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Showing 1–24 of 36 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: 2% chlorhexidine gluconate cloths Clear all
Completed Not applicable Interventional Results available

Use of 2% Chlorhexidine Cloths Reduce Surgical Site Infections

NCT02385708
View directory record Official record
Conditions
Surgical Site Infection
Interventions
2% Chlorohexidine Gluconate Standard of Care, 2% Chlorohexidine Gluconate Chin to Toe
Drug
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older
Enrollment
163 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 29, 2019 · Synced Sep 28, 2026, 6:13 PM EDT
Completed Phase 2 Interventional

Chlorhexidine Bathing Effect on Clostridium Difficile Rates

NCT02502682
View directory record Official record
Conditions
Clostridium Difficile
Interventions
Sage 2% Chlorhexidine Gluconate Cloth Patient Preoperative Skin Preparation
Drug
Lead sponsor
Jared Brooks
Other
Eligibility
18 Years and older
Enrollment
167 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Geneva, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 10, 2016 · Synced Sep 28, 2026, 6:13 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Treating Parents to Reduce NICU Transmission of Staphylococcus Aureus Trial

NCT02223520
View directory record Official record
Conditions
Staph Aureus Colonization, Staph Aureus Infection
Interventions
Mupirocin and Chlorhexidine, Placebo ointment and placebo cloths
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
Not listed
Enrollment
307 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 10, 2022 · Synced Sep 28, 2026, 6:13 PM EDT
Completed Not applicable Interventional Results available

Cost-Effectiveness Study Comparing Chlorhexidine Bathing With Active Surveillance Cultures to Prevent Methicillin-resistant Staphylococcus Aureus & Other Hospital Infections

NCT00779246
View directory record Official record
Conditions
Staphylococcal Infections
Interventions
Nasal swabs for MRSA culture, Chlorhexidine gluconate, Contact isolation
Other · Drug
Lead sponsor
Christiana Care Health Services
Other
Eligibility
18 Years and older
Enrollment
1,518 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated May 14, 2018 · Synced Sep 28, 2026, 6:13 PM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

A 96-hour Patch Test Study Using Healthy Human Volunteers to Assess the Skin Irritation Potential of 11 Topically Applied Formulations

NCT04942496
View directory record Official record
Conditions
Skin Irritancy Potential
Interventions
Chlorhexidine Gluconate, Hibi Universal Bathing System, 0.1% SLS, Distilled Water
Drug · Device · Other
Lead sponsor
Molnlycke Health Care AB
Industry
Eligibility
18 Years to 70 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Bozeman, Montana
Source: ClinicalTrials.gov public record
Updated Jun 27, 2021 · Synced Sep 28, 2026, 6:13 PM EDT
Completed Not applicable Interventional

Bacterial Decolonization Within Dyads

NCT06541145
View directory record Official record
Conditions
Bacterial Colonization
Interventions
Mupirocin, Chlorhexidine baths
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older · Female only
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Sep 28, 2026, 6:13 PM EDT
Completed Phase 3 Interventional Results available

2% Chlorhexidine Gluconate Skin Cloths to Prevent SSI in Spine Surgery Patients

NCT02490631
View directory record Official record
Conditions
Surgical Site Infections, Post Operative Complication
Interventions
2% chlorhexidine gluconate cloths
Drug
Lead sponsor
Vanderbilt University
Other
Eligibility
19 Years to 90 Years
Enrollment
158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 5, 2021 · Synced Sep 28, 2026, 6:13 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Single Dose CHG Pharmacokinetic Study

NCT03331263
View directory record Official record
Conditions
Surgical Skin Preparation
Interventions
Chlorhexidine Gluconate
Drug
Lead sponsor
Medline Industries
Industry
Eligibility
18 Years to 60 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Fargo, North Dakota
Source: ClinicalTrials.gov public record
Updated Dec 14, 2023 · Synced Sep 28, 2026, 6:13 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Irritation and Sensitization of Chlorhexidine Gluconate (CHG) Cloth

