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ClinicalTrials.gov public records Last synced Sep 8, 2026, 10:29 PM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Wrinkle Clear all
Completed Phase 3 Interventional Results available

Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Crow's Feet Lines and Frown Lines

NCT01224015
View directory record Official record
Conditions
Facial Rhytides, Crow's Feet Lines, Glabellar Lines
Interventions
normal saline, onabotulinumtoxinA 44 U, onabotulinumtoxinA 24 U
Drug · Biological
Lead sponsor
Allergan
Industry
Eligibility
18 Years and older
Enrollment
684 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Newport Beach, California
Source: ClinicalTrials.gov public record
Updated Feb 24, 2014 · Synced Sep 8, 2026, 10:29 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

In Vivo Study to Evaluate Tissue Remodeling Via Fibroblast Stimulation Following a Single SofWave Treatment

NCT07685821
View directory record Official record
Conditions
Lax Skin, Improve Facial Wrinkles
Interventions
Sofwave
Device
Lead sponsor
Sofwave Medical LTD
Industry
Eligibility
35 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Sep 8, 2026, 10:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Safety and Efficacy of SofWave Treatment to Lift the Upper Lip and Improve the Peri-Oral Rhytids

NCT06104514
View directory record Official record
Conditions
Rhytides, Wrinkle
Interventions
Sofwave
Device
Lead sponsor
Sofwave Medical LTD
Industry
Eligibility
35 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
6
States / cities
Palo Alto, California • San Diego, California • Lincolnshire, Illinois + 3 more
Source: ClinicalTrials.gov public record
Updated May 14, 2025 · Synced Sep 8, 2026, 10:29 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

A Safety and Effectiveness Study of the Tixel Device, (Fractional Peri-orbital Wrinkles Treatment ) Compared With Laser

NCT03454672
View directory record Official record
Conditions
Wrinkle
Interventions
Tixel, Laser
Device
Lead sponsor
Novoxel Ltd.
Industry
Eligibility
40 Years to 70 Years
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 22, 2024 · Synced Sep 8, 2026, 10:29 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Multicenter Study of the Safety and Effectiveness of Dermal Filler, Belotero®.

NCT00876265
View directory record Official record
Conditions
Facial Wrinkles
Interventions
Belotero, Zyplast
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
6
States / cities
Birmingham, Alabama • Los Angeles, California • San Francisco, California + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 25, 2013 · Synced Sep 8, 2026, 10:29 PM EDT
Completed Not applicable Interventional Results available

TEOSYAL® RHA Global Action, TEOSYAL® RHA Deep Lines, and Juvéderm® Ultra XC for the Correction of Nasolabial Folds

NCT02195427
View directory record Official record
Conditions
Nasolabial Folds, Wrinkles
Interventions
TEOSYAL® RHA Global Action, TEOSYAL® RHA Deep Lines
Device
Lead sponsor
Teoxane SA
Industry
Eligibility
22 Years and older
Enrollment
148 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
5
States / cities
Birmingham, Alabama • Beverly Hills, California • Santa Monica, California + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 24, 2018 · Synced Sep 8, 2026, 10:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

RHA® 4 NLF Cannula

NCT04754646
View directory record Official record
Conditions
Wrinkle, Nasolabial Fold, Aging
Interventions
Split-face injection of RHA® 4 with a cannula into a single NLF., Split-face injection of RHA® 4 with a needle (TSK 27G x ½") into the contralateral NLF.
Device
Lead sponsor
Teoxane SA
Industry
Eligibility
22 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
4
States / cities
Encinitas, California • West Palm Beach, Florida • Chapel Hill, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 8, 2023 · Synced Sep 8, 2026, 10:29 PM EDT
Completed Not applicable Interventional Results available

The Use of J-Plasma® for Dermal Resurfacing

NCT03286283
View directory record Official record
Conditions
Facial Wrinkles, Rhytides
Interventions
J-Plasma
Device
Lead sponsor
Apyx Medical
Industry
Eligibility
30 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
3
States / cities
Miami, Florida • Sarasota, Florida • Alpharetta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 26, 2022 · Synced Sep 8, 2026, 10:29 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Peri-orbital and Peri-oral Wrinkle Reduction Trial

NCT01981252
View directory record Official record
Conditions
Peri-orbital Wrinkles, Peri-oral Wrinkles
Interventions
Ulthera® System Treatment
Device
Lead sponsor
Ulthera, Inc
Industry
Eligibility
30 Years to 75 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
5
States / cities
Beverly Hills, California • Laguna Beach, California • Englewood, Colorado + 2 more
Source: ClinicalTrials.gov public record
Updated Nov 23, 2017 · Synced Sep 8, 2026, 10:29 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Spread of PrabotulinumtoxinA-xvfs Versus OnabotulinumtoxinA in the Treatment of Forehead Rhytides

NCT05807412
View directory record Official record
Conditions
Rhytides
Interventions
PrabotulinumtoxinA-Xvfs, OnabotulinumtoxinA
Drug
Lead sponsor
Lupo Center for Aesthetic and General Dermatology
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Mar 12, 2024 · Synced Sep 8, 2026, 10:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Efficacy of Micro-excisional Skin Removal by Micro-coring Device in Treatment of Wrinkles and Laxity of Face and Neck

NCT03583918
View directory record Official record
Conditions
Laxity; Skin
Interventions
HighThroughput Micro Coring Device
Device
Lead sponsor
Cytrellis Biosystems, Inc.
Industry
Eligibility
40 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
5
States / cities
Sacramento, California • Miami, Florida • New York, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 11, 2018 · Synced Sep 8, 2026, 10:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of M22 Synergistic Sequential Treatment (SST)

NCT02032771
View directory record Official record
Conditions
Improvement of Wrinkles/Elastosis and/or Pigmentation
Interventions
M22 IPL and ResurFX
Device
Lead sponsor
Lumenis Be Ltd.
Industry
Eligibility
30 Years to 65 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Sep 15, 2016 · Synced Sep 8, 2026, 10:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

TriActive+ Radiofrequency (RF) for Non-Invasive Treatment of Wrinkles and Rhytides

NCT01859611
View directory record Official record
Conditions
Wrinkles, Rhytides
Interventions
TriActive+ RF
Device
Lead sponsor
El. En. SpA
Industry
Eligibility
30 Years to 60 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
2
States / cities
Indianapolis, Indiana • New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 6, 2015 · Synced Sep 8, 2026, 10:29 PM EDT
Completed Phase 3 Interventional Results available

A Safety and Efficacy Study of OnabotulinumtoxinA in Upper Facial Rhytides

NCT02261493
View directory record Official record
Conditions
Facial Rhytides, Glabellar Rhytides
Interventions
OnabotulinumtoxinA, Normal Saline
Biological · Drug
Lead sponsor
Allergan
Industry
Eligibility
18 Years and older
Enrollment
787 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
10
States / cities
Little Rock, Arkansas • Los Angeles, California • Newport Beach, California + 6 more
Source: ClinicalTrials.gov public record
Updated Jul 24, 2017 · Synced Sep 8, 2026, 10:29 PM EDT
Completed Not applicable Interventional Results available

PicoWay™ 730 Resolve Fusion for Benign Pigmented Lesions and Wrinkles

NCT03774849
View directory record Official record
Conditions
Benign Pigmented Lesions, Facial Wrinkles
Interventions
PicoWay™ 532nm fractional handpiece, PicoWay™ 730nm wavelength, PicoWay™ 1064nm fractional handpiece
Device
Lead sponsor
Candela Corporation
Industry
Eligibility
21 Years to 80 Years
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Wayland, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 30, 2023 · Synced Sep 8, 2026, 10:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Clinical Study to Evaluate the Impact of aKwa Skincare System on Skin Health

NCT05476406
View directory record Official record
Conditions
Sin Health, Skin Hydration, Skin Wrinkles, Skin Porphyrins, Facial Skin Red Spots, Facial Skin Red Vasculature
Interventions
äKwä skincare system products, competitor products (control)
Other
Lead sponsor
4Life Research, LLC
Industry
Eligibility
18 Years to 55 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Sandy City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 26, 2022 · Synced Sep 8, 2026, 10:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Main Study: A Study to Evaluate the Effectiveness and Safety of GAL1906 for Correction of Wrinkles in the décolletage Area Sub-study: A Follow-up Study to Evaluate the Analysis of Mammograms Following Treatment for Correction of Wrinkles in Décolletage Area in the Investigational Study 43USRV1906

