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Showing 1–24 of 66 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Antibiotic Stewardship Clear all
Active, not recruiting Not applicable Interventional

Discharge Stewardship in Children's Hospitals

NCT05826873
View directory record Official record
Conditions
Pneumonia, Bacterial, Pneumonia Childhood, Urinary Tract Infections, Soft Tissue Infections, Skin Infections, Community-acquired Pneumonia
Interventions
Discharge antibiotic stewardship intervention
Behavioral
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
28 Days to 18 Years
Enrollment
1,131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
5
States / cities
St Louis, Missouri • Philadelphia, Pennsylvania • Salt Lake City, Utah + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 8, 2026 · Synced Sep 5, 2026, 8:05 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Pneumonia in the Intensive Care Unit (ICU) Setting

NCT02685930
View directory record Official record
Conditions
Pneumonia, Respiratory Failure
Interventions
Antibiotic de-escalation by ICU stewardship team with decreased exposure to broad spectrum antibiotics and shorter duration of therapy
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
364 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 7, 2018 · Synced Sep 5, 2026, 8:05 AM EDT
Completed No phase listed Observational

An Evaluation of a Antimicrobial Stewardship Recommendation Bundle for Staphylococcus Aureus Bloodstream Infections

NCT06211829
View directory record Official record
Conditions
Bacterial Infections
Interventions
Not listed
Lead sponsor
Methodist Health System
Other
Eligibility
18 Years to 85 Years
Enrollment
77 participants
Timeline
2022 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 5, 2025 · Synced Sep 5, 2026, 8:05 AM EDT
Completed Not applicable Interventional

ANti-infective Stewardship Using the Wisca Tool in the Electronic Medical Record

NCT03397433
View directory record Official record
Conditions
Bacterial Infections
Interventions
Information Technology physician assist
Other
Lead sponsor
Endeavor Health
Other
Eligibility
18 Years and older
Enrollment
9,673 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Evanston, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 26, 2020 · Synced Sep 5, 2026, 8:05 AM EDT
Completed Not applicable Interventional Results available

De-Implementation of Unnecessary Surgical Antibiotic Prophylaxis in Children

NCT04366440
View directory record Official record
Conditions
Surgical Site Infection
Interventions
Order set review and modification with facilitation, Order set review and modification
Behavioral · Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
0 Days to 75 Years
Enrollment
18,267 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
10
States / cities
St. Petersburg, Florida • Boston, Massachusetts • Ann Arbor, Michigan + 7 more
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Sep 5, 2026, 8:05 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Improving Antibiotic Use in Urgent Care Facilities

NCT03932708
View directory record Official record
Conditions
Antibiotic Side Effect, Behavioral Changes
Interventions
CDC Core Elements of Outpatient Stewardship
Behavioral
Lead sponsor
Intermountain Health Care, Inc.
Other
Eligibility
Not listed
Enrollment
700,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Murray, Utah
Source: ClinicalTrials.gov public record
Updated Mar 28, 2022 · Synced Sep 5, 2026, 8:05 AM EDT
Completed Not applicable Interventional Results available

Impact of a Procalcitonin Testing and Treatment Algorithm on Antibiotic Use and Outcomes in the Pediatric Intensive Care Unit

NCT03440918
View directory record Official record
Conditions
Sepsis, Procalcitonin, Antimicrobial Stewardship
Interventions
Procalcitonin-Guided Antimicrobial Stewardship, Baseline Antimicrobial Stewardship
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
2 Hours to 17 Years
Enrollment
271 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 21, 2020 · Synced Sep 5, 2026, 8:05 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Merck IISP Stewardship Grant for Antibiotic Best Practices

NCT01573195
View directory record Official record
Conditions
Antibiotic Resistant Infection
Interventions
Not listed
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
Not listed
Enrollment
1,285 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 17, 2014 · Synced Sep 5, 2026, 8:05 AM EDT
Completed Not applicable Interventional Results available

