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ClinicalTrials.gov public records Last synced Oct 11, 2026, 1:24 PM EDT

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Showing 25–48 of 59 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Anterior cervical discectomy and fusion Clear all
Not listed No phase listed Observational

A Retrospective Study to Examine the Effect of CMF Stimulation on Primary ACDF Patients

NCT05101057
View directory record Official record
Conditions
Degeneration of Cervical Intervertebral Disc
Interventions
SpinalogicTM Bone Graft Stimulator
Device
Lead sponsor
Encore Medical, L.P.
Industry
Eligibility
18 Years to 75 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
2
States / cities
San Diego, California • White Plains, New York
Source: ClinicalTrials.gov public record
Updated Dec 7, 2021 · Synced Oct 11, 2026, 1:24 PM EDT
Completed No phase listed Observational Results available

MaxAn Post Market Surveillance Validation

NCT01343693
View directory record Official record
Conditions
DDD, Deformity, Tumor, Fracture
Interventions
Not listed
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
6
States / cities
Montgomery, Alabama • Tallahassee, Florida • Indianapolis, Indiana + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 6, 2020 · Synced Oct 11, 2026, 1:24 PM EDT
Active, not recruiting No phase listed Observational

M6-C Post Approval Study (PAS)

NCT04122248
View directory record Official record
Conditions
Cervical Degenerative Disc Disease, Cervical Radiculopathy, Cervical Spinal Cord Compression, Cervical Disc Herniation
Interventions
standard radiographic imaging, cervical total disc replacement
Other · Device
Lead sponsor
Spinal Kinetics
Industry
Eligibility
21 Years to 68 Years
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
21
States / cities
Phoenix, Arizona • Sun City West, Arizona • Beverly Hills, California + 17 more
Source: ClinicalTrials.gov public record
Updated Jul 30, 2025 · Synced Oct 11, 2026, 1:24 PM EDT
Completed Phase 3 Interventional Results available

Performance of the Hedrocel(R) Cervical Fusion Device

NCT00758758
View directory record Official record
Conditions
Symptomatic Cervical Disc Disease
Interventions
Anterior Cervical Discectomy and Fusion
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years to 70 Years
Enrollment
231 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2009
U.S. locations
13
States / cities
Los Angeles, California • Clearwater, Florida • Orlando, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Aug 23, 2013 · Synced Oct 11, 2026, 1:24 PM EDT
Completed No phase listed Observational Results available

Post Approval Study Protocol for the Two Level Simplify® Cervical Artificial Disc

NCT04980378
View directory record Official record
Conditions
Cervical Degenerative Disc Disorder
Interventions
Simplify Disc
Device
Lead sponsor
NuVasive
Industry
Eligibility
Not listed
Enrollment
291 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
18
States / cities
Orange, California • Santa Monica, California • Thornton, Colorado + 15 more
Source: ClinicalTrials.gov public record
Updated Jan 8, 2026 · Synced Oct 11, 2026, 1:24 PM EDT
Completed No phase listed Observational

Osteocel® Plus in Anterior Cervical Discectomy and Fusion (ACDF)

NCT00942045
View directory record Official record
Conditions
Degenerative Disc Disease in Cervical Spine
Interventions
Biologic - Osteocel Plus
Biological
Lead sponsor
NuVasive
Industry
Eligibility
18 Years to 70 Years
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
17
States / cities
La Jolla, California • Redwood City, California • San Diego, California + 14 more
Source: ClinicalTrials.gov public record
Updated Dec 24, 2025 · Synced Oct 11, 2026, 1:24 PM EDT
Completed Not applicable Interventional Results available

Cellentra Viable Cell Bone Matrix (VCBM) Anterior Cervical Discectomy and Fusion Outcomes Study (VCBM/MaxAn)

NCT02182843
View directory record Official record
Conditions
Cervical Disc Degenerative Disorder
Interventions
Cellentra VCBM
Biological
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
6
States / cities
Phoenix, Arizona • Fort Wayne, Indiana • Paducah, Kentucky + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 15, 2019 · Synced Oct 11, 2026, 1:24 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Salt Water Gargling on Swallowing Following ACDF

