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ClinicalTrials.gov public records Last synced Oct 1, 2026, 2:26 AM EDT

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Showing 25–48 of 981 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Active older Adults Clear all
Recruiting Phase 4 Interventional

Bone, Exercise, Alendronate, and Caloric Restriction

NCT05764733
View directory record Official record
Conditions
Bone Loss
Interventions
Bisphosphonate, Resistance Training/Bone-Loading Exercise, Placebo
Drug · Behavioral · Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
60 Years and older
Enrollment
900 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
2
States / cities
Aurora, Colorado • Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Oct 1, 2026, 2:26 AM EDT
Suspended Not applicable Interventional Accepts healthy volunteers

Parent-Based Physical Activity Intervention for Black Families

NCT05910671
View directory record Official record
Conditions
Physical Inactivity
Interventions
Physical Activity Phone Calls and Notebook
Behavioral
Lead sponsor
East Carolina University
Other
Eligibility
19 Years to 65 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Greenville, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 3, 2023 · Synced Oct 1, 2026, 2:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Active Body and Mind Intervention for Older Adults

NCT05233813
View directory record Official record
Conditions
Well Aging
Interventions
Active Body and Mind
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
65 Years and older
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 10, 2022 · Synced Oct 1, 2026, 2:26 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Concurrent Aerobic Exercise and Cognitive Training to Prevent Alzheimer's in At-risk Older Adults

NCT04311736
View directory record Official record
Conditions
Mild Cognitive Impairment, Exercise Training
Interventions
Exergame, Cycling, Stretching
Behavioral
Lead sponsor
Moai Technologies LLC
Other
Eligibility
65 Years and older
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 17, 2020 · Synced Oct 1, 2026, 2:26 AM EDT
Completed Not applicable Interventional Results available

Sleep Well 24 (SWELL24) Healthy Sleep-Wake Behaviors in Older Adults

NCT05780983
View directory record Official record
Conditions
Insomnia Disorder
Interventions
education and coaching on developing healthy nighttime sleep and daytime activity behaviors
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
65 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Oct 1, 2026, 2:26 AM EDT
Completed Not applicable Interventional Results available

Brain Stimulation and Enhancing Cognition in Older Adults

NCT03653351
View directory record Official record
Conditions
Cognitive Impairment, Mild, Depressive Symptoms, Anxiety
Interventions
Active Transcranial Direct Current Stimulation (tDCS), Sham Transcranial Direct Current Stimulation (tDCS)
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
60 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
2
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 8, 2021 · Synced Oct 1, 2026, 2:26 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effect of Sage Extract Supplementation on Cognitive Function in Middle-Aged Men and Women

NCT07757529
View directory record Official record
Conditions
Cognitive Ability, General
Interventions
SageXtra, Placebo
Dietary Supplement
Lead sponsor
ESM Technologies, LLC
Industry
Eligibility
40 Years to 60 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
College Station, Texas
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 1, 2026, 2:26 AM EDT
Completed Phase 2 Interventional Results available

Study in Elderly Alzheimer's Patients to Assess Skin Tolerability, Irritation With 3, 7-Day Applications of DTP-System

NCT00916383
View directory record Official record
Conditions
Irritation/Irritant
Interventions
350 mg Donepezil Transdermal Patch, Placebo Patch
Drug
Lead sponsor
Teikoku Pharma USA, Inc.
Industry
Eligibility
65 Years and older
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
7
States / cities
Phoenix, Arizona • Fresno, California • Garden Grove, California + 4 more
Source: ClinicalTrials.gov public record
Updated Oct 28, 2021 · Synced Oct 1, 2026, 2:26 AM EDT
Completed Not applicable Interventional Results available

Hyperbaric Oxygen Therapy for Cognition in Diabetic Elderly at High Dementia Risk

NCT03036254
View directory record Official record
Conditions
Diabetes Mellitus
Interventions
HBOT intervention, Sham intervention
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
65 Years and older
Enrollment
155 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
2
States / cities
New York, New York • Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 11, 2025 · Synced Oct 1, 2026, 2:26 AM EDT
Recruiting Not applicable Interventional

Behavioral Activation for Independence in Older Veterans

NCT05493241
View directory record Official record
Conditions
Functional Independence
Interventions
Behavioral Activation for Independence in Older Veterans (ACTIVaTE), Usual care
Behavioral · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
65 Years and older
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Bedford, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 27, 2026 · Synced Oct 1, 2026, 2:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

USC Well Elderly Study 2

NCT00786344
View directory record Official record
Conditions
Aged
Interventions
Lifestyle Redesign
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
60 Years and older
Enrollment
460 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2008
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 6, 2008 · Synced Oct 1, 2026, 2:26 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Leveraging Behavioral Economics to Understand and Improve Financial Decision Making Among Vulnerable Older Adults

NCT07682740
View directory record Official record
Conditions
Financial Exploitation of Older Adults
Interventions
Participants receiving informational self-nudges to improve financial decision-making, Control - Participants receiving informational content on healthy eating and physical activity
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
60 Years and older
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Oct 1, 2026, 2:26 AM EDT
Completed Not applicable Interventional

Verizon mHealth Solution for Patients With Peripheral Artery Disease (PAD)

