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Showing 1–24 of 221 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Acceptance Therapy (ACT) Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Using Novel Behavioral Approaches to Improve Long-Term Weight Loss Outcomes

NCT02156752
View directory record Official record
Conditions
Obesity
Interventions
ACT, SR, WLO
Behavioral
Lead sponsor
The Miriam Hospital
Other
Eligibility
30 Years to 65 Years
Enrollment
190 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 17, 2019 · Synced Sep 15, 2026, 5:03 AM EDT
Recruiting Phase 1Phase 2 Interventional

Acceptance and Commitment Therapy for Adolescents and Young Adults With Sickle Cell Disease

NCT05685368
View directory record Official record
Conditions
Race-related Stress, Depression, Anxiety, Quality of Life, Stress Reaction
Interventions
ACT for SCD
Behavioral
Lead sponsor
Children's Hospital Los Angeles
Other
Eligibility
14 Years to 21 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 15, 2026, 5:03 AM EDT
Not listed Not applicable Interventional

An ACT-enhanced Weight Management and Fitness Program for Navy Personnel

NCT03029507
View directory record Official record
Conditions
Obesity, Overweight
Interventions
ACT Enhanced ShipShape, Standard ShipShape (SS)
Behavioral
Lead sponsor
Veterans Medical Research Foundation
Other
Eligibility
18 Years to 69 Years
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
2
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jan 18, 2022 · Synced Sep 15, 2026, 5:03 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Promoting the Well Being of Caregivers Via Telehealth

NCT05999448
View directory record Official record
Conditions
Caregivers, Parents
Interventions
Acceptance and Commitment Therapy (ACT), Culturally Informed Cognitive Behavioral Therapy (CICBT), Individual, Culturally Informed Cognitive Behavioral Therapy (CICBT), Group, Dialectical Behavioral Therapy (DBT), Durand Sleep Intervention, RUBI Intervention, Naturalistic Communication Intervention (NCI), Self-Guided Resources, Participation Enhancement Intervention (PEI)
Behavioral
Lead sponsor
Purdue University
Other
Eligibility
18 Years to 70 Years
Enrollment
800 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 20, 2023 · Synced Sep 15, 2026, 5:03 AM EDT
Not listed Not applicable Interventional

Examining Different Components of Online Acceptance and Commitment Therapy for People With Chiari Malformation

NCT05581472
View directory record Official record
Conditions
Chronic Pain, Chiari Malformation
Interventions
Online Acceptance and Commitment Therapy Intervention + Phone Coaching, Online Acceptance and Commitment Therapy Intervention without phone coaching
Behavioral
Lead sponsor
Kent State University
Other
Eligibility
18 Years and older
Enrollment
113 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Kent, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 14, 2023 · Synced Sep 15, 2026, 5:03 AM EDT
Not listed Not applicable Interventional

ACT and CBT Bibliotherapy for Perfectionism

NCT06057740
View directory record Official record
Conditions
Perfectionism
Interventions
Acceptance and commitment therapy (ACT), Cognitive behavioral therapy (CBT)
Behavioral
Lead sponsor
Utah State University
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Logan, Utah
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Sep 15, 2026, 5:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Early Phase Clinical Trial to Test the Feasibility of an ACT-based Physical Activity Promotion Program for Adults With Depressive Symptoms

NCT05407935
View directory record Official record
Conditions
Physical Inactivity
Interventions
ACTivity, Relaxercise
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years to 65 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Sep 15, 2026, 5:03 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Virtual ACT for Adolescent Stress

NCT04978610
View directory record Official record
Conditions
Chronic Illness
Interventions
Virtual Acceptance Commitment Therapy
Behavioral
Lead sponsor
Children's Hospital Los Angeles
Other
Eligibility
14 Years to 21 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Sep 15, 2026, 5:03 AM EDT
Completed Not applicable Interventional

Acceptance and Commitment Therapy, a Mindfulness-Based Approach for Treatment of Chronic Musculoskeletal Pain

NCT04502992
View directory record Official record
Conditions
Chronic Musculoskeletal Disease
Interventions
Acceptance and Committment Therapy
Behavioral
Lead sponsor
University of New Hampshire
Other
Eligibility
18 Years to 65 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Durham, New Hampshire
Source: ClinicalTrials.gov public record
Updated Aug 5, 2020 · Synced Sep 15, 2026, 5:03 AM EDT
Recruiting Not applicable Interventional

Acceptance and Commitment Therapy to Improve Disability in Chronic Migraine

NCT06795867
View directory record Official record
Conditions
Chronic Migraine
Interventions
acceptance and commitment therapy
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Sep 15, 2026, 5:03 AM EDT
Completed Phase 1 Interventional

Fear of Recurrence Pilot Intervention for Women With Breast Cancer

NCT01354041
View directory record Official record
Conditions
Cancer Recurrence
Interventions
Acceptance and Commitment Therapy
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older · Female only
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 26, 2014 · Synced Sep 15, 2026, 5:03 AM EDT
Completed Not applicable Interventional

Facilitating Adaptive Coping With Fear of Recurrence Among Breast Cancer Survivors

