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ClinicalTrials.gov public records Last synced Sep 30, 2026, 5:46 AM EDT

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Showing 25–48 of 63 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Acuvue Oasys Contact Lens Clear all
Completed Not applicable Interventional Results available

Clinical Comparison of Two Daily Wear Frequent Replacement Silicone Hydrogel Soft Contact Lenses

NCT04532099
View directory record Official record
Conditions
Refractive Errors, Ametropia
Interventions
Lehfilcon A contact lenses, Senofilcon A contact lenses, Comfilcon A contact lenses, Hydrogen peroxide-based cleaning and disinfecting solution
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
4
States / cities
Longwood, Florida • Maitland, Florida • Warwick, Rhode Island + 1 more
Source: ClinicalTrials.gov public record
Updated May 3, 2022 · Synced Sep 30, 2026, 5:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

PAVES Benchmarking Pilot Study of Daily Disposable Contact Lenses

NCT04032457
View directory record Official record
Conditions
Refractive Errors
Interventions
Phase A - olifilcon B with Tangible Coatings, Phase B - etafilcon A with Tangible Coatings
Device
Lead sponsor
Vision Service Plan
Industry
Eligibility
18 Years to 42 Years
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
6
States / cities
Atlanta, Georgia • Niles, Illinois • Carmel, Indiana + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 6, 2020 · Synced Sep 30, 2026, 5:46 AM EDT
Completed Not applicable Interventional Results available

Evaluation of Contact Lenses and Conjunctival Staining in Normal Patients

NCT00799422
View directory record Official record
Conditions
Conjunctival Staining
Interventions
Complete Easy Rub, ReNu MultiPlus, Clear Care, Contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Nov 16, 2012 · Synced Sep 30, 2026, 5:46 AM EDT
Completed Phase 4 Interventional Results available

Comparative Performance of PureVision, Acuvue Oasys and O2Optix

NCT00640341
View directory record Official record
Conditions
Myopia
Interventions
PureVision Contact Lens, Acuvue Oasys Contact Lens, O2Optix Contact lens
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
510 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Dec 12, 2011 · Synced Sep 30, 2026, 5:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Design Validation of Senofilcon A With New UV-blocking Additive

NCT03707821
View directory record Official record
Conditions
Visual Acuity
Interventions
senofilcon A TEST Lens, senofilcon A CONTROL Lens
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 49 Years
Enrollment
253 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
10
States / cities
Cupertino, California • Maitland, Florida • Tallahassee, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Dec 5, 2019 · Synced Sep 30, 2026, 5:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Ocular Characteristics in Contact Lens and Spectacle Wear

NCT03913377
View directory record Official record
Conditions
Visual Acuity
Interventions
Spectacles, ACUVUE OASYS®1-Day with HydraLuxe™ Technology
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 42 Years
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
3
States / cities
Jacksonville, Florida • Longwood, Florida • New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 4, 2021 · Synced Sep 30, 2026, 5:46 AM EDT
Completed Not applicable Interventional Results available

Clinical Assessment of a HYDRAGLYDE® Regimen

NCT03026257
View directory record Official record
Conditions
Refractive Errors, Myopia, Hypermetropia
Interventions
Lotrafilcon B contact lenses with added wetting agent, Samfilcon A contact lenses, POLYQUAD/ALDOX-preserved contact lens solution with added wetting agent, Hydrogen peroxide-based contact lens solution with added wetting agent, Senofilcon C contact lenses, Senofilcon A contact lenses, Comfilcon A contact lenses, Habitual Multi-Purpose Solution (HMPS)
Device
Lead sponsor
Alcon, a Novartis Company
Industry
Eligibility
18 Years and older
Enrollment
323 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
5
States / cities
Birmingham, Alabama • Cleveland, Ohio • Columbus, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 14, 2018 · Synced Sep 30, 2026, 5:46 AM EDT
Completed Not applicable Interventional

Clinical Performance Evaluation of Two Daily Disposable Silicone Hydrogel Toric Contact Lenses

NCT04254003
View directory record Official record
Conditions
Refractive Errors
Interventions
DT1 Toric contact lenses, AO1DfA contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
2
States / cities
Maitland, Florida • Eden Prairie, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 18, 2020 · Synced Sep 30, 2026, 5:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Multifocal Contact Lens Designs With and Without an HEV Blocker on Visual Function

NCT04995055
View directory record Official record
Conditions
Visual Acuity
Interventions
JJVC Investigational Multifocal Contact Lens TEST Lens, ACUVUE® OASYS Multifocal
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Jun 6, 2023 · Synced Sep 30, 2026, 5:46 AM EDT
Completed Not applicable Interventional Results available

Clinical Performance of Two Reusable Silicone Hydrogel Contact Lenses

NCT05431478
View directory record Official record
Conditions
Refractive Errors
Interventions
Serafilcon A contact lenses, Senofilcon A contact lenses, CLEAR CARE
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
5
States / cities
Maitland, Florida • Medina, Minnesota • Granville, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 21, 2023 · Synced Sep 30, 2026, 5:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Evaluation of a Reusable Multifocal Optical Design in a Presbyopic Population

NCT03581825
View directory record Official record
Conditions
Visual Acuity
Interventions
senofilcon A Multifocal, senofilcon A Sphere, etafilcon A Multifocal, etafilcon A Sphere
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
6
States / cities
Orlando, Florida • East Lansing, Michigan • Raytown, Missouri + 3 more
Source: ClinicalTrials.gov public record
Updated May 8, 2020 · Synced Sep 30, 2026, 5:46 AM EDT
Completed Not applicable Interventional Results available

