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ClinicalTrials.gov public records Last synced Nov 15, 2026, 7:15 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 423 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Botulinum toxin(Botox) Clear all

Conditions: Muscle Strength, Botulinum Toxins, Type A
Interventions: Botulinum Toxin, Type A, Saline; Drug
Lead sponsor: Loma Linda University; Other
Eligibility: 18 Years to 54 Years
Enrollment: 13 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2015
U.S. locations: 2
States / cities: Loma Linda, California

Conditions: Overactive Bladder
Interventions: OnabotulinumtoxinA 100 Units; Drug
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years to 90 Years · Female only
Enrollment: 41 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 2
States / cities: Greensboro, North Carolina • Winston-Salem, North Carolina

Conditions: Rhytides
Interventions: PrabotulinumtoxinA-Xvfs, OnabotulinumtoxinA; Drug
Lead sponsor: Lupo Center for Aesthetic and General Dermatology; Other
Eligibility: 18 Years to 65 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: New Orleans, Louisiana

Conditions: Stroke, Muscle Spasticity
Interventions: Botox (botulinum toxin); Drug
Lead sponsor: New York Presbyterian Hospital; Other
Eligibility: 18 Years to 80 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: New York, New York

Conditions: Atopic Dermatitis (AD)
Interventions: Onabotulinum Toxin Type A - Phase 1b, Onabotulinum Toxin Type A - Phase 2; Drug
Lead sponsor: Daniel Kaplan; Other
Eligibility: 18 Years and older
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 2
States / cities: Pittsburgh, Pennsylvania

Conditions: Essential Tremor of the Upper Limb
Interventions: NT 201, Placebo; Drug
Lead sponsor: Merz Pharmaceuticals GmbH; Industry
Eligibility: 18 Years and older
Enrollment: 78 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 9
States / cities: Tampa, Florida • Omaha, Nebraska • Las Vegas, Nevada + 6 more

Conditions: Muscle Spasticity
Interventions: botulinum toxin Type A, Normal Saline; Biological · Drug
Lead sponsor: Allergan; Industry
Eligibility: 18 Years to 85 Years
Enrollment: 468 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 2
States / cities: Downey, California • Daytona Beach, Florida

Conditions: Vaginismus
Interventions: BOTOX; Biological
Lead sponsor: Plastic Surgery Professional Association; Other
Eligibility: 20 Years to 40 Years · Female only
Enrollment: 31 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Manchester, New Hampshire

Conditions: Glabellar Frown Lines
Interventions: Botulinum purified neurotoxin, Type A; Biological
Lead sponsor: Evolus, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 352 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Santa Monica, California

Conditions: Overactive Bladder, Urinary Urge Incontinence, Overactive Bladder Syndrome, Urinary Incontinence, Urge, Urge Incontinence, Urinary Urgency, Urinary Frequency
Interventions: OnabotulinumtoxinA 100 UNT [Botox]; Drug
Lead sponsor: University of California, Irvine; Other
Eligibility: 18 Years and older · Female only
Enrollment: 116 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Orange, California

Conditions: Episodic Migraine
Interventions: BOTOX, Placebo; Drug
Lead sponsor: AbbVie; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 775 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 82
States / cities: Hoover, Alabama • Huntsville, Alabama • Phoenix, Arizona + 69 more

Conditions: Glabellar Frown Lines
Interventions: Botulinum Toxin Type A, Placebo; Drug
Lead sponsor: Galderma R&D; Industry
Eligibility: 18 Years and older
Enrollment: 359 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 8
States / cities: Birmingham, Alabama • Mobile, Alabama • San Diego, California + 5 more

Conditions: Esophageal Cancer Surgery, Esophagectomy, Delayed Gastric Emptying Following Procedure, Esophageal Diseases, Esophageal Achalasia, Pylorus Dysfunction, Esophageal Dysmotility
Interventions: Botulinum Toxin A (Botox ), Pyloromyotomy; Biological · Procedure
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years and older
Enrollment: 170 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Prostate Cancer, Lower Urinary Tract Symptoms, Radioactive Seed Implantation
Interventions: Botox injection, Saline injection; Drug
Lead sponsor: Emory University; Other
Eligibility: 18 Years and older · Male only
Healthy volunteers: Healthy volunteers not accepted
Timeline: Ends 2012
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Glabellar Frown Lines
Interventions: DWP-450 (Botulinum purified neurotoxin, Type A); Biological
Lead sponsor: Evolus, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 570 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: Convergence Insufficiency, Divergence Insufficiency, Hypertropia
Interventions: Prism, Orthoptic Exercises, Eye Muscle Surgery, Botox Injection; Device · Other · Procedure
Lead sponsor: Jaeb Center for Health Research; Other
Eligibility: 18 Years and older
Enrollment: 217 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: Norfolk, Virginia

