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ClinicalTrials.gov public records Last synced Nov 15, 2026, 5:25 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 91 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Carbohydrate restricted dietary intervention Clear all

Conditions: Breast Cancer
Interventions: Carbohydrate restricted dietary intervention, standard of care aromatase inhibitors; Other · Drug
Lead sponsor: Farin Amersi; Other
Eligibility: 18 Years and older · Female only
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Prediabetes, Healthy (Controls)
Interventions: Ketone Monoester (KE), Placebo; Dietary Supplement
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 60 Years to 75 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 2
States / cities: Birmingham, Alabama

Conditions: Obesity
Interventions: Low-Carbohydrate Diet, Intermittent Energy Restriction, Hunger Training; Behavioral
Lead sponsor: University of Arizona; Other
Eligibility: 18 Years and older
Enrollment: 9 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Tucson, Arizona

Conditions: Bipolar I Disorder, Psychosis, Schizoaffective Disorder
Interventions: Ketogenic diet, Dietary Guidelines for Americans; Other
Lead sponsor: Mclean Hospital; Other
Eligibility: 18 Years to 45 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Belmont, Massachusetts

Conditions: Diabetes Mellitus, Type 2, Diabetes Mellitus Type 2 in Obese
Interventions: low-fat vegan diet; Behavioral
Lead sponsor: Physicians Committee for Responsible Medicine; Other
Eligibility: 18 Years and older
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Heart Failure, Diabetes Mellitus
Interventions: 12-week supervised weight loss intervention; Procedure
Lead sponsor: University of California, Irvine; Other
Eligibility: 18 Years and older
Enrollment: 78 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2015
U.S. locations: 1
States / cities: Orange, California

Conditions: Microbiota, Cancer
Interventions: DASH Diet, standard American diet; Behavioral
Lead sponsor: H. Lee Moffitt Cancer Center and Research Institute; Other
Eligibility: 19 Years to 65 Years
Enrollment: 115 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Obesity, Ketogenic Dieting, Metabolic Syndrome, Bipolar Disorder, Schizophrenia, Weight Gain, Psychotropic Agents Causing Adverse Effects in Therapeutic Use, Brain Metabolic Disorder
Interventions: LCHF, Ketogenic Diet; Other
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Stanford, California

Conditions: Amputation, Phantom Limb Pain, Residual Limb Pain
Interventions: Low-Carbohydrate Diet; Behavioral
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years to 65 Years
Enrollment: 28 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Cardiovascular Diseases
Interventions: Ketogenic Diet; Other
Lead sponsor: Penn State University; Other
Eligibility: 25 Years to 45 Years
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: University Park, Pennsylvania

Conditions: Metabolic Syndrome, Obesity, Dyslipidemias
Interventions: Carbohydrate restricted group, Standard low fat diet; Other
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 10 Years to 18 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 2
States / cities: Birmingham, Alabama

Conditions: Breast Cancer
Interventions: Carbohydrate restricted dietary intervention, standard of care aromatase inhibitors; Other · Drug
Lead sponsor: Monica Mita; Other
Eligibility: 18 Years and older · Female only
Enrollment: 2 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Intra-Abdominal Fat
Interventions: IER+MED, MED/DER; Behavioral
Lead sponsor: University of Hawaii; Other
Eligibility: 35 Years to 69 Years
Enrollment: 260 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Honolulu, Hawaii

Conditions: Ketogenic Diet, Alcohol Drinking, Alcohol Use Disorder, Magnetic Resonance Imaging, Alcohol Intoxication
Interventions: Ketogenic diet; Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: 21 Years to 50 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Childhood Obesity
Interventions: TRE Group; Behavioral
Lead sponsor: University of Minnesota; Other
Eligibility: 3 Years and older
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Traumatic Brain Injury
Interventions: Ketogenic Diet; Other
Lead sponsor: Gillette Children's Specialty Healthcare; Other
Eligibility: 2 Years to 17 Years
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 2
States / cities: Minneapolis, Minnesota • Saint Paul, Minnesota