Effect of FID 114675A on Lens Wettability

NCT01342107
View directory record Official record
Conditions
Contact Lens Wettability
Interventions
FID 114675A multi-purpose disinfecting solution (MPDS), Soft contact lens, Blister pack solution
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Apr 13, 2012 · Synced Sep 30, 2026, 5:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Evaluation of Spherical Soft Contact Lenses, Toric Soft Contact Lenses and Spectacles in Low Astigmats

NCT05056870
View directory record Official record
Conditions
Visual Acuity
Interventions
ACUVUE Oasys 1-Day with HydraLuxe Technology for Astigmatism, ACUVUE Oasys 1-Day with HydraLuxe Technology
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 39 Years
Enrollment
174 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
13
States / cities
Rocklin, California • Longwood, Florida • Maitland, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Apr 27, 2023 · Synced Sep 30, 2026, 5:46 AM EDT
Withdrawn Not applicable Interventional

A Clinical Study Comparing the Comfort of Three Commercially Available Contact Lenses

NCT02298400
View directory record Official record
Conditions
Contact Lens Complication
Interventions
Acuvue® Oasys® Lenses (senofilcon A), 30-Day Bausch + Lomb PureVision (balafilcon A), Clariti® 1-Day (Somofilcon A)
Device
Lead sponsor
ORA, Inc.
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Andover, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 25, 2024 · Synced Sep 30, 2026, 5:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Prototype Lenses With Experimental UV/HEV Blocker

NCT04885296
View directory record Official record
Conditions
Visual Acuity
Interventions
TRP-200, JJVC Marketed Contact Lens
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 39 Years
Enrollment
228 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
12
States / cities
Jacksonville, Florida • Orange Park, Florida • Tallahassee, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Sep 1, 2022 · Synced Sep 30, 2026, 5:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Contact Lenses and Infiltrative Keratitis

NCT02186431
View directory record Official record
Conditions
Keratitis
Interventions
senofilcon A
Device
Lead sponsor
State University of New York College of Optometry
Other
Eligibility
18 Years to 30 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 12, 2016 · Synced Sep 30, 2026, 5:46 AM EDT
Completed Not applicable Interventional Results available

Clinical Performance of Two Frequent Replacement Silicone Hydrogel Multifocal Contact Lenses

NCT06469242
View directory record Official record
Conditions
Presbyopia
Interventions
Serafilcon A multifocal contact lenses, Senofilcon A multifocal contact lenses, CLEAR CARE® Cleaning & Disinfecting Solution
Device
Lead sponsor
Alcon Research
Industry
Eligibility
40 Years and older
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
8
States / cities
Los Angeles, California • Oakland, California • Maitland, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Oct 9, 2025 · Synced Sep 30, 2026, 5:46 AM EDT
Completed Not applicable Interventional Results available

Clinical Performance Evaluation of Two Frequent Replacement Silicone Hydrogel Toric Contact Lenses

NCT05959200
View directory record Official record
Conditions
Ametropia, Myopia, Hyperopia, Astigmatism
Interventions
Serafilcon A toric contact lenses, Senofilcon A toric contact lenses, CLEAR CARE
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
7
States / cities
Oakland, California • San Francisco, California • Maitland, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Nov 29, 2024 · Synced Sep 30, 2026, 5:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluating and Improving Functional Driving Vision of Patients With Astigmatism: Phase 3

NCT02950545
View directory record Official record
Conditions
Astigmatism
Interventions
Placebo Lenses, Spherical Lenses, Toric Lenses
Device
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 39 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 6, 2021 · Synced Sep 30, 2026, 5:46 AM EDT
Completed Not applicable Interventional Results available

Two Daily Disposable Contact Lenses in Symptomatic Patients

NCT03628599
View directory record Official record
Conditions
Myopia
Interventions
Delefilcon A contact lenses, Senofilcon A contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
4
States / cities
Bloomington, Illinois • Pittsburg, Kansas • Powell, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 5, 2019 · Synced Sep 30, 2026, 5:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of ACUVUE® OASYS 1-Day for Astigmatism Contact Lenses With Alternative Lidstock

NCT05713552
View directory record Official record
Conditions
Ocular Physiology
Interventions
Acuvue Oasys 1 Day for Astigmatism with Legacy lidstock, Acuvue Oasys 1 Day for Astigmatism with Amcor laminated lidstock
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 39 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 5, 2024 · Synced Sep 30, 2026, 5:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Wear Experience With One Week Reusable Contact Lenses in Habitual Two Week Reusable Lens Wearers

NCT06382064
View directory record Official record
Conditions
Myopia
Interventions
Biweekly replacement contact lenses, One week replacement contact lenses
Device
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 20, 2025 · Synced Sep 30, 2026, 5:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Product Feasibility of a New Silicone Hydrogel Contact Lens

NCT01309100
View directory record Official record
Conditions
Myopia
Interventions
Investigational Lens, Acuvue Oasys Lens, Air Optix Aqua Lens
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Apr 29, 2014 · Synced Sep 30, 2026, 5:46 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

The Impact of Contact Lens Coefficient of Friction (CoF) on the Development of Lid Wiper Epitheliopathy (LWE)

NCT03209505
View directory record Official record
Conditions
Lid Wiper Epitheliopathy
Interventions
Acuvue Oasys, Air Optix Night & Day Aqua
Device
Lead sponsor
University of Houston
Other
Eligibility
18 Years to 46 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 31, 2021 · Synced Sep 30, 2026, 5:46 AM EDT