Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 6, 2026, 12:15 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 189 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Aortic Valve Replacement Clear all

Conditions: Aortic Valve Disease, Aortic Stenosis
Interventions: Perceval valve, other stented biological valve; Device
Lead sponsor: Corcym S.r.l; Industry
Eligibility: 18 Years and older
Enrollment: 914 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2020
U.S. locations: 5
States / cities: Indianapolis, Indiana • Portland, Maine • Cleveland, Ohio + 2 more

Conditions: Heart Valve Diseases
Interventions: Trifecta valve; Device
Lead sponsor: Abbott Medical Devices; Industry
Eligibility: 18 Years and older
Enrollment: 245 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 6
States / cities: Minneapolis, Minnesota • Rochester, Minnesota • Asheville, North Carolina + 3 more

Conditions: Severe Symptomatic Calcified Native Aortic Valve Stenosis
Interventions: Cerebral Protection System-The SENTINEL System with TAVR, TAVR; Device
Lead sponsor: Claret Medical; Industry
Eligibility: 18 Years and older
Enrollment: 363 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 14
States / cities: Los Angeles, California • Washington D.C., District of Columbia • Clearwater, Florida + 9 more

Conditions: Heart Diseases, ASD - Atrial Septal Defect, VSD - Muscular Ventricular Septal Defect, PFO - Patent Foramen Ovale, PIVSD - Post Infarct Muscular Ventricular Septal Defect, Valvular Heart Disease
Interventions: Amplatzer™ Occlusion Devices, Epic™ Surgical Tissue Heart Valve devices; Device
Lead sponsor: Abbott Medical Devices; Industry
Eligibility: Not listed
Enrollment: 2,500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2039
U.S. locations: 13
States / cities: Los Angeles, California • Washington D.C., District of Columbia • Miami, Florida + 9 more

Conditions: Aortic Valve Stenosis
Interventions: HLT Transcatheter Aortic Valve System; Device
Lead sponsor: HLT Inc.; Industry
Eligibility: 70 Years and older
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2023
U.S. locations: 5
States / cities: Washington D.C., District of Columbia • Indianapolis, Indiana • New York, New York + 2 more

Conditions: Aortic Stenosis
Interventions: SAPIEN S3 valve; Device
Lead sponsor: Edwards Lifesciences; Industry
Eligibility: Not listed
Enrollment: 1,822 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 55
States / cities: La Jolla, California • Los Angeles, California • Palo Alto, California + 46 more

Conditions: Stroke
Interventions: Sentinel® Cerebral Protection System; Device
Lead sponsor: Boston Scientific Corporation; Industry
Eligibility: Not listed
Enrollment: 3,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 41
States / cities: Tucson, Arizona • Los Angeles, California • Sacramento, California + 37 more

Conditions: Aortic Valve Disease
Interventions: Aortic Valve Replacement; Device
Lead sponsor: Abbott Medical Devices; Industry
Eligibility: Not listed
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2028
U.S. locations: 9
States / cities: Los Angeles, California • Madera, California • Sacramento, California + 6 more

Conditions: Severe Aortic Stenosis
Interventions: Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI), Surgical Aortic Valve Replacement (SAVR); Device
Lead sponsor: Medtronic Cardiovascular; Industry
Eligibility: Not listed
Enrollment: 1,453 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2019
U.S. locations: 45
States / cities: Phoenix, Arizona • Los Angeles, California • Mountain View, California + 35 more

Conditions: This Study is Being Conducted to Collect Echocardiographic Data to Test the Lumify Ultrasound With Hemodynamic Automation Device
Interventions: Ultrasound imaging; Diagnostic Test
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Aortic Valve Stenosis
Interventions: Not listed
Lead sponsor: National Heart, Lung, and Blood Institute (NHLBI); NIH
Eligibility: 18 Years and older
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Aortic Stenosis, Disorder of Prosthetic Cardiac Valve, Aortic Valve Insufficiency, Mitral Valve Insufficiency, Hypertrophic Cardiomyopathy, Tricuspid Valve Insufficiency
Interventions: Blood Draw; Procedure
Lead sponsor: Mayo Clinic; Other
Eligibility: 21 Years and older
Enrollment: 378 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2020
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Aortic Valve Stenosis
Interventions: SAPIEN 3 THV, Optimal Heart Failure Therapy; Device · Biological
Lead sponsor: Cardiovascular Research Foundation, New York; Other
Eligibility: 18 Years and older
Enrollment: 178 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2025
U.S. locations: 46
States / cities: Chandler, Arizona • La Jolla, California • Los Angeles, California + 37 more

Conditions: Heart Defect, Congenital
Interventions: Xeltis Bioabsorbable Pulmonary Valved Conduit; Device
Lead sponsor: Xeltis; Industry
Eligibility: 2 Years to 21 Years
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2026
U.S. locations: 7
States / cities: Los Angeles, California • Aurora, Colorado • Hollywood, Florida + 4 more

Conditions: Aortic Stenosis, Cardiac Valve Replacement Complication, Fragility
Interventions: Not listed
Lead sponsor: Jewish General Hospital; Other
Eligibility: 70 Years and older
Enrollment: 800 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 4
States / cities: Boston, Massachusetts • Durham, North Carolina

