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ClinicalTrials.gov public records Last synced Oct 4, 2026, 3:53 AM EDT

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Showing 25–48 of 125 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Valve Regurgitation, Mitral Clear all
Completed Not applicable Interventional Results available

Magna® Mitral Pericardial Bioprostheses Post-Approval Study Protocol

NCT00853632
View directory record Official record
Conditions
Coronary Artery Disease, Mitral Valve Regurgitation, Mitral Valve Incompetence, Heart Failure
Interventions
CEP MAGNA MITRAL PERICARDIAL BIOPROSTHESES
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
329 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2024
U.S. locations
10
States / cities
Sacramento, California • Orlando, Florida • Chicago, Illinois + 7 more
Source: ClinicalTrials.gov public record
Updated May 14, 2025 · Synced Oct 4, 2026, 3:53 AM EDT
Recruiting Not applicable Interventional

Cephea Early Feasibility Study

NCT05061004
View directory record Official record
Conditions
Mitral Regurgitation
Interventions
Cephea Mitral Valve System
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2031
U.S. locations
20
States / cities
Phoenix, Arizona • Los Angeles, California • Sacramento, California + 15 more
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 4, 2026, 3:53 AM EDT
Recruiting No phase listed Observational

CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry

NCT04688190
View directory record Official record
Conditions
Mitral Regurgitation, Mitral Valve Disease, Mitral Annular Calcification
Interventions
Not listed
Lead sponsor
Universitätsklinikum Hamburg-Eppendorf
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2030
U.S. locations
9
States / cities
Tucson, Arizona • Los Angeles, California • Tampa, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Oct 4, 2026, 3:53 AM EDT
Recruiting No phase listed Observational

Abbott Cephea Mitral Valve Disease Registry

NCT07069673
View directory record Official record
Conditions
Mitral Regurgitation, Mitral Stenosis, Mitral Valve Disease, Mitral Valve (MV) Regurgitation, Mitral Annulus Calcification, Mitral Valve Replacement, Transcatheter Valve Replacement
Interventions
Not listed
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
24
States / cities
Birmingham, Alabama • Phoenix, Arizona • Thousand Oaks, California + 16 more
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Oct 4, 2026, 3:53 AM EDT
Not yet recruiting Not applicable Interventional

Importance of Point-of-Care Ultrasound for Early Detection of Valvular and Cardiac Diseases (IMPROVE)

NCT07756398
View directory record Official record
Conditions
Valvular Heart Disease Patients, Aortic Stenosis, Mitral Regurgitation, Left Ventricular Diastolic Dysfunction
Interventions
Kosmos Torso-One AI-guided Point-of-Care Ultrasound (EchoNous, Inc.)
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
65 Years to 85 Years
Enrollment
1,088 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Oct 4, 2026, 3:53 AM EDT
Active, not recruiting Not applicable Interventional

Edwards EVOQUE Eos MISCEND Study

NCT02718001
View directory record Official record
Conditions
Mitral Valve Regurgitation (Degenerative or Functional)
Interventions
Edwards EVOQUE Eos Mitral Valve Replacement System
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
123 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2033
U.S. locations
16
States / cities
Burlingame, California • Los Angeles, California • San Francisco, California + 13 more
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Oct 4, 2026, 3:53 AM EDT
Not listed Not applicable Interventional

Evaluating Infrasonic Hemodynography

NCT04636892
View directory record Official record
Conditions
Aortic Stenosis, Mitral Regurgitation, Pulmonary Hypertension, Heart Failure, Systolic, Cardiovascular Diseases, Coronary Artery Disease
Interventions
MindMics earbud
Other
Lead sponsor
Scripps Health
Other
Eligibility
Not listed
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Apr 16, 2024 · Synced Oct 4, 2026, 3:53 AM EDT
Terminated No phase listed Observational

A Feasibility Registry of Actigraphy Monitoring in Degenerative Mitral Regurgitation Subjects Receiving the MitraClip® Device

