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ClinicalTrials.gov public records Last synced Sep 26, 2026, 10:43 AM EDT

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Showing 1–24 of 414 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Valve Disease, Aortic Clear all
Completed No phase listed Observational Accepts healthy volunteers

Impact of Elastin Mediated Vascular Stiffness on End Organs

NCT02840448
View directory record Official record
Conditions
Williams Syndrome, Supravalvular Aortic Stenosis, Cardiovascular Disease
Interventions
Not listed
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
3 Years to 85 Years
Enrollment
159 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2024
U.S. locations
2
States / cities
Bethesda, Maryland • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Sep 26, 2026, 10:43 AM EDT
Completed No phase listed Observational Results available

Philips Intracardiac Echocardiography (ICE) Clinical Registry

NCT04950192
View directory record Official record
Conditions
Atrial Fibrillation, Stroke, Valve Disease, Heart, Atrial Septal Defect, Patent Foramen Ovale, Mitral Valve Disease, Tricuspid Valve Disease, Aortic Valve Disease
Interventions
ICE Image guidance
Device
Lead sponsor
Philips Clinical & Medical Affairs Global
Industry
Eligibility
18 Years and older
Enrollment
155 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
5
States / cities
Aurora, Colorado • Chicago, Illinois • Boston, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 5, 2025 · Synced Sep 26, 2026, 10:43 AM EDT
Completed No phase listed Observational

Improving Echo Measurements in the Diagnosis of Aortic Stenosis

NCT02146755
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Not listed
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
396 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
2
States / cities
Dallas, Texas • Plano, Texas
Source: ClinicalTrials.gov public record
Updated Jun 11, 2017 · Synced Sep 26, 2026, 10:43 AM EDT
Completed Not applicable Interventional

A Study to Evaluate a Computerized Stethoscope Called ©Voqx to Diagnose Heart Disease

NCT04960280
View directory record Official record
Conditions
Isolated Aortic Stenosis, Mitral Regurgitation
Interventions
©VoqX stethoscope
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Sep 26, 2026, 10:43 AM EDT
Recruiting Not applicable Interventional

Correlation Between an Impedance Cardiography Test for Decompensation and the Development of Left Ventricular Replacement Fibrosis

NCT07230964
View directory record Official record
Conditions
Aortic Stenosis
Interventions
Impedance Cardiography Upright/Supine Test
Device
Lead sponsor
Dermed Diagnostics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Sep 26, 2026, 10:43 AM EDT
Completed No phase listed Observational

Development of an Algorithm to Differentiate Heart Murmurs Using Electronic Stethoscopes

NCT04400513
View directory record Official record
Conditions
Murmur, Heart, Aortic Valve Stenosis, Tricuspid Regurgitation, Mitral Regurgitation, Innocent Murmurs, Heart Murmurs
Interventions
Use of Eko CORE and Eko DUO electronic stethoscopes
Device
Lead sponsor
Eko Devices, Inc.
Industry
Eligibility
18 Years and older
Enrollment
1,145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Springfield, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 14, 2023 · Synced Sep 26, 2026, 10:43 AM EDT
Completed Not applicable Interventional Results available

Clinical Investigation Of The Mitroflow Aortic Pericardial Heart Valve

NCT00630916
View directory record Official record
Conditions
Heart Valve Diseases
Interventions
Mitroflow Aortic Heart Valve
Device
Lead sponsor
Sorin Group USA, Inc.
Industry
Eligibility
18 Years and older
Enrollment
756 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
21
States / cities
Phoenix, Arizona • Tucson, Arizona • San Diego, California + 16 more
Source: ClinicalTrials.gov public record
Updated Sep 21, 2011 · Synced Sep 26, 2026, 10:43 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Phono- and Electrocardiogram Assisted Detection of Valvular Disease

NCT03458806
View directory record Official record
Conditions
Aortic Valve Stenosis, Mitral Regurgitation, Heart Murmurs, Valvular Heart Disease
Interventions
AS Algorithm 1, AS Algorithm 2, MR Algorithm 1, MR Algorithm 2
Diagnostic Test
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
156 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 1, 2021 · Synced Sep 26, 2026, 10:43 AM EDT
Terminated Phase 3 Interventional Results available

