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ClinicalTrials.gov public records Last synced Nov 6, 2026, 12:41 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 208 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Circadin Clear all

Conditions: Depression, Brain Injuries, Traumatic
Interventions: Buspirone, Mealatonin; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 64 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2028
U.S. locations: 2
States / cities: Boston, Massachusetts • Charlestown, Massachusetts

Conditions: Opioid Withdrawal, Opioid Use Disorder
Interventions: EmbracePlus Smartwatch, Corti Sensor; Device
Lead sponsor: Spark Biomedical, Inc.; Industry
Eligibility: 18 Years to 50 Years
Enrollment: 20 participants
Timeline: 2025 – 2027
U.S. locations: 2
States / cities: Center City, Minnesota • Columbus, Ohio

Conditions: Blindness
Interventions: Melatonin, Melatonin; Dietary Supplement · Biological
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 5 Years to 20 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2015
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Metabolic Syndrome, PreDiabetes, Hypertension, Obesity, Hyperlipidemias
Interventions: Exercise; Behavioral
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 19 Years to 45 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Long COVID, Long COVID-19, Hypersomnia, Sleep Disturbance
Interventions: Modafinil, Modafinil Placebo, Solriamfetol, Solriamfetol Placebo, Melatonin, Melantonin Placebo, Tailored lighting (TL) Active, Tailored lighting (TL) Placebo; Drug · Device
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 830 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 47
States / cities: Phoenix, Arizona • Tucson, Arizona • Palo Alto, California + 31 more

Conditions: ADHD - Attention Deficit Disorder With Hyperactivity, ADHD
Interventions: Not listed
Lead sponsor: Duke University; Other
Eligibility: 6 Years to 9 Years
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Sleep Disturbances
Interventions: Blue light, Red light; Other
Lead sponsor: Rensselaer Polytechnic Institute; Other
Eligibility: 65 Years and older
Enrollment: 46 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Troy, New York

Conditions: Breast Cancer
Interventions: Melatonin 3 mg; Drug
Lead sponsor: Dana-Farber Cancer Institute; Other
Eligibility: 18 Years and older · Female only
Enrollment: 95 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 2
States / cities: Boston, Massachusetts

Conditions: Sleep, Fatigue, Anxiety, Cancer, Depression
Interventions: Melatonin, Placebo for Melatonin, Methylphenidate; Drug · Other
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 169 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Circadian Rhythm Sleep Disorders, Non-24 Hour Sleep-Wake Disorder, Autism Spectrum Disorder, Smith-Magenis Syndrome
Interventions: tasimelteon; Drug
Lead sponsor: Vanda Pharmaceuticals; Industry
Eligibility: 3 Years to 17 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Sleep Disorders in Children
Interventions: Melatonin, Placebo; Dietary Supplement · Other
Lead sponsor: Loma Linda University; Other
Eligibility: 13 Years to 17 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 2
States / cities: Loma Linda, California

Conditions: Insomnia, Brain Injury
Interventions: Ramelteon, Placebo; Drug · Dietary Supplement
Lead sponsor: Kessler Foundation; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: West Orange, New Jersey

Conditions: Phenylketonuria (PKU)
Interventions: Kuvan, Large Neutral Amino Acid Therapy; Drug · Dietary Supplement
Lead sponsor: University of Southern California; Other
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Huntington Disease
Interventions: Melatonin, Placebo; Dietary Supplement · Other
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years to 75 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Dyspepsia
Interventions: Melatonin, Placebo; Dietary Supplement
Lead sponsor: Children's Mercy Hospital Kansas City; Other
Eligibility: 8 Years to 17 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Kansas City, Missouri

Conditions: Pain After TJA
Interventions: Melatonin 5 mg, Placebo Oral Tablet, Magnesium 500Mg Oral Tablet; Drug
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 99 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Stanford, California

Conditions: Sleep Deprivation, Critical Illness, Sleep-Wake Disorders, Bundle Care, Implementation Science, Delirium
Interventions: Nighttime noise & light reduction, Clustering patient-care interactions, Non-pharmacologic sleep aids, Daytime light exposure, Encourage out-of-bed activity, Medication management to support nighttime sleep; Behavioral · Other
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 62,500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 7
States / cities: La Jolla, California • San Francisco, California • Orlando, Florida + 4 more

Conditions: Prehypertension, Healthy
Interventions: melatonin; Dietary Supplement
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 18 Years and older
Enrollment: 31 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Normal Physiology
Interventions: Pupillometry, Light box exposure; Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 85 Years
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: PreDiabetes, Obesity, Inactivity/Low Levels of Exercise
Interventions: AM Exercise, PM Exercise; Behavioral
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 20 Years to 40 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Insomnia, Insomnia Disorder, Chronic Insomnia, Chronic Insomnia Disorder
Interventions: Sleep Hygiene Education, Melatonin IR, 3 mg, Melatonin IR, 5 mg, Diphenhydramine, 25 mg, Diphenhydramine, 50 mg, Doxepin, 3 mg, Doxepin, 6 mg, Trazodone, 50 mg, Trazodone, 100 mg, Placebo, Zolpidem, 5 mg, Zolpidem, 10 mg; Other · Dietary Supplement · Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 80 Years
Enrollment: 1,200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2032
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Traumatic Brain Injury, Critical Illness, Sleep
Interventions: melatonin, placebo; Drug · Other
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 6 Years to 18 Years
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Insomnia
Interventions: Light Exposure, Placebo; Other
Lead sponsor: Northwestern University; Other
Eligibility: 55 Years and older
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2029
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Sleep
Interventions: Melatonin; Dietary Supplement
Lead sponsor: University of Redlands; Other
Eligibility: 18 Years to 21 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Redlands, California

Search by objective public record fields.

Buspirone and Melatonin for Depression Following Traumatic Brain Injury

Sensing Physiological Symptoms of Opioid Withdrawal and Cravings in Patients With Opioid Use Disorder

Blind Child Melatonin Treatment Study

Exercise, Sleep Quality and Nocturnal Fat Oxidation in Metabolic Syndrome

RECOVER-SLEEP: Platform Protocol

Advancing Identification of Circadian Delay in ADHD Youth: Associations With Clinical Heterogeneity and Cognition

Individually Tailored Lighting System to Improve Sleep in Older Adults

Melatonin Versus Placebo in Breast Cancer

Combination Therapy for Treatment of Sleep Disturbance in Patients With Advanced Cancer

Study of the Pharmacokinetics and Safety of Tasimelteon in Children and Adolescents

Melatonin Adolescent Research Study

Effect of Rozerem on Sleep Among People With Traumatic Brain Injury

Effects of Kuvan on Melatonin Secretion

Melatonin for Huntington's Disease (HD) Gene Carriers With HD Related Sleep Disturbance - a Pilot Study

Melatonin in Pediatric FD Population

Improving Sleep Quality After Total Joint Arthroplasty ( TJA)

Sleep Harmonization Via Bundled Team-Based Interventions in the ICU

Effects and Mechanisms of Melatonin on Blood Pressure, Insulin Resistance, and Platelets

Impact of Sex and Age on Non-visual Light Input That Affects Sleep and Circadian Rhythms

Examining the Effects of Morning and Evening Exercise on Glucose Regulation in Adults With Prediabetes

A SMART Approach to Evaluating the Benefits of Common Prescription and OTC Medications for Insomnia

Sleep Management And Recovery After Traumatic Brain Injury in Kids: Pilot Intervention of Melatonin

Noradrenergic Dysregulation, Sleep and Cognition in Older Adults With Insomnia

Pharmacokinetics of Melatonin Administered in Oral, Lotion, and Bubble Bath Formulations