Conditions: Forehead Rhytid Complex, Glabellar Rhytid Complex
Interventions: Botulinum Toxin A; Procedure
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2022
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Moderate to Severe Glabellar Frown Lines
Interventions: NT 201; Drug
Lead sponsor: Merz Aesthetics GmbH; Industry
Eligibility: 18 Years and older
Enrollment: 241 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 5
States / cities: Encino, California • Newport Beach, California • San Diego, California + 2 more

Conditions: Facial Flushing
Interventions: botulinum toxin A, Saline Control; Drug · Other
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 16 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2027
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Parkinson Disease, Depression
Interventions: OnabotulinumtoxinA, Control; Biological
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 95 Years
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Scleroderma, Raynaud's Syndrome
Interventions: Onabotulinumtoxin A, sterile saline solution; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Cervical Dystonia
Interventions: Botulinum toxin type A; Biological
Lead sponsor: Ipsen; Industry
Eligibility: 18 Years and older
Enrollment: 108 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2008
U.S. locations: 14
States / cities: Phoenix, Arizona • Fountain Valley, California • Los Angeles, California + 10 more

Conditions: Post-stroke Spasticity of the Lower Limb
Interventions: IncobotulinumtoxinA (400 Units), Placebo Comparator; Drug
Lead sponsor: Merz Pharmaceuticals GmbH; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 290 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2015
U.S. locations: 12
States / cities: Downey, California • Long Beach, California • Fairfield, Connecticut + 9 more

Conditions: Compartment Syndrome of Leg
Interventions: Botox; Drug
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022
U.S. locations: 1
States / cities: Madison, Wisconsin

Search by objective public record fields.

Assessment of the Effect of Botulinum Toxin in Extensor Digitorum Brevis Via Strain Gauge and Nerve Conduction Studies

Is 10 Injections of Bladder Botox Less Painful Than 20 Injections?

Spread of PrabotulinumtoxinA-xvfs Versus OnabotulinumtoxinA in the Treatment of Forehead Rhytides

Exploring Advanced Imaging Techniques to Characterize Botulinum Toxin Diffusion in Human Muscle

The Impact of Botox on Neuroimmune Interactions in Atopic Dermatitis

A Study to Investigate the Efficacy and Safety of NT 201 (Botulinum Toxin) Compared With Placebo for the Treatment of Adult Participants With Essential Tremor in the Arm

BOTOX® Treatment in Adult Patients With Post-Stroke Lower Limb Spasticity

Botox Injection for Treatment of Vaginismus

Safety Study of DWP-450 (Botulinum Purified Neurotoxin, Type A) Injection to Treat Glabellar Lines

Intradetrusor Botulinum Toxin A for OAB Via 1 Versus 10 Injections: A Randomized Clinical Trial

Study of BOTOX Injections in Prevention of Migraine in Adult Participants With Episodic Migraine

Safety and Efficacy Study of Botulinum Toxin for the Treatment of Glabellar Frown Lines

Effectiveness of Methods for Pyloric Drainage in esophagecTomY: Botox vs. Pyloromyotomy

Botulinum Toxin Injection With Prostate Brachytherapy

Safety Study of DWP-450 (Botulinum Toxin, Type a) to Treat Glabellar Lines - EV-006

A Prospective Observational Study of Adult Strabismus

Treatment of Forehead/Glabellar Rhytide Complex With Botulinum Toxin A Injection

Study to Investigate the Safety and Duration of Effect of Different Botulinum Toxin A (NT 201) Dose Groups Following the Treatment of Glabellar Frown Lines

Treatment of Facial Flushing With Botulinum Toxin A Injections

Trial of OnabotulinumtoxinA for Depression in Parkinson Disease

Efficacy of Botulinum Toxin In Scleroderma-Associated Raynaud's Syndrome

Open-label Extension Study of AbobotulinumtoxinA (Dysport®) for the Treatment of Cervical Dystonia

Efficacy and Safety Study of Botulinum Toxin Type A Against Placebo to Treat Spasticity in the Leg After a Stroke

Botox for the Treatment of Recurrent Chronic Exertional Compartment Syndrome