- Conditions
- Hepatic Insufficiency
- Interventions
- LY3841136
- Drug
- Lead sponsor
- Eli Lilly and Company
- Industry
- Eligibility
- 18 Years to 85 Years
- Enrollment
- 36 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2026 – 2027
- U.S. locations
- 2
- States / cities
- Orlando, Florida • San Antonio, Texas
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- Conditions
- Diffuse Astrocytoma, IDH-Wildtype (Grade 2-4), Diffuse Hemispheric Glioma, H3 G34-mutant, Diffuse Midline Glioma, H3 K27-Altered, Diffuse Pediatric-type High-grade Glioma, H3-wildtype and IDH-wildtype, Glioblastoma, IDH-wildtype, Glioma
- Interventions
- 177Lu-PSMA-617, 68Ga-PSMA-PET scan/ MRI, Quality of Life Questionnaires, Temozolomide
- Drug · Diagnostic Test · Behavioral
- Lead sponsor
- Memorial Sloan Kettering Cancer Center
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 20 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2027
- U.S. locations
- 7
- States / cities
- Basking Ridge, New Jersey • Middletown, New Jersey • Montvale, New Jersey + 4 more
- Conditions
- Healthy Participants With Lower-than-average Mental Well-being
- Interventions
- Context 1, Context 2, Placebo, Psilocybin
- Behavioral · Drug
- Lead sponsor
- Robin Carhart-Harris, PhD, MA
- Other
- Eligibility
- 21 Years to 70 Years
- Enrollment
- 120 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2024 – 2028
- U.S. locations
- 1
- States / cities
- San Francisco, California
- Conditions
- Lupus Nephritis, Primary Membranous Nephropathy
- Interventions
- Fludarabine, Cyclophosphamide, NKX019
- Drug
- Lead sponsor
- Nkarta, Inc.
- Industry
- Eligibility
- 18 Years to 75 Years
- Enrollment
- 120 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2024 – 2027
- U.S. locations
- 17
- States / cities
- Little Rock, Arkansas • Tustin, California • Gainesville, Florida + 14 more
- Conditions
- Plasma Cell Disorder
- Interventions
- 100gm HDAA, 125gm HDAA, 75gm HDAA
- Drug
- Lead sponsor
- University of Arkansas
- Other
- Eligibility
- 18 Years to 100 Years
- Enrollment
- 18 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2024 – 2028
- U.S. locations
- 1
- States / cities
- Little Rock, Arkansas
- Conditions
- Prostate Cancer
- Interventions
- AAA617
- Drug
- Lead sponsor
- Novartis Pharmaceuticals
- Industry
- Eligibility
- 18 Years to 100 Years · Male only
- Enrollment
- 700 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2033
- U.S. locations
- 24
- States / cities
- Scottsdale, Arizona • Orange, California • Santa Monica, California + 19 more
- Conditions
- Advanced Solid Tumor Cancer
- Interventions
- ABBV-CLS-484, Programmed Cell Death-1 (PD-1) Inhibitor, Vascular Endothelial Growth Factor Receptor (VEGFR) Tyrosine Kinase Inhibitor (TKI)
- Drug
- Lead sponsor
- Calico Life Sciences LLC
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 248 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2021 – 2026
- U.S. locations
- 15
- States / cities
- Tucson, Arizona • New Haven, Connecticut • Baltimore, Maryland + 11 more
- Conditions
- Glioma, Malignant
- Interventions
- 2141-V11, D2C7-IT
- Drug
- Lead sponsor
- Darell Bigner
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 90 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2021 – 2028
- U.S. locations
- 1
- States / cities
- Durham, North Carolina
- Conditions
- DNA Damage, Immune System Disorder
- Interventions
- Zinc Picolinate 15 Mg
- Drug
- Lead sponsor
- University of New Mexico
- Other
- Eligibility
- 21 Years to 64 Years
- Enrollment
- 100 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2019 – 2027
- U.S. locations
- 1
- States / cities
- Albuquerque, New Mexico
- Conditions
- Alcohol Use Disorder
- Interventions
- Baseline [C-11]NOP-1A PET scan, Hydrocortisone, Post-hydrocortisone [C-11]NOP-1A PET scan
- Radiation · Drug
- Lead sponsor
- Rajesh Narendran
- Other
- Eligibility
- 18 Years to 55 Years
- Enrollment
- 90 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2026 – 2032
- U.S. locations
- 1
- States / cities
- Pittsburgh, Pennsylvania
- Conditions
- Advanced Cancer
- Interventions
- UI-102
- Drug
- Lead sponsor
- United Immunity, co., Ltd.
