic
Lead sponsor
New York Institute of Technology
Other
Eligibility
40 Years to 80 Years · Male only
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Old Westbury, New York
Source: ClinicalTrials.gov public record
Updated Jul 27, 2017 · Synced Jun 26, 2026, 2:12 AM EDT
Not listed No phase listed Observational

Reversal of Battle-Related Aging (ROBRA) in a Special Operations Forces Cohort

NCT05855876
View directory record Official record
Conditions
Post-Traumatic Stress Disorder, Traumatic Brain Injury
Interventions
subanesthetic ketamine infusions and bilateral cervical sympathetic blocks
Procedure
Lead sponsor
Stella Center
Other
Eligibility
40 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Westmont, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 16, 2023 · Synced Jun 26, 2026, 2:12 AM EDT
Completed No phase listed Observational

Assessing Eye Tracking Features Following Sports-Related Concussion

NCT02103803
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
8 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 12, 2015 · Synced Jun 26, 2026, 2:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Novel Protection Against Potential Brain, Hearing and Vision Injury During Blast Wave Exposure

NCT03017924
View directory record Official record
Conditions
Concussion, Mild
Interventions
Q collar
Device
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 15, 2021 · Synced Jun 26, 2026, 2:12 AM EDT
Terminated No phase listed Observational Results available

Study of Airway Pressure Release Ventilation and Intracranial Pressure in Patients With Severe Traumatic Brain Injury

NCT02507973
View directory record Official record
Conditions
Injury, Brain, Traumatic, Traumatic Brain Injury
Interventions
Airway Pressure Release Ventilation, Low Tidal Volume Ventilation
Other
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
14 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 27, 2022 · Synced Jun 26, 2026, 2:12 AM EDT
Completed Not applicable Interventional

Human-Animal Interaction to Promote Recovery Following Pediatric Brain Injury

NCT04016961
View directory record Official record
Conditions
Brain Injuries, Acquired Brain Injury, Traumatic Brain Injury
Interventions
AAT - Dog, TAU - No Dog
Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
6 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 16, 2024 · Synced Jun 26, 2026, 2:12 AM EDT