NCT02472561
View directory record Official record
Conditions
Peripheral Artery Disease
Interventions
Fitbit Physical Activity Monitor, mHealth Glucometer, mHealth Blood Pressure
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 5, 2018 · Synced Oct 1, 2026, 2:26 AM EDT
Terminated Phase 3 Interventional

Efficacy, Safety & Pharmacokinetic (PK) Study of HLD200 in Children Aged 4-5 Years With ADHD

NCT06431256
View directory record Official record
Conditions
Attention Deficit Hyperactivity Disorder
Interventions
HLD200 methylphenidate hydrochloride capsules, Placebo HLD200 capsules
Drug
Lead sponsor
Ironshore Pharmaceuticals and Development, Inc
Other
Eligibility
4 Years to 5 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
13
States / cities
Dothan, Alabama • Anaheim, California • Jacksonville, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Nov 6, 2025 · Synced Oct 1, 2026, 2:26 AM EDT
Active, not recruiting Phase 1Phase 2 Interventional Results available

A Study to Learn About Vepdegestrant When Given With PF-07220060 to People With Advanced or Metastatic Breast Cancer.

NCT06206837
View directory record Official record
Conditions
Breast Cancer
Interventions
vepdegestrant, PF-07220060
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years and older
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
34
States / cities
Fayetteville, Arkansas • Rogers, Arkansas • Springdale, Arkansas + 22 more
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 1, 2026, 2:26 AM EDT
Completed Phase 4 Interventional Results available

The Use of Intranasal Calcitonin to Improve Pain and Activity in Elderly Pelvic Ring Injuries

NCT03812991
View directory record Official record
Conditions
Pelvic Ring Fractures
Interventions
Miacalcin Calcitonin Salmon Nasal Spray
Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
65 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 11, 2024 · Synced Oct 1, 2026, 2:26 AM EDT
Completed Not applicable Interventional Results available

CogXergaming to Promote Physical Activity and Cognitive Function in Frail Older Adults

NCT04534686
View directory record Official record
Conditions
Frail Older Adults
Interventions
CogXergaming, Matter of Balance Training
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
60 Years and older
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 28, 2025 · Synced Oct 1, 2026, 2:26 AM EDT
Completed Phase 3 Interventional

An Eight-week Study Evaluating the Efficacy of a 100mg Dose of Saredutant Once Daily, in Elderly Patients With Major Depressive Disorder

NCT00415142
View directory record Official record
Conditions
Depressive Disorder
Interventions
saredutant (SR48968), placebo, escitalopram
Drug
Lead sponsor
Sanofi
Industry
Eligibility
60 Years to 64 Years
Enrollment
393 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Bridgewater, New Jersey
Source: ClinicalTrials.gov public record
Updated May 24, 2016 · Synced Oct 1, 2026, 2:26 AM EDT
Completed Not applicable Interventional Results available

Physical Activity Behavior Change for Older Adults After Dysvascular Amputation

NCT02738086
View directory record Official record
Conditions
Amputation, Diabetes Mellitus, Type 2, Peripheral Artery Disease
Interventions
Physical Activity Behavior Change (PABC)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
50 Years to 85 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 18, 2020 · Synced Oct 1, 2026, 2:26 AM EDT
Completed Not applicable Interventional

Advancing Rehabilitation Paradigms for Older Adults in Skilled Nursing Facilities

NCT05492240
View directory record Official record
Conditions
Aging, Functional Recovery, Skilled Nursing Facility, Medically Complex, Deconditioning
Interventions
i-STRONGER, Usual Care
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
50 Years to 120 Years
Enrollment
4,383 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
2
States / cities
Aurora, Colorado • Frisco, Texas
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Oct 1, 2026, 2:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Patient Centered-Rehabilitation ver111090.1

NCT03034954
View directory record Official record
Conditions
Cognitive Change
Interventions
Active HD-tDCS, Sham HD-tDCS
Device
Lead sponsor
University of Michigan
Other
Eligibility
50 Years and older
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 16, 2018 · Synced Oct 1, 2026, 2:26 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Influence of Cognition on Activity and Participation in People With Stroke

NCT05919251
View directory record Official record
Conditions
Stroke, Cognitive Change, Neurological Injury, Cognitive Impairment, Activity, Motor
Interventions
Ageless Grace
Behavioral
Lead sponsor
Saint Joseph's University, Philadelphia
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 26, 2023 · Synced Oct 1, 2026, 2:26 AM EDT
Recruiting Not applicable Interventional

Dietary Intervention to Mitigate Post-Acute COVID-19 Syndrome

NCT05977179
View directory record Official record
Conditions
Post-Acute COVID-19 Syndrome, Fatigue
Interventions
Dietary intervention to mitigate Post-Acute COVID-19 Syndrome, Attention Control
Other
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
50 Years to 94 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Oct 1, 2026, 2:26 AM EDT
Recruiting Not applicable Interventional

Remote tDCS and Chair Yoga for Chronic Knee Pain in Alzheimer's Patients

NCT07303998
View directory record Official record
Conditions
Alzheimer&Amp;#39;s Disease, Other Dementias
Interventions
Active tDCS paired with active online chair yoga
Device
Lead sponsor
University of Arizona
Other
Eligibility
60 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Dec 26, 2025 · Synced Oct 1, 2026, 2:26 AM EDT