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Showing 1–17 of 17 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: BIV-CRT Clear all
Recruiting Not applicable Interventional

Left vs Left Randomized Clinical Trial

NCT05650658
View directory record Official record
Conditions
Heart Failure, Heart Failure With Reduced Ejection Fraction, AV Block, LBBB, RBBB, Intraventricular Conduction Delay, Pacing-Induced Cardiomyopathy
Interventions
His/LBBP, BiVP
Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years and older
Enrollment
2,136 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
57
States / cities
Gilbert, Arizona • Tucson, Arizona • Little Rock, Arkansas + 46 more
Source: ClinicalTrials.gov public record
Updated Oct 1, 2025 · Synced Sep 1, 2026, 2:19 PM EDT
Recruiting Not applicable Interventional

His-Bundle Corrective Pacing in Heart Failure

NCT05265520
View directory record Official record
Conditions
Right Bundle-Branch Block, Heart Failure, His-bundle Pacing, Cardiac Resynchronization Therapy
Interventions
His-CRT implantation, BIV-CRT implantation
Procedure
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
14
States / cities
Phoenix, Arizona • Los Angeles, California • Tampa, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Sep 1, 2026, 2:19 PM EDT
Terminated Phase 1 Interventional

Cardiac Resynchronization and Iodine Meta-Iodobenzylguanidine (MIBG) Imaging

NCT01522378
View directory record Official record
Conditions
Congestive Heart Failure
Interventions
123 iodine metaiodobenzylguanidine
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 25, 2017 · Synced Sep 1, 2026, 2:19 PM EDT
Completed Not applicable Interventional Results available

AdaptResponse Clinical Trial

NCT02205359
View directory record Official record
Conditions
Heart Failure With Left Bundle Branch Block
Interventions
aCRT ON, aCRT OFF
Device
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years and older
Enrollment
3,797 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2022
U.S. locations
90
States / cities
Mesa, Arizona • Phoenix, Arizona • Little Rock, Arkansas + 76 more
Source: ClinicalTrials.gov public record
Updated Nov 28, 2023 · Synced Sep 1, 2026, 2:19 PM EDT
Recruiting No phase listed Observational

The WiSE®-UP Registry (The WiSE System Utilization & Performance Registry)

NCT07098858
View directory record Official record
Conditions
Heart Failure
Interventions
The Wise System
Device
Lead sponsor
EBR Systems, Inc.
Industry
Eligibility
Not listed
Enrollment
320 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2032
U.S. locations
5
States / cities
Jonesboro, Arkansas • Naples, Florida • Ann Arbor, Michigan + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Sep 1, 2026, 2:19 PM EDT
Completed Not applicable Interventional Results available

Conduction System Pacing Optimized Therapy

NCT04905290
View directory record Official record
Conditions
Heart Failure
Interventions
Left ventricular coronary sinus (BiV) configuration, Conduction system pacing-only configuration, Conduction System Pacing Optimized Therapy (CSPOT) configuration
Device
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
7
States / cities
Tampa, Florida • Chicago, Illinois • Houma, Louisiana + 4 more
Source: ClinicalTrials.gov public record
Updated Apr 14, 2025 · Synced Sep 1, 2026, 2:19 PM EDT
Terminated Not applicable Interventional

Adaptive Cardiac Resynchronization Therapy in Patients With RBBB

NCT05936294
View directory record Official record
Conditions
Right Bundle-Branch Block
Interventions
Optimization of CRT Device
Diagnostic Test
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years to 89 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
2
States / cities
Little Rock, Arkansas • Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 6, 2023 · Synced Sep 1, 2026, 2:19 PM EDT
Active, not recruiting Not applicable Interventional

SyncAV Post-Market Trial

NCT04100148
View directory record Official record
Conditions
Congestive Heart Failure
Interventions
SyncAV programmed ON, Fixed AV delay
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
1,686 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
30
States / cities
Huntsville, Alabama • Phoenix, Arizona • Scottsdale, Arizona + 25 more
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Sep 1, 2026, 2:19 PM EDT
Terminated Not applicable Interventional

Effect of Cardiac Resynchronization Therapy (CRT) on Left Ventricular Assist Device (LVAD) Function

NCT04153786
View directory record Official record
Conditions
LVAD (Left Ventricular Assist Device) Driveline Infection
Interventions
Temporary changes in an already-implanted medical device (biventricular pacemaker)
Other
Lead sponsor
University of California, Davis
Other
Eligibility
Not listed
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Nov 6, 2024 · Synced Sep 1, 2026, 2:19 PM EDT
Completed Not applicable Interventional Results available

Adaptive Cardiac Resynchronization Therapy Study

NCT00980057
View directory record Official record
Conditions
Heart Failure
Interventions
Adaptive CRT (aCRT), Echo
Device
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years and older
Enrollment
522 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
55
States / cities
Huntsville, Alabama • Anchorage, Alaska • Phoenix, Arizona + 52 more
Source: ClinicalTrials.gov public record
Updated Oct 15, 2018 · Synced Sep 1, 2026, 2:19 PM EDT
Terminated Not applicable Interventional Results available

Dual Site Left Ventricular (LV) Pacing

NCT00944125
View directory record Official record
Conditions
Congestive Heart Failure, LV Dysfunction
Interventions
Dual Site LV Pacing, BiV Pacing
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
40 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
2
States / cities
Lake Geneva, Wisconsin • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 20, 2024 · Synced Sep 1, 2026, 2:19 PM EDT
Completed No phase listed Observational Results available

MultiPoint Pacing™ Post Market Study

NCT02832622
View directory record Official record
Conditions
Heart Failure
Interventions
MPP, BiV/MPP
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
2,169 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
110
States / cities
Birmingham, Alabama • Huntsville, Alabama • Avondale, Arizona + 99 more
Source: ClinicalTrials.gov public record
Updated Feb 16, 2021 · Synced Sep 1, 2026, 2:19 PM EDT
Completed Not applicable Interventional

Does Echocardiographically Guided Ventriculo-Ventricular Optimization Yield a Sustained Improvement in Echocardiographic Parameters in Cardiac Resynchronization Therapy Patients? (DEVISE CRT)

NCT00737490
View directory record Official record
Conditions
Cardiomyopathy, Heart Failure
Interventions
"Sequential Arm" (Promote , model # 2207-36 or Atlas HF , model # V-343), "Simultaneous Arm" (Promote , model # 2207-36 or Atlas HF , model # V-343)
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2011
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 31, 2014 · Synced Sep 1, 2026, 2:19 PM EDT
Active, not recruiting Not applicable Interventional

REsynchronization Comparison In LBBB and Normal or Mildly Reduced VENTricular Function With CRT (REINVENT-CRT)

NCT05652218
View directory record Official record
Conditions
Left Ventricular Ejection Fraction, Heart Failure (HF), Left Bundle-Branch Block
Interventions
LB-CRT, BIV-CRT
Device
Lead sponsor
Inova Health Care Services
Other
Eligibility
Not listed
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
2
States / cities
Durham, North Carolina • Falls Church, Virginia
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 1, 2026, 2:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Strategic Management to Optimize Response To Cardiac Resynchronization Therapy

NCT03089281
View directory record Official record
Conditions
Heart Failure
Interventions
CRT-D
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
699 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
41
States / cities
Birmingham, Alabama • Huntsville, Alabama • Tucson, Arizona + 37 more
Source: ClinicalTrials.gov public record
Updated Apr 4, 2022 · Synced Sep 1, 2026, 2:19 PM EDT
Terminated Not applicable Interventional Results available

Pacing Affects Cardiovascular Endpoints in Patients With Right Bundle-Branch Block (The PACE-RBBB Trial)

NCT01169493
View directory record Official record
Conditions
Heart Failure, Right Bundle-Branch Block
Interventions
VVI-40, RV DDD-40, BiV DDD-40
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
2
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 22, 2016 · Synced Sep 1, 2026, 2:19 PM EDT
Terminated Not applicable Interventional Results available

Biventricular Versus Right Ventricular Pacing

NCT06298669
View directory record Official record
Conditions
Heart Failure
Interventions
Biventricular Pacing, Right Ventricular Pacing
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Dec 9, 2024 · Synced Sep 1, 2026, 2:19 PM EDT