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ClinicalTrials.gov public records Last synced Oct 18, 2026, 12:09 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 1,537 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Challenges Clear all
Recruiting No phase listed Observational

Evaluation of Patients With Non-obstructive Coronary Arteries

NCT00823563
View directory record Official record
Conditions
Chest Pain, Ischemia
Interventions
30 cc blood draw, Intravascular ultrasound (IVUS), Coronary pressure/flow wire testing, Coronary pressure/flow testing: Acetycholine challenge, Procedure: Coronary pressure/flow testing: Nitroglycerin challenge, Procedure: Procedure: Coronary pressure/flow testing: Adenosine challenge
Procedure
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2047
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jun 5, 2025 · Synced Oct 18, 2026, 12:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

AFRI Childhood Obesity Prevention Challenge Area

NCT04469816
View directory record Official record
Conditions
Clinical Trial
Interventions
Family Check-Up 4 Health, Services as Usual
Behavioral · Other
Lead sponsor
Arizona State University
Other
Eligibility
2 Years to 5 Years
Enrollment
217 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2024
U.S. locations
4
States / cities
Avondale, Arizona • Tempe, Arizona
Source: ClinicalTrials.gov public record
Updated May 25, 2025 · Synced Oct 18, 2026, 12:09 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Diagnosis of Gestational Diabetes Based on a 50-gram Glucose Challenge

NCT07643987
View directory record Official record
Conditions
Abnormal Glucose Complicating Pregnancy
Interventions
Not listed
Lead sponsor
Methodist Health System
Other
Eligibility
18 Years and older · Female only
Enrollment
351 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jun 12, 2026 · Synced Oct 18, 2026, 12:09 PM EDT
Completed Not applicable Interventional

T Cell Receptor (TCR) Sequencing and Transcriptional Profiling in Adult Celiac Disease Patients Undergoing Gluten Challenge

NCT04614571
View directory record Official record
Conditions
Celiac Disease
Interventions
Gluten Powder
Dietary Supplement
Lead sponsor
Regeneron Pharmaceuticals
Industry
Eligibility
18 Years to 75 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 27, 2024 · Synced Oct 18, 2026, 12:09 PM EDT
Completed Early Phase 1 Interventional Results available

Pilot Study on Mindfulness for Tobacco and Alcohol in University Students

NCT01679236
View directory record Official record
Conditions
Nicotine Dependence, Alcohol Use
Interventions
Mindfulness Training for Smokers, Interactive Learning for Smokers
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 29 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 24, 2014 · Synced Oct 18, 2026, 12:09 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Homologous Re-infection With Dengue 1 or Dengue 3

NCT05967455
View directory record Official record
Conditions
Dengue
Interventions
Dengue virus 1 Live Virus Human Challenge (DENV-1-LVHC), Dengue virus 3 Live Virus Human Challenge (DENV-3-LVHC)
Biological
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years to 55 Years
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Nov 13, 2024 · Synced Oct 18, 2026, 12:09 PM EDT
Not yet recruiting Not applicable Interventional

Supporting Older Adults Remotely

NCT07878169
View directory record Official record
Conditions
Severe Mental Illness
Interventions
Supporting Older Adults Remotely (SOAR), Peer support as usual
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
50 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 16, 2026 · Synced Oct 18, 2026, 12:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Pitt Center for Emergency Responder Wellness

NCT05357586
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Depression, Anxiety, Alcohol Use Disorder
Interventions
Unified Protocol for Transdiagnostic Treatment of Emotional Disorders
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 20, 2024 · Synced Oct 18, 2026, 12:09 PM EDT
Completed Not applicable Interventional

Gestational Diabetes Diagnostic Methods

NCT01540396
View directory record Official record
Conditions
Gestational Diabetes
Interventions
Dietary modification and medications
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 4, 2016 · Synced Oct 18, 2026, 12:09 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Study to Assess the Electrophysiology, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Response Using Magnetic Resonance Imaging of SAGE-718 Using a Ketamine Challenge in Healthy Subjects

NCT03770780
View directory record Official record
Conditions
Healthy Volunteer
Interventions
SAGE-718, Placebo
Drug
Lead sponsor
Supernus Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
2
States / cities
Long Beach, California • Berlin, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 17, 2025 · Synced Oct 18, 2026, 12:09 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Observational Digital Biomarker Discovery in Respiratory Virus Challenge Studies

NCT04772170
View directory record Official record
Conditions
Influenza, Respiratory Virus, Coronavirus
Interventions
Not listed
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 65 Years
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Oct 18, 2026, 12:09 PM EDT
Completed Phase 4 Interventional Results available

Evaluation of the Efficacy of Topical Ophthalmic Steroids in a Modified Conjunctival Allergen Challenge (CAC) Model

NCT00689078
View directory record Official record
Conditions
Allergic Conjunctivitis
Interventions
Prednisolone Acetate 1%, Prednisolone Acetate 0.12%, Loteprednol Etabonate 0.2%, Placebo
Drug
Lead sponsor
ORA, Inc.
Industry
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
Andover, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 2, 2020 · Synced Oct 18, 2026, 12:09 PM EDT
Completed Not applicable Interventional