Dissemination and Implementation of a Videoconference Antimicrobial Stewardship Team

NCT05319561
View directory record Official record
Conditions
Common Infections, Urinary Tract Infections, Pneumonia
Interventions
Antibiotic Use Report
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
2
States / cities
Cleveland, Ohio • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Sep 5, 2026, 8:05 AM EDT
Completed Not applicable Interventional Results available

The INSPIRE-ASP PNA Trial

NCT03697070
View directory record Official record
Conditions
Pneumonia
Interventions
INSPIRE CPOE Smart Prompt, Routine Care
Other
Lead sponsor
Harvard Pilgrim Health Care
Other
Eligibility
18 Years and older
Enrollment
44,780 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
59
States / cities
Riverside, California • San Jose, California • Thousand Oaks, California + 51 more
Source: ClinicalTrials.gov public record
Updated Jan 28, 2025 · Synced Sep 5, 2026, 8:05 AM EDT
Recruiting Not applicable Interventional

Lung Ultrasound for Guiding Antibiotic Use in Pediatric Pneumonia

NCT06921993
View directory record Official record
Conditions
Pneumonia Childhood, Pneumonia, Lung Ultrasound, Antibiotic Stewardship
Interventions
LUNG ULTRASOUND
Diagnostic Test
Lead sponsor
Meyer Children's Hospital IRCCS
Other
Eligibility
3 Years to 10 Years
Enrollment
659 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
4
States / cities
San Diego, California • New Haven, Connecticut • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 2, 2026 · Synced Sep 5, 2026, 8:05 AM EDT
Completed Not applicable Interventional

The DETOURS Trial: De-escalating Empiric Treatment: Opting Out of Rx for Selected Patients With Suspected Sepsis - Opt-Out Protocol Trial

NCT03517007
View directory record Official record
Conditions
Antibiotic Stewardship
Interventions
Opt-Out Protocol
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
762 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
10
States / cities
Atlanta, Georgia • Fayetteville, Georgia • Newnan, Georgia + 6 more
Source: ClinicalTrials.gov public record
Updated Feb 5, 2025 · Synced Sep 5, 2026, 8:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Immediate v. Delayed CT/NG Test for Treatment in the ED

NCT01989130
View directory record Official record
Conditions
Reproductive Tract Infections
Interventions
Roche AMPLICOR CT/NG, Cepheid Xpert CT/NG Test
Device
Lead sponsor
George Washington University
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 12, 2019 · Synced Sep 5, 2026, 8:05 AM EDT
Not yet recruiting Not applicable Interventional

Empowerment Program to Reduce Treatment of Asymptomatic Bacteriuria in Veterans With Spinal Cord Injury

NCT07430904
View directory record Official record
Conditions
Spinal Cord Injury, Spinal Cord Disease
Interventions
Empowerment Program
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2032
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 5, 2026, 8:05 AM EDT
Recruiting Not applicable Interventional

Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis

NCT05975671
View directory record Official record
Conditions
Sepsis, Sepsis Mrsa, Sepsis Bacteremia, Antimicrobial - Induced Nephropathy, Sepsis, Severe, Septic Shock, Septic Syndrome
Interventions
Multifaceted de-implementation strategy to reduce vancomycin overuse
Behavioral
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
Not listed
Enrollment
52,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
4
States / cities
Atlanta, Georgia • Baltimore, Maryland • St Louis, Missouri + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 18, 2025 · Synced Sep 5, 2026, 8:05 AM EDT
Recruiting Not applicable Interventional

Diagnostic Stewardship Intervention to Reduce Inappropriate Antibiotic Use for Urinary Tract Infections in Primary Care

NCT07246837
View directory record Official record
Conditions
Urinary Tract Infection(UTI), Antimicrobial Stewardship, Primary Care
Interventions
MSCC Educational Tool
Behavioral
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years and older
Enrollment
252 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Sep 5, 2026, 8:05 AM EDT
Completed Not applicable Interventional

