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ClinicalTrials.gov public records Last synced Sep 4, 2026, 10:28 PM EDT

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Showing 1–14 of 14 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Closed loop auditory stimulation Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Optimizing Brain Excitability in Depression

NCT07242105
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Active Single-Pulse TMS, Sham Single-Pulse TMS, TARGET-optimized TMS, Non-optimized (Open-Loop) TMS, EEG Recording, Intracranial EEG (iEEG) Recording
Device · Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 65 Years
Enrollment
145 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
2
States / cities
Iowa City, California • Stanford, California
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Sep 4, 2026, 10:28 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Sleep Spindles and Memory in Rolandic Epilepsy

NCT04569708
View directory record Official record
Conditions
Rolandic Epilepsy, Rolandic Epilepsy, Benign, Centrotemporal Epilepsy, Centrotemporal; EEG Spikes, Epilepsy of Childhood, Epilepsy; Seizure, Epilepsy
Interventions
Closed loop auditory stimulation
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
4 Years to 18 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Sep 4, 2026, 10:28 PM EDT
Recruiting Not applicable Interventional

A Novel Digital Music-based Autonomous Personalized Walking Intervention to Improve Gait and Walking Automaticity in Parkinson Disease

NCT07705373
View directory record Official record
Conditions
Parkinson's Disease (PD)
Interventions
MR-005 (MedRhythms, Inc., Portland, ME)
Device
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
40 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
3
States / cities
Boston, Massachusetts • St Louis, Missouri • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 23, 2026 · Synced Sep 4, 2026, 10:28 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Personalized Performance Optimization Platform

NCT06979570
View directory record Official record
Conditions
Sensory Science, Performance Assessment, Countermeasure Evaluation, Neurocognitive Function, Psychological Factors
Interventions
AttentivU
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 64 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
2
States / cities
Cambridge, Massachusetts • Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Sep 4, 2026, 10:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Slow-wave Enhancement in Adults Aged 30-49

NCT04611828
View directory record Official record
Conditions
Sleep
Interventions
Philips SmartSleep
Device
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
30 Years to 49 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jan 27, 2021 · Synced Sep 4, 2026, 10:28 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Restoring Spindle and Thalamocortical Efficiency in Early-Course Schizophrenia Patients Using Auditory Stimulation

NCT05956951
View directory record Official record
Conditions
Schizophrenia
Interventions
Closed-loop auditory stimulation, Sham auditory stimulation
Device
Lead sponsor
Fabio Ferrarelli
Other
Eligibility
18 Years to 40 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Sep 4, 2026, 10:28 PM EDT
Completed Not applicable Interventional Results available

HIRREM Hot Flashes Study

NCT03512002
View directory record Official record
Conditions
Vasomotor Symptoms, Hot Flashes, Menopause
Interventions
HIRREM, Continued Current Care
Device · Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
40 Years and older · Female only
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated May 22, 2023 · Synced Sep 4, 2026, 10:28 PM EDT
Completed Not applicable Interventional Results available

HIRREM in Military Personnel

NCT03230890
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
HIRREM
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 13, 2023 · Synced Sep 4, 2026, 10:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Closed Loop Acoustic Stimulation During Sedation With Dexmedetomidine

NCT04206059
View directory record Official record
Conditions
Sleep, Sedation Complication
Interventions
MRI, Quantitative Sensory Testing (QST), Home sleep study, Acoustic stimulation (65 decibels or db) up-slope of EEG with QST, Acoustic stimulation (65db) down-slope of EEG with QST, 0 db with QST, Dexmedetomidine, Breathe-Squeeze Task
Radiation · Diagnostic Test · Other + 1 more
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 40 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Sep 4, 2026, 10:28 PM EDT
Completed Not applicable Interventional Results available

HIRREM Developmental Study

NCT02709369
View directory record Official record
Conditions
Sleep Initiation and Maintenance Disorders, Anxiety, Post-Traumatic Stress Disorder, Hot Flashes, Headache, Traumatic Brain Injury, Post Concussion Symptoms
Interventions
HIRREM
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
11 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 23, 2019 · Synced Sep 4, 2026, 10:28 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Effects of Auditory Stimulation During Sleep on Brain Networks in Schizophrenia

NCT06386588
View directory record Official record
Conditions
Schizophrenia
Interventions
Closed loop auditory stimulation during sleep
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 45 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 13, 2025 · Synced Sep 4, 2026, 10:28 PM EDT
Completed Not applicable Interventional Results available

Study of the Effects of HIRREM-SOP for Insomnia

NCT03607994
View directory record Official record
Conditions
Insomnia, Sleep Deprivation
Interventions
HIRREM-SOP, NCC
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 30, 2022 · Synced Sep 4, 2026, 10:28 PM EDT
Completed Not applicable Interventional Results available

HIRREM for Stage 1 Primary Hypertension

NCT03479697
View directory record Official record
Conditions
Hypertension, Blood Pressure, Cardiovascular Diseases, Cardiovascular Risk Factor, Autonomic Nervous System Imbalance
Interventions
HIRREM, Continued Current Care
Device · Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 19, 2023 · Synced Sep 4, 2026, 10:28 PM EDT
Active, not recruiting Not applicable Interventional

Neurotechnology Following Traumatic Brain Injury

NCT03649958
View directory record Official record
Conditions
Post-Concussion Symptoms, Insomnia, Pain, Chronic, Depressive Symptoms
Interventions
HIRREM-SOP or Cereset, Cereset 2x
Device
Lead sponsor
Brain State Technologies, LLC
Industry
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
2
States / cities
Bethesda, Maryland • Fort Bragg, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 13, 2023 · Synced Sep 4, 2026, 10:28 PM EDT