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ClinicalTrials.gov public records Last synced Nov 15, 2026, 9:35 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 241–264 of 423 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Botulinum toxin(Botox) Clear all

Conditions: Sialorrhea
Interventions: MYOBLOC, PLACEBO; Drug · Other
Lead sponsor: Solstice Neurosciences, LLC, a subsidiary of US WorldMeds, LLC; Industry
Eligibility: 18 Years to 85 Years
Enrollment: 187 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 24
States / cities: Loma Linda, California • Los Angeles, California • National City, California + 21 more

Conditions: Wound; Abdomen, Abdominal Wall
Interventions: Botulinum Toxin Type A, Placebo; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2015
U.S. locations: 2
States / cities: Rochester, Minnesota • Saint Paul, Minnesota

Conditions: Spasticity
Interventions: intramuscular Botox versus oral baclofen; Drug
Lead sponsor: Vanderbilt University; Other
Eligibility: 18 Years and older
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Stroke With Hemiparesis
Interventions: Botulinum Toxin commonly known as BOTOX®, Placebo; Drug
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 75 Years
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2015
U.S. locations: 1
States / cities: New York, New York

Conditions: Intrinsic Aging of Skin, Solar Elastosis
Interventions: Right lateral orbital injection of Botox Cosmetic or Dysport, Left lateral orbital injection of Botox Cosmetic or Dysport; Drug
Lead sponsor: The Maas Clinic; Other
Eligibility: 18 Years and older
Enrollment: 90 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2014
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Migraine
Interventions: Botulinum toxin type A; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 37 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2023
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Spasticity of the Upper and Lower Limb Due to Cerebral Causes
Interventions: IncobotulinumtoxinA; Drug
Lead sponsor: Merz Pharmaceuticals GmbH; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 155 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 6
States / cities: Doral, Florida • Indianapolis, Indiana • New York, New York + 3 more

Conditions: Adolescent Idiopathic Scoliosis
Interventions: AbobotulinumtoxinA, Placebos, Custom Thoracolumbosacral Orthosis; Drug · Device
Lead sponsor: Johns Hopkins University; Other
Eligibility: 10 Years to 16 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2026
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Upper Extremity Spasticity, Stroke, Acquired Brain Injury
Interventions: Functional Electrical Stimulation (FES) through the Ness H200; Device
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years to 70 Years
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Temporomandibular Joint Disorders, Bruxism, Temporomandibular Joint Dysfunction Syndrome, Myofascial Pain Dysfunction Syndrome, Temporomandibular Joint
Interventions: onabotulinumtoxinA; Drug
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Amyotrophic Lateral Sclerosis, Sialorrhea
Interventions: Botulinum toxin type B (Myobloc), Injection of salivary glands; Drug · Procedure
Lead sponsor: The University of Texas Health Science Center at San Antonio; Other
Eligibility: 21 Years to 85 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2007
U.S. locations: 2
States / cities: Kansas City, Kansas • Charlotte, North Carolina

Conditions: Spinal Cord Injuries
Interventions: Bladder chemodenervation (Botox), Bladder Sham (Saline) Injection Procedure; Drug · Procedure
Lead sponsor: University of Washington; Other
Eligibility: 18 Years to 65 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Glabellar Frown Lines
Interventions: botulinum toxin, Placebo; Biological
Lead sponsor: Galderma R&D; Industry
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 13
States / cities: Manhattan Beach, California • Vista, California • New Orleans, Louisiana + 8 more

Conditions: Post Traumatic Stiffness
Interventions: Botulinum Toxin Type A, Saline; Drug
Lead sponsor: Columbia University; Other
Eligibility: 18 Years and older
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2010
U.S. locations: 1
States / cities: New York, New York

Conditions: Herpes Labialis
Interventions: onabotulinumtoxinA, Bacteriostatic normal saline; Drug · Other
Lead sponsor: DeNova Research; Other
Eligibility: 18 Years to 64 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Facial Contouring
Interventions: OnabotulinumtoxinA, JUVÉDERM, CoolSculpting Elite System, SkinMedica Products, KYBELLA; Drug · Device · Other
Lead sponsor: AbbVie; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 130 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 10
States / cities: Redondo Beach, California • Vista, California • Washington D.C., District of Columbia + 7 more

Conditions: Overactive Bladder, Overactive Bladder Syndrome, Urinary Urgency, Urinary Incontinence, Urinary Frequency/Urgency, Urinary Bladder, Overactive
Interventions: OnabotulinumtoxinA 100Unit Injection; Drug
Lead sponsor: Corewell Health East; Other
Eligibility: 18 Years and older
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Royal Oak, Michigan

Conditions: Lateral Canthal Lines, Crow's Feet, Facial Wrinkles
Interventions: Botulinum Toxin Type A, Placebo; Drug
Lead sponsor: Revance Therapeutics, Inc.; Industry
Eligibility: 30 Years to 60 Years
Enrollment: 73 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Carpometacarpal Sprain, Thumb Sprain, Clostridium; Botulinum
Interventions: Botulinum toxin, Standard-of-care corticosteroid injections; Drug
Lead sponsor: Rhode Island Hospital; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Lateral Canthal Lines
Interventions: botulinum toxin, Placebo; Biological
Lead sponsor: Galderma R&D; Industry
Eligibility: 18 Years and older
Enrollment: 303 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 8
States / cities: Manhattan Beach, California • San Diego, California • Solana Beach, California + 5 more

Conditions: Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS)
Interventions: BOTOX, Placebo for BOTOX; Drug
Lead sponsor: AbbVie; Industry
Eligibility: 18 Years to 75 Years · Female only
Enrollment: 83 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 40
States / cities: Homewood, Alabama • Mobile, Alabama • Buena Park, California + 32 more

Conditions: Stroke, Muscle Spasticity, Motor Neuron Disease
Interventions: botulinum toxin Type A, saline; Biological · Drug
Lead sponsor: Allergan; Industry
Eligibility: 18 Years and older
Enrollment: 155 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2009
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Moderate to Severe Glabellar Frown Lines
Interventions: IncobotulinumtoxinA (Xeomin) (20 Units), Placebo; Drug
Lead sponsor: Merz Pharmaceuticals GmbH; Industry
Eligibility: 18 Years and older
Enrollment: 271 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 8
States / cities: Englewood, Colorado • Aventura, Florida • Coral Gables, Florida + 5 more

Conditions: Hallux Abducto Valgus
Interventions: Botulinum toxin type A, Placebo; Biological · Drug
Lead sponsor: Ipsen; Industry
Eligibility: 18 Years and older
Enrollment: 186 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 29
States / cities: Jonesboro, Arkansas • Little Rock, Arkansas • Castro Valley, California + 25 more

Search by objective public record fields.

Efficacy and Safety Study of MYOBLOC® in the Treatment of Sialorrhea in Adult Subjects

The Biomechanical Effects of Flaccid Paralysis Induced by Botulinum Toxin a After Damage Control Laparotomy

Botox vs. Baclofen for Upper Limb Spasticity

Study of Botulinum Toxin and Recovery of Hand Function After Stroke

Onabotulinum Toxin Type A and Abobotulinum Toxin Type A Crow's Feet Rhytid Study

(Botox) Mechanisms of Action in Altering the Molecular Environment in Which Pain Fibers Exist

Efficacy and Safety Dose Titration Study of Botulinum Toxin Type A to Treat Spasticity in the Leg and Arm

Dysport ® as an Adjunctive Treatment to Bracing in the Management of Adolescent Idiopathic Scoliosis

Efficacy of Functional Electrical Stimulation (FES) in Persons Receiving Botulinum Neurotoxin for Upper Extremity Spasticity

Botox for Treatment of TMJ Disorder With Bruxism

Study of Myobloc in the Treatment of Sialorrhea (Drooling) in Patients With Amyotrophic Lateral Sclerosis (ALS)

Early BOTOX After Spinal Cord Injury

Treatment of Moderate to Severe Glabellar Lines

Botulinum Toxin as a Novel Treatment for Prevention of Post-Traumatic Elbow Stiffness

Botulinum Toxin A for Herpes Labialis

A Study to Evaluate Patient Satisfaction With the Overall Face and Neck Appearance After Combined Treatment of OnabotulinumtoxinA, JUVÉDERM® Products, KYBELLA, CoolSculpting Elite and SkinMedica Products

OnabotulinumtoxinA Bladder Injection Study

Safety and Efficacy Study of RT001 to Treat Moderate to Severe Lateral Canthal Lines

Injection of Botulinum Toxin for Thumb Carpometacarpal Arthritis

Treatment of Moderate to Severe Lateral Canthal Lines

Study of BOTOX Injections to Assess Change in Disease Activity and Adverse Events in Adult Female Participants With Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS)

Safety Study of Botulinum Toxin Type A in Post-Upper Limb Stroke Patients With Reduced Lung Function

IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Glabellar Frown Lines

Dysport in Hallux Abducto Valgus (HAV) Phase IIa