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ClinicalTrials.gov public records Last synced Oct 9, 2026, 2:24 AM EDT

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Showing 49–72 of 160 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Bupivacaine Injection 0.5% Clear all
Completed Phase 4 Interventional

Transmuscular Quadratus Lumborum Block Plus Pericapsular Injection vs Pericapsular Injection

NCT04353414
View directory record Official record
Conditions
Hip Pain Chronic
Interventions
Transmuscular Quadratus Lumborum Block, Pericapsular injection, Bupivacaine Hydrochloride
Procedure · Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 65 Years
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 2, 2022 · Synced Oct 9, 2026, 2:24 AM EDT
Not listed Phase 3 Interventional

Corticosteroid vs. Amniotic Fluid Injections in Patients With Trigger Finger

NCT03583151
View directory record Official record
Conditions
Stenosing Tenosynovitis
Interventions
Amniotic fluid injection, Steroid injection
Biological
Lead sponsor
J&M Shuler
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 11, 2018 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Phase 3 Interventional

A Sequenced Strategy for Improving Outcomes in People With Knee Osteoarthritis Pain

NCT04504812
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Duloxetine, Intra-Articular Injection, Nerve Procedure with long acting blocks, Nerve Procedure with nerve ablation, Pain Coping Skills Training, Best Practices
Drug · Combination Product · Procedure + 2 more
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
1,937 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
24
States / cities
Sacramento, California • San Diego, California • Aurora, Colorado + 19 more
Source: ClinicalTrials.gov public record
Updated Apr 9, 2026 · Synced Oct 9, 2026, 2:24 AM EDT
Recruiting Phase 4 Interventional

Liposomal Bupivacaine Versus Plain Bupivacaine After Intercostal Injections For Pain Management After Thoracoscopy

NCT03737292
View directory record Official record
Conditions
Pain, Postoperative, Pharmacokinetics
Interventions
Exparel, Bupivacaine
Drug
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 12, 2026 · Synced Oct 9, 2026, 2:24 AM EDT
Terminated Phase 4 Interventional Results available

Liposomal Bupivacaine vs Continuous Nerve Catheters for Below the Knee Amputations

NCT05140499
View directory record Official record
Conditions
Pain, Postoperative, Amputation
Interventions
Liposomal bupivacaine, Bupivacaine Hydrochloride 0.5 % Injectable Solution
Drug
Lead sponsor
Aurora Quaye
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Portland, Maine
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Oct 9, 2026, 2:24 AM EDT
Withdrawn Phase 4 Interventional

Effective Pain Management During Shoulder Replacement Surgery With EXPAREL

NCT03474510
View directory record Official record
Conditions
Pain, Postoperative, Shoulder Osteoarthritis
Interventions
local infiltration of liposomal bupivacaine, continuous infusion of ropivacaine interscalene nerve block
Drug · Other
Lead sponsor
TriHealth Inc.
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 1, 2021 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Para-cervical Block Prior to Laparoscopic Hysterectomy as an Adjuvant Treatment to Reduce Postoperative Pain.

NCT03027661
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Bupivacaine, 0.9% Sodium Chloride
Drug
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Chattanooga, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 15, 2018 · Synced Oct 9, 2026, 2:24 AM EDT
Terminated Phase 4 Interventional

Pain Management After Total Shoulder Arthroplasty

NCT03219983
View directory record Official record
Conditions
Glenohumeral Arthritis, Total Shoulder Arthroplasty
Interventions
Ropivacaine, liposomal bupivacaine
Drug
Lead sponsor
The Christ Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 6, 2017 · Synced Oct 9, 2026, 2:24 AM EDT
Terminated Phase 4 Interventional Results available

Phase 4, Controlled Study in Adult Subjects Undergoing Primary, 1-2 Level, Open Lumbar Spinal Fusion Surgery

NCT03015961
View directory record Official record
Conditions
Postoperative Pain Management
Interventions
EXPAREL and bupivacaine HCl, Bupivacaine HCl
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
15
States / cities
Gilbert, Arizona • Phoenix, Arizona • Sacramento, California + 12 more
Source: ClinicalTrials.gov public record
Updated Oct 13, 2021 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Phase 4 Interventional Results available

Greater Occipital Nerve Block for Migraine Prophylaxis

NCT00915473
View directory record Official record
Conditions
Migraine Headache
Interventions
bupivicaine, normal saline, methylprednisolone, lidocaine
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 75 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Mar 20, 2014 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Phase 4 Interventional Results available

Local Infiltration Analgesia With and Without EXPAREL Following Total Knee Arthroplasty

NCT02713490
View directory record Official record
Conditions
Pain
Interventions
EXPAREL, Bupivacaine
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older · Male only
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
17
States / cities
Fremont, California • Loma Linda, California • Fort Lauderdale, Florida + 13 more
Source: ClinicalTrials.gov public record
Updated Dec 11, 2020 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Regional TAP Block for Bariatric Patients