NCT05364450
View directory record Official record
Conditions
Breast Neoplasm, Breast Cancer, Breast Carcinoma, Malignant Neoplasm of Breast, Cancer of Breast, Mammary Neoplasms, Human, Human Mammary Carcinoma, Malignant Tumor of Breast, Mammary Cancer, Mammary Carcinoma, Human, Anxiety, Fear
Interventions
Enhanced Usual Care, Acceptance Commitment Therapy, Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 99 Years · Female only
Enrollment
390 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Dec 3, 2024 · Synced Sep 15, 2026, 5:03 AM EDT
Completed Not applicable Interventional

iOmit: Reducing Intentional Insulin Misuse in Type 1 Diabetes

NCT02980627
View directory record Official record
Conditions
Type 1 Diabetes Mellitus, Eating Disorders
Interventions
Therapy with Mobile App Enhancement
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 55 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
2
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 10, 2019 · Synced Sep 15, 2026, 5:03 AM EDT
Completed No phase listed Observational Results available

Pandemic Acceptance and Commitment Therapy (Pan-ACT): Telehealth Delivery With Older Veterans

NCT05433662
View directory record Official record
Conditions
Psychological Stress
Interventions
Pandemic Acceptance and Commitment Therapy (Pan-ACT)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
60 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Tuscaloosa, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Sep 15, 2026, 5:03 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Comparative Effectiveness of Mobile Health Smoking Cessation Approaches Among Underserved Patients in Primary Care

NCT05415761
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
iCanQuit, iCanQuit+Motiv8, Florida quit line
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
21 Years and older
Enrollment
1,332 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Sep 15, 2026, 5:03 AM EDT
Completed Not applicable Interventional

Online Acceptance and Commitment Therapy for Chronic Pain in Sample of People With Chiari Malformation

NCT04089670
View directory record Official record
Conditions
Chronic Pain, Chiari Malformation
Interventions
Online Acceptance and Commitment Therapy Intervention
Behavioral
Lead sponsor
Kent State University
Other
Eligibility
18 Years to 65 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Kent, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 4, 2021 · Synced Sep 15, 2026, 5:03 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Acceptance Commitment Therapy for Caregivers of People with Memory Loss

NCT05749939
View directory record Official record
Conditions
Caregiver Burden, Behavioral and Psychiatric Symptoms of Dementia, Depressive Symptoms, Quality of Life, Psychological Flexibility, Sleep Quality, Positive Aspects of Caregiving
Interventions
Acceptance and Commitment Therapy
Behavioral
Lead sponsor
Utah State University
Other
Eligibility
18 Years and older
Enrollment
121 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Logan, Utah
Source: ClinicalTrials.gov public record
Updated Dec 5, 2024 · Synced Sep 15, 2026, 5:03 AM EDT
Completed Not applicable Interventional

ACT Workshops: A Novel Delivery Modality to Increase Access to Care for Rural Veterans

NCT05196464
View directory record Official record
Conditions
Access to Care, Psychological Distress
Interventions
Acceptance and Commitment Therapy (ACT) Workshop, Treatment as usual (TAU)
Behavioral
Lead sponsor
Syracuse VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Apr 21, 2024 · Synced Sep 15, 2026, 5:03 AM EDT
Not yet recruiting Not applicable Interventional

ACT for Veterans With IBD and Mental Health Challenges

NCT07397195
View directory record Official record
Conditions
Inflammatory Bowel Diseases, Crohn's Disease, Ulcerative Colitis, Depressive Disorder, Anxiety Disorder, Stress Disorders, Post-Traumatic
Interventions
Acceptance and Commitment Therapy
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2028 – 2032
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Sep 15, 2026, 5:03 AM EDT
Completed Phase 2 Interventional Results available

Benzodiazepine Discontinuation in Opioid Agonist Therapy

NCT04109118
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Distress Tolerance - Benzodiazepine Discontinuation (DT-BD), BZD discontinuation protocol
Behavioral · Drug
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 10, 2022 · Synced Sep 15, 2026, 5:03 AM EDT
Completed Phase 4 Interventional Results available

Novel Pharmacotherapy Approaches in Smokers With Serious Mental Illness

NCT04011280
View directory record Official record
Conditions
Bipolar Disorder, Schizophrenia, Schizoaffective Disorder, Nicotine Dependence
Interventions
Varenicline
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 70 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jun 21, 2023 · Synced Sep 15, 2026, 5:03 AM EDT
Recruiting Not applicable Interventional

Type I Hybrid Effectiveness-Implementation Trial of Primary Care Brief Mindfulness Training for Veterans

NCT06162741
View directory record Official record
Conditions
Post Traumatic Stress Disorder (PTSD), Depression, Anxiety
Interventions
Primary Care Brief Mindfulness Training (PCBMT), Moving Forward (MF)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
4
States / cities
Phoenix, Arizona • San Diego, California • St Louis, Missouri + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 15, 2026, 5:03 AM EDT
Completed Not applicable Interventional

Acceptance and Commitment Therapy vs. Supportive Psychotherapy With Cystic Fibrosis Patients

NCT04114227
View directory record Official record
Conditions
Cystic Fibrosis
Interventions
Acceptance and Commitment Therapy adapted for Cystic Fibrosis (ACT with CF), Supportive Psychotherapy (Treatment as Usual Control)
Behavioral
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 14, 2024 · Synced Sep 15, 2026, 5:03 AM EDT
Completed Not applicable Interventional

Evaluation of the ACT on Health Program

NCT03932994
View directory record Official record
Conditions
Overweight and Obesity
Interventions
ACT on Health
Behavioral
Lead sponsor
Utah State University
Other
Eligibility
18 Years and older
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Logan, Utah
Source: ClinicalTrials.gov public record
Updated Mar 23, 2020 · Synced Sep 15, 2026, 5:03 AM EDT