Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 15, 2026, 5:39 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 353 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Bupropion Hydrochloride Clear all

Conditions: Binge-Eating Disorder, Obesity
Interventions: Cognitive-Behavioral Therapy (CBT), NB Medication (on-going from acute treatment); Behavioral · Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Tobacco Cessation
Interventions: Tailored behavioral counseling, Tobacco cessation pharmacotherapy; Behavioral · Drug
Lead sponsor: Iowa City Veterans Affairs Medical Center; Federal
Eligibility: 18 Years to 99 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Smoking, Nicotine Dependence
Interventions: Naltrexone, Bupropion; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2005
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Major Depressive Disorder, Neuroticism, Cognitive Change, Stress
Interventions: Sertraline, bupropion, desvenlafaxine; Drug
Lead sponsor: David Steffens; Other
Eligibility: 65 Years and older
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Farmington, Connecticut

Conditions: Tobacco Use Disorder
Interventions: Memantine, bupropion, placebo; Drug
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 21 Years to 45 Years
Enrollment: 45 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2009
U.S. locations: 1
States / cities: New York, New York

Conditions: Nicotine Dependence, Nicotine Withdrawal
Interventions: Bupropion, Varenicline; Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 121 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Sleep Disturbance, Fatigue, Inflammatory Bowel Disease
Interventions: Behavioral Counseling, bupropion-SR; Behavioral · Drug
Lead sponsor: Eva Szigethy; Other
Eligibility: 15 Years to 30 Years
Enrollment: 99 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2016
U.S. locations: 2
States / cities: Pittsburgh, Pennsylvania

Conditions: Depression
Interventions: Paroxetine, Bupropion; Drug
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 18 Years to 65 Years
Enrollment: 101 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2013
U.S. locations: 1
States / cities: New York, New York

Conditions: Smoking Cessation
Interventions: AXS-05 (dextromethorphan-bupropion), Bupropion, Placebo; Drug
Lead sponsor: Axsome Therapeutics, Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 705 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 28
States / cities: Phoenix, Arizona • Little Rock, Arkansas • Lemon Grove, California + 24 more

Conditions: Depressive Disorder, Major, Major Depressive Disorder (MDD)
Interventions: Bupropion Hydrochloride Extended-release, Extended-release Venlafaxine; Drug
Lead sponsor: GlaxoSmithKline; Industry
Eligibility: 18 Years and older
Enrollment: 347 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2005
U.S. locations: 45
States / cities: Mesa, Arizona • Phoenix, Arizona • Scottsdale, Arizona + 40 more

Conditions: Schizophrenia and Disorders With Psychotic Features, Tobacco Use Disorder
Interventions: Bupropion, Contingent reinforcement plus placebo, non-contingent reinforcement plus bupropion, Non-contingent reinforcement plus placebo; Drug
Lead sponsor: Brown University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 57 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2003 – 2009
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Nicotine Dependence
Interventions: Bupropion SR, Nicotine Patch, Placebo Patch and Placebo Pill; Drug
Lead sponsor: Southern Illinois University Carbondale; Other
Eligibility: 18 Years to 55 Years
Enrollment: 197 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2013
U.S. locations: 1
States / cities: Carbondale, Illinois

Conditions: Heart Failure, Methamphetamine Use Disorder
Interventions: MUD Management (contingency management +/- adjunctive MUD pharmacotherapy), HF GDMT management; Other
Lead sponsor: University of Southern California; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 2
States / cities: Los Angeles, California

Conditions: Smoking, Smoking Cessation
Interventions: Coordinated Care, Usual Care; Other
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Enrollment: 633 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2015
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: HIV Infections, Depression
Interventions: Bupropion, Placebo; Drug
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older · Male only
Enrollment: 41 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2004
U.S. locations: 2
States / cities: New York, New York