Conditions: Aortic Valve Stenosis
Interventions: Echocardiography, Computed tomography, Magnetic resonance imaging, Blood biomarkers, Stress echocardiography; Other
Lead sponsor: Laval University; Other
Eligibility: 21 Years to 90 Years
Enrollment: 320 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2024
U.S. locations: 2
States / cities: Rochester, Minnesota • Pittsburgh, Pennsylvania

Conditions: Mitral Annular Calcification, Mitral Stenosis, Mitral Regurgitation, Mitral Valve Disease
Interventions: Transseptal ViMAC; Device
Lead sponsor: Mayra Guerrero; Other
Eligibility: 18 Years and older
Enrollment: 210 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2030
U.S. locations: 16
States / cities: Gilbert, Arizona • Phoenix, Arizona • Tucson, Arizona + 12 more

Conditions: Aortic Valve Stenosis
Interventions: Transcatheter Aortic Valve Replacement; Procedure
Lead sponsor: The Society of Thoracic Surgeons; Other
Eligibility: 18 Years and older
Enrollment: 16,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2035
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Aortic Stenosis, Aortic Valve Stenosis
Interventions: Standardized Invasive Hemodynamics; Diagnostic Test
Lead sponsor: University of British Columbia; Other
Eligibility: Not listed
Enrollment: 49 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 6
States / cities: Tucson, Arizona • Boca Raton, Florida • Indianapolis, Indiana + 3 more

Conditions: Heart Valve Diseases
Interventions: Mitroflow Aortic Heart Valve; Device
Lead sponsor: Sorin Group USA, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 756 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2007
U.S. locations: 21
States / cities: Phoenix, Arizona • Tucson, Arizona • San Diego, California + 16 more

Conditions: Calcific Aortic Stenosis, Calcific Aortic Stenosis - Bicuspid Valve, Aortic Valve Disease, Aortic Valve Calcification, Aortic Diseases, Aortic Aneurysm, Aortic Valve Cusp Abnormality, Aortic Valve Disease Mixed, Aortic Valve Insufficiency
Interventions: Patients scheduled to undergo aortic valve replacement or aortic surgery at BIDMC will be approached for participation in this study.; Procedure
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 20 Years and older
Enrollment: 1,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Symptomatic Severe Native Aortic Stenosis, Aortic Stenosis
Interventions: TAVR Device, Siegel TAVR Device; Device
Lead sponsor: MiRus; Industry
Eligibility: 18 Years and older
Enrollment: 1,025 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Aortic Stenosis
Interventions: Lotus Valve System, CoreValve/Evolut R Transcatheter Aortic Valve Replacement System, LOTUS Edge Valve System; Device
Lead sponsor: Boston Scientific Corporation; Industry
Eligibility: Not listed
Enrollment: 1,425 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2021
U.S. locations: 49
States / cities: Phoenix, Arizona • Scottsdale, Arizona • La Jolla, California + 40 more

Conditions: Aortic Valve Stenosis
Interventions: Daily Activity Goal, Resistance Exercises, Daily Activity Recording; Behavioral
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 85 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 5
States / cities: Boston, Massachusetts • Lebanon, New Hampshire • Morristown, New Jersey + 2 more

Search by objective public record fields.

Perceval Sutureless Implant Versus Standard-Aortic Valve Replacement

Post-Approval Study Protocol of the St. Jude Medical Trifecta Valve

Cerebral Protection in Transcatheter Aortic Valve Replacement

Abbott Structural Heart Device Registry

Transfemoral Replacement of Aortic Valve With HLT MeriDIAN Valve Early Feasibility Trial

PARTNER II Trial: S3iCAP

PROTECTED TAVR: Stroke PROTECTion With SEntinel During Transcatheter Aortic Valve Replacement

SJM Masters HP 15mm Rotatable Mechanical Heart Valve as Aortic Valve Replacement Therapy

Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Symptomatic Severe Aortic Stenosis in High Risk and Very High Risk Subjects Who Need Aortic Valve Replacement

Testing Automated Echocardiography

X-ray Fluoroscopy Fused With Computed Tomography (XFC) Technical Development

Biomarkers in Aortic Stenosis - B.A.S.S.

Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD)

Xeltis Bioabsorbable Pulmonary Valved Conduit Pivotal Study

Frailty Assessment Before Cardiac Surgery & Transcatheter Interventions

Multicenter Prospective Study of Low-Flow Low-Gradient Aortic Stenosis (TOPAS Study)

The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter vaLves).

STS/ACC Transcatheter Valve Therapy Registry (TVT Registry)

Standardized Invasive Hemodynamics for Elevated Gradients Post TAVR (DISCORDANCE TAVR)

Clinical Investigation Of The Mitroflow Aortic Pericardial Heart Valve

Identification of Genetic Causes of Calcific Aortic Valve Disease

STAR Trial (Siegel Transcatheter Aortic Valve Replacement in Patients With Symptomatic Severe Aortic Stenosis)

Safety and Efficacy Study of Lotus Valve for Transcatheter Aortic Valve Replacement

A pragmatiC sTrategy to Promote actIVity and Enhance Quality of Life AFTER Transcatheter Aortic Valve Replacement