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ClinicalTrials.gov public records Last synced Oct 11, 2026, 8:52 AM EDT

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Showing 73–96 of 158 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: 'Menthol' flavor Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Addiction and Behavior Related to Menthol Cigarette Substitutes

NCT04844762
View directory record Official record
Conditions
Smoking (Tobacco) Addiction
Interventions
Menthol cigarettes substitutes, Usual brand menthol cigarettes and substitutes, Menthol cigarettes substitutes and menthol cigarettes
Behavioral
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
18 Years to 50 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 9, 2024 · Synced Oct 11, 2026, 8:52 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Perceptions of Cigarette Smoking in Young Adults

NCT03953508
View directory record Official record
Conditions
Smoking, Cigarette
Interventions
Cigarette flavor type
Other
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 26 Years
Enrollment
199 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Dec 16, 2024 · Synced Oct 11, 2026, 8:52 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Study to Understand the Analgesic Properties of Topically Applied Menthol When Used in a Marathon.

NCT07565246
View directory record Official record
Conditions
Muscle Soreness
Interventions
Observational
Other
Lead sponsor
Reckitt Benckiser Healthcare (UK) Limited
Industry
Eligibility
18 Years and older
Enrollment
367 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Deerfield, Illinois
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Oct 11, 2026, 8:52 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD210903: A Study to Determine Subject Puffing Patterns of a Heated Tobacco Product With Four Non-Combusted Cigarette Variants in an Ambulatory Setting

NCT05307822
View directory record Official record
Conditions
Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
Interventions
Non-combusted cigarette variant 42001401, Non-combusted cigarette variant 42001399, Non-combusted cigarette variant 40007386, Non-combusted cigarette variant 42001402
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years and older
Enrollment
194 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
7
States / cities
Sandy Springs, Georgia • Lexington, Kentucky • Charlotte, North Carolina + 4 more
Source: ClinicalTrials.gov public record
Updated Mar 27, 2023 · Synced Oct 11, 2026, 8:52 AM EDT
Completed Phase 1 Interventional Results available

Effects of E-cigarette Flavors on Youth TCORS 2.0

NCT03634839
View directory record Official record
Conditions
Nicotine Use Disorder
Interventions
Flavoring Agents, Nicotine
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 20 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 9, 2024 · Synced Oct 11, 2026, 8:52 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

User Acceptability of a Nicotine Lactate Delivery System (P3L)

NCT02643693
View directory record Official record
Conditions
Smoking
Interventions
P3L, VUSE, CC
Other
Lead sponsor
Philip Morris Products S.A.
Industry
Eligibility
19 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 1, 2019 · Synced Oct 11, 2026, 8:52 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users

NCT02102100
View directory record Official record
Conditions
Nicotine Dependence
Interventions
nicotine, menthol
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 30 Years
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
2
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 19, 2020 · Synced Oct 11, 2026, 8:52 AM EDT
Completed Early Phase 1 Interventional Results available

Nicotine's Potential Abuse With Menthol

NCT04535362
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Nicotine
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 35 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 26, 2024 · Synced Oct 11, 2026, 8:52 AM EDT
Completed No phase listed Observational

Room Air Levels of Harmful and Potentially Harmful Constituents After Heated Tobacco Product Use and Cigarettes

NCT06476405
View directory record Official record
Conditions
Tobacco Smoking, Tobacco Use
Interventions
Not listed
Lead sponsor
Altria Client Services LLC
Industry
Eligibility
22 Years to 65 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Stockbridge, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Oct 11, 2026, 8:52 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Impact of Menthol Flavoring on Switching in Adult Menthol Smokers

NCT05555069
View directory record Official record
Conditions
Smoking Reduction
Interventions
Menthol-flavored electronic cigarette, Tobacco-flavored electronic cigarette
Other
Lead sponsor
Nikki Nollen, PhD, MA
Other
Eligibility
21 Years and older
Enrollment
800 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 23, 2026 · Synced Oct 11, 2026, 8:52 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effective Ads for Quitting Smoking

NCT06485479
View directory record Official record
Conditions
Smoking Behaviors
Interventions
Intervention ads, Control ads
Behavioral
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
21 Years and older
Enrollment
1,236 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 3, 2025 · Synced Oct 11, 2026, 8:52 AM EDT
Not listed Not applicable Interventional

Comparison of Prescription Lidocaine Patch to Over the Counter Lidocaine Patch and Placebo for Back Pain and Arthritis

NCT02749123
View directory record Official record
Conditions
Back Pain, Arthritis
Interventions
lidocaine 5% patch, lidocaine 3.6%, menthol 1.25%, Placebo
Drug
Lead sponsor
J.A.R. Laboratories
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Barrington, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 22, 2016 · Synced Oct 11, 2026, 8:52 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Text Message and Mail Delivery of Tailored Educational Materials to Improve Access to Resources for Smoking Cessation of Menthol Tobacco Cigarettes

NCT07857681
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Educational Intervention, Internet-Based Intervention, Smartphone Application-based Intervention, Smoking Cessation Intervention, Text Message-Based Navigation Intervention
Other · Behavioral
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
18 Years and older
Enrollment
600 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Oct 5, 2026 · Synced Oct 11, 2026, 8:52 AM EDT
Completed Not applicable Interventional