Conditions: Methamphetamine, Amphetamine Dependence, Pharmacogenetics, Methamphetamine Dependence, Substance Abuse
Interventions: Bupropion; Drug
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older
Enrollment: 84 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Acute Coronary Syndrome, Depression
Interventions: Problem Solving Therapy, Sertraline, citalopram, or bupropion, Standard care; Behavioral · Drug · Other
Lead sponsor: Columbia University; Other
Eligibility: 35 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 5
States / cities: New Haven, Connecticut • Atlanta, Georgia • St Louis, Missouri + 2 more

Conditions: Major Depressive Disorder, Nicotine Dependence
Interventions: bupropion and smoking cessation behavioral intervention; Drug
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2007
U.S. locations: 1
States / cities: Stanford, California

Conditions: Smoking Cessation, Alcohol Drinking
Interventions: Nicotine Replacement Therapy, Bupropion, Cognitive Behavioral Treatment, Mobile Contingency Management, Mobile Monitoring; Other · Drug · Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Smoking Cessation
Interventions: High intensity disease management, Low intensity disease management, Comparison group, Bupropion; Behavioral · Drug
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 750 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Kansas City, Kansas

Conditions: Depression
Interventions: Bupropion; Drug
Lead sponsor: Uma Rao; Other
Eligibility: 12 Years to 50 Years
Enrollment: 130 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2014
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Healthy
Interventions: Reference naltrexone 8 mg SR/bupropion 90 mg SR combination trilayer tablets (2 tablets), Test naltrexone 8 mg SR/bupropion 90 mg SR combination trilayer tablets (2 tablets); Drug
Lead sponsor: Orexigen Therapeutics, Inc; Industry
Eligibility: 18 Years to 60 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014
U.S. locations: 1
States / cities: Overland Park, Kansas

Conditions: Nicotine Dependence
Interventions: Zyban; Drug
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 21 Years to 60 Years
Enrollment: 104 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2011
U.S. locations: 1
States / cities: West Los Angeles, California

Conditions: Major Depressive Disorder
Interventions: AXS-05, Bupropion; Drug
Lead sponsor: Axsome Therapeutics, Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 350 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 40
States / cities: Bellflower, California • Lafayette, California • Oceanside, California + 34 more

Search by objective public record fields.

Behavioral and Pharmacologic Treatment of Binge Eating and Obesity: Specialist Treatment

A Stepped Care Approach to Treating Tobacco Use in Rural Veterans

Low-Dose Naltrexone Combined With Bupropion to Stop Smoking With Less Weight Gain

Predictors of Cognitive Outcomes in Geriatric Depression

The Effects of Memantine and Bupropion on Acute, Reinforcing, and Conditioned Effects of Cigarettes - 1

Human Laboratory Study of Varenicline and Bupropion for Nicotine Dependence

Treating Disrupted Sleep in Individuals With Inflammatory Bowel Disease

Paroxetine/Bupropion in Suicide Attempters/Ideators With Major Depression

Studying NMDA and Sigma-1 in Smoking Cessation Treatment (SUMMIT)

Sexual Functioning Study With Antidepressants

Contingent Incentives Plus Bupropion for Smoking in People With Schizophrenia

Nicotine Replacement Therapy (NRT) and Bupropion Mechanisms of Effectiveness in Smokers

Methamphetamine Use Disorder Support in Heart Failure Pilot Study

Connect to Quit for Smoking

Bupropion For Reducing High-Risk Behaviors in Depressed Men Who Have Sex With Men (MSM)

Study of Medical Treatment for Methamphetamine Addiction

Comparison of Depression Interventions After Acute Coronary Syndrome

Treatment of Nicotine Dependence and Acute Depression

Mobile Contingency Management for Concurrent Abstinence From Alcohol and Smoking

Disease Management for Smoking Cessation

Hormone and Sleep Response to Antidepressant Treatment in Adolescents and Adults With Depression

Bioequivalence Study Comparing Naltrexone SR/Bupropion SR Trilayer Tablets From Two Manufacturers

Brain Reaction to Treatment of Nicotine Dependence

A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms