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Showing 1–24 of 230 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Conditions
Epilepsies, Partial
Interventions
Vagus Nerve Stimulation Therapy
Device
Lead sponsor
Cyberonics, Inc.
Industry
Eligibility
12 Years and older
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
23
States / cities
Phoenix, Arizona • Sun City, Arizona • Los Angeles, California + 19 more
Conditions
Ischemic Stroke, Upper Extremity Problem
Interventions
Vivistim System
Device
Lead sponsor
MicroTransponder Inc.
Industry
Eligibility
19 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Recruiting Not applicable Interventional Accepts healthy volunteers

Evaluation of a Device to Reduce Motion Sickness and Spatial Disorientation

NCT06892340
Conditions
Motion Sickness
Interventions
Transcutaneous Auricular Neurostimulation device
Device
Lead sponsor
59th Medical Wing
Federal
Eligibility
18 Years to 50 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
San Antonio, Texas
Conditions
Opioid Withdrawal, Opioid Use Disorder (OUD)
Interventions
Sparrow Link (Active tAN), Sparrow Link (Sham tAN)
Device
Lead sponsor
Payel Roy
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Recruiting Not applicable Interventional

At-Home taVNS - Stroke Rehab

NCT06616831
Conditions
Stroke, Stroke, Ischemic, Stroke Hemorrhagic
Interventions
Remote Transcutaneous Auricular Vagal Nerve Stimulation Paired with Task-Specific Training
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 80 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Charleston, South Carolina
Conditions
Prader-Willi Syndrome
Interventions
tVNS, intermittent stimulation, tVNS, continuous stimulation
Device
Lead sponsor
Foundation for Prader-Willi Research
Other
Eligibility
10 Years to 40 Years
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
18
States / cities
Palo Alto, California • San Diego, California • Aurora, Colorado + 14 more
Conditions
Blood Loss, Surgical
Interventions
Volta tAN System, SHAM Volta tAN System
Device
Lead sponsor
University Surgical Vascular
Industry
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Watkinsville, Georgia
Conditions
Cervical Spinal Cord Injury
Interventions
Active VNS, Sham VNS, Arm rehabilitation
Device · Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Houston, Texas
Conditions
Hearing Loss
Interventions
Electrical stimulator
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
New York, New York
Recruiting Not applicable Interventional Accepts healthy volunteers

Vagus Nerve Stimulation for Reaction Time

NCT07528742
Conditions
Healthy Subjects (HS)
Interventions
vagus nerve stimulation
Device
Lead sponsor
Youngstown State University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Youngstown, Ohio
Conditions
Epilepsy
Interventions
M106 VNS Therapy System
Device
Lead sponsor
Cyberonics, Inc.
Industry
Eligibility
12 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
15
States / cities
Phoenix, Arizona • Stanford, California • Tampa, Florida + 12 more
Completed Not applicable Interventional Accepts healthy volunteers Results available

Noninvasive Vagus Nerve Stimulation (VNS) for Neuromotor Adaptations

NCT03628976
Conditions
Healthy Young Adults
Interventions
tVNS, Motor training
Other
Lead sponsor
Georgia Institute of Technology
Other
Eligibility
18 Years to 39 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Atlanta, Georgia
Conditions
Neuropathic Pain
Interventions
taVNS Video, Educational materials, TMS Video
Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 80 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Miami, Florida
Conditions
Myocardial Infarction, Tachyarrhythmia
Interventions
Parasym device (active, current (mA) < discomfort threshold), Parasym device (sham, current (mA) = 0)
Device
Lead sponsor
Hippocration General Hospital
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Suspended Not applicable Interventional Accepts healthy volunteers

taVNS for Letter Learning in Dyslexia

NCT06127550
Conditions
Dyslexia
Interventions
active taVNS, sham taVNS
Device
Lead sponsor
University of Florida
Other
Eligibility
10 Years to 12 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Gainesville, Florida
Conditions
Acute Respiratory Distress Syndrome, Acute Lung Injury, Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Traumatic Brain Injury
Interventions
nVNS, SOC
Device · Other
Lead sponsor
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Other
Eligibility
12 Years to 80 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Conditions
Epilepsy
Interventions
Not listed
Lead sponsor
Cyberonics, Inc.
Industry
Eligibility
7 Years and older
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
7
States / cities
Atlanta, Georgia • Peoria, Illinois • Louisville, Kentucky + 4 more
Conditions
Major Depressive Disorder
Interventions
Active transcutaneous vagus nerve stimulation, Sham transcutaneous vagus nerve stimulation
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
24 Years to 45 Years · Female only
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Charlestown, Massachusetts
Conditions
Diabetes Mellitus, Type 2
Interventions
Ultrasound Vagus Nerve Stimulation (DECIMA)
Device
Lead sponsor
Aucta Technologies, Inc.
Industry
Eligibility
21 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Scottsdale, Arizona
Active, not recruiting Not applicable Interventional

Noninvasive Vagal Nerve Stimulation

NCT06816004
Conditions
Multiple Sclerosis
Interventions
Remotely Supervised Transcranial Direct Current Stimulation (RS - tDCS), Remotely Supervised Transcutaneous Auricular Vagus Nerve Stimulation (RS - taVNS), Remotely Supervised Transcutaneous Cervical Vagus Nerve Stimulation (RS - tcVNS)
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
25 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
New York, New York
Terminated Not applicable Interventional Accepts healthy volunteers

Transcutaneous Auricular Vagus Nerve Stimulation to Enhance Motor Learning

NCT05316519
Conditions
Neurological Injury, Motor Disorders, Paresis
Interventions
Transcutaneous Vagus Nerve Stimulation
Other
Lead sponsor
VA Pittsburgh Healthcare System
Federal
Eligibility
18 Years to 75 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Completed Not applicable Interventional Results available

Auricular Vagus Nerve Stimulation for Chronic Pain

NCT03959111
Conditions
Low Back Pain
Interventions
Stimulation at Location 1, Stimulation at Location 2
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Charlestown, Massachusetts
Conditions
Autism Spectrum Disorder, Intellectual Disability, Autonomic Nervous System, Developmental Disability
Interventions
Vagus Nerve Stimulation
Device
Lead sponsor
New York State Institute for Basic Research
Government
Eligibility
12 Years to 40 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
New York, New York • Staten Island, New York
Conditions
Chronic Stroke
Interventions
Vagus Nerve Stimulation (VNS) Device, Sham VNS Device, Upper Extremity Rehabilitation
Device · Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
22 Years to 79 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
New York, New York • Richardson, Texas