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 140 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2031
- U.S. locations
- 3
- States / cities
- Dallas, Texas • Houston, Texas • San Antonio, Texas
- Conditions
- Smoking, Tobacco
- Interventions
- P2611222, P2613422, P2615122, P2615422, P2615522
- Other
- Lead sponsor
- RAI Services Company
- Industry
- Eligibility
- 21 Years to 65 Years
- Enrollment
- 1,280 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2026 – 2027
- U.S. locations
- 7
- States / cities
- Maitland, Florida • Atlanta, Georgia • St Louis, Missouri + 4 more
- Conditions
- Shift Work
- Interventions
- 15-min nap, 30-min nap, 45-min nap, 60-min nap, No-nap
- Behavioral
- Lead sponsor
- University of Pittsburgh
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 130 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2026 – 2030
- U.S. locations
- 1
- States / cities
- Pittsburgh, Pennsylvania
- Conditions
- Neuropathic Pain Management
- Interventions
- tACS 10Hz, tACS 20Hz, tACS Sham
- Device
- Lead sponsor
- The University of Texas Health Science Center, Houston
- Other
- Eligibility
- 18 Years to 75 Years
- Enrollment
- 14 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2028
- U.S. locations
- 1
- States / cities
- Houston, Texas
- Conditions
- Motor Recovery
- Interventions
- tACS 10Hz, tACS 20Hz, tACS Sham
- Device
- Lead sponsor
- The University of Texas Health Science Center, Houston
- Other
- Eligibility
- 18 Years to 75 Years
- Enrollment
- 14 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2028
- U.S. locations
- 1
- States / cities
- Houston, Texas
- Conditions
- Central Nervous System Lymphoma
- Interventions
- Aspiration, Biospecimen Collection, CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/mem T-lymphocytes, Catheterization, Computed Tomography, Cyclophosphamide, Fludarabine, Leukapheresis, Lumbar Puncture, Magnetic Resonance Imaging, Positron Emission Tomography
- Procedure · Biological · Drug
- Lead sponsor
- City of Hope Medical Center
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 20 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2028
- U.S. locations
- 1
- States / cities
- Duarte, California
- Conditions
- Carcinoma, Non-Small-Cell Lung
- Interventions
- Denosumab 120 MG/1.7 ML Subcutaneous Solution [XGEVA], Tyrosine Kinase Inhibitor, Zoledronic Acid 4 MG/100 ML Intravenous Solution [ZOMETA]
- Drug · Biological
- Lead sponsor
- University of Colorado, Denver
- Other
- Eligibility
- 18 Years to 100 Years
- Enrollment
- 100 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2028
- U.S. locations
- 2
- States / cities
- Aurora, Colorado • Lone Tree, Colorado
- Conditions
- Apraxia of Speech
- Interventions
- Sham, Soterix 1x1 line tDCS low-intensity stimulator
- Device
- Lead sponsor
- NYU Langone Health
- Other
- Eligibility
- 18 Years to 99 Years
- Enrollment
- 24 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2019 – 2027
- U.S. locations
- 2
- States / cities
- New York, New York • White Plains, New York
- Conditions
- Advanced Cancer
- Interventions
- Spiritual Care Intervention #1, Spiritual Care Intervention #2, Spiritual Care Intervention #3
- Behavioral
- Lead sponsor
- Weill Medical College of Cornell University
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 288 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2029
- U.S. locations
- 3
- States / cities
- New York, New York • Galveston, Texas • Houston, Texas
- Conditions
- Advanced Lung Carcinoma, CRC (Colorectal Cancer), KRAS G12A, KRAS G12C, KRAS G12D, KRAS G12S, KRAS G12V, Metastatic Colorectal Cancer (CRC), Metastatic Non-Small Lung Cell Cancer, Metastatic Pancreatic Ductal Adenocarcinoma, NSCLC, Non-Small Cell Lung Cancer, PDAC - Pancreatic Ductal Adenocarcinoma, Solid Tumor, Adult
- Interventions
- BBO-10203, BBO-11818, Cetuximab, Gemcitabine, Nab-paclitaxel, Pembrolizumab, Pemetrexed, Platinum chemotherapy (cisplatin or carboplatin), mFOLFIRINOX, mFOLFOX6
- Drug
- Lead sponsor
- TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 665 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2029
- U.S. locations
- 16
- States / cities
- Los Angeles, California • Sacramento, California • San Diego, California + 12 more
- Conditions
- Prediabetes
- Interventions
- ≥10,000 daily steps (≥5 days/week) and stopping evening snacking
- Behavioral
- Lead sponsor
- Baylor College of Medicine
- Other
- Eligibility
- 12 Years to 18 Years
- Enrollment
- 80 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2029
- U.S. locations
- 1
- States / cities
- Houston, Texas
- Conditions
- Emergency Contraception
- Interventions
- Etonogestrel implant with Oral Levonorgestrel emergency contraception 1.5mg, Etonogestrel implant with oral placebo
- Drug · Device
- Lead sponsor
- Lori Gawron
- Other
- Eligibility
- 18 Years to 35 Years · Female only
- Enrollment
- 790 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2023 – 2028
- U.S. locations
- 1
- States / cities
- Salt Lake City, Utah
- Conditions
- Pregnancy
- Interventions
- Mother receives voucher valued at 100% of cost of name-brand IUD (March 4, 2019-March 31, 2023), Mother receives voucher valued at 50% of cost of name-brand IUD (August 26, 2018-March 3, 2019)
- Behavioral
- Lead sponsor
- University of Michigan
- Other
- Eligibility
- 0 Years to 17 Years
- Enrollment
- 4,700 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2018 – 2049
- U.S. locations
- 9
- States / cities
- Ann Arbor, Michigan • Detroit, Michigan • Ferndale, Michigan + 6 more
- Conditions
- Chronic Fatigue Syndrome, Fibromyalgia, Healthy, Multiple Sclerosis
- Interventions
- DPA-714 PET/MRI
- Drug
- Lead sponsor
- University of Alabama at Birmingham
- Other
- Eligibility
- 18 Years to 65 Years
- Enrollment
- 120 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2019 – 2028
- U.S. locations
- 1
- States / cities
- Birmingham, Alabama