NCT04717934
View directory record Official record
Conditions
Wrinkle
Interventions
GAL1906
Device
Lead sponsor
Galderma R&D
Industry
Eligibility
22 Years and older · Female only
Enrollment
211 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
14
States / cities
Birmingham, Alabama • Scottsdale, Arizona • Redondo Beach, California + 11 more
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Sep 8, 2026, 10:29 PM EDT
Completed Not applicable Interventional Results available

Study To Assess A Radiofrequency Microneedling Device For Dermatologic Conditions

NCT05097157
View directory record Official record
Conditions
Wrinkle, Fine Lines, Crepey Skin, Acne Scars, Acne, Enlarged Pores, Stretch Marks, Loose Skin
Interventions
Potenza
Device
Lead sponsor
Cynosure, Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
4
States / cities
Sacramento, California • Hunt Valley, Maryland • Westford, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 8, 2022 · Synced Sep 8, 2026, 10:29 PM EDT
Completed Not applicable Interventional Results available

Evaluation of the Efficacy and Tolerance of a Light Therapy Mask on Mild to Moderate Brown Spots and Moderate to Severe Facial Wrinkles

NCT03312543
View directory record Official record
Conditions
Skin Aging
Interventions
Active Mask, Sham Mask
Device
Lead sponsor
Johnson & Johnson Consumer Inc. (J&JCI)
Industry
Eligibility
35 Years to 70 Years · Female only
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Broomall, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 4, 2019 · Synced Sep 8, 2026, 10:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pilot Study of Triphala and Rubia Cordifolia on Gut Microbiome and Skin

NCT03477825
View directory record Official record
Conditions
Sebum Production, Stool Microbiome, Transepidermal Water Loss, Facial Brrightness, Erythema, Wrinkles, Facial Shine
Interventions
Placebo Oral Tablet, Rubia Cordifolia, Triphala
Dietary Supplement
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 60 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated May 14, 2019 · Synced Sep 8, 2026, 10:29 PM EDT
Completed Not applicable Interventional

Evaluation of the Efficacy of a Cosmetic Light Mask

NCT07054710
View directory record Official record
Conditions
Fine Lines, Contour, Sagging Skin, Dark Spots, Wrinkles, Firmness, Skin Tone, Radiance/Luminosity
Interventions
LED Light Treatment, Vibration Only
Device
Lead sponsor
Therabody, Inc.
Industry
Eligibility
35 Years to 65 Years
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Piscataway, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 8, 2025 · Synced Sep 8, 2026, 10:29 PM EDT
Completed Phase 2 Interventional Results available

Efficacy and Safety of DaxibotulinumtoxinA (DAXI) for Injection for Treatment of Upper Facial Lines

NCT04259086
View directory record Official record
Conditions
Upper Facial Lines (Glabellar Lines, Forehead Lines, & Lateral Canthal Lines)
Interventions
DaxibotulinumtoxinA for injection
Drug
Lead sponsor
Revance Therapeutics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
6
States / cities
Manhattan Beach, California • San Diego, California • Santa Monica, California + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 26, 2023 · Synced Sep 8, 2026, 10:29 PM EDT
Completed Not applicable Interventional

The Effect of Almonds on Facial Aesthetics and Modulation of the Microbiome and Lipidome

NCT03729700
View directory record Official record
Conditions
Wrinkle
Interventions
Almond
Other
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 100 Years · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jul 6, 2021 · Synced Sep 8, 2026, 10:29 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Non-invasive Rejuvenation of the Periorbital Area and Lower Eyelid

NCT07028203
View directory record Official record
Conditions
Periorbital Wrinkles, Periorbital Area, Under-eyes Dark Circles, Crows Feet
Interventions
Treatment with BTL-785 with the applicator BTL-785-7-11
Device
Lead sponsor
BTL Industries Ltd.
Industry
Eligibility
21 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
3
States / cities
Sacramento, California • Solana Beach, California • Youngstown, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 18, 2025 · Synced Sep 8, 2026, 10:29 PM EDT