Impact of Cognitive Behavioral Therapy on PTSD-CVD Link

NCT06429293
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Cognitive processing therapy
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 18, 2026, 12:09 PM EDT
Completed Not applicable Interventional

The Impact of Routine Follow-up Contacts After a Pediatric ED Visit for Youth With Suicide Risk

NCT06616701
View directory record Official record
Conditions
Suicidal Ideation
Interventions
Follow up call
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
8 Years to 21 Years
Enrollment
401 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 25, 2025 · Synced Oct 18, 2026, 12:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

30-to-90 Day Challenge: Effects of Alcohol Cessation on Health Outcomes

NCT03353701
View directory record Official record
Conditions
Alcohol Drinking, Chronic Inflammation, Neurocognitive Dysfunction, Liver Diseases, HIV Infections
Interventions
Contingency Management (CM)
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
50 Years to 75 Years
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2024
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Sep 3, 2024 · Synced Oct 18, 2026, 12:09 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Diagnostic Challenges in IC (and Male CPPS)

NCT00672087
View directory record Official record
Conditions
Chronic Prostatitis With Chronic Pelvic Pain Syndrome, Chronic Bacterial Prostatitis, Asymptomatic Inflammatory Prostatitis, Painful Bladder Syndrome, Cystitis, Interstitial
Interventions
Genomic and proteomic biomarker discovery
Genetic
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 4, 2020 · Synced Oct 18, 2026, 12:09 PM EDT
Completed No phase listed Observational

The Heroes Circle Opioid Project

NCT03595007
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
Kids Kicking Cancer program
Behavioral
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 75 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 30, 2024 · Synced Oct 18, 2026, 12:09 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Dose Escalation PfSPZ-CVac

NCT03083847
View directory record Official record
Conditions
Malaria
Interventions
Chloroquine Phosphate, Pyrimethamine, Sanaria PfSPZ Challenge
Drug · Biological
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 50 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 1, 2021 · Synced Oct 18, 2026, 12:09 PM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Assessment Of The Effects Of Single Doses Of An Investigational Drug, Given Alone Or With Donepezil, On Scopolamine-Induced Changes In Memory And Learning In Healthy Adults

NCT01345864
View directory record Official record
Conditions
Healthy
Interventions
Scopolamine + Donepezil Placebo + PF-04995274 Placebo, Scopolamine + Donepezil 5 mg + PF-04995274 Placebo, Scopolamine + Donepezil 10mg + PF-04995274 Placebo, Scopolamine + Donepezil Placebo + PF-04995274 0.25 mg, Scopolamine + Donepezil Placebo + PF-04995274 15 mg
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 55 Years
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 17, 2011 · Synced Oct 18, 2026, 12:09 PM EDT
Completed Not applicable Interventional

OT Intervention Via Telehealth for Children With ASD and ADHD

NCT03957993
View directory record Official record
Conditions
Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder
Interventions
Occupational Therapy via Telehealth, Standard of Care Occupational Therapy
Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
4 Years to 18 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 16, 2020 · Synced Oct 18, 2026, 12:09 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

PfSPZ Vaccine: Dose Optimization With Heterologous Challenge in Healthy Malaria-Naïve Adults

NCT02601716
View directory record Official record
Conditions
Malaria
Interventions
PfSPZ Vaccine, CHMI (7G8), CHMI (NF135.C10)
Biological
Lead sponsor
Sanaria Inc.
Industry
Eligibility
18 Years to 50 Years
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
2
States / cities
Baltimore, Maryland • Silver Spring, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 16, 2018 · Synced Oct 18, 2026, 12:09 PM EDT
Not yet recruiting Not applicable Interventional

Scaling Out S.A.F.E. Firearm Across Two Health Systems as a Universal Suicide Prevention Strategy (SCALE ASPIRE)

NCT07009314
View directory record Official record
Conditions
Suicide
Interventions
Implementation package (training, facilitation, electronic health record nudge)
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
5,442 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2029
U.S. locations
2
States / cities
Aurora, Colorado • Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 18, 2026 · Synced Oct 18, 2026, 12:09 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Factors Involved in Asthma and Airway Inflammation

NCT00001887
View directory record Official record
Conditions
Asthma, Healthy
Interventions
Not listed
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
Not listed
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2001
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 18, 2026, 12:09 PM EDT
Completed Not applicable Interventional Results available

Implementation of Smoking Cessation Within NCI Community Oncology Research Program (NCORP) Sites

NCT03291587
View directory record Official record
Conditions
Smoking Cessation
Interventions
Personnel Training and Coaching Calls
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
1,094 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
49
States / cities
Newark, Delaware • Augusta, Georgia • Savannah, Georgia + 36 more
Source: ClinicalTrials.gov public record
Updated Jul 25, 2022 · Synced Oct 18, 2026, 12:09 PM EDT