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Showing 1–24 of 75 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Twin Diseases Clear all
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Volunteers

NCT00001246
View directory record Official record
Conditions
Attention Deficit Hyperactivity Disorder, Schizophrenia, Attention Deficit Disorder With Hyperactivity
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
3 Years to 120 Years
Enrollment
4,274 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 1990
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Jul 21, 2026, 6:30 PM EDT
Terminated No phase listed Observational

Automated Myocardial Performance Index Using Samsung HERA W10

NCT04140669
View directory record Official record
Conditions
Twin to Twin Transfusion Syndrome, Congenital Diaphragmatic Hernia, Neural Tube Defects, Lower Urinary Tract Infection
Interventions
Automated Myocardial Performance Index (MPI)
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 12, 2022 · Synced Jul 21, 2026, 6:30 PM EDT
Not yet recruiting No phase listed Observational

TDAP in Burn Patients (Group 2)

NCT07223684
View directory record Official record
Conditions
Sepsis, Burn Injury, Wound Healing, Critical Illness, Multiple Organ Dysfunction Syndrome
Interventions
Observational Cohort (No Intervention)
Other
Lead sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Other
Eligibility
18 Years to 80 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
3
States / cities
Tampa, Florida • Atlanta, Georgia • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Jul 21, 2026, 6:30 PM EDT
Active, not recruiting Not applicable Interventional

Randomized Controlled Trial of Digital Twin Precision Treatment: A Novel Whole Body Digital Twin Enabled Precision Treatment for Type 2 Diabetes

NCT05181449
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
Twin Precision Treatment
Behavioral
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 75 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Twinsburg, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 17, 2025 · Synced Jul 21, 2026, 6:30 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Examining the Role of Genetics in Determining the Immune Response to an HIV Vaccine in HIV-Uninfected Adult Twins

NCT01054872
View directory record Official record
Conditions
HIV Infections
Interventions
HIV-1 DNA plasmid vaccine, HIV-1 recombinant Ad5 vaccine
Biological
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 50 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2016
U.S. locations
2
States / cities
Boston, Massachusetts • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 14, 2021 · Synced Jul 21, 2026, 6:30 PM EDT
Completed No phase listed Observational

The Utility of MRI Scoring to Predict Neurodevelopmental Outcomes in Survivors of Twin-to-Twin Transfusion Syndrome

NCT02249624
View directory record Official record
Conditions
Fetofetal Transfusion
Interventions
Not listed
Lead sponsor
Catherine Cibulskis, MD
Other
Eligibility
Up to 3 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2024
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 23, 2024 · Synced Jul 21, 2026, 6:30 PM EDT
Not yet recruiting Not applicable Interventional

The Efficacy of the KARL STORZ Curved Fetoscope and Straight Fetoscope for Laser Photocoagulation of Placental Anastomoses

NCT06084247
View directory record Official record
Conditions
Twin to Twin Transfusion Syndrome
Interventions
Curved KARL STORZ fetoscope, Conventional Scopes
Device
Lead sponsor
Jimmy Espinoza
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 13, 2025 · Synced Jul 21, 2026, 6:30 PM EDT
Completed No phase listed Observational Results available

Memory and the Hippocampus in Twins

NCT00638885
View directory record Official record
Conditions
PTSD, Stress Disorders, Post-Traumatic
Interventions
Not listed
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
50 Years to 70 Years · Male only
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Decatur, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 14, 2015 · Synced Jul 21, 2026, 6:30 PM EDT
Completed Not applicable Interventional

Laser Photocoagulation in Twin to Twin Transfusion Syndrome

NCT02506049
View directory record Official record
Conditions
Twin to Twin Transfusion Syndrome
Interventions
S-LPC:Selective Laser Photocoagulation
Device
Lead sponsor
University of Tennessee
Other
Eligibility
16 Weeks to 27 Weeks · Female only
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2020
U.S. locations
2
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 12, 2020 · Synced Jul 21, 2026, 6:30 PM EDT
Not listed Not applicable Interventional

Double Blinded, Randomized Clinical Trial of the Twin Star ECSPRESS Monitoring System for the Reduction of the Incidence of Fasciotomy

NCT01879696
View directory record Official record
Conditions
Compartment Syndrome
Interventions
ECSPRESS catheter with active vacuum
Device
Lead sponsor
Twin Star Medical, Inc.
Industry
Eligibility
18 Years to 44 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 17, 2013 · Synced Jul 21, 2026, 6:30 PM EDT
Recruiting No phase listed Observational

Laser Photocoagulation of Communicating Vessels in Twin-to-Twin Transfusion Syndrome

NCT05008744
View directory record Official record
Conditions
Twin to Twin Transfusion as Antepartum Condition, Monochorionic Diamniotic Placenta
Interventions
Fetoscopic laser ablation
Procedure
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
Female only
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2031
U.S. locations
2
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 18, 2024 · Synced Jul 21, 2026, 6:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Cohort Study of Weight Loss and Gliosis

NCT03578887
View directory record Official record
Conditions
Obesity, Gliosis, Weight-Loss
Interventions
Behavioral Weight Loss Program, Roux-en-Y Gastric Bypass or Sleeve Gastrectomy
Behavioral · Procedure
Lead sponsor
University of Washington
Other
Eligibility
25 Years to 64 Years
Enrollment
112 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 3, 2025 · Synced Jul 21, 2026, 6:30 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

T Cell Responses to Varicella Zoster Virus (VZV) Vaccine SLVP020

NCT01911065
View directory record Official record
Conditions
Herpes Zoster
Interventions
Zostavax™
Biological
Lead sponsor
Stanford University
Other
Eligibility
40 Years and older
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Dec 17, 2023 · Synced Jul 21, 2026, 6:30 PM EDT
Not yet recruiting Not applicable Interventional