PROACT Xa - A Trial to Determine if Participants With an On-X Aortic Valve Can be Maintained Safely on Apixaban

NCT04142658
View directory record Official record
Conditions
Aortic Valve Disease, Aortic Valve Stenosis, Aortic Valve Failure
Interventions
Apixaban 5 MG, Apixaban 2.5 MG, Warfarin, On-X Aortic Mechanical Valve
Drug · Device
Lead sponsor
Artivion Inc.
Industry
Eligibility
18 Years and older
Enrollment
863 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
62
States / cities
Tucson, Arizona • Little Rock, Arkansas • Loma Linda, California + 50 more
Source: ClinicalTrials.gov public record
Updated Mar 19, 2024 · Synced Sep 26, 2026, 10:43 AM EDT
Completed Phase 4 Interventional Results available

Pre-operative Prophylaxis With Vancomycin and Cefazolin in Pediatric Cardiovascular Surgery Patients

NCT01619982
View directory record Official record
Conditions
Congenital Heart Diseases, Aortic Valve Disorder
Interventions
Cefazolin 25 mg/kg body weight and Vancomycin hydrochloride, Cefazolin 30 mg/kg body weight
Drug
Lead sponsor
Stanford University
Other
Eligibility
Up to 18 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated May 15, 2018 · Synced Sep 26, 2026, 10:43 AM EDT
Active, not recruiting Not applicable Interventional Results available

Medtronic Evolut Transcatheter Aortic Valve Replacement in Low Risk Patients

NCT02701283
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Medtronic Transcatheter Aortic Valve Replacement Systems, Surgical Aortic Valve Replacement (SAVR)
Device
Lead sponsor
Medtronic Cardiovascular
Industry
Eligibility
Not listed
Enrollment
2,223 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2029
U.S. locations
61
States / cities
Phoenix, Arizona • La Jolla, California • Los Angeles, California + 53 more
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Sep 26, 2026, 10:43 AM EDT
Active, not recruiting No phase listed Observational

Genomic Investigation of Cardiovascular Diseases

NCT00722748
View directory record Official record
Conditions
Coronary Artery Disease, Myocardial Infarction, Atrial Fibrillation, Aortic Stenosis, Mitral Regurgitation, Idiopathic Cardiomyopathy
Interventions
Not listed
Lead sponsor
Scripps Translational Science Institute
Other
Eligibility
18 Years and older
Enrollment
15,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2030
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jan 15, 2025 · Synced Sep 26, 2026, 10:43 AM EDT
Completed No phase listed Observational

Extended ECG Monitoring in HCM Patients

NCT04056715
View directory record Official record
Conditions
Hypertrophic Cardiomyopathy, Nonsustained Ventricular Tachycardia, Ventricular Tachycardia, Atrial Fibrillation, Arrhythmia
Interventions
Zio XT
Device
Lead sponsor
iRhythm Technologies, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 28, 2023 · Synced Sep 26, 2026, 10:43 AM EDT
Active, not recruiting No phase listed Observational

Stress Aortic Valve Index for Assessing Risk in Aortic Valve Stenosis Patients

NCT04514250
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Not listed
Lead sponsor
Catharina Ziekenhuis Eindhoven
Other
Eligibility
50 Years and older
Enrollment
52 participants
Timeline
2021 – 2028
U.S. locations
2
States / cities
Worcester, Massachusetts • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 13, 2024 · Synced Sep 26, 2026, 10:43 AM EDT
Recruiting Not applicable Interventional

Comparison of Single vs. Dual Perclose Devices for Large-Bore Access Closure in TAVR

NCT06871774
View directory record Official record
Conditions
Transcatheter Aortic Valve Replacement
Interventions
Single Perclose Pro vascular closure device, Dual Perclose vascular closure device
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Sep 26, 2026, 10:43 AM EDT
Completed No phase listed Observational