Conditions: Sleep Deprivation, Nutritional Intervention
Interventions: Ketogenic Intervention, Mediterranean Intervention, Placebo, Ketone Ester; Other · Dietary Supplement
Lead sponsor: Ohio State University; Other
Eligibility: 18 Years to 40 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Prostate Cancer
Interventions: Low carbohydrate diet; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 20 Years and older · Male only
Enrollment: 83 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2018
U.S. locations: 3
States / cities: Los Angeles, California • Durham, North Carolina

Conditions: B-cell Acute Lymphoblastic Leukemia, Obesity
Interventions: IDEAL2 Intervention; Behavioral
Lead sponsor: Etan Orgel; Other
Eligibility: 7 Years to 25 Years
Enrollment: 240 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2032
U.S. locations: 16
States / cities: Los Angeles, California • Orange, California • San Francisco, California + 13 more

Conditions: Healthy
Interventions: FDG, Ketone Drink, Ketogenetic Diet; Drug · Dietary Supplement · Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Mild Cognitive Impairment, Metabolic Syndrome
Interventions: Dietary intervention; Behavioral
Lead sponsor: Bristlecone Health, Inc.; Industry
Eligibility: 35 Years to 80 Years
Enrollment: 98 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Maple Grove, Minnesota

Conditions: NAFLD, Fatty Liver, Obesity, Metabolic Syndrome
Interventions: Diet Intervention; Other
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 11 Years to 17 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Human Immunodeficiency Virus (HIV) Infection, Hypercholesterolemia
Interventions: Soy Pretzel, Wheat Pretzel; Dietary Supplement · Other
Lead sponsor: Ohio State University; Other
Eligibility: 18 Years and older
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2023
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Diet Modification, Lung Cancer
Interventions: Special Diet Therapy (low-carb), Special Diet Therapy (low-fat), Special Diet Therapy (USDA control); Behavioral
Lead sponsor: Fred Hutchinson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Seattle, Washington

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BREADS: Breast Adjuvant Diet Study

Effects of Exogenous Ketones on Cognitive Function in Older Adults With Prediabetes?

Testing the Effect of Multiple Weight Management Modalities for Chronic Disease Risk Reduction in a Clinical Setting

Ketogenic and Nutritional Interventions for First Episode Bipolar Disorder

The Effect of a Low-fat Vegan Dietary Intervention on Intracellular Lipid, Insulin Sensitivity, and Glycemic Control in Type 2 Diabetes

Effects of a High Protein Diet on Clinical Outcomes in Heart Failure

DASH INtervention to INvestigate the Gut

Impact of a Ketogenic Diet on Metabolic and Psychiatric Health in Patients With Bipolar or Schizophrenia Illness

The Pain in Amputees Reduced by Administration of Diet Examination

Ketogenic Diet in Healthy Adults With Differing BMI

Effect of Low Carbohydrate Versus Low Fat Diet in the Treatment of Dyslipidemia in Obese Children With Metabolic Syndrome

NEOBREADS: Neoadjuvant Breast Diet Study

The Healthy Diet and Lifestyle Study II

Effects of Ketogenic Diet on Alcohol Intoxication

Piloting a Family-Based Intervention of Time-Restricted Eating to Treat Obesity

Ketogenic Diet Following Moderate to Severe Pediatric Traumatic Brain Injury

Ketone Conferred Resiliency Against Sleep Restriction With Nutritional Intervention.

Carbohydrate Restriction and Prostate Cancer Growth

Caloric Restriction and Activity to Reduce Chemoresistance in B-ALL

Comparison of the Short-Term Effect of Dietary Carbohydrate Restriction Versus Exogenous Ketone Supplementation on Myocardial Glucose Suppression and Timing to Achieve a State of Ketosis Using FDG PET/CT Serial Imaging

Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation

Low Carbohydrate Diet: The Effects on Non Alcoholic Fatty Liver Disease in Obese Teens With Metabolic Syndrome

Soy Modulation of Immune Activation, LDL- Levels, and Lowering Inflammation by Pretzel Isoflavone Dietary Intervention

Reducing Insulin, Growth Hormones, and Tumors