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Showing 1–24 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Caffeine supplement Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Assessment of a Pre-Workout Dietary Supplement

NCT02952014
View directory record Official record
Conditions
Dietary Modification
Interventions
C4 Extreme, C4 Extreme (without Advantra Z, Placebo
Dietary Supplement
Lead sponsor
Texas A&M University
Other
Eligibility
18 Years to 40 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
College Station, Texas
Source: ClinicalTrials.gov public record
Updated Nov 1, 2016 · Synced Sep 10, 2026, 10:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

An Evaluation of the Effects of a Non-Caffeinated Energy Dietary Supplement

NCT04895800
View directory record Official record
Conditions
Health Behavior
Interventions
Phytovive, Placebo, Caffeine
Dietary Supplement
Lead sponsor
Nova Southeastern University
Other
Eligibility
18 Years to 50 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Davie, Florida
Source: ClinicalTrials.gov public record
Updated Jun 8, 2021 · Synced Sep 10, 2026, 10:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of a Thermogenic Dietary Supplement on Metabolic, Hemodynamic, and Mood Responses

NCT03678116
View directory record Official record
Conditions
Energy Metabolism, Heart Rate, Blood Pressure, Mood
Interventions
Sugar Pill (placebo), Caffeine (plus Teacrine and Cayenne), Caffeine (plus Teacrine)
Drug · Dietary Supplement
Lead sponsor
University of Mary Hardin-Baylor
Other
Eligibility
18 Years to 35 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Belton, Texas
Source: ClinicalTrials.gov public record
Updated Mar 27, 2019 · Synced Sep 10, 2026, 10:09 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Licorice Botanical Dietary Supplements - Metabolism and Safety in Women

NCT03948243
View directory record Official record
Conditions
Food-drug Interaction
Interventions
Licorice, Alprazolam 2 MG, Caffeine 100 MG, Tolbutamide 250 mg, Dextromethorphan 30mg
Dietary Supplement · Drug
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
40 Years to 79 Years · Female only
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 5, 2023 · Synced Sep 10, 2026, 10:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pre-workout Supplement Versus Caffeine on Energy Expenditure.

NCT04539054
View directory record Official record
Conditions
Healthy
Interventions
ENGN Shred, Nutricost caffeine powder, Crystal Light
Dietary Supplement
Lead sponsor
Northern Illinois University
Other
Eligibility
19 Years to 29 Years · Male only
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
DeKalb, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 3, 2020 · Synced Sep 10, 2026, 10:09 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Strategies to Augment Ketosis: Ketone Conferred Resiliency Against Sleep Restriction

NCT05519644
View directory record Official record
Conditions
Sleep Deprivation
Interventions
Sleep Deprivation, Heart Rate, Sleep Monitoring, Diet, Exercise Performance, Surveys, McGill Pain Questionnaire, Shortened Profile of Mood States, Pittsburg Sleep Index, Cognitive performance, Marksmanship Performance, Quick Board, Advanced Medical Technologies Inc, Jump Test, CGM/CKM, Blood Draw, Ketone Supplement
Other · Behavioral · Biological + 1 more
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 40 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 31, 2026 · Synced Sep 10, 2026, 10:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Investigation of Dietary Supplement Liquid Shot Products on Mental Energy, Cognition (Acuity),and Mood

NCT06384586
View directory record Official record
Conditions
Cognition, Mental Fatigue, Mood
Interventions
Placebo shot, Functional energy shot
Dietary Supplement
Lead sponsor
The Water Street Collective
Industry
Eligibility
18 Years to 30 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Iselin, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 24, 2024 · Synced Sep 10, 2026, 10:09 PM EDT
Terminated Not applicable Interventional

IDE-ALERTS Continued Access Study

NCT04316481
View directory record Official record
Conditions
Acute Coronary Syndrome
Interventions
AngelMed Guardian System
Device
Lead sponsor
Angel Medical Systems
Industry
Eligibility
21 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Jun 2, 2022 · Synced Sep 10, 2026, 10:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Whole Coffee Fruit Concentrate Pilot Study 1

NCT01965795
View directory record Official record
Conditions
Brain-derived Neurotrophic Factor (BDNF), Cognitive Function, Affect
Interventions
Whole Coffee Fruit Concentrate (WCFC), Nutrim
Dietary Supplement
Lead sponsor
University of California, Los Angeles
Other
Eligibility
40 Years to 55 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 18, 2015 · Synced Sep 10, 2026, 10:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of a Caffeine Blend on Reaction Time, Mental Performance and Focus in Athletic Males

NCT03019523
View directory record Official record
Conditions
Mental Fatigue
Interventions
Caffeine Blend, Sugar Pill
Dietary Supplement · Other
Lead sponsor
University of Mary Hardin-Baylor
Other
Eligibility
18 Years to 25 Years · Male only
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Belton, Texas
Source: ClinicalTrials.gov public record
Updated Jan 24, 2017 · Synced Sep 10, 2026, 10:09 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effects of Neo40(TM) With Caffeine on Cycling Time Trial Performance

NCT01710761
View directory record Official record
Conditions
Healthy
Interventions
Placebo, Nitrate supplement with caffeine
Dietary Supplement
Lead sponsor
University of Texas at Austin
Other
Eligibility
21 Years to 49 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jan 22, 2013 · Synced Sep 10, 2026, 10:09 PM EDT
Not listed Phase 1Phase 2 Interventional Accepts healthy volunteers

Study of the Effects of an Oral Nitric Oxide Supplement on Blood Pressure in Prehypertensive Adults