Assessment of Myocardial Tissue Damage in Aortic Stenosis

NCT02101619
View directory record Official record
Conditions
Aortic Stenosis
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
65 Years and older
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 16, 2016 · Synced Sep 26, 2026, 10:43 AM EDT
Completed Not applicable Interventional

Response Inhibition Training for Children With Williams Syndrome

NCT02212314
View directory record Official record
Conditions
Williams Syndrome
Interventions
Response Inhibition Training
Behavioral
Lead sponsor
University of Wisconsin, Milwaukee
Other
Eligibility
10 Years to 17 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 30, 2017 · Synced Sep 26, 2026, 10:43 AM EDT
Completed Not applicable Interventional

Impact of a Patient Decision Aid for Treatment of Aortic Stenosis

NCT04103931
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
"Treatment Choices for Aortic Stenosis" Decision Aid
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 85 Years
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
2
States / cities
Aurora, Colorado • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 4, 2022 · Synced Sep 26, 2026, 10:43 AM EDT
Not listed No phase listed Observational

Multicenter Prospective Study of Low-Flow Low-Gradient Aortic Stenosis (TOPAS Study)

NCT01835028
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Echocardiography, Computed tomography, Magnetic resonance imaging, Blood biomarkers, Stress echocardiography
Other
Lead sponsor
Laval University
Other
Eligibility
21 Years to 90 Years
Enrollment
320 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2024
U.S. locations
2
States / cities
Rochester, Minnesota • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 20, 2021 · Synced Sep 26, 2026, 10:43 AM EDT
Not listed No phase listed Observational

Extended Ambulatory Monitoring Improves Risk Stratification in Hypertrophic Cardiomyopathy

NCT03182153
View directory record Official record
Conditions
Hypertrophic Cardiomyopathy
Interventions
Extended Cardiac Monitoring
Device
Lead sponsor
Atlantic Health System
Other
Eligibility
18 Years to 65 Years
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Morristown, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 26, 2018 · Synced Sep 26, 2026, 10:43 AM EDT
Completed No phase listed Observational

MRI Assessment of RV Function: Patients With TOF or Aortic Coarctation

NCT00277901
View directory record Official record
Conditions
Congenital Disorders
Interventions
Not listed
Lead sponsor
Children's Healthcare of Atlanta
Other
Eligibility
Up to 21 Years
Enrollment
390 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2009
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Dec 1, 2014 · Synced Sep 26, 2026, 10:43 AM EDT
Completed Not applicable Interventional Results available

The Medtronic TAVR 2.0 US Clinical Study

NCT02738853
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Medtronic Transcatheter Aortic Valve 2.0 Replacement System
Device
Lead sponsor
Medtronic Cardiovascular
Industry
Eligibility
Not listed
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
8
States / cities
New Haven, Connecticut • Kansas City, Kansas • Boston, Massachusetts + 4 more
Source: ClinicalTrials.gov public record
Updated Mar 20, 2023 · Synced Sep 26, 2026, 10:43 AM EDT
Active, not recruiting Not applicable Interventional

Evolut™ EXPAND TAVR II Pivotal Trial

NCT05149755
View directory record Official record
Conditions
Moderate Aortic Valve Stenosis
Interventions
Medtronic Evolut PRO+ TAVR System, or Evolut FX TAVR System, and guideline-directed management and therapy (GDMT)
Device
Lead sponsor
Medtronic Cardiovascular
Industry
Eligibility
65 Years and older
Enrollment
650 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2034
U.S. locations
52
States / cities
Birmingham, Alabama • Phoenix, Arizona • Scottsdale, Arizona + 47 more
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Sep 26, 2026, 10:43 AM EDT
Completed Phase 1 Interventional

FEIBA and Use of Blood Products in Cardiac Surgery

NCT02577614
View directory record Official record
Conditions
Cardiovascular Disease
Interventions
FEIBA, Normal Saline
Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 100 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 13, 2020 · Synced Sep 26, 2026, 10:43 AM EDT