Antimicrobial Stewardship for Primary Care Pediatricians

NCT01806103
View directory record Official record
Conditions
Acute Sinusitis, Streptococcal Pharyngitis, Pneumonia, Viral Infection
Interventions
Antimicrobial Stewardship Bundle
Behavioral
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
Not listed
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 6, 2013 · Synced Sep 5, 2026, 8:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Broad Implementation of Outpatient Stewardship

NCT05127161
View directory record Official record
Conditions
Acute Respiratory Tract Infection, Otitis Media, Pharyngitis, Acute Sinusitis
Interventions
Broad Implementation of Outpatient Stewardship (BIOS) intervention
Behavioral
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
6 Months to 12 Years
Enrollment
1,032 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
5
States / cities
Plantation, Florida • Cleveland, Ohio • Hershey, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Sep 5, 2026, 8:05 AM EDT
Completed Not applicable Interventional Results available

INSPIRE Trial for Abdominal Infections

NCT05423743
View directory record Official record
Conditions
Abdominal (ABD) Infection
Interventions
Arm 1: Routine Care, Arm 2: INSPIRE Stewardship Bundle for Abdominal Infection
Other
Lead sponsor
Harvard Pilgrim Health Care
Other
Eligibility
18 Years and older
Enrollment
198,480 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
101
States / cities
Riverside, California • San Jose, California • Thousand Oaks, California + 79 more
Source: ClinicalTrials.gov public record
Updated Aug 14, 2025 · Synced Sep 5, 2026, 8:05 AM EDT
Completed No phase listed Observational

Blood Culture Improvement Guidelines and Diagnostic Stewardship for Antibiotic Reduction in Critically Ill Children

NCT03441126
View directory record Official record
Conditions
Sepsis, Bacteremia
Interventions
Multicenter Quality Improvement program
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
Not listed
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
5
States / cities
St Louis, Missouri • Cleveland, Ohio • Portland, Oregon + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 10, 2022 · Synced Sep 5, 2026, 8:05 AM EDT
Completed Not applicable Interventional

Using Probability of Community-Acquired Pneumonia to Tailor Antimicrobials Among Inpatients

NCT05976581
View directory record Official record
Conditions
Pneumonia, Pneumonia, Viral, Pneumonia, Bacterial
Interventions
Electronic alert, Structured communication of test results
Behavioral
Lead sponsor
Jonathan Baghdadi
Other
Eligibility
18 Years and older
Enrollment
107 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Sep 5, 2026, 8:05 AM EDT
Active, not recruiting Not applicable Interventional

RELAX: Reducing Length of Antibiotics for Children With Ear Infections

NCT05608993
View directory record Official record
Conditions
Acute Otitis Media, Pediatric Infectious Disease, Ear Infection
Interventions
High Intensity Intervention, Low Intensity Intervention
Other
Lead sponsor
Intermountain Health Care, Inc.
Other
Eligibility
2 Years to 17 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 16, 2025 · Synced Sep 5, 2026, 8:05 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

BrighT STAR LIBRA: Leveraging Implementation Science for Blood Culture Reduction Approaches

NCT06187662
View directory record Official record
Conditions
Blood Culture Rates, Antibiotic Stewardship, Implementation Science
Interventions
Checklist, Targeted Messaging
Behavioral
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
8
States / cities
Los Angeles, California • San Francisco, California • Wilmington, Delaware + 4 more
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Sep 5, 2026, 8:05 AM EDT
Completed Not applicable Interventional Results available

Ventilator-associated Pneumonia (VAP) Diagnostic Stewardship Trial

NCT05176353
View directory record Official record
Conditions
VAP - Ventilator Associated Pneumonia
Interventions
VAP diagnostic stewardship bundle
Other
Lead sponsor
University of Michigan
Other
Eligibility
Not listed
Enrollment
4,892 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 2, 2024 · Synced Sep 5, 2026, 8:05 AM EDT