NCT02858245
View directory record Official record
Conditions
Mitral Regurgitation
Interventions
No intervention - registry
Other
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
8
States / cities
Phoenix, Arizona • Los Angeles, California • Aurora, Colorado + 5 more
Source: ClinicalTrials.gov public record
Updated May 7, 2018 · Synced Oct 4, 2026, 3:53 AM EDT
Completed Phase 2 Interventional Results available

Comparing the Effectiveness of Repairing Versus Replacing the Heart's Mitral Valve in People With Severe Chronic Ischemic Mitral Regurgitation

NCT00807040
View directory record Official record
Conditions
Mitral Valve Insufficiency, Coronary Artery Disease
Interventions
Mitral Valve Repair with Annuloplasty, Mitral Valve Replacement
Procedure
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
251 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
18
States / cities
Los Angeles, California • Atlanta, Georgia • Marietta, Georgia + 15 more
Source: ClinicalTrials.gov public record
Updated Mar 15, 2019 · Synced Oct 4, 2026, 3:53 AM EDT
Recruiting Not applicable Interventional

Reduction or Elimination of Mitral Regurgitation With the SATURN TMVR System (CASSINI-US)

NCT07130994
View directory record Official record
Conditions
Mitral Regurgitation, Heart Disease
Interventions
Mitral Valve Replacement
Device
Lead sponsor
InnovHeart
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2032
U.S. locations
5
States / cities
Los Angeles, California • Sacramento, California • Thousand Oaks, California + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Oct 4, 2026, 3:53 AM EDT
Recruiting Not applicable Interventional

TVMR With the INNOVALVE System Trial - Early Feasibility Study

NCT04919980
View directory record Official record
Conditions
Mitral Valve Regurgitation (Degenerative or Functional)
Interventions
INNOVALVE system
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2034
U.S. locations
21
States / cities
Los Angeles, California • Palo Alto, California • Naples, Florida + 15 more
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Oct 4, 2026, 3:53 AM EDT
Active, not recruiting Not applicable Interventional Results available

Implantation of a Permanent Interatrial Shunt to Reduce Left Atrial Filling Pressures Following MitraClip

NCT04729933
View directory record Official record
Conditions
Heart Failure, Mitral Regurgitation
Interventions
V-Wave Shunt Placement
Device
Lead sponsor
samir kapadia
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2030
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Oct 4, 2026, 3:53 AM EDT
Active, not recruiting Not applicable Interventional Results available

PARTNER 3 Trial - Mitral Valve in Valve

NCT03193801
View directory record Official record
Conditions
Mitral Valve Insufficiency, Mitral Valve Disease, Mitral Valve Regurgitation, Heart Failure
Interventions
Edwards SAPIEN 3 transcatheter valve, Model 9600TFX
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
Not listed
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2031
U.S. locations
9
States / cities
Atlanta, Georgia • Chicago, Illinois • Evanston, Illinois + 6 more
Source: ClinicalTrials.gov public record
Updated Nov 5, 2025 · Synced Oct 4, 2026, 3:53 AM EDT
Completed Not applicable Interventional Results available

Expanded Clinical Study of the Tendyne Mitral Valve System

NCT02321514
View directory record Official record
Conditions
Mitral Valve Regurgitation
Interventions
Tendyne Mitral Valve System
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
191 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2025
U.S. locations
13
States / cities
Scottsdale, Arizona • Washington D.C., District of Columbia • Clearwater, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Jul 17, 2025 · Synced Oct 4, 2026, 3:53 AM EDT
Active, not recruiting Not applicable Interventional Results available

Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

NCT03433274
View directory record Official record
Conditions
Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease, Heart, Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease
Interventions
Tendyne Mitral Valve System, MitraClip System
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2028
U.S. locations
73
States / cities
Birmingham, Alabama • Phoenix, Arizona • Scottsdale, Arizona + 60 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Oct 4, 2026, 3:53 AM EDT
Completed Not applicable Interventional

Mitral Loop Cerclage(MLC) for Reducing Functional Mitral Regurgitation

NCT02471664
View directory record Official record
Conditions
Functional Mitral Regurgitation, Heart Failure
Interventions
Mitral Loop Cerclage Annuloplasty
Device
Lead sponsor
Tau-MEDICAL Co., Ltd.
Industry
Eligibility
20 Years to 85 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 13, 2017 · Synced Oct 4, 2026, 3:53 AM EDT
Completed No phase listed Observational