NCT06475365
View directory record Official record
Conditions
Degeneration Spine, Cervical Radiculopathy, Cervical Stenosis, Cervical Spondylosis, Cervical Myelopathy, Dysphagia
Interventions
Sodium chloride gargle
Other
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 18, 2025 · Synced Oct 11, 2026, 1:24 PM EDT
Terminated Not applicable Interventional Results available

Prospective Study of Fusion Rates Using Spira-C Device for Anterior Cervical Discectomy and Fusion Surgery

NCT03786432
View directory record Official record
Conditions
Cervical Radiculopathy, Cervical Disc Disease
Interventions
Spira-C Interbody Device
Device
Lead sponsor
Corewell Health East
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Royal Oak, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 28, 2023 · Synced Oct 11, 2026, 1:24 PM EDT
Active, not recruiting Not applicable Interventional

Study of Posterior Cervical Stabilization System (PCSS) as Part of Circumferential Fusion to Treat Multilevel DDD

NCT04229017
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Anterior Cervical Discectomy and Fusion, Posterior Cervical Stabilization System (PCSS)
Procedure · Device
Lead sponsor
Providence Medical Technology, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
236 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
17
States / cities
Phoenix, Arizona • Encinitas, California • Los Gatos, California + 14 more
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Oct 11, 2026, 1:24 PM EDT
Completed Phase 3 Interventional Results available

PCM Cervical Disc System

NCT00578812
View directory record Official record
Conditions
Radiculopathy, Myelopathy
Interventions
Anterior Cervical Discectomy and Fusion (ACDF), PCM Cervical Disc
Device
Lead sponsor
NuVasive
Industry
Eligibility
18 Years to 65 Years
Enrollment
494 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2014
U.S. locations
23
States / cities
Beverly Hills, California • Greenwood Village, Colorado • Washington D.C., District of Columbia + 18 more
Source: ClinicalTrials.gov public record
Updated Jul 7, 2015 · Synced Oct 11, 2026, 1:24 PM EDT
Active, not recruiting Not applicable Interventional

The Synergy Disc for the Treatment of 2 Level Cervical Degenerative Disc Disease Compared With Cervical Fusion Surgery

NCT05740176
View directory record Official record
Conditions
Cervical Degenerative Disc Disease
Interventions
Anterior Cervical Discectomy and Fusion
Device
Lead sponsor
Synergy Spine Solutions
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
23
States / cities
Scottsdale, Arizona • Beverly Hills, California • Los Angeles, California + 20 more
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 11, 2026, 1:24 PM EDT
Completed No phase listed Observational Results available

ViBone in Cervical and Lumbar Spine Fusion

NCT03425682
View directory record Official record
Conditions
Spondylosis, Cervical Spondylosis, Spondylolisthesis, Herniated Nucleus Pulposus, Degenerative Disc Disease
Interventions
ViBone
Other
Lead sponsor
Elutia Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
118 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
4
States / cities
San Diego, California • Danbury, Connecticut • Annapolis, Maryland + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 4, 2025 · Synced Oct 11, 2026, 1:24 PM EDT
Completed Not applicable Interventional Results available

LDR Spine USA Mobi-C(R) Cervical Disc Prosthesis IDE

NCT00389597
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Cervical Artificial Disc
Device
Lead sponsor
LDR Spine USA
Industry
Eligibility
18 Years to 69 Years
Enrollment
599 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2015
U.S. locations
24
States / cities
Phoenix, Arizona • Escondido, California • Laguna Hills, California + 21 more
Source: ClinicalTrials.gov public record
Updated Dec 11, 2017 · Synced Oct 11, 2026, 1:24 PM EDT
Completed No phase listed Observational

PEEK and Allograft Spacers Evaluation in Spinal Fusion Surgeries

NCT01406405
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Posterior/Transforaminal Lumbar Interbody Fusion (P/TLIF), Anterior Cervical Discectomy and Fusion (ACDF)
Procedure
Lead sponsor
Justin Parker Neurological Institute
Other
Eligibility
18 Years to 70 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 27, 2019 · Synced Oct 11, 2026, 1:24 PM EDT
Terminated No phase listed Observational Results available