Artificial Intelligence-based Methods to Predict Disease Progression in Youth With Type 2 Diabetes

NCT07116902
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
phone application, Standard of Care (SOC)
Device · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
10 Years to 21 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
2
States / cities
Oakland, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 3, 2025 · Synced Jul 21, 2026, 6:30 PM EDT
Recruiting No phase listed Observational

Selective Fetal Growth Restriction in Monochorionic Twins - an International Investigation

NCT05952583
View directory record Official record
Conditions
Twin; Pregnancy, Affecting Fetus or Newborn, Fetal Growth Retardation, Twin Monochorionic Diamniotic Placenta, Twin Diseases
Interventions
Ultrasound
Diagnostic Test
Lead sponsor
Leiden University Medical Center
Other
Eligibility
18 Years to 50 Years
Enrollment
274 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 14, 2024 · Synced Jul 21, 2026, 6:30 PM EDT
Completed No phase listed Observational

Verification of Risk Assignment for Whole Chromosome Using SNP-based NIPT in Vanishing Twin Pregnancies

NCT05004337
View directory record Official record
Conditions
Vanishing Twin, Trisomy 21, Trisomy 13, Trisomy 18
Interventions
Not listed
Lead sponsor
Natera, Inc.
Industry
Eligibility
18 Years and older · Female only
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
21
States / cities
Los Angeles, California • Palo Alto, California • Aurora, Colorado + 15 more
Source: ClinicalTrials.gov public record
Updated Sep 24, 2024 · Synced Jul 21, 2026, 6:30 PM EDT
Not listed Not applicable Interventional

The TAPS Trial - Fetoscopic Laser Surgery for Twin Anemia Polycythemia Sequence

NCT04432168
View directory record Official record
Conditions
Twin Anemia Polycythemia Sequence
Interventions
Fetoscopic Laser Surgery, Standard Treatment
Procedure · Other
Lead sponsor
Leiden University Medical Center
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 15, 2020 · Synced Jul 21, 2026, 6:30 PM EDT
Recruiting Not applicable Interventional

Evaluation of Laparotomy With Trans-Amniotic Suture Placement in TTTS Surgery

NCT06991400
View directory record Official record
Conditions
Twin to Twin Transfusion Syndrome, Twin Anemia-Polycythemia Sequence
Interventions
Trans-Amniotic Suture Placement
Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
18 Years and older · Female only
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated May 27, 2025 · Synced Jul 21, 2026, 6:30 PM EDT
Withdrawn Phase 2Phase 3 Interventional Accepts healthy volunteers

Vaginal Progesterone in Twins With Short Cervix

NCT01812239
View directory record Official record
Conditions
Premature Birth
Interventions
Vaginal Progesterone gel., fetal fibronectin swab., Placebo gel
Drug · Procedure
Lead sponsor
Obstetrix Medical Group
Industry
Eligibility
18 Years to 60 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
San Jose, California
Source: ClinicalTrials.gov public record
Updated Dec 18, 2014 · Synced Jul 21, 2026, 6:30 PM EDT
Recruiting No phase listed Observational

Developing Brain, Impulsivity and Compulsivity

NCT04631042
View directory record Official record
Conditions
Typical Development, Obsessive Compulsive Disorder, Conduct Disorder, Attention Deficit Hyperactivity Disorder, Autism Spectrum Disorder
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
6 Years to 80 Years
Enrollment
1,100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2031
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Jul 21, 2026, 6:30 PM EDT
Completed No phase listed Observational

Safety and Survival of Genetically Modified White Blood Cells in HIV-Infected Persons - A Study in Identical Twin Pairs

NCT00001353
View directory record Official record
Conditions
Acquired Immunodeficiency Syndrome, HIV Infection
Interventions
Genetically Marked Syngeneic T Lymphocytes
Drug
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
Not listed
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1993 – 2002
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jul 21, 2026, 6:30 PM EDT
Recruiting Not applicable Interventional

A Prospective Study on the Role of Karl Storz Curved and Straight Fetoscopes (11508AAK and 11506AAK) for Fetoscopic Intrauterine Procedures

NCT06056635
View directory record Official record
Conditions
Fetal Conditions, Maternal; Procedure, Pregnancy Related, Twin to Twin Transfusion Syndrome, In Utero Procedure Affecting Fetus or Newborn, Chorion; Abnormal, Twin Reversal Arterial Perfusion Syndrome, Twin Monochorionic Monoamniotic Placenta, Chorioangioma, Vasa Previa
Interventions
Karl Storz Curved Scope, Karl Storz Straight Scope
Device
Lead sponsor
Boston Children's Hospital
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 24, 2024 · Synced Jul 21, 2026, 6:30 PM EDT
Completed No phase listed Observational

Maternal and Umbilical Cord Hormone Concentrations in Twin and Singleton Pregnancies

NCT00341263
View directory record Official record
Conditions
Normal Pregnancy
Interventions
Not listed
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years to 60 Years · Female only
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2020
U.S. locations
1
States / cities
Hanover, New Hampshire
Source: ClinicalTrials.gov public record
Updated Feb 20, 2020 · Synced Jul 21, 2026, 6:30 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Changes in Cognition and Psychiatric Disorder Symptoms During Cannabis Abstinence Using a Novel Discordant Twin Design

NCT05160688
View directory record Official record
Conditions
Cannabis
Interventions
Contingency management
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
31 Years to 47 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Jul 21, 2026, 6:30 PM EDT