NCT02224625
View directory record Official record
Conditions
Surgery
Interventions
2% CHG Cloth solution, Vehicle Cloth, Active Comparator, Saline, SLS
Drug · Device · Other
Lead sponsor
Medline Industries
Industry
Eligibility
16 Years and older
Enrollment
249 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Butte, Montana
Source: ClinicalTrials.gov public record
Updated Mar 8, 2017 · Synced Sep 28, 2026, 6:13 PM EDT
Completed Phase 4 Interventional

Animal-Assisted Visitation Program Chlorhexidine Trial

NCT04171817
View directory record Official record
Conditions
Methicillin-resistant Staphylococcus Aureus, Clostridium Difficile, Pseudomonas Aeruginosa
Interventions
Chlorhexidine
Drug
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
3 Years to 17 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
3
States / cities
Baltimore, Maryland • St Louis, Missouri • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Sep 28, 2026, 6:13 PM EDT
Terminated Phase 2 Interventional Results available

Preoperative Application of Chlorhexidine to Reduce Infection With Cesarean Section After Labor

NCT03423147
View directory record Official record
Conditions
Cesarean Section, Surgical Site Infection, Nosocomial Infection
Interventions
2% chlorhexidine gluconate cloth, 4% Chlorhexidine gluconate vaginal scrub
Drug
Lead sponsor
Angela Bianco
Other
Eligibility
18 Years and older · Female only
Enrollment
319 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 22, 2023 · Synced Sep 28, 2026, 6:13 PM EDT
Completed Phase 4 Interventional Results available

Mupirocin-Iodophor ICU Decolonization Swap Out Trial

NCT03140423
View directory record Official record
Conditions
Staphylococcus Aureus
Interventions
Arm 1. Routine Care (Mupirocin/CHG), Arm 2. Iodophor/CHG Decolonization
Drug
Lead sponsor
Harvard Pilgrim Health Care
Other
Eligibility
Not listed
Enrollment
353,323 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
137
States / cities
Riverside, California • San Jose, California • Thousand Oaks, California + 103 more
Source: ClinicalTrials.gov public record
Updated Mar 29, 2025 · Synced Sep 28, 2026, 6:13 PM EDT
Completed Phase 1 Interventional

Skin Cleansing With Chlorhexidine to Decrease Hospital Acquired Infections

NCT00130221
View directory record Official record
Conditions
Nosocomial Infection, Bacteremia, Sepsis, Pneumonia, Urinary Tract Infection, Clostridium Infection
Interventions
2% chlorhexidine gluconate impregnated cloth, Daily bathing with Bar soap
Drug · Other
Lead sponsor
Cook County Health
Government
Eligibility
16 Years and older
Enrollment
208 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 17, 2023 · Synced Sep 28, 2026, 6:13 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Preoperative Chlorhexidine Gluconate (CHG) Cloth on Healthy Subjects

NCT02222896
View directory record Official record
Conditions
Surgery
Interventions
Chlorhexidine Gluconate, Vehicle, DynaHex-2
Drug · Other
Lead sponsor
Medline Industries
Industry
Eligibility
16 Years and older
Enrollment
347 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Sterling, Virginia
Source: ClinicalTrials.gov public record
Updated May 20, 2021 · Synced Sep 28, 2026, 6:13 PM EDT
Completed Phase 4 Interventional

Daily Chlorhexidine Bathing and Infection Rates in Critically-ill Patients

NCT02033187
View directory record Official record
Conditions
Healthcare Associated Infections
Interventions
Chlorhexidine bathing, Non-chlorhexidine bathing
Other
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older
Enrollment
12,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 9, 2014 · Synced Sep 28, 2026, 6:13 PM EDT
Completed Phase 1 Interventional Results available

Pilot Study: Safety of Chlorhexidine (CHG) Baths in Patients Less Than 2 Months of Age

NCT02326467
View directory record Official record
Conditions
Chlorhexidine Allergy, Infection, Rash
Interventions
Chlorhexidine gluconate
Drug
Lead sponsor
Celeste Chandonnet
Other
Eligibility
36 Weeks to 48 Weeks
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 26, 2021 · Synced Sep 28, 2026, 6:13 PM EDT
Completed Not applicable Interventional Results available