NCT04051684
View directory record Official record
Conditions
Bariatric Surgery, Transverse Abdominal Plane Regional Blocks
Interventions
Transverse abdominal plane block, Ropivacaine
Procedure · Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years to 100 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Dec 3, 2019 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Not applicable Interventional

Interscalene Bupivacaine With Either Liposomal Bupivacaine or Continuous Peripheral Nerve Block for Shoulder Arthroscopy

NCT03816982
View directory record Official record
Conditions
Shoulder Pain
Interventions
Single-injection bupivacaine HCl plus liposomal bupivacaine, Single-injection bupivacaine HCl plus a subsequent bupivacaine CISB
Procedure
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 23, 2023 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Phase 4 Interventional Results available

Single Shot Versus OnQ Pump in Extremity Fractures

NCT02280291
View directory record Official record
Conditions
Pain, Fracture
Interventions
Ankle SSB, Ankle OnQ, DR SSB, DR OnQ
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 90 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 30, 2020 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Phase 4 Interventional

Measuring Opioid Use After Rotator Cuff Repair: Comparing the Effects of Standard vs. Extended-release Nerve Blocks

NCT05482113
View directory record Official record
Conditions
Rotator Cuff Tears
Interventions
Liposomal bupivacaine, Bupivacaine Hcl 0.25% Inj
Drug
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 1, 2022 · Synced Oct 9, 2026, 2:24 AM EDT
Recruiting Phase 4 Interventional

EXPAREL Post-tonsillectomy Clinical Trial

NCT03420638
View directory record Official record
Conditions
Tonsillectomy
Interventions
Adjunct Exparel (bupivacaine liposome suspension 1.3%), Standard Care
Drug · Other
Lead sponsor
Paul Hoff
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
2
States / cities
Ann Arbor, Michigan • Ypsilanti, Michigan
Source: ClinicalTrials.gov public record
Updated May 19, 2021 · Synced Oct 9, 2026, 2:24 AM EDT
Not listed Phase 3 Interventional

Intra-articular Analgesia Versus Adductor Canal Block for Arthroscopic Knee Surgery

NCT05004506
View directory record Official record
Conditions
Post-Operative Pain, Chronic
Interventions
Adductor Canal Block, Intra-articular Injection
Drug
Lead sponsor
Loyola University
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 12, 2022 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Femoral Nerve Block Versus Adductor Canal Nerve Block for Peri-Operative Analgesia Following Anterior Cruciate Ligament (ACL) Reconstruction: Evaluation of Post-operative Pain and Strength

NCT03033589
View directory record Official record
Conditions
Pain
Interventions
Marcaine 0.25 % Injectable Solution
Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
16 Years and older
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparing Two Injection Sites of Local Anesthetic for Hand Surgery

NCT02112006
View directory record Official record
Conditions
Hand Injury, Wrist Injury, Finger Injury
Interventions
0.5% bupivacaine injected in the forearm, 20-30ml of 0.5% bupivacaine.
Procedure
Lead sponsor
Jose Soberon, MD
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Mar 22, 2016 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Neurophysiology of Weakness and Exercise in Rotator Cuff Tendinopathy

NCT02971072
View directory record Official record
Conditions
Acute Pain, Atrophic, Goals, Impairment, Infiltration, Injury, Muscle Weakness, Pain, Pathology, Shoulder Pain, Syndrome, Tendinopathy
Interventions
Subacromial injection, Physical Therapy
Procedure · Other
Lead sponsor
University of Oregon
Other
Eligibility
21 Years to 45 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2021
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 13, 2022 · Synced Oct 9, 2026, 2:24 AM EDT
Withdrawn Not applicable Interventional

Bupivacaine Injections Into Uterosacral Ligaments During Robotic Assisted Total Hysterectomies

NCT02230735
View directory record Official record
Conditions
Pain
Interventions
Bipivacaine 0.5% with epinephrine, Normal Saline
Drug
Lead sponsor
Souza, Amanda, M.D.
Individual
Eligibility
21 Years to 65 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Farmington Hills, Michigan
Source: ClinicalTrials.gov public record
Updated May 5, 2016 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Phase 1 Interventional Results available

Transversus Abdominis Plane (TAP) Block Using Liposomal Bupivacaine in Metabolic and Bariatric Surgery Patients

NCT05537883
View directory record Official record
Conditions
Morbid Obesity, Bariatric Surgery Candidate
Interventions
Liposomal bupivacaine, Bupivacaine Injection
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 11, 2025 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Not applicable Interventional

Effect of Reparel Knee Sleeve With Knee Injection

NCT04859764
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Reparel knee sleeve, Corticosteroid injection, Placebo knee sleeve
Device · Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 99 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 21, 2026 · Synced Oct 9, 2026, 2:24 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Paracervical Injection and Opioid Use After Vaginal Hysterectomy for Prolapse

NCT07213635
View directory record Official record
Conditions
Opioid Use, Surgical Recovery, Vaginal Hysterectomy, Prolapse Pelvic, Postoperative Pain
Interventions
Bupivacaine-epinephrine, Normal saline
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older · Female only
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 2, 2026 · Synced Oct 9, 2026, 2:24 AM EDT