Atrioventricular Valve Regurgitation Vena Contracta; Echo Versus MRI

NCT01504880
View directory record Official record
Conditions
Tricuspid Valve Regurgitation, Non-rheumatic, Mitral Valve Regurgitation
Interventions
Not listed
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
Not listed
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2019
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 6, 2020 · Synced Oct 4, 2026, 3:53 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Comparison Study of Echocardiography and Cardiovascular Magnetic Resonance Imaging in the Assessment of Mitral and Aortic Regurgitation

NCT04038879
View directory record Official record
Conditions
Mitral Regurgitation, Aortic Regurgitation
Interventions
MRI
Diagnostic Test
Lead sponsor
Atlantic Health System
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2023
U.S. locations
1
States / cities
Morristown, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 6, 2019 · Synced Oct 4, 2026, 3:53 AM EDT
Completed Not applicable Interventional Results available

ProspeCtive, nOn-randoMized, MulticENter Clinical Evaluation of Edwards Pericardial Bioprostheses With a New Tissue Treatment Platform (COMMENCE)

NCT01757665
View directory record Official record
Conditions
Aortic Stenosis, Mitral Stenosis, Aortic Valve Insufficiency, Mitral Valve Insufficiency, Heart Failure
Interventions
Edwards Aortic and Mitral Bioprostheses Models 11000A and 11000M
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
777 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2026
U.S. locations
29
States / cities
Birmingham, Alabama • Los Angeles, California • Sacramento, California + 20 more
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Oct 4, 2026, 3:53 AM EDT
Recruiting Not applicable Interventional

Home-Based Cardiac Rehabilitation Using a Novel Mobile Health Exercise Regimen Following Transcatheter Heart Valve Interventions

NCT06077201
View directory record Official record
Conditions
Valvular Heart Disease
Interventions
HBCR hands-off, HBCR interactive
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 4, 2026 · Synced Oct 4, 2026, 3:53 AM EDT
Recruiting No phase listed Observational

Annuloplasty Rings and Band Post-Market Clinical Follow-Up Study

NCT04761120
View directory record Official record
Conditions
Mitral Regurgitation, Tricuspid Regurgitation, Valvular Heart Disease
Interventions
Abbott SJM Rigid Saddle Ring, Abbott SJM Séguin Ring, Abbott SJM Tailor Ring, Abbott SJM Tailor Band
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
550 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2031
U.S. locations
2
States / cities
Durham, North Carolina • Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Oct 4, 2026, 3:53 AM EDT
Terminated Not applicable Interventional Results available

Edwards Cardioband System ACTIVE Pivotal Clinical Trial (ACTIVE)

NCT03016975
View directory record Official record
Conditions
Functional Mitral Regurgitation, Mitral Regurgitation, Mitral Insufficiency
Interventions
Edwards Cardioband System, Guideline Directed Medical Therapy
Device · Drug
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
24
States / cities
Los Angeles, California • Palo Alto, California • Aurora, Colorado + 18 more
Source: ClinicalTrials.gov public record
Updated Nov 30, 2023 · Synced Oct 4, 2026, 3:53 AM EDT
Recruiting Not applicable Interventional

Transcatheter Mitral Valve Repair for Inotrope Dependent Cardiogenic Shock

NCT05298124
View directory record Official record
Conditions
Cardiogenic Shock, Mitral Regurgitation
Interventions
Transcatheter edge-to-edge repair, Medical therapy
Device · Other
Lead sponsor
Ottawa Heart Institute Research Corporation
Other
Eligibility
18 Years and older
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Oct 4, 2026, 3:53 AM EDT
Completed No phase listed Observational

Invasive Hemodynamic Response to Transcatheter Edge-to-Edge Mitral Valve Repair

NCT04200378
View directory record Official record
Conditions
Mitral Regurgitation
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 23, 2024 · Synced Oct 4, 2026, 3:53 AM EDT