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ClinicalTrials.gov public records Last synced Nov 15, 2026, 1:10 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 313–336 of 423 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Botulinum toxin(Botox) Clear all

Conditions: Overactive Bladder
Interventions: Hydrodistention, Botulinum toxin-A; Procedure · Drug
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years and older · Female only
Enrollment: 3 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Migraine Disorders, Headache, Migraine, Pediatrics
Interventions: OnabotulinumtoxinA, Placebo (Saline); Drug · Other
Lead sponsor: University of California, Irvine; Other
Eligibility: 8 Years to 17 Years
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 2
States / cities: Irvine, California • Orange, California

Conditions: Upper Limb Spasticity
Interventions: Botulinum toxin type A, BoNT-A, Rehabilitation Therapy; Drug · Other
Lead sponsor: JoAnn Harnar; Other
Eligibility: 18 Years and older
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Albuquerque, New Mexico

Conditions: Cerebral Palsy
Interventions: Upper Extremity Tendon transfer, Botulinum Toxin injections in Upper Extremity, Regularly ongoing therapy; Procedure
Lead sponsor: Shriners Hospitals for Children; Other
Eligibility: 4 Years to 17 Years
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2013
U.S. locations: 10
States / cities: Sacramento, California • Wilmington, Delaware • Washington D.C., District of Columbia + 7 more

Conditions: Glabellar Frown Lines
Interventions: IncobotulinumtoxinA, OnabotulinumtoxinA; Drug
Lead sponsor: Merz North America, Inc.; Industry
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014
U.S. locations: 10
States / cities: Los Angeles, California • Sacramento, California • Santa Monica, California + 6 more

Conditions: Platysma Prominence
Interventions: NT 201, NT 201 Placebo; Drug
Lead sponsor: Merz Aesthetics GmbH; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 73 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 7
States / cities: Washington D.C., District of Columbia • Aventura, Florida • Coral Gables, Florida + 3 more

Conditions: Drug-resistant Focal Seizure
Interventions: OnabotulinumtoxinA 145 UNT [Botox]; Drug
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 18 Years to 85 Years
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Migraine Disorders
Interventions: onabotulinumtoxinA, Topiramate; Biological · Drug
Lead sponsor: Allergan; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 282 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 32
States / cities: Phoenix, Arizona • Encinitas, California • Fresno, California + 28 more

Conditions: Torticollis, Cervical Dystonia
Interventions: Botulinum Toxin A; Drug
Lead sponsor: Henry Ford Health System; Other
Eligibility: 18 Years to 90 Years
Enrollment: 7 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Pediatrics, Muscle Spasticity, Cerebral Palsy, Stroke
Interventions: Botulinum Toxin Type A; Biological
Lead sponsor: Allergan; Industry
Eligibility: 2 Years to 17 Years
Enrollment: 220 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2018
U.S. locations: 24
States / cities: Pasadena, California • Pomona, California • San Diego, California + 19 more

Conditions: Raynaud's Syndrome
Interventions: botulinum toxin A; Drug
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 89 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Benign Prostatic Hyperplasia
Interventions: botulinum toxin Type A, Normal saline; Drug
Lead sponsor: Allergan; Industry
Eligibility: 45 Years and older · Male only
Enrollment: 315 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Newport Beach, California

Conditions: Cervical Dystonia Adults ,, Abnormal Head Position and Neck Pain for These 7 Muscle Groups: Splenius,Scalene,Sterno-cleido-mastoid,Levator Scapulae,Semispinalis,Trapezius,and Longissimus.
Interventions: Gadolinium, Efficacy of Botox intramuscularly at Week 6, Efficacy of Botox intramuscularly at Week 12, Efficacy of Botox intramuscularly at Week 18, Efficacy of Botox intramuscularly at Week 24, Efficacy of Botox intramuscularly at Week 30, Efficacy of Botox subdermally at Week 6, Efficacy of Botox subdermally at Week 12, Efficacy of Botox subdermally at Week 18, Efficacy of Botox subdermally at Week 24, Efficacy of Botox subdermally at Week 30, Adverse Reactions of Botox intramuscularly, Adverse Reactions of Botox subdermally; Drug
Lead sponsor: li nguyen; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Westminster, California

Conditions: Leg Spasticity
Interventions: Botulinum toxin type A, Placebo; Biological · Drug
Lead sponsor: Ipsen; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 388 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 17
States / cities: Scottsdale, Arizona • Downey, California • Oxnard, California + 12 more

Conditions: Urinary Incontinence, Overactive Bladder With Urinary Incontinence
Interventions: OnabotulinumtoxinA and Hydrogel admixture, Placebo and Hydrogel admixture; Drug
Lead sponsor: Allergan; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 383 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 61
States / cities: Birmingham, Alabama • Mobile, Alabama • Tucson, Arizona + 55 more

