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ClinicalTrials.gov public records Last synced Nov 4, 2026, 5:33 AM EST

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Showing 25–39 of 39 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: AFO Clear all
Completed No phase listed Observational

Evaluation of the Effect of an Ankle Foot Orthoses for Ambulatory Function

NCT01336517
View directory record Official record
Conditions
Hemiplegia, Spastic
Interventions
Not listed
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 18, 2011 · Synced Nov 4, 2026, 5:33 AM EST
Withdrawn Not applicable Interventional

Investigating the Effects of Sensory Input Orthotics in Disorders of Posture and Movement

NCT04091594
View directory record Official record
Conditions
Cerebral Palsy
Interventions
Flexible orthotic, Standard orthotic
Device
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
6 Months to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 8, 2020 · Synced Nov 4, 2026, 5:33 AM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

Improving Mobility in Peripheral Artery Disease Using an Ankle Foot Orthosis

NCT02902211
View directory record Official record
Conditions
Peripheral Artery Disease
Interventions
Ankle foot orthosis, Control/standard of care
Device · Other
Lead sponsor
University of Nebraska
Other
Eligibility
40 Years to 85 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2023
U.S. locations
2
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Aug 20, 2024 · Synced Nov 4, 2026, 5:33 AM EST
Recruiting Not applicable Interventional

Improving Walking After a Lower Limb Injury Using a Custom Motorized Orthosis

NCT06923293
View directory record Official record
Conditions
Lower Limb Injury
Interventions
Utilization of motorized orthosis
Device
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 80 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 26, 2025 · Synced Nov 4, 2026, 5:33 AM EST
Recruiting Not applicable Interventional

AFO Prescription to Optimize Post-Stroke Function

NCT06692686
View directory record Official record
Conditions
Ankle Foot Orthosis (AFO), Stroke Patients, Post-Stroke Hemiparesis
Interventions
Pre-fabricated (PF) ankle-foot orthosis (AFO), Carbon-strut (CS) ankle-foot orthosis (AFO), Multifunctional articulating (MA) ankle-foot orthosis (AFO)
Device
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
4
States / cities
Downey, California • Jacksonville, Florida • Charleston, South Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 21, 2025 · Synced Nov 4, 2026, 5:33 AM EST
Not listed Phase 2 Interventional

Smart Ankle-Foot Orthosis to Improve Stroke Outcomes: Smart AFO

NCT05619484
View directory record Official record
Conditions
Stroke
Interventions
Smart AFO
Device
Lead sponsor
Orthocare Innovations, LLC
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
3
States / cities
Troy, Michigan • Salt Lake City, Utah • Edmonds, Washington
Source: ClinicalTrials.gov public record
Updated Oct 10, 2023 · Synced Nov 4, 2026, 5:33 AM EST
Terminated Not applicable Interventional

Toe Walker Gait Trial

NCT01208142
View directory record Official record
Conditions
Gait
Interventions
standard of care treatment, Ankle Flexion Dynasplint
Other · Device
Lead sponsor
Dynasplint Systems, Inc.
Industry
Eligibility
1 Year to 18 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2010
U.S. locations
2
States / cities
Columbus, Ohio • Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Aug 12, 2013 · Synced Nov 4, 2026, 5:33 AM EST
Completed Not applicable Interventional Results available

Bracing for Walking in Parkinson's Disease

NCT03192046
View directory record Official record
Conditions
Gait Disorders, Neurologic, Parkinson Disease
Interventions
Carbon Fiber Ankle Foot Orthosis (AFO), Standardized walking/exercise program
Device · Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
30 Years to 85 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Nov 4, 2026, 5:33 AM EST
Completed Early Phase 1 Interventional Results available

Testing an Adjustable Ankle Orthosis During Walking in Cerebral Palsy

NCT06262191
View directory record Official record
Conditions
Cerebral Palsy
Interventions
Differential and adjustable stiffness AFO (DAS-AFO)
Device
Lead sponsor
Northern Arizona University
Other
Eligibility
8 Years to 35 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Flagstaff, Arizona
Source: ClinicalTrials.gov public record
Updated May 25, 2025 · Synced Nov 4, 2026, 5:33 AM EST
Completed Not applicable Interventional

Robotic Knee Orthosis-assisted Walking in CP

NCT06887764
View directory record Official record
Conditions
Crouch Gait, Cerebral Palsy (CP)
Interventions
RKO-assisted walking in individuals with CP
Device
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
8 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 18, 2026 · Synced Nov 4, 2026, 5:33 AM EST
Completed Phase 2 Interventional Results available

OHI--Randomized Control Trial to Evaluate Efficacy, Acceptability, and Perception of Benefit of an Innovative Custom AFO

NCT02819011
View directory record Official record
Conditions
Accidental Falls, Fall Due to Loss of Equilibrium, High Risk of Falls Due to Mobility Limitation, Diabetes, Arthritis, Cancer, Peripheral Arterial Disease, Parkinson's Disease, End Stage Renal Failure on Dialysis
Interventions
MBB AFO, Control
Device · Other
Lead sponsor
Bijan Najafi, PhD
Other
Eligibility
65 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 27, 2020 · Synced Nov 4, 2026, 5:33 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Comparative Effect of Carbon Fiber Orthosis Cuff Design on Preference, Comfort, and Mechanics

NCT05456295
View directory record Official record
Conditions
Healthy, Lower Limb Injury, Post-Traumatic Osteoarthritis
Interventions
Carbon Fiber Custom Dynamic Orthosis (CDO)
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 65 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Nov 4, 2026, 5:33 AM EST
Terminated Not applicable Interventional Results available

The Effects of Ankle Foot Orthoses on Gait Efficiency in Children With Acute Lymphoblastic Leukemia and Foot Drop

NCT01001390
View directory record Official record
Conditions
Foot Drop, Acute Lymphoblastic Leukemia
Interventions
AFO Device
Device
Lead sponsor
St. Jude Children's Research Hospital
Other
Eligibility
6 Years to 18 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 27, 2014 · Synced Nov 4, 2026, 5:33 AM EST
Recruiting Phase 2 Interventional

Smart AFO and 5-Azacitidine to Enhance Mobility in Children With Cerebral Palsy

NCT07434492
View directory record Official record
Conditions
Cerebral Palsy
Interventions
Smart Ankle-Foot Orthosis, 5-Azacitidine, Placebo
Device · Drug
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
8 Years to 17 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Nov 4, 2026, 5:33 AM EST
Completed Not applicable Interventional Results available

Ankle-foot Orthoses for Peripheral Artery Disease

NCT02280200
View directory record Official record
Conditions
Peripheral Artery Disease
Interventions
AFO to improve outcomes
Device
Lead sponsor
University of Minnesota
Other
Eligibility
40 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Missoula, Montana
Source: ClinicalTrials.gov public record
Updated Jul 31, 2019 · Synced Nov 4, 2026, 5:33 AM EST