NCT01937754
View directory record Official record
Conditions
Prehypertension
Interventions
Nitric Oxide supplement, Placebo
Dietary Supplement
Lead sponsor
Neogenis Laboratories
Other
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2013
U.S. locations
1
States / cities
Beverly Hills, California
Source: ClinicalTrials.gov public record
Updated Sep 9, 2013 · Synced Sep 10, 2026, 10:09 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

2021 PMT iAge® Intervention Trial by Edifice Health

NCT04983017
View directory record Official record
Conditions
Chronic Inflammation, Inflammaging
Interventions
Dietary supplement, Placebo
Dietary Supplement · Other
Lead sponsor
Edifice Health
Industry
Eligibility
18 Years and older
Enrollment
781 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
2
States / cities
Greenbrae, California • Suwanee, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Sep 10, 2026, 10:09 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Cocoa-rich Bioflavanol Supplementation Effects During Cold Exposure

NCT04359082
View directory record Official record
Conditions
Cold Exposure, Manual Dexterity, Gut Microbiome
Interventions
CocoaVia supplement, Placebo Pill
Dietary Supplement · Other
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
18 Years to 49 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Natick, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 29, 2021 · Synced Sep 10, 2026, 10:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Whole Coffee Cherry Study

NCT04986956
View directory record Official record
Conditions
Effect of Drug
Interventions
Whole coffee cherry extract, Placebo
Dietary Supplement
Lead sponsor
Auburn University
Other
Eligibility
40 Years to 65 Years
Enrollment
323 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Auburn, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 29, 2024 · Synced Sep 10, 2026, 10:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Guayusa Extract on Exercise Training

NCT05820399
View directory record Official record
Conditions
Desire to Exercise, Exercise Training, Physical Exertion
Interventions
Organic Guayusa Extract, Placebo
Dietary Supplement
Lead sponsor
Nathaniel Jenkins
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Apr 18, 2023 · Synced Sep 10, 2026, 10:09 PM EDT
Not listed Early Phase 1 Interventional Accepts healthy volunteers

Skin Rejuvenation With Topical Extract and Other Nutraceuticals

NCT05734703
View directory record Official record
Conditions
Wrinkle, Spot Pigmented, Lines Skin
Interventions
Nutraceutical Topical
Drug
Lead sponsor
Medical Life Care Planners, LLC
Other
Eligibility
50 Years and older
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Clearwater, Florida
Source: ClinicalTrials.gov public record
Updated Feb 20, 2023 · Synced Sep 10, 2026, 10:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Consumption of 4D Dietary Supplement on Perceptual-Cognitive and Visual-Motor Performance

NCT04988919
View directory record Official record
Conditions
Dietary Supplementation
Interventions
4D, placebo
Dietary Supplement
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years to 40 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Oct 7, 2021 · Synced Sep 10, 2026, 10:09 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers

Assessing the Effectiveness of an N-of-1 Platform Using Study of Cognitive Enhancers

NCT04056650
View directory record Official record
Conditions
Cognitive Performance
Interventions
L-theanine, Caffeine supplement, N1 app
Drug · Dietary Supplement · Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 11, 2021 · Synced Sep 10, 2026, 10:09 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Short-term Effects of Caffeine and a Multi-ingredient Pre-workout on Exercise Performance

NCT07024940
View directory record Official record
Conditions
Coffee, Anthocyanins, Exercise Performance
Interventions
Ethiopian Coffee, Supplement, Water (Placebo)
Other · Dietary Supplement
Lead sponsor
St. Louis University
Other
Eligibility
18 Years to 35 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 18, 2025 · Synced Sep 10, 2026, 10:09 PM EDT
Not yet recruiting Not applicable Interventional

Percepta for Cognitive Optimization

NCT07612449
View directory record Official record
Conditions
Mild Cognitive Impairment (MCI), Memory
Interventions
Percepta, Placebo
Dietary Supplement
Lead sponsor
Cerebrum DAO Association
Other
Eligibility
40 Years to 85 Years
Enrollment
154 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Wilmington, Delaware
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Sep 10, 2026, 10:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Influence of Caffeinated and Non-caffeinated Pre-workout Supplements on Resistance Exercise Performance

NCT04712578
View directory record Official record
Conditions
Resistance Training, Caffeine, Dietary Supplements
Interventions
Caffeinated pre-workout supplement, Non-caffeinated pre-workout supplement, Placebo
Dietary Supplement
Lead sponsor
Texas Tech University
Other
Eligibility
18 Years to 40 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Jun 2, 2021 · Synced Sep 10, 2026, 10:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Changes in Metabolic Rate and Perceptual Indicators After Acute Ingestion of Paraxanthine

NCT05811923
View directory record Official record
Conditions
Metabolic Syndrome, Caffeine
Interventions
Venous Blood Collection, Resting Metabolic Rate Determination, Mood State, Visual Analog Scales
Other
Lead sponsor
Lindenwood University
Other
Eligibility
18 Years to 39 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Saint Charles, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 12, 2023 · Synced Sep 10, 2026, 10:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of AMATEA™️ on Physiological Measures and Gaming Performance in Active Gamers: a Placebo Controlled, Double-blind, Randomized Study

NCT04234529
View directory record Official record
Conditions
Healthy
Interventions
AMATEA™, Caffeine, Placebo
Dietary Supplement · Other
Lead sponsor
University of Memphis
Other
Eligibility
18 Years to 40 Years
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 8, 2021 · Synced Sep 10, 2026, 10:09 PM EDT