Conditions: Bruxism
Interventions: Botulinum toxin type A, Placebo arm; Drug
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 18 Years to 80 Years
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Stress (Psychology), Stress, Healthy Adult Female Participants, Stress, Psychologic, Stress, Psychological Cumulative, Stress, Physiological, Stress Response, Stress Levels, Stress Perception
Interventions: Intramuscular injection, OnabotulinumtoxinA (Botox®) Injections, Sodium Chloride; Procedure · Drug · Other
Lead sponsor: Center for Advanced Facial Plastic Surgery; Other
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 4 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Beverly Hills, California

Conditions: Lateral Canthal Lines, Crow's Feet, Facial Wrinkles
Interventions: RT001; Drug
Lead sponsor: Revance Therapeutics, Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010
U.S. locations: 3
States / cities: Birmingham, Alabama • San Diego, California • Omaha, Nebraska

Conditions: Synkinesis
Interventions: Neuromuscular Retraining Therapy (4 months), Chemodenervation (4 months), Neuromuscular Retraining + Chemodenervation; Other · Drug
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years to 89 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Pelvic Pain, Dyspareunia, Pelvic Floor Dysfunction
Interventions: Botulinum toxin A 50u, Botulinum toxin A 100u, Botulinum toxin A 150u; Drug
Lead sponsor: EvergreenHealth; Other
Eligibility: 18 Years and older · Female only
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Kirkland, Washington

Conditions: Platysma Prominence
Interventions: OnabotulinumtoxinA; Drug
Lead sponsor: AbbVie; Industry
Eligibility: 18 Years and older
Enrollment: 292 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 25
States / cities: Glendale, Arizona • Scottsdale, Arizona • Encino, California + 22 more

Conditions: Glabellar Frown Lines
Interventions: botulinum toxin Type A, normal saline (placebo); Biological · Drug
Lead sponsor: Allergan; Industry
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011
U.S. locations: 1
States / cities: East Chicago, Illinois

Conditions: Peripheral Neuropathy Due to Chemotherapy
Interventions: IncobotulinumtoxinA (Xeomin®, Merz) (INA), Normal saline; Drug
Lead sponsor: Medical College of Wisconsin; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Milwaukee, Wisconsin

Conditions: Parkinson Disease
Interventions: Onabotulinumtoxin A Injection, Placebo; Drug · Other
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 45 Years to 80 Years
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Search by objective public record fields.

Evaluation of Botulinum Toxin A Alone Versus Botulinum Toxin A With Hydrodistension for Treatment of Overactive Bladder

Effectiveness of Onabotulinumtoxin A (Botox) in Pediatric Patients Experiencing Migraines: A Study in the Pediatric Pain Population

Efficacy and Safety Study of Botulinum Neurotoxin A With Rehabilitation Versus Botulinum Neurotoxin A Alone in Treatment of Post-stroke Spasticity

Comparison of Tendon Transfer, Botox Injections and Ongoing Treatment in Hemiplegic Cerebral Palsy

The Treatment of Glabellar Frown Lines

A Study of NT 201 Doses in the Treatment of Platysma Prominence

BOTOX Effects on Seizure Severity and Susceptibility

Efficacy and Safety Study of BOTOX® Compared to Topiramate for the Prevention of Chronic Migraine in Adults

Effects of Botulinum Toxin in Cervical Dystonia

BOTOX® Open-Label Treatment in Pediatric Upper Limb Spasticity

Botulinum Toxin in the Treatment of Raynaud's

Safety and Efficacy of Botulinum Toxin Type A to Treat Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia

ASIS for Botox in Cervical Dystonia

Dysport® Adult Lower Limb Spasticity Study

BOTOX® Intravesical Instillation in Participants With Overactive Bladder and Urinary Incontinence

Study of the Safety and Efficacy of Botox in Bruxism

Impact of OnabotulinumtoxinA (BOTOX®) on Stress

Safety Study of Two Repeat Doses of RT001 for the Treatment of Moderate to Severe Lateral Canthal Lines in Adults

Mixed Methods Investigation of Chronic Facial Paralysis in Individuals With Synkinesis

A Trial of Pelvic Floor Chemodenervation in Patients Undergoing Physical Therapy for High Tone Pelvic Floor Dysfunction

A Study To Assess the Safety of OnabotulinumtoxinA (BOTOX) Intramuscular Injection in Adult Participants With Platysma Prominence

Patient Satisfaction Study of BOTOX® Cosmetic in the Treatment of Moderate to Severe Frown Lines

Botulinum Toxin A for the Treatment of Chemotherapy Induced Peripheral Neuropathy

Effectiveness of Botox on Reducing Rest Tremor in Parkinson's Disease