Feasibility of a Culturally-Specific Video Text Cessation Intervention With AA Quitline Callers

NCT03927976
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
Path2Quit - culturally specific text message intervention
Behavioral
Lead sponsor
Case Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 16, 2020 · Synced Oct 11, 2026, 8:52 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Use Behavior, Nicotine Uptake, and Subjective Effects Comparison of Tobacco and Menthol e-Liquids by ENDS Consumers

NCT05134415
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
RELX ENDS Tobacco Flavor 1, RELX ENDS Tobacco Flavor 2, RELX ENDS Menthol Flavor 1, RELX ENDS Menthol Flavor 2
Other
Lead sponsor
Cheerain HK Limited
Industry
Eligibility
22 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Burbank, California
Source: ClinicalTrials.gov public record
Updated Dec 13, 2021 · Synced Oct 11, 2026, 8:52 AM EDT
Completed Not applicable Interventional Results available

Smoking Cessation in Menthol Flavored Cigarette Smokers

NCT02342327
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
switch to non-menthol cigarettes prior to cessation attempt, continue smoking menthol cigarettes prior to cessation attempt
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 64 Years
Enrollment
122 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 28, 2021 · Synced Oct 11, 2026, 8:52 AM EDT
Completed Phase 3 Interventional Results available

Placebo-Controlled Onset-of-Action Study of Flurbiprofen Utilizing the Double-Stopwatch Method

NCT01986361
View directory record Official record
Conditions
Acute Pharyngitis, Sore Throat
Interventions
flurbiprofen, placebo
Drug
Lead sponsor
Reckitt Benckiser LLC
Industry
Eligibility
18 Years and older
Enrollment
122 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Storrs, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 28, 2017 · Synced Oct 11, 2026, 8:52 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Modeling Tobacco Regulatory Impacts in Appalachia Using the Experimental Tobacco Marketplace

NCT06234722
View directory record Official record
Conditions
Tobacco Use, Cigarette Use
Interventions
Very Low Nicotine Cigarette, Reduced nicotine regulatory environment, Restriction on characterizing flavors in combustible nicotine products, Restriction on characterizing flavors in noncombustible nicotine products
Drug · Behavioral
Lead sponsor
Mikhail N Koffarnus
Other
Eligibility
21 Years and older
Enrollment
473 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 9, 2026 · Synced Oct 11, 2026, 8:52 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

COMET Study 1: Filter Ventilated Cigarette Substitution in the ETM

NCT03306173
View directory record Official record
Conditions
Substance-Related Disorders
Interventions
Commercially available cigarette
Other
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
21 Years to 65 Years
Enrollment
142 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 7, 2025 · Synced Oct 11, 2026, 8:52 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

The Influence of Menthol Gel During Exercise With Heat

NCT05302804
View directory record Official record
Conditions
Acute Exercise, Heat Exposure
Interventions
Menthol Gel, Control Gel
Drug
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years to 45 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Apr 24, 2024 · Synced Oct 11, 2026, 8:52 AM EDT
Recruiting Not applicable Interventional

Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction

NCT06077240
View directory record Official record
Conditions
Smoking, Smoking Behaviors, Nicotine Dependence
Interventions
E-cigarette with 2.4% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 2.4% Nicotine with Tobacco Flavor Only, E-cigarette with 5% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 5% Nicotine with Tobacco Flavor Only, Tobacco Pouches with 3mg Nicotine with Menthol and Tobacco Flavors, Tobacco Pouches with 3mg Nicotine with Tobacco Flavor Only, Tobacco Pouches with 6mg Nicotine with Menthol and Tobacco Flavors, Tobacco Pouches with 6mg Nicotine with Tobacco Flavor Only
Behavioral
Lead sponsor
Yale University
Other
Eligibility
21 Years and older
Enrollment
256 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Oct 11, 2026, 8:52 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of E-Cigarettes in Menthol Smokers

NCT05949034
View directory record Official record
Conditions
E-cigarette Use, Smoking Behaviors
Interventions
JUUL E-Cigarette Device
Device
Lead sponsor
University of Southern California
Other
Eligibility
21 Years and older
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 20, 2023 · Synced Oct 11, 2026, 8:52 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD200907: A Study to Assess Elements of Abuse Liability for a Heated Tobacco Product With Four Non-Combusted Cigarette Variants

NCT05114863
View directory record Official record
Conditions
Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
Interventions
Product A1, Product B, Product C, Product D, Product A2, Product E, Product F, Product G, Product H, Product N
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 27, 2022 · Synced Oct 11, 2026, 8:52 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Responses of Adults Smoking Nondaily and Daily in the Experimental Tobacco Marketplace

NCT06988371
View directory record Official record
Conditions
Tobacco Use, Cigarette Use
Interventions
Reduced nicotine regulatory environment, Restriction on characterizing flavors in combustible nicotine products, Restriction on characterizing flavors in noncombustible nicotine products
Behavioral
Lead sponsor
Bethany Shorey Fennell, PhD
Other
Eligibility
18 Years and older
Enrollment
747 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Oct 11, 2026, 8:52 AM EDT