Trial of 2% Chlorhexidine Bathing on Nosocomial Infections in the Surgical Intensive Care Unit

NCT01640925
View directory record Official record
Conditions
Cross Infection, Pneumonia, Ventilator-associated, Catheter-related Infections, Infection Due to Indwelling Urinary Catheter, Surgical Wound Infection
Interventions
Chlorhexidine gluconate, Standard bathing
Drug · Other
Lead sponsor
Joshua Swan
Other
Eligibility
18 Years and older
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 26, 2018 · Synced Sep 28, 2026, 6:13 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Eliminate Risk of Cardiac Surgical Site Events

NCT01425697
View directory record Official record
Conditions
Surgical Site Infections
Interventions
2% Chlorhexidine Gluconate cloths, Standard of Care preoperative preparation.
Other
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
739 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
4
States / cities
Lexington, Kentucky • Ridgewood, New Jersey • Rochester, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 1, 2013 · Synced Sep 28, 2026, 6:13 PM EDT
Completed Phase 2 Interventional Results available

STaph Aureus Resistance-Treat Early and Repeat (STAR-TER)

NCT03489629
View directory record Official record
Conditions
Cystic Fibrosis
Interventions
Trimethoprim Sulfamethoxazole (TMP/SMX), Minocycline, Mupirocin, Chlorhexidine Gluconate, Environmental Decontamination
Drug · Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
2 Years to 45 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2026
U.S. locations
9
States / cities
Denver, Colorado • Indianapolis, Indiana • Ann Arbor, Michigan + 6 more
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Sep 28, 2026, 6:13 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Study of Bathing With Chlorhexidine Impregnated Cloths on Nosocomial Infections in the Pediatric Intensive Care Unit

NCT00549393
View directory record Official record
Conditions
Nosocomial Infections
Interventions
2% Chlorhexidine gluconate cloth
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
2 Months to 25 Years
Enrollment
5,659 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
5
States / cities
Washington D.C., District of Columbia • Baltimore, Maryland • St Louis, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 13, 2017 · Synced Sep 28, 2026, 6:13 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Chlorhexidine Cloths to Reduce Surgical Site Infection in Cesarean Deliveries

NCT04202471
View directory record Official record
Conditions
Surgical Site Infection
Interventions
Chlorhexidine Cloth
Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 50 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Sep 23, 2020 · Synced Sep 28, 2026, 6:13 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Irrisept C.Acnes Study

NCT03938467
View directory record Official record
Conditions
Rate of Positive Culture Growth for C.Acnes From Specimens Obtained From the Shoulders of Patients Undergoing Primary Shoulder Arthroplasty
Interventions
Antiseptic Cleanser
Drug
Lead sponsor
Orthopaedic Associates of Michigan, PC
Other
Eligibility
18 Years and older
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 20, 2024 · Synced Sep 28, 2026, 6:13 PM EDT
Completed Not applicable Interventional Results available

Active Bathing to Eliminate Infection (ABATE Infection) Trial

NCT02063867
View directory record Official record
Conditions
Healthcare Associated Infections, Methicillin Resistant Staphylococcus Aureus, Multi Drug Resistant Organisms
Interventions
Arm 2: Decolonization
Drug
Lead sponsor
University of California, Irvine
Other
Eligibility
12 Years and older
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
52
States / cities
West Hills, California • Thornton, Colorado • Bradenton, Florida + 42 more
Source: ClinicalTrials.gov public record
Updated Jul 11, 2019 · Synced Sep 28, 2026, 6:13 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pre-operative Preparation Using 2% Chlorhexidine Cloth For Shoulder Surgery

NCT01090479
View directory record Official record
Conditions
Post-operative Surgical Site Infections
Interventions
2% Chlorhexidine cloth
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 22, 2023 · Synced Sep 28, 2026, 6:13 PM EDT