Diabetes and Glycosylation in Cervical Spondylosis

NCT02758899
View directory record Official record
Conditions
Diabetes, Cervical Myelopathy, Cervical Spondylosis
Interventions
Not listed
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 75 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 10, 2021 · Synced Oct 11, 2026, 1:24 PM EDT
Completed No phase listed Observational

Trinity Evolution in Anterior Cervical Disectomy and Fusion (ACDF)

NCT00951938
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Not listed
Lead sponsor
Orthofix Inc.
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
13
States / cities
Encinitas, California • Redding, California • Parker, Colorado + 10 more
Source: ClinicalTrials.gov public record
Updated Apr 8, 2014 · Synced Oct 11, 2026, 1:24 PM EDT
Completed Not applicable Interventional Results available

Measuring Dysphagia After ACDF Surgery Through A Novel Wearable Sensor

NCT04921800
View directory record Official record
Conditions
Cervical Spine Fusion
Interventions
Anterior Cervical Discectomy & Fusion, Application of ADAM mechanoacoustic skin sensor
Procedure · Device
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 88 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 9, 2025 · Synced Oct 11, 2026, 1:24 PM EDT
Not yet recruiting No phase listed Observational

Post-operative Outcomes of Anterior Cervical Discectomy and Fusion Surgery With and Without Drain Placement

NCT06938607
View directory record Official record
Conditions
ACDF Surgery
Interventions
Drain
Device
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years to 75 Years
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Oct 11, 2026, 1:24 PM EDT
Not listed Phase 1Phase 2 Interventional

Randomized Controlled Trials of the Effects of Decadron on Swallowing, Airway, and Arthrodesis

NCT01065961
View directory record Official record
Conditions
Swallowing
Interventions
Decadron, Saline
Drug
Lead sponsor
Albany Medical College
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2016
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Feb 10, 2010 · Synced Oct 11, 2026, 1:24 PM EDT
Completed Not applicable Interventional

Pivotal IDE Study of the BRYAN(R) Cervical Disc Prosthesis in the Treatment of DDD Versus ACDF

NCT00437190
View directory record Official record
Conditions
Radiculopathy, Myelopathy, Cervical Degenerative Disc Disease
Interventions
ATLANTIS™ Cervical Plate System and allograft, BRYAN Cervical Disc Prosthesis
Device
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
21 Years and older
Enrollment
494 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2016
U.S. locations
38
States / cities
Phoenix, Arizona • Little Rock, Arkansas • Campbell, California + 31 more
Source: ClinicalTrials.gov public record
Updated May 13, 2016 · Synced Oct 11, 2026, 1:24 PM EDT
Recruiting Not applicable Interventional

Anterior Cervical Discectomy and Fusion (ACDF) - Behavioral Intervention

NCT06520579
View directory record Official record
Conditions
Dysphagia
Interventions
Proactive pharyngeal-laryngeal Exercise Program, Premier Protein Clear ® High Protein, Hydration Counseling
Behavioral · Dietary Supplement
Lead sponsor
NYU Langone Health
Other
Eligibility
21 Years to 99 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 27, 2026 · Synced Oct 11, 2026, 1:24 PM EDT
Completed Not applicable Interventional

Anesthetic to Reduce Dysphagia After Anterior Cervical Discectomy and Fusion Surgery

NCT02376205
View directory record Official record
Conditions
Dysphagia
Interventions
bupivacaine hydrochloride 0.5% solution, 0.9% NaCl solution
Drug
Lead sponsor
Justin Parker Neurological Institute
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 13, 2020 · Synced Oct 11, 2026, 1:24 PM EDT
Completed Phase 4 Interventional Results available

Narcotic Free TIVA and Incidence of Unacceptable Movements Under Anesthesia During ACDF Surgery

NCT03643796
View directory record Official record
Conditions
Anterior Cervical Discectomy and Fusion (ACDF)
Interventions
Remifentanil, Ketamine, Dexmedetomidine
Drug
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years to 80 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Sep 18, 2023 · Synced Oct 11, 2026, 1:24 PM EDT